Anticancer agent 47

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Anticancer agent 47 

Anticancer agent 47 (compound 4j) 是一种有效的抗癌剂。Anticancer agent 47 显示出抗增殖活性。Anticancer agent 47 诱导细胞凋亡 (apoptosis) 和细胞周期停滞在 G0/G1 期。Anticancer agent 47 在体内显示出抗肿瘤活性。

Anticancer agent 47

Anticancer agent 47 Chemical Structure

CAS No. : 2461795-23-1

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生物活性

Anticancer agent 47 (compound 4j) is a potent anticancer agent. Anticancer agent 47 shows antiproliferative activities. Anticancer agent 47 induces apoptosis and cell cycle arrest at G0/G1 phase. Anticancer agent 47 shows shows antitumor activities in vivo[1].

体外研究
(In Vitro)

Anticancer agent 47 (compound 4j) shows antiproliferative activities with IC50s of 1.6, 0.72, 7.07 µM for HepG2, A549, H596 cells, respectively[1].
Anticancer agent 47 (0.8, 1.6, 3.2 µM; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase[1].
Anticancer agent 47 (5 µM; 5h) significantly increases ROS production[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: HepG2, H596 cells
Concentration: 0.8, 1.6, 3.2 µM
Incubation Time: 24 h
Result: Induced apoptosis with the apoptotic cell rates were 14.23, 20.47 and 27.66% at 0.8, 1.6, 3.2 µM in HepG2 cell, respectively.

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 0.8, 1.6, 3.2 µM
Incubation Time: 24 h
Result: Showed 48.54%, 49.60% and 53.00% cells were at G0/G1 phase at 0.6, 1.2 and 2.4 µM, respectively.

体内研究
(In Vivo)

Anticancer agent 47 (20 mg/kg; i.v.; once every 2 days for 19 days) shows antitumor activities[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (HepG2 xenografts)[1]
Dosage: 20 mg/kg
Administration: I.v.; once every 2 days for 19 days
Result: Effectively inhibited tumor growth with the 58.7% tumor inhibition rate.

分子量

366.39

Formula

C19H14N2O4S
CAS 号

2461795-23-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wu L, et al. Synthesis and biological evaluation of β-lapachone-monastrol hybrids as potential anticancer agents. Eur J Med Chem. 2020 Oct 1;203:112594.

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