ART-IN-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

ART-IN-1 

ART-IN-1 (compound 7) 是一种选择性的 PARP 抑制剂，其对 PARP2, TNKS2, PARP10, PARP14, PARP15 的 IC50 值分别为 19, 22, 2.4, >100, 1.1 µM。

ART-IN-1

ART-IN-1 Chemical Structure

CAS No. : 2418014-98-7

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生物活性

ART-IN-1 (compound 7) is a selective PARP inhibitor with IC50s of 19, 22, 2.4, >100, 1.1 µM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively[1].

IC50 & Target[1]

TNKS2

22 μM (IC50)

PARP15

1.1 μM (IC50)

PARP2

19 μM (IC50)

PARP14

>100 μM (IC50)

PARP10

2.4 μM (IC50)

体外研究
(In Vitro)

ART-IN-1 (compound 7) (0-100 µM) shows inhibition of PARP2, TNKS2, PARP10, PARP14, PARP15 with IC50s of 19, 22, 2.4, >100, 1.1 µM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

259.32

Formula

C14H13NO2S
CAS 号

2418014-98-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Maksimainen MM, et al. Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs. Bioorg Med Chem. 2021;52:116511.

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