SZL P1-41

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SZL P1-41  纯度: ≥98.0%

SZL P1-41 是一种特异的 Skp2 抑制剂，结合在 Skp2 的 F-box 域以防止与 Skp1 关联和 Skp2 SCF 复合物形成。与 Skp2 缺乏一样，SZL P1-41 增加 p27 介导的凋亡/衰老，同时损害 Akt 驱动的糖酵解。具有抗肿瘤活性。

SZL P1-41

SZL P1-41 Chemical Structure

CAS No. : 222716-34-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1089 In-stock
5 mg ￥990 In-stock
10 mg ￥1800 In-stock
25 mg ￥3700 In-stock
50 mg ￥6500 In-stock
100 mg ￥11000 In-stock
200 mg   询价  
500 mg   询价  

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SZL P1-41 相关产品

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生物活性

SZL P1-41 is a specific Skp2 inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities[1][2].

IC50 & Target

Skp2[1]
体外研究
(In Vitro)

SZL P1-41 (5-20μM; 24 hours) induces endogenous p27 protein expression in PC3 cells and also induced expression of p21, another Skp2 substrate[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

SZL P1-41 (40-80 mg/kg; i.p.) displays a potent effect on inhibiting prostate and lung tumor growth in Nude mice bearing A549 and PC3 tumor xenografts[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

420.52

Formula

C24H24N2O3S
CAS 号

222716-34-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 2.5 mg/mL (5.95 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3780 mL 11.8900 mL 23.7801 mL
5 mM 0.4756 mL 2.3780 mL 4.7560 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Chan CH et al. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 1;154(3):556-68.

    [2]. Chan CH, et al. Skp2: a dream target in the coming age of cancer therapy. Cell Cycle. 2014;13(5):679-80.

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