LSD1/ER-IN-1 | 赛默飞Alfa aesar官网

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

LSD1/ER-IN-1

LSD1/ER-IN-1 (compound 11g) 是一种有效的 ER 和 LSD1 抑制剂，其IC₅₀ 为 1.55 μM (LSD1)。LSD1/ER-IN-1 对 ERα 蛋白有高亲和力选择性，α/β 比为7.11。LSD1/ER-IN-1 对 MCF-7 乳腺癌细胞具有良好的抗增殖活性，其 IC₅₀ 为8.79 μM。

LSD1/ER-IN-1 Chemical Structure

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生物活性

LSD1/ER-IN-1 (compound 11g) is a potent ER and LSD1 inhibitor, with an IC₅₀ of 1.55 μM (LSD1). LSD1/ER-IN-1 has high affinity selectivity for ERα protein, with α/β ratio of 7.11. LSD1/ER-IN-1 shows good antiproliferative activity against MCF-7 breast cancer cells, with an IC₅₀ of 8.79 μM^[1].

IC₅₀ & Target

ERα

ERβ

体外研究
(In Vitro)

LSD1/ER-IN-1 (compound 11g) (0-30 μM, 24 h) induces apoptosis in MCF-7 cells in a dose-dependent manner^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

455.46

Formula

C₂₃H₁₈FNO₆S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. He M, et al. Design, synthesis and biological evaluation of novel dual-acting modulators targeting both estrogen receptor α (ERα) and lysine-specific demethylase 1 (LSD1) for treatment of breast cancer. Eur J Med Chem. 2020 Jun 1;195:112281.

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