Lupulone

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Lupulone 

Lupulone 是一种在啤酒花植物 H.lupulus 中发现的 β 酸,具有多种生物活性,包括抗菌、抗氧化和抗癌特性。

Lupulone Lupulone

Lupulone Chemical Structure

CAS No. : 468-28-0

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生物活性

Lupulone is a beta-acid from the hop plant H. lupulus with diverse biological activities including antibacterial, antioxidant, and anticarcinogenic properties[1][2][3].

分子量

414.58

Formula

C26H38O4

CAS 号

468-28-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tagashira M, et al. Antioxidative activity of hop bitter acids and their analogues. Biosci Biotechnol Biochem. 1995 Apr;59(4):740-2.

    [2]. Lamy V, et al. Lupulone, a hop bitter acid, activates different death pathways involving apoptotic TRAIL-receptors, in human colon tumor cells and in their derived metastatic cells. Apoptosis 13(10), 1232-1242 (2008).

    [3]. Bocquet L, et al. Phenolic Compounds from Humulus lupulus as Natural Antimicrobial Products: New Weapons in the Fight against Methicillin Resistant Staphylococcus aureus, Leishmania mexicana and Trypanosoma brucei Strains. Molecules. 2019 Mar 14;24(6):1024.

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DYSP-C34

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

DYSP-C34 

DYSP-C34 是一种有效的、生物相容的和超声波 (US) 触发的多功能分子机器。DYSP-C34 具有多种有利特性,例如改善亲脂/亲水平衡、增强超声波诱导的 ROS 产生能力和更好的细胞通透性,从而导致出色的肿瘤靶向效率和显着的声动力疗法 (SDT) 介导的肿瘤消退。 DYSP-C34 通过直接刺激 APC 表现出温和的免疫原性。

DYSP-C34

DYSP-C34 Chemical Structure

CAS No. : 2559734-98-2

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生物活性

DYSP-C34 is a potent, biocompatible, and ultrasound (US)-triggered multifunctional molecular machine. DYSP-C34 has multiple favorable properties, such as improved lipophilic/hydrophilic balance, intensified US-induced ROS production capacity, and better cellular permeability, resulting in the excellent tumor target efficiency and notable sonodynamic therapy (SDT)-mediated tumor regression. DYSP-C34 exhibits mild immunogenicity by stimulating APCs directly[1].

分子量

817.88

Formula

C45H47N5O10

CAS 号

2559734-98-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wang L, et al. An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression. Sci Adv. 2021;7(43):eabj4796.

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Carubicin hydrochloride(Synonyms: Carminomycin hydrochloride; Carminomicin I hydrochloride)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Carubicin hydrochloride (Synonyms: Carminomycin hydrochloride; Carminomicin I hydrochloride) 纯度: 98.67%

Carubicin hydrochloride 是一种微生物衍生的化合物。Carubicin hydrochloride 是 VHL 缺陷型 (VHL-/-) CCRCC 细胞增殖的有效抑制剂。Carubicin hydrochloride 还通过独立于 p53 或缺氧诱导因子 HIF2 的机制诱导细胞凋亡 (apoptosis)。Carubicin hydrochloride具有研究癌症疾病的潜力。

Carubicin hydrochloride(Synonyms: Carminomycin hydrochloride; Carminomicin I hydrochloride)

Carubicin hydrochloride Chemical Structure

CAS No. : 52794-97-5

规格 价格 是否有货 数量
5 mg ¥4300 In-stock
10 mg ¥6800 In-stock
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Carubicin hydrochloride 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Apoptosis Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Microbial Metabolite Library

生物活性

Carubicin hydrochloride is a microbially-derived compound. Carubicin hydrochloride is an effective inhibitor of VHL-defective (VHL−/−) CCRCC cell proliferation. Carubicin hydrochloride also induces apoptosis by a mechanism independent of p53 or hypoxia-inducible factor HIF2. Carubicin hydrochloride has the potential for the research of cancer diseases[1][2].

分子量

549.95

Formula

C26H28ClNO10

CAS 号

52794-97-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : 62.5 mg/mL (113.65 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8183 mL 9.0917 mL 18.1835 mL
5 mM 0.3637 mL 1.8183 mL 3.6367 mL
10 mM 0.1818 mL 0.9092 mL 1.8183 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (3.78 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.78 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (3.78 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Woldemichael GM, et al. Carminomycin I is an apoptosis inducer that targets the Golgi complex in clear cell renal carcinoma cells. Cancer Res. 2011 Jan 1;71(1):134-42.

    [2]. Tevyashova AN, et al. Carminomycin, 14-hydroxycarminomycin and its novel carbohydrate derivatives potently kill human tumor cells and their multidrug resistant variants. J Antibiot (Tokyo). 2004 Feb;57(2):143-50.

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TC113

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

TC113 

TC113 是吉西他滨 (Gemcitabine) 的 c(RGDyK) 偶联物。A549 细胞可通过整合素 αvβ3 将 TC113 内化。TC113 对WM266.4 和 A549 细胞显示出强大的抗增殖特性。

TC113

TC113 Chemical Structure

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生物活性

TC113 is a c(RGDyK)-Based conjugate of Gemcitabine (GEM). TC113 could be internalized by A549 cells through integrin αvβ3. TC113 shows potent antiproliferative properties against WM266.4 and A549 cells[1].

分子量

908.86

Formula

C37H50F2N12O13

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chatzisideri T, et al. Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine. J Med Chem. 2022;65(1):271-284.

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VEGFR-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

VEGFR-IN-1 

VEGFR-IN-1 (compound 3) 是一种有效的血管生成抑制剂,对于 KDRFlt-1、c-Kit、EGF-R 和 c-Src,IC50 分别为 0.02、0.18、0.24、7.3 和 7 µM。

VEGFR-IN-1

VEGFR-IN-1 Chemical Structure

CAS No. : 269390-69-4

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生物活性

VEGFR-IN-1 (compound 3) is a potent angiogenesis inhibitor with IC50s of 0.02, 0.18, 0.24 7.3, and 7 µM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively[1].

IC50 & Target[1]

KDR

0.02 μM (IC50)

Flt-1

0.18 μM (IC50)

EGFR

0.24 μM (IC50)

分子量

337.80

Formula

C19H16ClN3O

CAS 号

269390-69-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Furet P, et al. Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorg Med Chem Lett. 2003;13(18):2967-2971.

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Phostriecin

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Phostriecin 

Phostriecin 是一种由 Streptomyces pulveraceus 生产的抗肿瘤抗生素。 Phostriecin 是 2A 型 (PP2A) 的强抑制剂和 1 型 (PP1) 丝氨酸/苏氨酸蛋白磷酸酶的弱抑制剂,IC50< /sub>s 值分别为 3.2 nM 和 131 μM。Phostriecin 具有研究癌症的潜力。

Phostriecin

Phostriecin Chemical Structure

CAS No. : 131774-59-9

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生物活性

Phostriecin is an antitumor antibiotic produced by Streptomyces pulveraceus. Phostriecin is a strong inhibitor of type 2A (PP2A) and a weak inhibitor of type 1 (PP1) serine/threonine protein phosphatases with IC50s of 3.2 nM and 131 μM, respectively. Phostriecin has the potential for the research of cancer[1].

分子量

491.51

Formula

C24H37NaO7P

CAS 号

131774-59-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Walsh AH, et al. Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett. 1997 Oct 27;416(3):230-4.

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DYSP-C34

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

DYSP-C34 

DYSP-C34 是一种有效的、生物相容的和超声波 (US) 触发的多功能分子机器。DYSP-C34 具有多种有利特性,例如改善亲脂/亲水平衡、增强超声波诱导的 ROS 产生能力和更好的细胞通透性,从而导致出色的肿瘤靶向效率和显着的声动力疗法 (SDT) 介导的肿瘤消退。 DYSP-C34 通过直接刺激 APC 表现出温和的免疫原性。

DYSP-C34

DYSP-C34 Chemical Structure

CAS No. : 2559734-98-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

DYSP-C34 is a potent, biocompatible, and ultrasound (US)-triggered multifunctional molecular machine. DYSP-C34 has multiple favorable properties, such as improved lipophilic/hydrophilic balance, intensified US-induced ROS production capacity, and better cellular permeability, resulting in the excellent tumor target efficiency and notable sonodynamic therapy (SDT)-mediated tumor regression. DYSP-C34 exhibits mild immunogenicity by stimulating APCs directly[1].

分子量

817.88

Formula

C45H47N5O10

CAS 号

2559734-98-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wang L, et al. An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression. Sci Adv. 2021;7(43):eabj4796.

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SANT 2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

SANT 2 

SANT 2 是 Hh 信号通路的有效拮抗剂。Hedgehog (Hh) 信号传导在胚胎发育和成人组织稳态的细胞信号传导中起重要作用。SANT 2 具有研究多种恶性肿瘤的潜力,包括 Gorlin 综合征 (一种易患基底细胞癌、髓母细胞瘤和横纹肌肉瘤的疾病)、前列腺癌、胰腺癌和乳腺癌。

SANT 2

SANT 2 Chemical Structure

CAS No. : 329196-48-7

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生物活性

SANT 2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers[1].

分子量

479.96

Formula

C26H26ClN3O4

CAS 号

329196-48-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Büttner A, et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem. 2009 Jul 15;17(14):4943-54.

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5,8-Epidioxyergosta-6,9(11),22-trien-3-ol(Synonyms: 9,11-Dehydroergosterol peroxide; 9(11)-DHEP)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (Synonyms: 9,11-Dehydroergosterol peroxide; 9(11)-DHEP)

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide),一种来自药用蘑菇的重要甾体,对几种肿瘤类型具有抗肿瘤活性。5,8-Epidioxyergosta-6,9(11),22-trien-3-ol 通过诱导 CDKN1A 表达抑制 HT29 细胞生长,从而导致细胞周期停滞和凋亡。

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol(Synonyms: 9,11-Dehydroergosterol peroxide;  9(11)-DHEP)

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol Chemical Structure

CAS No. : 86363-50-0

规格 是否有货
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生物活性

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis[1][2].

IC50 & Target[1]

Microbial Metabolite

 

体外研究
(In Vitro)

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide) is an effective inhibitor of HL60 leukemia cell growth and apoptosis-inducer[1].
Apoptosis induced by 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl‑1 dependent[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

426.63

Formula

C28H42O3

CAS 号

86363-50-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kobori M, Yoshida M, Ohnishi-Kameyama M, Takei T, Shinmoto H. 5alpha,8alpha-Epidioxy-22E-ergosta-6,9(11),22-trien-3beta-ol from an edible mushroom suppresses growth of HL60 leukemia and HT29 colon adenocarcinoma cells. Biol Pharm Bull. 2006;29(4):755-759.

    [2]. Zheng L, et al. Apoptosis induced by 9,11 dehydroergosterol peroxide from Ganoderma Lucidum mycelium in human malignant melanoma cells is Mcl 1 dependent. Mol Med Rep. 2018;18(1):938-944.

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MHY908

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

MHY908 

MHY908 是 PPARα 和 PPARγ 的有效双重激动剂。MHY908 还通过抑制蘑菇酪氨酸酶活性抑制黑色素生成。

MHY908

MHY908 Chemical Structure

CAS No. : 1393371-39-5

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生物活性

MHY908 is a potent dual agonist of PPARα and PPARγ[1]. MHY908 also inhibits melanogenesis through inhibition of mushroom tyrosinase activity[2].

分子量

347.82

Formula

C17H14ClNO3S

CAS 号

1393371-39-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Park MH, et al. Potent anti-diabetic effects of MHY908, a newly synthesized PPAR α/γ dual agonist in db/db mice. PLoS One. 2013 Nov 14;8(11):e78815.

    [2]. Park MH, et al. Inhibition of melanogenesis by 2-[4-(5-chlorobenzo[d]thiazol-2-yl)phenoxy]-2-methylpropanoic acid (MHY908). Arch Pharm Res. 2015 Apr;38(4):505-11.

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VEGFR-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

VEGFR-IN-1 

VEGFR-IN-1 (compound 3) 是一种有效的血管生成抑制剂,对于 KDRFlt-1、c-Kit、EGF-R 和 c-Src,IC50 分别为 0.02、0.18、0.24、7.3 和 7 µM。

VEGFR-IN-1

VEGFR-IN-1 Chemical Structure

CAS No. : 269390-69-4

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生物活性

VEGFR-IN-1 (compound 3) is a potent angiogenesis inhibitor with IC50s of 0.02, 0.18, 0.24 7.3, and 7 µM for KDR, Flt-1, c-Kit, EGF-R, and c-Src, respectively[1].

IC50 & Target[1]

KDR

0.02 μM (IC50)

Flt-1

0.18 μM (IC50)

EGFR

0.24 μM (IC50)

分子量

337.80

Formula

C19H16ClN3O

CAS 号

269390-69-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Furet P, et al. Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorg Med Chem Lett. 2003;13(18):2967-2971.

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Zaragozic acid B

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Zaragozic acid B 

Zaragozic acid B 是一种真菌代谢产物,是法尼基蛋白转移酶 (FPTase) 和角鲨烯合成酶 (squalene synthases) 的有效抑制剂。Zaragozic acid B 是一种潜在的抗癌药物。

Zaragozic acid B

Zaragozic acid B Chemical Structure

CAS No. : 146389-61-9

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生物活性

Zaragozic acid B, a fungal metabolite, is a potent inhibitor of both farnesyl-protein transferase (FPTase) and squalene synthases. Zaragozic acid B is a potential anticancer drug[1].

体外研究
(In Vitro)

Zaragozic acid B is a very potent inhibitor of squalene synthases from all three sources (RSS: rat liver microsome; YSS: Candida albicans; HSS: Hep G2 cells) with the IC50 values range from 0.22 to 0.67 nM[1].
Zaragozic acid B inhibits bovine FPTase (IC50=100 nM), human FPTase (IC50=185 nM)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

730.84

Formula

C39H54O13

CAS 号

146389-61-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Leeyuan Huang, et al. New fungal metabolites as potential antihypercholesterolemics and anticancer agents. Canadian Journal of Botany • December 1995.

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R110

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

R110 

R110 是一种有效的,竞争性的 巨噬细胞迁移抑制因子 (MIF2) 互变异构酶抑制剂,IC50 为 15 μM。R110 具有研究癌症疾病的潜力。

R110

R110 Chemical Structure

CAS No. : 1985622-33-0

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生物活性

R110 is a potent, competitive inhibitor of macrophage migration inhibitory factor 2 (MIF2) tautomerase with an IC50 of 15 μM. R110 has the potential for the research of cancer diseases[1].

IC50 & Target

IC50: 15 μM (MIF2)[1]

分子量

308.83

Formula

C15H17ClN2OS

CAS 号

1985622-33-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Xiao Z, et al. Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells. J Med Chem. 2022 Feb 10;65(3):2059-2077.

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SANT 2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

SANT 2 

SANT 2 是 Hh 信号通路的有效拮抗剂。Hedgehog (Hh) 信号传导在胚胎发育和成人组织稳态的细胞信号传导中起重要作用。SANT 2 具有研究多种恶性肿瘤的潜力,包括 Gorlin 综合征 (一种易患基底细胞癌、髓母细胞瘤和横纹肌肉瘤的疾病)、前列腺癌、胰腺癌和乳腺癌。

SANT 2

SANT 2 Chemical Structure

CAS No. : 329196-48-7

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生物活性

SANT 2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers[1].

分子量

479.96

Formula

C26H26ClN3O4

CAS 号

329196-48-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Büttner A, et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem. 2009 Jul 15;17(14):4943-54.

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Fusarochromanone(Synonyms: FC-101)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Fusarochromanone (Synonyms: FC-101)

Fusarochromanone (FC-101) 是一种真菌代谢物,具有有效的抗血管生成和抗癌活性。Fusarochromanone 激活的 JNK 通路归因于活性氧 (ROS) 的诱导。

Fusarochromanone(Synonyms: FC-101)

Fusarochromanone Chemical Structure

CAS No. : 802915-53-3

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生物活性

Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity[1]. Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS)[2].

体外研究
(In Vitro)

Fusarochromanone (FC101; 10 μM; 24 hours) induces apoptosis and an increase in proportion of cells in the sub-G1 phase in both HaCat and P9-WT cell lines[1].
Fusarochromanone (FC101; 0-1 μM; 24 h) induces the cleavage of both caspase-3 and PARP, a well-known substrate for activated caspases. FC101 does not affect the expression of the anti-apoptotic proteins, Bcl-2, Bcl-XL, Mcl-1, or the pro-apoptotic proteins BAD, BAK, BAX[1].
Fusarochromanone (FC101) exhibits very potent in-vitro growth inhibitory effects (IC50 ranging from 10 nM-2.5 μM) against HaCat (pre-malignant skin), P9-WT (malignant skin), MCF-7 (low malignant breast), MDA-231 (malignant breast), SV-HUC (premalignant bladder), UM-UC14 (malignant bladder), and PC3 (malignant prostate) in a time-course and dose-dependent manner, with the UM-UC14 cells being the most sensitive.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: HaCat and P9-WT cell lines
Concentration: 10 μM
Incubation Time: 24 hours
Result: Showed cells in the G2 and M phases of the cell cycle for both cell lines.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.05 μM, 0.1 μM, 0.2 μM, 0.5 μM, 1 μM
Incubation Time: 24 hours
Result: Induced the cleavage of both caspase-3 and PARP.

体内研究
(In Vivo)

Fusarochromanone (8 mg/kg; IP; 5 days per week; for 3.5 weeks) Is well tolerated, non-toxic, and achieved a 30% reduction in tumor size at a dose of 8 mg/kg/day[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID Beige mice (CB17/Icr.Cg-PrkdcscidLystbg/Crl) injected with SRB12-p9 cells[1]
Dosage: 8 mg/kg
Administration: IP; 5 days per week; for 3.5 weeks
Result: Achieved a 30% reduction in tumor size at a dose of 8 mg/kg/day.

分子量

292.33

Formula

C15H20N2O4

CAS 号

802915-53-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Elahe Mahdavian, et al.Biological activities of fusarochromanone: a potent anti-cancer agent. BMC Res Notes. 2014 Sep 3;7:601.

    [2]. Ying Gu, et al.Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5. Oncotarget. 2015 Dec 8;6(39):42322-33.

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MIF2-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

MIF2-IN-1 

MIF2-IN-1 (compound 5d) 是一种有效的 MIF2 互变异构酶抑制剂,IC50 为 1.0 μM。MIF2-IN-1 通过 MAPK 通路诱导细胞周期停滞来抑制非小细胞肺癌细胞的增殖。MIF2-IN-1 具有研究癌症疾病的潜力。

MIF2-IN-1

MIF2-IN-1 Chemical Structure

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生物活性

MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases[1].

IC50 & Target

IC50: 1.0 μM (MIF2)[1]

分子量

480.50

Formula

C26H19F3N2O2S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Xiao Z, et al. Thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione Derivative Inhibits d-Dopachrome Tautomerase Activity and Suppresses the Proliferation of Non-Small Cell Lung Cancer Cells. J Med Chem. 2022 Feb 10;65(3):2059-2077.

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Zaragozic acid B

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Zaragozic acid B 

Zaragozic acid B 是一种真菌代谢产物,是法尼基蛋白转移酶 (FPTase) 和角鲨烯合成酶 (squalene synthases) 的有效抑制剂。Zaragozic acid B 是一种潜在的抗癌药物。

Zaragozic acid B

Zaragozic acid B Chemical Structure

CAS No. : 146389-61-9

规格 是否有货
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250 mg   询价  
500 mg   询价  

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生物活性

Zaragozic acid B, a fungal metabolite, is a potent inhibitor of both farnesyl-protein transferase (FPTase) and squalene synthases. Zaragozic acid B is a potential anticancer drug[1].

体外研究
(In Vitro)

Zaragozic acid B is a very potent inhibitor of squalene synthases from all three sources (RSS: rat liver microsome; YSS: Candida albicans; HSS: Hep G2 cells) with the IC50 values range from 0.22 to 0.67 nM[1].
Zaragozic acid B inhibits bovine FPTase (IC50=100 nM), human FPTase (IC50=185 nM)[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

730.84

Formula

C39H54O13

CAS 号

146389-61-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Leeyuan Huang, et al. New fungal metabolites as potential antihypercholesterolemics and anticancer agents. Canadian Journal of Botany • December 1995.

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HP1328

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

HP1328 

HP1328 是 FLT3 受体酪氨酸激酶 (FLT3/ITD 突变) 的有效抑制剂。HP1328 是一种基于苯并咪唑支架的化合物。HP1328 显着降低白血病负担并延长 FLT3/ITD 白血病小鼠的生存期。

HP1328

HP1328 Chemical Structure

CAS No. : 2245074-20-6

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生物活性

HP1328 is a potent inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1328 is a benzoimidazole scaffold-based compound. HP1328 significantly reduces the leukemia burden and prolongs the survival of mice with FLT3/ITD leukemia[1].

分子量

389.45

Formula

C23H23N3O3

CAS 号

2245074-20-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tian T, et al. Identification of the Benzoimidazole Compound as a Selective FLT3 Inhibitor by Cell-Based High-Throughput Screening of a Diversity Library. J Med Chem. 2022 Feb 24;65(4):3597-3605.

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CXCR2 antagonist 3

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CXCR2 antagonist 3 

CXCR2 antagonist 3 (compound 11h) 是 CXC 趋化因子受体 2 (CXCR2) 的有效拮抗剂。CXCR2 antagonist 3 对 CXCR2 表现出两位数的纳摩尔效力,并显着抑制中性粒细胞浸润到气囊中。CXCR2 antagonist 3 可减少中性粒细胞和 MDSC 的浸润,并增强 CD3+ T 淋巴细胞向 Pan02 肿瘤组织的浸润。

CXCR2 antagonist 3

CXCR2 antagonist 3 Chemical Structure

CAS No. : 2647464-92-2

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生物活性

CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3+ T lymphocytes into the Pan02 tumor tissues[1].

分子量

362.38

Formula

C17H15FN2O4S

CAS 号

2647464-92-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Dong Y, et al. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J Med Chem. 2021;64(22):16626-16640.

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HP1142

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

HP1142 

HP1142 是 FLT3 受体酪氨酸激酶 (FLT3/ITD 突变) 的有效和具有选择性抑制剂。HP1142 是一种基于苯并咪唑支架的化合物。HP1142 具有研究FLT3/ITD 白血病的潜力。

HP1142

HP1142 Chemical Structure

CAS No. : 381173-58-6

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生物活性

HP1142 is a potent and selective inhibitor of FLT3 receptor tyrosine kinase (FLT3/ITD mutation). HP1142 is a benzoimidazole scaffold-based compound. HP1142 has the potential for the research of FLT3/ITD leukemia[1].

分子量

359.42

Formula

C22H21N3O2

CAS 号

381173-58-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tian T, et al. Identification of the Benzoimidazole Compound as a Selective FLT3 Inhibitor by Cell-Based High-Throughput Screening of a Diversity Library. J Med Chem. 2022 Feb 24;65(4):3597-3605.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务