S-Trityl-L-cysteine(Synonyms: NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

S-Trityl-L-cysteine (Synonyms: NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine)

S-Trityl-L-cysteine (NSC 83265) 是一种选择性的别构驱动蛋白 Eg5 抑制剂，抑制基础 ATPase 活性的 IC50 为 1 μM，抑制微管激活的 ATPase 活性的 IC50 为 140 nM。S-Trityl-L-cysteine 具有抗肿瘤活性。

S-Trityl-L-cysteine(Synonyms: NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine)

S-Trityl-L-cysteine Chemical Structure

CAS No. : 2799-07-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities[1][2].

IC50 & Target[1]

Eg5

 

体外研究
(In Vitro)

S-Trityl-L-cysteine binds to a unique pocket in the Eg5 motor domain formed by secondary structural elements (helix a2/loop L5/helix a3)[1].
S-Trityl-L-cysteine (1-20 µM; for 72 h) could mediate cell apoptosis, as well as cell cycle arrest, in a dose-dependent manner. S-Trityl-L-cysteine-mediated apoptosis and cell cycle arrest were triggered by activation of the mitogen-activated protein kinase and nuclear factor kB signaling pathways[1].
S-Trityl-L-cysteine induces mitotic arrest in HeLa cells (IC50 of 700 nM) with characteristic monoastral spindles[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

363.47

Formula

C22H21NO2S
CAS 号

2799-07-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wei Wu, et al. S-trityl-L-cysteine, a novel Eg5 inhibitor, is a potent chemotherapeutic strategy in neuroblastoma. Oncol Lett. 2018 Jul;16(1):1023-1030.

    [2]. Salvatore DeBonis, et al. In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities. Mol Cancer Ther. 2004 Sep;3(9):1079-90.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务