Antitumor agent-59

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Antitumor agent-59 

Antitumor agent-59 (Compound 13b) 是一种有效的抗肿瘤剂。Antitumor agent-59 有效抑制 HCT116 细胞增殖和迁移。Antitumor agent-59 诱导 HCT116 细胞凋亡 (apoptosis)，在 G2/M 期阻滞细胞周期。

Antitumor agent-59

Antitumor agent-59 Chemical Structure

CAS No. : 2409952-04-9

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生物活性

Antitumor agent-59 (Compound 13b) is a potent antitumor agent. Antitumor agent-59 effectively inhibits the proliferation and migration of HCT116 cells. Antitumor agent-59 induces HCT116 cell apoptosis and arrests the cell cycle at the G2/M phase[1].

体外研究
(In Vitro)

Antitumor agent-59 (Compound 13b) (72 h) shows antitumor activities with IC50 values of 0.032 ± 0.0071, 0.20 ± 0.020, 0.73 ± 0.12 and 0.58 ± 0.15 μM against HCT116, MCF-7, A549 and HUVEC cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

770.78

Formula

C43H36F2N6O6
CAS 号

2409952-04-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Liang H, et al. Discovery of novel bis-evodiamine derivatives with potent antitumor activity. Bioorg Med Chem. 2022 Jul 1;65:116793.

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