生物活性分子抑制剂 特异性抑制剂 激动剂 化合物库 重组蛋白 Adapalene (Synonyms: 阿达帕林; CD271) 纯度: ≥98.0%
Adapalene (CD271) 是第三代合成类视黄醇,局部应用于痤疮。Adapalene 是一种有效的 RAR 激动剂,对 RARβ、RARγ、RARα 的 AC50 值分别为 2.3 nM、9.3 nM 和 22 nM。Adapalene 还以非竞争性方式抑制 GOT1 的酶活性。Adapalene 具有抗肿瘤活性。
Adapalene Chemical Structure
CAS No. : 106685-40-9
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10 mM * 1 mL in DMSO | ¥660 | In-stock | |
50 mg | ¥600 | In-stock | |
100 mg | ¥960 | In-stock | |
500 mg | ¥2000 | In-stock | |
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Adapalene 相关产品
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生物活性 |
Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity[1][2][3]. |
IC50 & Target |
AC50: 2.3 nM (RARβ), 9.3 nM (RARγ), and 22 nM (RARα)[1] |
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体外研究 (In Vitro) |
Adapalene (1-200 μM; 24 h) inhibits the viability of ES-2, HOV-7, MCF-7 , Hela, SW1990, HT1080, and MM-468 cells, with IC50s of 10.36 μM, 10.81 μM, 12.00 μM, 19.08 μM, 19.52 μM, 21.70 μM, and 31.47 μM, respectively[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[2]
Apoptosis Analysis[2]
Cell Cycle Analysis[3]
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体内研究 (In Vivo) |
Adapalene (15-100 mg/kg; p.o. daily for 21 days) inhibits the growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice[3]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
412.52 |
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Formula |
C28H28O3 |
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CAS 号 |
106685-40-9 |
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中文名称 |
阿达帕林 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 20 mg/mL (48.48 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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