EGFR-IN-55

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

EGFR-IN-55 

EGFR-IN-55 (Compound 8a) 是一种有效的 EGFR 抑制剂,对 EGFRWTEGFRL858R/T790MIC50 值分别为 70 nM 和 3.9 nM。EGFR-IN-55 阻滞 NCI-H1975 细胞 G0/G1 期,具有抗癌活性。

EGFR-IN-55

EGFR-IN-55 Chemical Structure

CAS No. : 2057423-46-6

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生物活性

EGFR-IN-55 (Compound 8a) is a potent EGFR inhibitor with IC50 values of 70 nM and 3.9 nM against EGFRWT and EGFRL858R/T790M, respectively. EGFR-IN-55 arrests NCI-H1975 cells in G0/G1 phase and shows anticancer activity[1].

IC50 & Target

EGFRL858R/T790M

3.9 nM (IC50)

EGFRWT

70 nM (IC50)

分子量

526.42

Formula

C25H25Cl2N7O2

CAS 号

2057423-46-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Shao J, et al. Design, synthesis and SAR study of 2-aminopyrimidines with diverse Michael addition acceptors for chemically tuning the potency against EGFRL858R/T790M. Bioorg Med Chem. 2020 Oct 1;28(19):115680.

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