SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a K_d of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro^[1].

Kd: 80 nM (chromobox 2 chromodomain)^[1]

SW2_152F inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

921.35

C₄₄H₆₀Cl₃N₇O₈

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sijie Wang, et al. A Potent, Selective CBX2 Chromodomain Ligand and Its Cellular Activity During Prostate Cancer Neuroendocrine Differentiation. Chembiochem. 2021 Jul 1;22(13):2335-2344.