Gü2602

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Gü2602 

Gü2602 是一种有效的、可逆的组织蛋白酶 K (cathepsin K (CatK)) 抑制剂，对 成熟 CatK (mCatK) 的 Ki 值为 0.013 nM。Gü2602 抑制组织蛋白酶 K 酶原的自催化激活。

Gü2602

Gü2602 Chemical Structure

CAS No. : 1627094-88-5

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生物活性

Gü2602 is a potent, reversible cathepsin K (CatK) inhibitor with a Ki of 0.013 nM for mature CatK (mCatK). Gü2602 suppresses the autocatalytic activation of the cathepsin K zymogen[1].

IC50 & Target

Ki: 0.013 nM (mCatK)[1]
分子量

318.37

Formula

C16H22N4O3
CAS 号

1627094-88-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Benýšek J, et al. Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes. J Enzyme Inhib Med Chem. 2022 Dec;37(1):515-526.

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