CRM1 degrader 1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CRM1 degrader 1 

CRM1 degrader 1 (1l) 是一种低毒的染色体区域维护 1 (CRM1) 降解剂。CRM1 是几种肿瘤抑制因子的唯一核输出蛋白，这是一种生长调节蛋白，是一种有吸引力的癌症药物靶点。CRM1 degrader 1 诱导胃癌凋亡 (Apoptosis) 并选择性抑制胃癌的增殖。

CRM1 degrader 1

CRM1 degrader 1 Chemical Structure

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生物活性

CRM1 degrader 1 (1l) is a low toxic chromosome region maintenance 1 (CRM1) degrader. CRM1 is the sole nuclear exporter of several tumor suppressor, a growth regulatory protein as an attractive cancer drug target. CRM1 degrader 1 induces the apoptosis in gastric carcinoma and selectively inhibits proliferation of gastric cancer[1].

分子量

260.33

Formula

C16H20O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Xu HW, et al. A low toxic CRM1 degrader: Synthesis and anti-proliferation on MGC803 and HGC27. Eur J Med Chem. 2020;206:112708.

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