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ARN5187
ARN5187 是一种亲溶酶体 REV-ERBβ 配体,抑制 REV-ERB 介导的转录调控和细胞自噬。ARN5187 显示出溶酶体效力和细胞毒性。 ARN5187 诱导细胞凋亡 (apoptosis)。
ARN5187 Chemical Structure
CAS No. : 1287451-26-6
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100 mg | 询价 | ||
250 mg | 询价 | ||
500 mg | 询价 |
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生物活性 |
ARN5187 is a lysosomotropic REV-ERBβ ligand with a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 shows lysosomotropic potency and cytotoxicity. ARN5187 induces apoptosis[1][2]. |
IC50 & Target |
REV-ERBβ[1] |
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体外研究 (In Vitro) |
ARN5187 (compound 1) (0-100 µM; 48 h) shows cytotoxicity with EC50 of 23.5 µM in BT-474 cells and IC50 of 30.14 µM, >100 µM for BT-474 and HMEC cells, respectively[1][2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity Assay[1]
RT-PCR[1]
Western Blot Analysis[1]
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分子量 |
397.53 |
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Formula |
C24H32FN3O |
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CAS 号 |
1287451-26-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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