c-Met-IN-10

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

c-Met-IN-10 

c-Met-IN-10 (compound 26a) 是一种高效的 c-Met 激酶抑制剂,IC50 为 16 nM。c-Met-IN-10 对癌细胞 A549、H460 和 HT-29 有抑制活性。c-Met-IN-10 抑制 HT-29 细胞集落形成,诱导 HT-29 和 A549 细胞凋亡 apoptosis,抑制 A549 细胞移动。c-Met-IN-10 可用于抗癌研究。

c-Met-IN-10

c-Met-IN-10 Chemical Structure

CAS No. : 2415291-03-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer[1].

IC50 & Target[1]

c-Met

16 nM (IC50)

分子量

516.48

Formula

C26H21FN6O5

CAS 号

2415291-03-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Liu J, et al. Design, synthesis and biological evaluation of novel N-[4-(2-fluorophenoxy)pyridin-2-yl]cyclopropanecarboxamide derivatives as potential c-Met kinase inhibitors. Eur J Med Chem. 2020;194:112244.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务