Ftase inhibitor I(Synonyms: B581)

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Ftase inhibitor I (Synonyms: B581)

Ftase inhibitor I (B581) 是一种有效的,选择性的拟肽法尼基转移酶 FTase 抑制剂。Ftase inhibitor I 对 FTase 的选择性优于香叶基香叶基类异戊二烯 (Ras-GG) 或脂肪酸肉豆蔻酸酯 (Myr-Ras)

Ftase inhibitor I(Synonyms: B581)

Ftase inhibitor I Chemical Structure

CAS No. : 149759-96-6

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生物活性

Ftase inhibitor I (B581) is a potent, selective and peptidomimetic farnesyl transferase (FTase) inhibitor. Ftase inhibitor I shows selectivity for FTase over geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)[1].

体外研究
(In Vitro)

Ftase inhibitor I (B581) inhibits the ability of only Ras-F-transformed cells, but not geranylgeranyl isoprenoid (Ras-GG) or the fatty acid myristate (Myr-Ras)- (or Raf-) transformed cells, to grow in soft agar[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

470.69

Formula

C22H38N4O3S2

CAS 号

149759-96-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. A D Cox, et al. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. J Biol Chem. 1994 Jul 29;269(30):19203-6.

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