ZINC194100678

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ZINC194100678 

ZINC194100678 是一种有效的 PAK1 抑制剂，IC50 为 8.37 μM。ZINC194100678 可抑制 MDA-MB-231 细胞增殖。ZINC194100678 可用于抗癌研究。

ZINC194100678

ZINC194100678 Chemical Structure

CAS No. : 1995025-05-2

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生物活性

ZINC194100678 is a potent PAK1 inhibitor with an IC50 value of 8.37 μM. ZINC194100678 can inhibit MDA-MB-231 cell proliferation. ZINC194100678 can be used for researching anticancer[1].

IC50 & Target

PAK1

8.37 μM (IC50)

体外研究
(In Vitro)

ZINC194100678 (0-50 μM; 48 hours) exhibits potent antiproliferative activity with an IC50 value of 40.16 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: MDA-MB-231[1]
Concentration: 0-50 μM
Incubation Time: 48 hours
Result: Exhibited potent antiproliferative activity with an IC50 value of 40.16 μM.

分子量

219.24

Formula

C10H13N5O
CAS 号

1995025-05-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Zhang J, et al. Design, synthesis and biological evaluation of 1H-pyrazolo [3,4-d]pyrimidine derivatives as PAK1 inhibitors that trigger apoptosis, ER stress and anti-migration effect in MDA-MB-231 cells. Eur J Med Chem. 2020;194:112220.

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