Aurora kinase inhibitor-9

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Aurora kinase inhibitor-9 

Aurora kinase inhibitor-9 (compound 9d) 是一种有效的 AURKA/B 双极光激酶抑制剂，Aurora A, Aurora B 的 IC50s 分别为 0.093, 0.09 µM。Aurora kinase inhibitor-9 具有广谱抗增殖活性。

Aurora kinase inhibitor-9

Aurora kinase inhibitor-9 Chemical Structure

CAS No. : 2419107-09-6

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生物活性

Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B dual aurora kinase inhibitor with IC50s of 0.093, 0.09 µM for Aurora A, Aurora B, respectively. Aurora kinase inhibitor-9 shows broad spectrum anti-proliferative activity[1].

IC50 & Target[1]

Aurora A

0.093 μM (IC50)

Aurora B

0.09 μM (IC50)

分子量

454.33

Formula

C19H17Cl2N3O4S
CAS 号

2419107-09-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Al-Sanea MM, et al. Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights. Bioorg Med Chem. 2020 Jul 1;28(13):115525.

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