SW2_152F

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

SW2_152F 

SW2_152F 是一种有效的选择性 chromobox 2 chromodomain (CBX2 ChD) 抑制剂,Kd 为 80 nM。SW2_152F 在体外对 CBX2 ChD 的选择性比其他 CBX paralogs 高 24-1000 倍。

SW2_152F

SW2_152F Chemical Structure

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生物活性

SW2_152F is a potent, selective chromobox 2 chromodomain (CBX2 ChD) inhibitor with a Kd of 80 nM. SW2_152F displays 24-1000-fold selectivity for CBX2 ChD over other CBX paralogs in vitro[1].

IC50 & Target

Kd: 80 nM (chromobox 2 chromodomain)[1]

体外研究
(In Vitro)

SW2_152F inhibits CBX2 chromatin binding in cells, and blocks neuroendocrine differentiation of prostate cancer cell lines in response to androgen deprivation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

921.35

Formula

C44H60Cl3N7O8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Sijie Wang, et al. A Potent, Selective CBX2 Chromodomain Ligand and Its Cellular Activity During Prostate Cancer Neuroendocrine Differentiation. Chembiochem. 2021 Jul 1;22(13):2335-2344.

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