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HS-1793
HS-1793 是一种 resveratrol 类似物，在多种癌细胞中具有抗肿瘤 (antitumor) 活性。HS-1793 诱导细胞凋亡 (apoptosis)。
HS-1793 Chemical Structure
CAS No. : 927885-00-5
| 规格 |
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是否有货 |
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| 100 mg |
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询价 |
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| 250 mg |
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询价 |
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| 500 mg |
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询价 |
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* Please select Quantity before adding items.
| 生物活性 |
HS-1793 is a resveratrol analogue with antitumor activities in a variety of cancer cell lines[1]. HS-1793 induces cell apoptosis[2].
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体外研究
(In Vitro) |
HS-1793 (0-100 µM, 24 h) suppresses proliferation of MCF-7, MDA-MB-231 and HCT116 cells[1][2].
HS-1793 (0-50 µM, 4 h) inhibits hypoxia-induced HIF-1α protein in MCF-7 and MDA-MB-231 cells unrelated to cell death, downregulates hypoxia-induced VEGF expression, and suppresses hypoxia-induced mRNA expression of VEGF at the transcriptional level[1].
HS-1793 (0-100 µM, 24 h) induces apoptosis, promotes G2/M cell cycle arrest, and inhibits Akt and ERK phosphorylation in HCT116 cells[2].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay[1]
| Cell Line: |
MCF-7, MDA-MB-231 and MCF-10A |
| Concentration: |
0-100 μM |
| Incubation Time: |
24 h |
| Result: |
Showed antiproliferation activity with IC50 values of 26.3±3.2, 48.2±4.2 and >100 μM against MCF-7, MDA-MB-231 and MCF-10A, respectively. |
Western Blot Analysis[1]
| Cell Line: |
MCF-7, MDA-MB-231 |
| Concentration: |
12.5, 25 and 50 μM |
| Incubation Time: |
4 h |
| Result: |
Downregulated HIF-1α expression in a concentration-dependent manner in both cell lines. |
RT-PCR[1]
| Cell Line: |
MCF-7, MDA-MB-231 |
| Concentration: |
12.5, 25 and 50 μM |
| Incubation Time: |
4 h |
| Result: |
Downregulated the expression of VEGF mRNA, with the more marked results observed in MDA-MB-231 cells. |
Cell Proliferation Assay[2]
| Cell Line: |
HCT116 |
| Concentration: |
12.5, 25, 50 and 100 µM |
| Incubation Time: |
1, 2 and 4 days |
| Result: |
Significantly reduced the cell viability concentration- and time-dependently. Significantly suppressed proliferation of colon cancer cell line HCT116. |
Apoptosis Analysis[2]
| Cell Line: |
HCT116 |
| Concentration: |
12.5, 25, 50 and 100 µM |
| Incubation Time: |
24 h |
| Result: |
Induced cell apoptosis in a dose-dependent manner. Caused chromatin condensation and fragmentation. |
Western Blot Analysis[2]
| Cell Line: |
HCT116 |
| Concentration: |
12.5, 25, 50 and 100 µM |
| Incubation Time: |
24 h |
| Result: |
Effectively induced the reduction of pro-caspase-8 and pro-caspase-3 at 100 µM. Activated caspase-8 and caspase-3. Caused the PARP cleavage. Slightly downregulated the level of antiapoptotic protein Bcl-2 at 100 µM. Promoted an increase in the release of cytochrome c from the mitochondria into the cytosol. Decreased the expression of G2/M cell cycle regulatory protein cyclin B1, Cdc2 and Cdc25C. Decreased the level of CDK4 and CDK6. Decreased Akt phosphorylation and reduced total Akt at high-concentration. Decreased the phosphorylation of ERK1/2 without affecting the protein level. |
Cell Cycle Analysis[2]
| Cell Line: |
HCT116 |
| Concentration: |
12.5, 25 and 50 µM |
| Incubation Time: |
24 h |
| Result: |
Induced the accumulation of cells in the G2/M phase in a concentration-dependent manner. |
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体内研究
(In Vivo) |
HS-1793 (5 and 10 mg/kg; i.p.; twice a week, 4 weeks) significantly inhibits MDA-MB-231 xenograft tumor growth and in a dose-dependent manner and relatively hampers angiogenesis with non-toxicity[1].
Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: |
Five-week-old female BALB/c nude mice injected with MDA-MB-231 cells[1] |
| Dosage: |
5 mg/kg and 10 mg/kg (dissolved in PBS containing 0.1% v/v dimethyl sulfoxide (DMSO)) |
| Administration: |
Intraperitoneal injection, twice a week, 4 weeks |
| Result: |
Significantly inhibited MDA-MB-231 xenograft tumor growth in a dose-dependent manner with non-toxicity. Significantly lowered Ki-67 (a proliferation marker) and CD31 expression. Successfully suppressed the expression of HIF-1α and VEGF in tumor tissues. |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis.
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| 参考文献 |
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[1]. Kim DH, et al. HS-1793, a resveratrol analogue, downregulates the expression of hypoxia-induced HIF-1 and VEGF and inhibits tumor growth of human breast cancer cells in a nude mouse xenograft model. Int J Oncol. 2017 Aug;51(2):715-723.
[2]. Kim DH, et al. Resveratrol analogue, HS-1793, induces apoptotic cell death and cell cycle arrest through downregulation of AKT in human colon cancer cells. Oncol Rep. 2017 Jan;37(1):281-288.
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