上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
TK216 纯度: 99.88%
TK216 是一种口服有效的 E26 转录因子 (ETS) 抑制剂。TK216 直接结合 EWS-FLI1 并抑制 EWS-FLI1 蛋白质相互作用。TK216 可以阻止 EWS-FLI1 与 RNA 解旋酶 A 的结合。TK216 具有抗癌活性。
TK216 Chemical Structure
CAS No. : 1903783-48-1
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1980 | In-stock | |
5 mg | ¥1800 | In-stock | |
10 mg | ¥3150 | In-stock | |
25 mg | ¥6300 | In-stock | |
50 mg | ¥11000 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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TK216 相关产品
•相关化合物库:
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生物活性 |
TK216 is an orally active and potent E26 transformation specific (ETS) inhibitor[1]. TK216 directly binds EWS-FLI1 and inhibits EWS-FLI1 protein interactions. TK216 blocks the binding between EWS-FLI1 and RNA helicase A. TK216 has anticancer activity[2]. |
IC50 & Target |
ETS[1] |
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体外研究 (In Vitro) |
TK216 (500 nM; for 24-72 hours) induces apoptosis in DLBCL cell lines[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis Analysis[1]
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体内研究 (In Vivo) |
TK216 (po; 100 mg/kg; twice daily for 13 days) results in tumor growth inhibition of the TMD-8 xenograft model[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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分子量 |
376.23 |
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Formula |
C19H15Cl2NO3 |
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CAS 号 |
1903783-48-1 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 250 mg/mL (664.49 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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