Zn(BQTC)

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Zn(BQTC) 

Zn(BQTC) 是一种高效的线粒体 DNA (mtDNA)核 DNA (nDNA) 抑制剂。Zn(BQTC) 对 mtDNA 和 nDNA 造成严重损伤,继而破坏线粒体和核功能。Zn(BQTC) 促进 DNA 损伤诱导的细胞凋亡信号通路。Zn(BQTC) 对 A549R 细胞具有选择抗增殖活性。Zn(BQTC) 可用于抗癌研究。

Zn(BQTC)

Zn(BQTC) Chemical Structure

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生物活性

Zn(BQTC) is a highly potent mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) inhibitor. Zn(BQTC) causes severe damage to the mtDNA and nDNA, sequentially disruptes mitochondrial and nuclear functions. Zn(BQTC) promotes the DNA damage-induced apoptotic signaling pathway. Zn(BQTC) has selectively antiproliferative activity against A549R cells. Zn(BQTC) can be used for researching anticancer[1].

IC50 & Target

IC50: 10 nM in A549R cells[1]

体外研究
(In Vitro)

Zn(BQTC) (0-100 μM; 6 hours) exhibits highly and selectively antiproliferative activity against A549R with an IC50 of 10 nM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line: A549R, A549 and HL-7702[1]
Concentration: 0-100 μM
Incubation Time: 6 hours
Result: Exhibited potent antiproliferative activity against A549R and A549 cells with IC50s of 10 nM and 11.59 μM, but low activity against HL-7702 with an IC50 over 100 μM.

分子量

650.92

Formula

C30H36Cl2N5O3Zn

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wang ZF, et al. Novel bifluorescent Zn(II)-cryptolepine-cyclen complexes trigger apoptosis induced by nuclear and mitochondrial DNA damage in cisplatin-resistant lung tumor cells [published online ahead of print, 2022 Apr 30]. Eur J Med Chem. 2022;238:114418.

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