Tin-protoporphyrin IX(Synonyms: 锡原卟啉IX; SnPPIX; Stannous protoporphyrin IX)

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Tin-protoporphyrin IX (Synonyms: 锡原卟啉IX; SnPPIX; Stannous protoporphyrin IX) 纯度: ≥95.0%

Tin-protoporphyrin IX (SnPPIX) 是有效的血红素加氧酶-1 (HO-1) 抑制剂。 Tin-protoporphyrin IX (SnPPIX) 使 PDAC 管腺癌肿瘤对化疗敏感。

Tin-protoporphyrin IX(Synonyms: 锡原卟啉IX; SnPPIX; Stannous protoporphyrin IX)

Tin-protoporphyrin IX Chemical Structure

CAS No. : 14325-05-4

规格 价格 是否有货 数量
5 mg ￥2500 In-stock
10 mg ￥4000 In-stock
50 mg ￥9500 In-stock
100 mg   询价  
200 mg   询价  

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Tin-protoporphyrin IX 相关产品

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生物活性

Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1].

IC50 & Target

IC50: Heme oxygenase-1 (HO-1)[1]
体外研究
(In Vitro)

Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Capan-1, CD18/HPAF, PDAC cells
Concentration: 20 μM, 50 μM
Incubation Time: 24 or 72 hours
Result: Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM.

体内研究
(In Vivo)

Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male and female athymic nude mice with PDAC cell-derived xenograft tumors[1]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20
Result: Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine).

分子量

750.26

Formula

C34H32Cl2N4O4Sn
CAS 号

14325-05-4
中文名称

锡原卟啉IX
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

0.1 M NaOH : 14.29 mg/mL (19.05 mM; ultrasonic and adjust pH to 12 with NaOH)

DMF : 1 mg/mL (1.33 mM; Need ultrasonic and warming)

DMSO : 0.5 mg/mL (0.67 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3329 mL 6.6644 mL 13.3287 mL
5 mM 0.2666 mL 1.3329 mL 2.6657 mL
10 mM 0.1333 mL 0.6664 mL 1.3329 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Abdalla MY,et al.Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition.Transl Res. 2019 May;207:56-69.

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