FLT3/ITD-IN-1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

FLT3/ITD-IN-1 

FLT3/ITD-IN-1 (Compound 1) 是一种有效的 FLT3-ITD 抑制剂，对 FLT3 和 FLT3-ITD 的 IC50 值分别为 38.2 nM 和 144.1 nM。FLT3/ITD-IN-1 对急性髓系白血病细胞具有良好的抗增殖活性。

FLT3/ITD-IN-1

FLT3/ITD-IN-1 Chemical Structure

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生物活性

FLT3/ITD-IN-1 (Compound 1) is a potent FLT3 internal tandem duplications (FLT3-ITD) inhibitor with IC50 values of 38.2 nM and 144.1 nM against FLT3 and FLT3-ITD, respectively. FLT3/ITD-IN-1 displays excellent antiproliferative activities against acute myeloid leukemia cell lines[1].

IC50 & Target

IC50: 38.2 nM (FLT3), 144.1 nM (FLT3-ITD)[1]
分子量

366.42

Formula

C19H22N6O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Chen Y, et al. Discovery and structure – activity relationship exploration of pyrazolo[1,5-a]pyrimidine derivatives as potent FLT3-ITD inhibitors. Bioorg Med Chem. 2021 Oct 15;48:116422.

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