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Epibrassinolide (Synonyms: 表油菜素内酯; 24-Epibrassinolide; B1105; BP55) 纯度: ≥98.0%
Epibrassinolide (24-Epibrassinolide) 是一种广泛存在的植物生长激素,具有缓解植物重金属和农药胁迫潜力。Epibrassinolide (24-Epibrassinolide) 在各种癌细胞中是一种潜在的凋亡诱导剂,而不影响非肿瘤细胞生长。
Epibrassinolide Chemical Structure
CAS No. : 78821-43-9
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1045 | In-stock | |
5 mg | ¥950 | In-stock | |
10 mg | ¥1350 | In-stock | |
50 mg | ¥2700 | In-stock | |
100 mg | ¥3350 | In-stock | |
500 mg | ¥6750 | In-stock | |
1 g | 询价 | ||
5 g | 询价 |
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Epibrassinolide 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Food-Sourced Compound Library
生物活性 |
Epibrassinolide (24-Epibrassinolide) is a ubiquitously occurring plant growth hormone which shows great potential to alleviate heavy metals and pesticide stress in plants[1]. Epibrassinolide is a potential apoptotic inducer in various cancer cells without affecting the non-tumor cell growth[2]. |
IC50 & Target |
Plant growth regulator, Apoptosis inducer[1] |
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体外研究 (In Vitro) |
Epibrassinolide (EBR) is a biologically active compound of the brassinosteroids, steroid-derived plant growth regulator family. Cells are incubated with various doses (0-100 μM) of Epibrassinolide for 24 or 48 h and cell viability is determined by MTT assay. Epibrassinolide induced cell viability loss in dose- and time-dependent manner compared to untreated samples in LNCaP and DU145 prostate cancer cells. Increasing concentrations of Epibrassinolide is more effective on LNCaP cell viability loss than DU145 cells suggesting that androgen-dependent cells are more sensitive to Epibrassinolide than androgen-independent prostate cancer cells. In further experiments, 25 μM Epibrassinolide is selected due to its moderate cytotoxic effect on both cell lines. The effect of Epibrassinolide treatment is examined on cell proliferation by counting the cell number within 96 h. A higher and earlier inhibition of cell proliferation is observed in LNCaP than DU145 cells[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
480.68 |
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Formula |
C28H48O6 |
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CAS 号 |
78821-43-9 |
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中文名称 |
表油菜素内酯;布拉西诺内酯;欧洲油菜素 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (208.04 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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Cell Assay [1] |
LNCaP (CRL-1740) and DU145 (CRL-2698) human prostate cancer cell lines are used. PNT1a normal prostate epithelial cell line is used. Cells are grown in RPMI 1640 medium, supplemented with 10 % fetal bovine serum, 10,000 U penicillin/mL and 10 mg streptomycin/mL. Cells are cultured at 37°C in a humidified 5 % CO2 incubator (HERA cell 150). Cells are seeded overnight and then treated with the desired drug concentrations. Cells are seeded at 1×104 density per well in 96-well plates and exposed to various concentrations of Epibrassinolide for 24 and 48 h. 10 μL MTT dye (5 mg/mL) is added to each well and cells are kept at 37°C for 4 h. The resulting formazan crystals are solubilized in 200 μL DMSO. The density of the solubilized formazan is read at 570 nm spectrophotometrically[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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