Chloroacetamido-C4-NHBoc

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Chloroacetamido-C4-NHBoc 

Chloroacetamido-C4-NHBoc 是一种 PROTAC linker,属于 alkyl/ether 类。可用于合成 PROTAC 分子。

Chloroacetamido-C4-NHBoc

Chloroacetamido-C4-NHBoc Chemical Structure

CAS No. : 133264-58-1

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生物活性

Chloroacetamido-C4-NHBoc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

264.75

Formula

C11H21ClN2O3

CAS 号

133264-58-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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PLK4-IN-3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PLK4-IN-3 

PLK4-IN-3 是PLK4-IN-1 的绝对构型。PLK4-IN-1 (Example A6) 是PLK4 的抑制剂,其IC50 值为 ≤0.1 μM。

PLK4-IN-3

PLK4-IN-3 Chemical Structure

CAS No. : 1247001-86-0

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生物活性

PLK4-IN-3 is a less active absolute stereochemistry of PLK4-IN-1. PLK4-IN-1 is a PLK4 inhibitor, with an IC50 of 0.65 μM[1].

IC50 & Target[1]

PLK4

≤ 0.1 μM (IC50)

分子量

431.23

Formula

C18H14IN3O2

CAS 号

1247001-86-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Peter Brent Sampson, et al. KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME. Patent. WO2011123946A1.

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Methyl acetate-PEG1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Methyl acetate-PEG1 

Methyl acetate-PEG1 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Methyl acetate-PEG1

Methyl acetate-PEG1 Chemical Structure

CAS No. : 58349-37-4

规格 是否有货
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生物活性

Methyl acetate-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

134.13

Formula

C5H10O4

CAS 号

58349-37-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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m-PEG3-phosphonic acid

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

m-PEG3-phosphonic acid 

m-PEG3-phosphonic acid 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

m-PEG3-phosphonic acid

m-PEG3-phosphonic acid Chemical Structure

CAS No. : 96962-42-4

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生物活性

m-PEG3-phosphonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

228.18

Formula

C7H17O6P

CAS 号

96962-42-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PLK4-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PLK4-IN-1 

PLK4-IN-1 (Example A6) 是 PLK4 的抑制剂,其 IC50 值为 ≤ 0.1 μM。

PLK4-IN-1

PLK4-IN-1 Chemical Structure

CAS No. : 1247001-12-2

规格 是否有货
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生物活性

PLK4-IN-1 (Example A6) is a PLK4 inhibitor, with an IC50 of ≤ 0.1 μM[1].

IC50 & Target

IC50: ≤ 0.1 μM (PLK4)[1].

分子量

431.23

Formula

C18H14IN3O2

CAS 号

1247001-12-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Peter Brent Sampson, et al. KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME. Patent. WO2011123946A1.

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I-PEG6-OH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

I-PEG6-OH 

I-PEG6-OH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

I-PEG6-OH

I-PEG6-OH Chemical Structure

CAS No. : 136399-07-0

规格 是否有货
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250 mg   询价  
500 mg   询价  

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生物活性

I-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

392.23

Formula

C12H25IO6

CAS 号

136399-07-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Hydroxy-PEG3-ethyl acetate

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Hydroxy-PEG3-ethyl acetate 

Hydroxy-PEG3-ethyl acetate 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Hydroxy-PEG3-ethyl acetate

Hydroxy-PEG3-ethyl acetate Chemical Structure

CAS No. : 118988-04-8

规格 是否有货
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生物活性

Hydroxy-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

236.26

Formula

C10H20O6

CAS 号

118988-04-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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BMSpep-57

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

BMSpep-57 

BMSpep-57 是一种有效的大环肽类抑制剂,抑制 PD-1/PD-L1 相互作用,IC50 为 7.68 nM。BMSpep-57 与 PD-L1 结合,MST 和 SPR 测定表明,Kd 分别为 19 nM 和 19.88 nM。BMSpep-57 通过增加 PBMC 中 IL-2 的产生促进 T 细胞功能。

BMSpep-57

BMSpep-57 Chemical Structure

CAS No. : 1629655-80-6

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BMSpep-57 的其他形式现货产品:

BMSpep-57 hydrochloride

生物活性

BMSpep-57 is a potent and competitive macrocyclic peptide inhibitor of PD-1/PD-L1 interaction with an IC50 of 7.68 nM. BMSpep-57 binds to PD-L1 with Kds of 19 nM and 19.88 nM in MST and SPR assays, respectively. BMSpep-57 facilitates T cell function by in creasing IL-2 production in PBMCs[1].

IC50 & Target

IC50: 7.68 nM (PD-1/PD-L1 interaction)[1]

体外研究
(In Vitro)

In a ELISA competition assay, BMSpep-57 inhibits PD-1/PD-L1 binding up to 98.1% 300 nM. And it shows a concentration dependent inhibition of PD-1/PD-L1 binding with an IC50 of 7.68 nM[1].
BMSpep-57 induced high levels of IL-2 at 1 µM and 500 nM concentrations in  SEB-stimulated peripheral blood mononuclear cells[1].
BMSpep-57 (0.2-10 μM; 24 hours) does not show any effect on the Jurkat, CHO and HepG2 cells’ viability at the various concentrations tested[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1868.17

Formula

C89H126N24O19S

CAS 号

1629655-80-6

Sequence

{mercaptoacetic acid}-Phe-Ala-Asn-Pro-His-Leu-Ser-Trp-Ser-Trp-{norleucine}-{norleucine}-Arg-Cys-Gly (Sulfide bridge:mercaptoacetic acid 1-Cys15)

Sequence Shortening

{mercaptoacetic acid}-FANPHLSWSW-{norleucine}-{norleucine}-RCG (Sulfide bridge:mercaptoacetic acid 1-Cys15)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Aravindhan Ganesan, et al. Comprehensive in vitro characterization of PD-L1 small molecule inhibitors.Sci Rep . 2019 Aug 27;9(1):12392.

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DBCO-PEG4-GGFG-DX8951

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

DBCO-PEG4-GGFG-DX8951 

DBCO-PEG4-GGFG-DX8951 是抗体-药物偶联物的一部分,由 DNA 拓扑异构酶 I 抑制剂 DX8951 和不可降解的 ADC linker DBCO-PEG4-GGFG 连接而成。

DBCO-PEG4-GGFG-DX8951

DBCO-PEG4-GGFG-DX8951 Chemical Structure

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生物活性

DBCO-PEG4-GGFG-DX8951 is a drug-linker conjugate for ADC with potent antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the non-cleavable ADC linker DBCO-PEG4-GGFG[1].

IC50 & Target

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linke[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1375.45

Formula

C72H79FN10O17

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Anish Thomas, et al. Antibody-drug conjugates for cancer therapy. Lancet Oncol. 2016 Jun;17(6):e254-e262.

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Methyl acetate-PEG1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Methyl acetate-PEG1 

Methyl acetate-PEG1 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Methyl acetate-PEG1

Methyl acetate-PEG1 Chemical Structure

CAS No. : 58349-37-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Methyl acetate-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

134.13

Formula

C5H10O4

CAS 号

58349-37-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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I-PEG5-OH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

I-PEG5-OH 

I-PEG5-OH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

I-PEG5-OH

I-PEG5-OH Chemical Structure

CAS No. : 1883516-31-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

I-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

348.18

Formula

C10H21IO5

CAS 号

1883516-31-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

I-PEG6-OH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

I-PEG6-OH 

I-PEG6-OH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

I-PEG6-OH

I-PEG6-OH Chemical Structure

CAS No. : 136399-07-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

I-PEG6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

392.23

Formula

C12H25IO6

CAS 号

136399-07-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Sel-green

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Sel-green 

Sel-green 是一种选择性的硒醇荧光探针,用于定量硒酶硫氧蛋白还原酶中的 Sec 含量,并对活细胞中的 Sec 进行荧光呈像。

Sel-green

Sel-green Chemical Structure

CAS No. : 1574299-37-8

规格 价格 是否有货
5 mg ¥3500 询问价格 & 货期
10 mg ¥5800 询问价格 & 货期

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生物活性

Sel-green, a selective selenol fluorescent probe, is applied to quantify the Sec content in the selenoenzyme thioredoxin reductase and image endogenous Sec in live HepG2 cells[1].

体外研究
(In Vitro)

Sel-green displays >20-fold selectivity of Sec over DTT[1]. Sel-green is suitable for identifying the selenol species metabolized from various selenocompounds in cells, which helps to clarify the mechanism underlying the cytotoxicity of different selenocompounds[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

462.43

Formula

C19H18N4O8S

CAS 号

1574299-37-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

DMSO : 50 mg/mL (108.12 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1625 mL 10.8124 mL 21.6249 mL
5 mM 0.4325 mL 2.1625 mL 4.3250 mL
10 mM 0.2162 mL 1.0812 mL 2.1625 mL

参考文献
  • [1]. Baoxin Zhang, et al. Selective selenol fluorescent probes: design, synthesis, structural determinants, and biological applications. J Am Chem Soc. 2015 Jan 21;137(2):757-69.

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Ph-PEG3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ph-PEG3 

Ph-PEG3 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Ph-PEG3

Ph-PEG3 Chemical Structure

CAS No. : 7204-16-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

226.27

Formula

C12H18O4

CAS 号

7204-16-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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Seph-PAO

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Seph-PAO 

Seph-PAO 是连接sepharose 荧光基团的 PAO,可用于检测硫氧还蛋白还原酶 (TrxR)。

Seph-PAO

Seph-PAO Chemical Structure

CAS No. : 851461-65-9

规格 是否有货
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250 mg   询价  
500 mg   询价  

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生物活性

Seph-PAO is the modified PAO attached a sepharose fluorophore and is used to detect the thioredoxin reductase (TrxR)[1].

CAS 号

851461-65-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dongzhu Duan, et al. Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells. J Biol Chem. 2016 May 6;291(19):10021-31.

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I-PEG5-OH

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

I-PEG5-OH 

I-PEG5-OH 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

I-PEG5-OH

I-PEG5-OH Chemical Structure

CAS No. : 1883516-31-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

I-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

348.18

Formula

C10H21IO5

CAS 号

1883516-31-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Bis-acrylate-PEG5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Bis-acrylate-PEG5 

Bis-acrylate-PEG5 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Bis-acrylate-PEG5

Bis-acrylate-PEG5 Chemical Structure

CAS No. : 59256-52-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Bis-acrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

346.37

Formula

C16H26O8

CAS 号

59256-52-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

8-Bromo-ATP(Synonyms: 8-Bromoadenosine 5′-triphosphate; 8-Br-ATP)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

8-Bromo-ATP (Synonyms: 8-Bromoadenosine 5′-triphosphate; 8-Br-ATP)

8-Bromo-ATP (8-Bromoadenosine 5′-triphosphate),一种 ATP 类似物,是一种嘌呤能 P2X receptor 受体的激动剂。8-Bromo-ATP 对多发性骨髓瘤细胞具有细胞毒性,IC50 为 23.1 μM。

8-Bromo-ATP(Synonyms: 8-Bromoadenosine 5

8-Bromo-ATP Chemical Structure

CAS No. : 23567-97-7

规格 是否有货
1 mg 询价

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生物活性

8-Bromo-ATP (8-Bromoadenosine 5′-triphosphate), an ATP analogue, is a purinergic P2X receptor agonist. 8-Bromo-ATP shows cytotoxic to multiple myeloma cells with an IC50 of 23.1 μM[1][2][3].

体外研究
(In Vitro)

8-Bromo-ATP (10-50 μM; 5 days) treatment shows cytotoxic to multiple myeloma[3].
Fluorescence measurements are made possible through the use of 8-Bromo-ATP, which selectively quenched certain tryptophan residues of the ATPase. 8-Bromo-ATP enhances the rate of dephosphorylation of native ATPase 2-3-fold when added in the absence of divalent cations[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: MM 1.s cells
Concentration: 10 μM, 20 μM, 30 μM, 40 μM, 50 μM
Incubation Time: 5 days
Result: Showed cytotoxic to multiple myeloma.

分子量

586.08

Formula

C10H15BrN5O13P3

CAS 号

23567-97-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Howson, W, et al. Synthesis and biological evaluation of ATP analogues acting at putative purinergic P2X-receptors (on the guinea pig bladder). Eur. J. Med. Chem. 23(5), 433-439 (1988).

    [2]. P Champeil, et al. ATP regulation of sarcoplasmic reticulum Ca2+-ATPase. Metal-free ATP and 8-bromo-ATP bind with high affinity to the catalytic site of phosphorylated ATPase and accelerate dephosphorylation. J Biol Chem. 1988 Sep 5;263(25):12288-94.

    [3]. Li Wang, et al. Cationic phospholiposomes: efficient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cells. J Liposome Res. 2011 Dec;21(4):306-14.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Ph-PEG3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ph-PEG3 

Ph-PEG3 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Ph-PEG3

Ph-PEG3 Chemical Structure

CAS No. : 7204-16-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

226.27

Formula

C12H18O4

CAS 号

7204-16-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Bis-methacrylate-PEG5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Bis-methacrylate-PEG5 

Bis-methacrylate-PEG5 是一种 PROTAC linker,属于 PEG 类。可用于合成 PROTAC 分子。

Bis-methacrylate-PEG5

Bis-methacrylate-PEG5 Chemical Structure

CAS No. : 13497-24-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Bis-methacrylate-PEG5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

374.43

Formula

C18H30O8

CAS 号

13497-24-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务