Enalapril(Synonyms: 依那普利; MK-421)

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Enalapril (Synonyms: 依那普利; MK-421)

Enalapril (MK-421) 是一种血管紧张素转换酶 (ACE) 抑制剂，可用于高血压疾病的研究。

Enalapril(Synonyms: 依那普利; MK-421)

Enalapril Chemical Structure

CAS No. : 75847-73-3

规格 价格 是否有货
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Enalapril 的其他形式现货产品:

Enalapril maleate

生物活性

Enalapril (MK-421) is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research[1][2].

体外研究
(In Vitro)

Enalapril (10-20 μM) has an antiarrhythmic effect in ultrafiltered PV sleeve preparation isolated from canine hearts which can inhibit EAD and DAD-induced activity[1].
Enalapril (50 μM, 24 hours) inhibits the induction of apoptosis by patient serum only when used prior to treatment of HUVEC with Alzheimer’s disease (AD) serum[2].
Pure Enalapril has better thermal stability than pure Enalapril[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: Human umbilical vein ECs (HUVECs)
Concentration: 50 μM
Incubation Time: 24 hours
Result: Inhibited the induction of apoptosis by patient serum.

体内研究
(In Vivo)

Enalapril (intraperitoneal injection, 0.03 mg/kg, once, 1 hour) reduces infarct volume due to middle cerebral artery occlusion and lower or higher doses are ineffective in Male NMRI mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NMRI mice 20-40 g[4]
Dosage: 0.03 mg/kg
Administration: Intraperitoneal injection; once; 1 hour
Result: Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg.

Clinical Trial

分子量

376.45

Formula

C20H28N2O5
CAS 号

75847-73-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Serge Sicouri, et al. Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations. J Cardiovasc Electrophysiol. 2011 Jun;22(6):698-705.

    [2]. Rokhsareh Meamar, et al. Enalapril protects endothelial cells against induced apoptosis in Alzheimer’s disease. J Res Med Sci. 2013 Mar;18(Suppl 1):S1-5.

    [3]. Talita A Cunha, et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS PharmSciTech. 2013 Sep;14(3):1150-7.

    [4]. A Ravati, et al. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. Eur J Pharmacol. 1999 May 28;373(1):21-33.

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