Ertapenem sodium(Synonyms: 厄他培南钠; L-749345; MK-826)

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Ertapenem sodium (Synonyms: 厄他培南钠; L-749345; MK-826) 纯度: 99.09%

Ertapenem sodium (L-749345; MK-826) 属于长效的碳青霉烯，是一种 β-内酰胺抗生素，具有广泛的抗菌谱。Ertapenem sodium 对革兰氏阳性菌和革兰氏阴性菌均有活性，包括肠杆菌科、肺炎链球菌和大多数种类的厌氧菌。

Ertapenem sodium(Synonyms: 厄他培南钠; L-749345; MK-826)

Ertapenem sodium Chemical Structure

CAS No. : 153773-82-1

规格 价格 是否有货 数量
10 mg ￥600 In-stock
50 mg ￥1400 In-stock
100 mg ￥2400 In-stock
200 mg   询价  
500 mg   询价  

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生物活性

Ertapenem sodium (L-749345), a long-acting Carbapenem, is a β-lactam antibiotic with a broad antibacterial spectrum. Ertapenem sodium is active against both Gram-positive and Gram-negative bacteria, including Enterobacteriaceae, Streptococcus pneumoniae and most species of anaerobic bacteria[1][2].

体外研究
(In Vitro)

Ertapenem sodium inhibits Streptococcus pneumoniae with MIC50s values < 1mg/L[2].
Ertapenem sodium exhibits a bactericidal mode of action as shown by time-killing curves and exhibits a short postantibiotic effect (PAE) of 1.4-2.6 h against the Gram-positive strains but no PAE against Gram-negative strains[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Ertapenem sodium (50 mg/kg; s.c.; q6h; for 24 hours) shows substantial bactericidal activity against S. pneumoniae in the murine thigh infection model[3].
Ertapenem sodium exhibits an AUC0-24 of 586 mg•h/L, Cmax of 140 mg/L following subcutaneous injection (mice 50 mg/kg)[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Specific-pathogen-free female ICR mice (~25 g), thigh infection model[3]
Dosage: 50 mg/kg
Administration: Subcutaneous injection, q6h, for 24 hours
Result: Showed substantial bactericidal activities.
Animal Model: Specific-pathogen-free female ICR mice (~25 g), thigh infection model[3]
Dosage: 20 mg/kg, 50 mg/kg, 100 mg/kg (Pharmacokinetic Analysis)
Administration: Subcutaneous injection
Result: AUC0-24 (586 mg•h/L), Cmax (140 mg/L) at 50 mg/kg q6h dosing regimen.

Clinical Trial

分子量

497.50

Formula

C22H24N3NaO7S
CAS 号

153773-82-1
中文名称

厄他培南钠；尔他培南钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。
溶解性数据
In Vitro: 

H2O : 62.5 mg/mL (125.63 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0101 mL 10.0503 mL 20.1005 mL
5 mM 0.4020 mL 2.0101 mL 4.0201 mL
10 mM 0.2010 mL 1.0050 mL 2.0101 mL

*

请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。
参考文献

  • [1]. Monique Curran, et al. Ertapenem: a review of its use in the management of bacterial infections. Drugs. 2003;63(17):1855-78.

    [2]. I Odenholt. Ertapenem: a new carbapenem. Expert Opin Investig Drugs. 2001 Jun;10(6):1157-66.

    [3]. Dawei Xuan, et al. Pharmacodynamic Assessment of Ertapenem (MK-0826) against Streptococcus pneumoniae in a Murine Neutropenic Thigh Infection Model. Antimicrob Agents Chemother. 2002 Sep; 46(9): 2990–2995.

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