四环素

描述

化学结构：四环素

应用

Description

Chemical structure: tetracycline

放线菌酮

应用

环己酰亚胺被广泛用于筛选抗 CHX 的酵母和真菌菌株，控制蛋白合成的抑制作用（用于检测短寿蛋白和蛋白表达的超诱导作用），并诱导细胞凋亡或通过死亡受体促进细胞凋亡。研究表明，它可以选择性清除动脉粥样硬化斑块中的巨噬细胞并激活无积聚的马卵母细胞。

Description

Cycloheximide is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques and activate cumulus-free equine oocytes.

多西环素一水合物

Description

In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.It has also been used as an antimicrobial agent.

氟米松

Description

Flumethasone pivalate is a topical difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. A prompt decrease in inflammation, exudation and itching is experienced after application. It is commonly used in veterinary practice and has been used in cortisol assays to study early porcine conceptus development.

丝裂霉素C

Description

Mitomycin C is an antitumor antibiotic.Mitomycin C is used as an inhibitor for studies of cell-free protein biosynthesis. It also inhibits DNA synthesis. It has been used as a genotoxic agent for tumor cells.Mitomycin C has been used:to cease mitosisin phosphate buffer saline (PBS) for inactivation and plating mouse embryonic fibroblasts (MEFs)as mutagen in mutagenicity assay

来自仙人掌链霉菌的丝裂霉素C

Description

Mitomycin C is produced by a strain of actinomyces,Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.

Preparation instructions

Mitomycin C is soluble in DMSO at 1.0 mg/mL

来自仙人掌链霉菌的丝裂霉素C

Description

Chemical structure: aziridineMitomycin C is produced by a strain of actinomyces,Streptomyces caespitosus. It contains three anticancer moieties, quinine, urethane, and aziridine groups. It is used to generate mitotically inactive feeder cells in cell culture systems, such as the mitotically inactive fibroblasts used in embryonic stem cell systems.

Preparation instructions

Mitomycin C is soluble in water at .5 mg/mL, with a pH of 6.0-7.5. It undergoes rapid degradation in acidic solutions with pH<6, and is mostly likely to retain activity in solutions with a pH between 6-9.

来自仙人掌链霉菌的丝裂霉素C

描述

丝裂霉素C是全身性化疗化合物，是从头状链霉菌中获得的抗生素。它是鉴定的第一种生物还原性烷基化剂，是3-氨基-5-羟基苯甲酸（AHBA）、D-葡萄糖胺、L-蛋氨酸和氨甲酰基磷酸的衍生物。化学结构：氮丙啶

应用

头状链霉菌丝裂霉素C已用于处理饲养层，如PMEF（原代小鼠胚胎成纤维细胞）和CD1小鼠胚胎成纤维细胞（MEF），还用于培养人胚胎干细胞（hESC）。它还用于处理BLC（基底样癌）细胞系。

适用性

原理

制备说明

丝裂霉素C可以0.5mg/mL溶于水，pH为6.0-7.5。 它在pH<6的酸性溶液中会迅速降解，在pH 6-9的溶液中最有可能保持活性。

外形

Description

Mitomycin C is a systemic chemotherapy compound and an antibiotic obtained fromStreptomyces caespitosus. It is the first bioreductive alkylating agent to be identified and is a derivative of 3-amino-5-hydroxybenzoic acid (AHBA), D-glucosamine, L-methionine and carbamoyl phosphate.Chemical structure: AziridineMitomycin C fromStreptomyces caespitosushas been used for the treatment of feeder layers such as, PMEF (primary mouse embryonic fibroblasts) and CD1 mouse embryonic fibroblasts (MEFs) for the culture of hESCs (human embryonic stem cells). It has also been used for the treatment of BLC (basal-like cancer) cell line.

阿德福韦酯

Description

Adefovir is used to treat hepatitis B infections. It is used to study organ-specific toxicity and immune mechanisms of Adefovir treatment.

锂莫匹罗星

Description

Lithium mupirocin as been used to study mupirocin resistance in staphylococcus aureus and in mycoplasma susceptibility studies .

次黄嘌呤

一般描述

次黄嘌呤(6-羟嘌呤)，一种嘌呤衍生物，是天然化合物。它是腺嘌呤的脱氨基形式，也是一磷酸腺苷(AMP)的分解产物。

应用

次黄嘌呤是一种营养添加剂，适用于细菌、寄生虫（ 恶性疟原虫 ）和动物细胞等多种细胞培养应用。 次黄嘌呤是杂交瘤技术所用选择培养基的组分。 次黄嘌呤已被用于： 作为HEPES (4-(2-羟乙基)-1-哌嗪乙烷磺酸) -buffered Roswell park memorial institute (RPMI)补充剂，培养 镰状疟原虫 菌株IT/FCR3 制备Dulbecco′改性′s培养基 (DMEM) + MXH，用于选择嵌合修饰痘苗病毒安卡拉株(MVA) 产生超氧阴离子 用于制备杂交瘤选择和维持培养基。

General Description

Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).

Application

Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite ( Plasmodium falciparum ) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies. Hypoxanthine has been used: as a supplement in HEPES (4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid) -buffered Roswell park memorial institute (RPMI) to culture Plasmodium falciparum strain IT/FCR3 in the preparation of Dulbecco′s modified eagle′s medium (DMEM) + MXH for the selection of chimeric modified vaccinia virus ankara (MVA) to generate superoxide anions to prepare hybridoma selection and maintenance media.

聚唾液酸

产品介绍：

聚唾液酸是一类线性、均一多聚α-2,8和/或α-2,9糖苷键连接的线性聚合物，它主要通过典型的糖苷键附着在脊椎动物神经系统神经黏附分子上(neural cell adhesion molecule,NCAM)。聚唾液酸通过改变NCAM的黏附性调节神经细胞发育、神经导向以及突触形成，从而在神经发育中起关键作用。聚唾液酸是白色不定型高聚合物, 在酸的作用下容易降解成单体的唾液酸。它也是一种白色、无定形的固体粉末，水溶性较好，热稳定较好，在酸性环境中不稳定，容易被降解成寡聚唾液酸或者单体N-乙酰神经氨酸。聚唾液酸水溶性优良, 低黏度, 生物相容性好, 并且在生物体内可以降解。近年聚唾液酸在医药、食品添加剂和化妆品领域受到热捧，市场前景广阔。

用途：

1）神经再生

聚唾液酸在神经再生方面起着决定性作用。在胚胎发育期，聚唾液酸以高含量存在于脊椎动物的大脑和中枢神经系统。聚唾液酸对周围神经再生具有促进作用，尤其能刺激神经细胞轴突的生长。

2）药物修饰

聚唾液酸与药物的结合，可以使药物的活性得到显著提高，延缓药物的半衰期。是目前发现最好的替代PEG的多肽与蛋白类药物的可降解缓释剂。

3）组织工程材料

聚唾液酸作为一种新型生物材料，可以作为支架材料应用在组织工程领域中。聚唾液酸作为支架材料不仅可以诱导和支持神经原细胞再生，加速神经创伤的愈合，无需进行二次手术，在体内可以被完全吸收。

4）肿瘤治疗药物

研究表明：如果降低了人类肿瘤中多聚唾液酸的表达，可以降低肿瘤细胞的分离，从而阻止肿瘤转移。多聚唾液酸作为肿瘤治疗靶点的药物成为阻止肿瘤转移的一种新手段。

应用：

1）神经再生 

聚唾液酸在神经再生方面起着决定性的作用，在胚胎发育期，聚唾液酸以高含量存在于在脊椎动物的大脑和中枢神经系统，在生长期，聚唾液酸结合在神经元表面的神经细胞粘附分子末端，参与细胞迁移，轴突引导，突触形成和神经系统的功能可塑性。聚唾液酸逐渐被认定为现代神经修复手术中脚手架最佳材料，还可以加速神经创伤的愈合。

2）延长药物半衰期 

聚唾液酸结构上众多羧基造成其高度的亲水性以及在机体中聚唾液酸受体的缺失，能够延长聚唾液酸化的药物在血液循环中的半衰期，提高了药物的溶解性和稳定性，减少了给药频率，且有助于降低药物的免疫原性和抗原性。聚唾液酸是目前发现的最为理想的蛋白药物缓释材料，聚唾液酸化的天冬酰胺酶、干扰素和胰岛素已用于临床试验，其效果比PEG（聚乙二醇）化干扰素的半衰期更长。 

3）运输载体 

聚唾液酸具有生物可降解性，且分解后产物无毒，又由于其独特的T-独立性抗原，因而不会诱发免疫记忆，大分子的聚唾液酸尤其适合作为小分子药物或酶的运输载体，能改善药物分子稳定性，并降低其在血液中的免疫原性。 

4）良好的水化能力和组织修复功能

在化妆品行业作为保湿剂和损伤组织的修复作用。

替卡西林二钠盐

Description

Chemical structure: ß-lactamTicarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. It is commonly used in combination with clavulanate in order to improve it′s efficacy. It is used to study appropriate dosing in pediatric patients who have cystic fibrosis.

替考拉宁

Description

Teicoplanin is a glycopeptide antibiotic produced byActinoplanes teichomiceticusthat is effective against Gram-positive bacteria resistant to β-lactam antibiotics. Teicoplanin and vancomycin have been used clinically for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. Product T0578 is a mixture of six primary teicoplanins; primarily teicoplanins A2 group.

氯己定二葡萄糖酸盐溶液

应用

氯己定已被用于研究精油与氯己定二葡糖酸盐联合使用时，如何改善皮肤消毒效果 ，并可用于皮肤渗透研究 。 用氯己定慢性冲洗已经证明可以降低NaCl的咸味和奎宁的苦味。可用于研究双（双胍）分子破坏膜的作用机制。

Description

Chlorhexidine has been used to study how essential oils improve skin antisepsis when combined with chlorhexidine digluconate and is used for skin permeation studies . Chronic rinsing with chlorhexidine has been shown to decrease the saltiness of NaCl and the bitterness of quinine.Used to study mechanism of membrane dysruption by bis(biguanide) molecules.

甲氧苄啶

描述

化学结构：嘧啶

应用

甲氧苄啶是最主要的抗细菌剂。 它有二氢叶酸还原酶抑制活性和原核酶选择性。 它被用来治疗尿道感染，轻度急性前列腺炎，复发性膀胱炎，怀孕期间无症状菌尿和呼吸道感染。主要作为抗细菌剂。 二氢叶酸还原酶抑制活性和原核酶选择性。

Description

Chemical structure: pyrimidineTrimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

甲氧苄啶

描述

化学结构：嘧啶

应用

甲氧苄啶主要用作抗菌剂。用于结核分枝杆菌的敏感性研究和流感嗜血杆菌的耐药性研究。主要作为抗细菌剂。 二氢叶酸还原酶抑制活性和原核酶选择性。

Description

Chemical structure: pyrimidineTrimethoprim is primarily used as an antibacterial agent. It is used in susceptibility studies ofMycobacterium tuberculosisand mechanism of resistance studies inHaemophilus influenzae.Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

甲氧苄啶乳酸盐

Description

Chemical structure: pyrimidineTrimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.

甲氧苄氨嘧啶现成溶液

Description

Trimethoprim is used at a final concentration of ~4μg/mL for antibacterial activty.

甲氧西林钠盐

Description

Methicillin is used to study bacterium susceptibility , methicillin-resistance in Staphylococcus aureus , and to inhibit cell-wall synthesis .