Silane PEG Maleimide Cat. No. PG2-MLSL-5k 5000 Da 100 mg修饰性聚乙二醇

上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。

Silane PEG Maleimide

Cat. No. PG2-MLSL-5k Silane PEG Maleimide           Cat. No. PG2-MLSL-5k     5000 Da    100 mg
Specification 5000 Da
Unit Size 100 mg
Price $325.00

Qty Add to Cart

Description:

Ethoxy or methoxyl silane functionalized polyethylene glycol, silane PEG (PEG-Si) is a surface reactive PEG derivative that can be used to modify glass, silica and other surfaces via the reaction between hydroxyl group and ethoxyl/methoxyl silane. Pegylation can greatly suppress the non-specific binding of charged molecules to the modified surfaces. And they have wide applications for medica device, biomems or biocompatible material development.

Physical Properties:

  • Off-white/white solid or viscous liquid depends on molecule weight;
  • Soluble in regular aqeous solution as well as most organic solvents;

Storage Conditions:

  • Store at -20 0C, desiccated. Silane PEG tends to hydrolyze from moisture. Avoid frequent thaw and frozen.

Reaction Procedures:

Generally, silane PEG is first dissolved in a mixture of ethanol/water solution, then allow the solution to contact with oxidized glass or silica surface for 30 min to 2 hours. Under this condition, silane PEG should bind to the material covalently.

Materials Required:

  • Pegylation solution: Ethanol/water (w/w, 95%/5%);
  • Silane PEG stock solution, 10~50 mg/mL in pegylation solution, prepare in fresh.
  • Washing solution: Distilled water.

Reaction Steps:

1. Dissolve targeted materials in Pegylation buffer.

2. Add silane PEG stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. 10~50 molar excess of silane PEG needed for optimal conjugation;

3. Allow mixture agitates at room temperature for 30 min at room temperature or 2 hours at 4 -20 0C.

4. Wash out unreacted materials either by distilled water.

Documents
  • SDS
  • DataSheet