Sirt1/2-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Sirt1/2-IN-1 

Sirt1/2-IN-1 (Compound 7) 是一种 SIRT1SIRT2 抑制剂,对 SIRT1、SIRT2 和 SIRT3IC50 值分别为 1.81、2.10 和 20.5 µg/mL。Sirt1/2-IN-1 表现出 α-微管蛋白的超乙酰化活性,IC50 值为 32.05 µg/mL。Sirt1/2-IN-1 具有明显抗癌活性。

Sirt1/2-IN-1

Sirt1/2-IN-1 Chemical Structure

CAS No. : 2402779-21-7

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生物活性

Sirt1/2-IN-1 (Compound 7) is a SIRT1 and SIRT2 inhibitor with IC50 values of 1.81, 2.10 and 20.5 µg/mL against SIRT1, SIRT2 and SIRT3, respectively. Sirt1/2-IN-1 displays activity in hyperacetylation of α-tubulin protein with an IC50 of 32.05 µg/mL. Sirt1/2-IN-1 shows prominent anticancer activity[1].

IC50 & Target

SIRT1

1.81 μg/mL (IC50)

SIRT2

2.10 μg/mL (IC50)

SIRT3

20.5 μg/mL (IC50)

分子量

420.93

Formula

C22H13ClN2OS2

CAS 号

2402779-21-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Khalil NA, et al. Synthesis of certain benzothieno[3,2-d]pyrimidine derivatives as a selective SIRT2 inhibitors. Eur J Med Chem. 2020 Feb 1;187:111926.

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