Galectin-3 antagonist 2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Galectin-3 antagonist 2 

半乳糖凝集素-3 是一种β半乳糖苷特异性碳水化合物识别蛋白(凝集素),有促进B细胞前体急性淋巴细胞白血病(BCP-ALL)细胞的迁移和承受药物治疗的能力。

Galectin-3 antagonist 2

Galectin-3 antagonist 2 Chemical Structure

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生物活性

Galectin-3 is a β Galactoside specific carbohydrate recognition protein (lectin) has the ability to promote the migration of B cell precursor acute lymphoblastic leukemia (BCP-ALL) cells and withstand drug therapy.

分子量

461.42

Formula

C22H23NO10

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bum-Erdene K,et al. Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia. J Med Chem. 2022 Apr 28;65(8):5975-5989.

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FEN1-IN-2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

FEN1-IN-2 

FEN1-IN-2 (compound 20) 是瓣内切酶 1 (FEN1) 的抑制剂,其对 FEN1 和 XPG 的 IC50 值分别为3 nM 和 226 nM。

FEN1-IN-2

FEN1-IN-2 Chemical Structure

CAS No. : 824983-94-0

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生物活性

FEN1-IN-2 (compound 20) is a flap endonuclease 1 (FEN1) inhibitor, with IC50 values of 3 nM and 226 nM for FEN1 and XPG, respectively[1].

IC50 & Target

IC50: 3 nM (FEN1), 226 nM (XPG)[1].

分子量

393.42

Formula

C20H15N3O4S

CAS 号

824983-94-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. L Nathan Tumey, et al. The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors. Bioorg Med Chem Lett. 2005 Jan 17;15(2):277-81.

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Norathyriol(Synonyms: Mangiferitin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Norathyriol (Synonyms: Mangiferitin)

Norathyriol (Mangiferitin) 是芒果苷的天然代谢物。 Norathyriol 以非竞争性方式抑制 α-葡萄糖苷酶 (α-glucosidase ),IC50 为 3.12 μM。Norathyriol 还抑制 PPARαPPARβPPARγIC50 分别为 92.8 µM、102.4 µM 和 153.5 µM。具有抗氧化、抗癌、抗菌、抗炎、抗菌活性。

Norathyriol(Synonyms: Mangiferitin)

Norathyriol Chemical Structure

CAS No. : 3542-72-1

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生物活性

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

IC50 & Target[2]

PPARα

92.8 μM (IC50)

PPARβ

102.4 μM (IC50)

PPARγ

153.5 μM (IC50)

体外研究
(In Vitro)

Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest[3].
Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cells[3] Cell Growth Assay WB

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Mouse skin epidermal JB6 P+ cells
Concentration: 0, 1, 10, or 25 µM
Incubation Time: 24 or 72 hours
Result: Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death.

Western Blot Analysis[3]

Cell Line: JB6 P+ cells
Concentration: 0, 1, 10, or 25 µM
Incubation Time: 2 hours
Result: Inhibited UVB-induced phosphorylation of ERKs and p90RSK.

体内研究
(In Vivo)

Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1].
Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Kunming mice weighing 18-22 g[4]
Dosage: 0.92, 1.85 and 3.7 mg/kg
Administration: Administered intragastrically; twice daily for five times
Result: The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.

分子量

260.20

Formula

C13H8O6

CAS 号

3542-72-1

中文名称

芒果苷元

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhi-Long Shi, et al. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochem Res Int. 2017;2017:1206015.

    [2]. Ashley S Wilkinson,et al. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 2008 May 14;56(9):3037-42.

    [3]. Jixia Li, et al. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70.

    [4]. Yanfen Niu, et al. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. Pharm Biol. 2016 Sep;54(9):1680-6.

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OICR-9429-N-C2-NH2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

OICR-9429-N-C2-NH2 

OICR-9429-N-C2-NH2 是 Wd40 重复域蛋白 5 (WDR5) 的配体,可用于合成 PROTAC。详细信息请参考专利文献 WO2019246570A1 中的中间体 2。

OICR-9429-N-C2-NH2

OICR-9429-N-C2-NH2 Chemical Structure

CAS No. : 2407457-55-8

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生物活性

OICR-9429-N-C2-NH2 is a ligand for Wd40 repeat domain protein 5 (WDR5) extracted from patent WO2019246570A1, intermediate 2. OICR-9429-N-C2-NH2 can be used in the synthesis of PROTACs[1].

IC50 & Target

Ligand for Target Protein for PROTAC[1]

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

597.67

Formula

C31H38F3N7O2

CAS 号

2407457-55-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jin J, et, al. Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use. WO2019246570A1.

    [2]. Chung CW, et, al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.

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cis-Tiliroside(Synonyms: 顺式银椴苷)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

cis-Tiliroside (Synonyms: 顺式银椴苷)

cis-Tiliroside 是一种山奈酚衍生物,是一种黄酮苷。cis-Tiliroside在 A549 细胞系中表现出比 trans-Tiliroside 更好的细胞毒性。

cis-Tiliroside(Synonyms: 顺式银椴苷)

cis-Tiliroside Chemical Structure

CAS No. : 163956-16-9

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生物活性

cis-Tiliroside, a kaempferol derivative, is a flavonoid glycoside. cis-Tiliroside exhibits better cytotoxic activity than trans-Tiliroside in A549 cell line[1].

体外研究
(In Vitro)

cis-Tiliroside has CC50s of 68.05 μg/mL and 18.82 μg/mL for A549 cell line in 24 h or 48 h, respectively. trans-Tiliroside has CC50s of 149.90 μg/mL and 144.74 μg/mL for A549 cell line in 24 h or 48 h, respectively[1].
cis-Tiliroside exhibits better cytotoxic activity than kaempferol, which has CC50s of 129.15 μg/mL and 113.48 μg/mL for A549 cell line in 24 h or 48 h, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

594.52

Formula

C30H26O13

CAS 号

163956-16-9

中文名称

顺式银椴苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chi-Ren Liao, et al. Studies on cytotoxic constituents from the leaves of Elaeagnus oldhamii Maxim. in non-small cell lung cancer A549 cells. Molecules. 2014 Jul 4;19(7):9515-34.

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Pom-8PEG

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Pom-8PEG 

Pom-8PEG,一种 E3 连接酶配体-linker 偶联物,包含一个用于 E3 泛素连接酶的 cereblon (CRBN) 配体和一个 8 单元 PEG 连接子。Pom-8PEG 可用于合成 PROTAC,如 IDO1 PROTAC 降解剂。

Pom-8PEG

Pom-8PEG Chemical Structure

CAS No. : 2488761-03-9

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50 mg ¥10500 In-stock
100 mg ¥17000 In-stock
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生物活性

Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader[1].

IC50 & Target[1]

Cereblon

 

分子量

625.66

Formula

C29H43N3O12

CAS 号

2488761-03-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献
  • [1]. Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10(10):1943-1953.

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Dehydroglyasperin C

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Dehydroglyasperin C 

Dehydroglyasperin C 是一种异黄酮,是一种有效的 NAD(P)H:氧化醌还原酶 (NQO1) 和 phase 2 酶诱导剂。Dehydroglyasperin C 具有抗氧化、神经保护、癌症化学预防和抗炎活性。

Dehydroglyasperin C

Dehydroglyasperin C Chemical Structure

CAS No. : 199331-35-6

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生物活性

Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities[1][2][3].

体外研究
(In Vitro)

Dehydroglyasperin C (0.1-1 μM; 24 h) blocks the PDGF-induced progression through the G0/G1 to S phase of the cell cycle, and down-regulates the expression of CDK; 2, cyclin E, CDK4 and cyclin D1. Dehydroglyasperin C significantly attenuates PDGF-stimulated phosphorylation of PDGF receptor-β, phospholipase C-γ1, AKT and extracellular-regulated kinase 1/2, and DGC inhibits cell migration and the dissociation of actin filaments by PDGF[1].
Dehydroglyasperin C (0.1-1 μM; 24 h) treatment significantly decreases PDGF-induced cell number and DNA synthesis in a dose-dependent manner without any cytotoxicity in human aortic smooth muscle cells (HASMC)[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis[1]

Cell Line: Human aortic smooth muscle cells (HASMC)
Concentration: 0.1 μM, 0.5 μM, 1 μM
Incubation Time: 24 hours
Result: Blocked the PDGF-induced progression through the G0/G1 to S phase of the cell cycle.

Western Blot Analysis[1]

Cell Line: Human aortic smooth muscle cells (HASMC)
Concentration: 0.1 μM, 0.5 μM, 1 μM
Incubation Time: 24 hours
Result: Down-regulated the expression of CDK; 2, cyclin E, CDK4 and cyclin D1.

体内研究
(In Vivo)

In ICR mice, Dehydroglyasperin C (5 mg/kg; once) combined with CCl4 shows reduced lipid droplet formation in liver tissue, as assessed by histological examination. Further, DGC demonstrated a slight protective effect against centrilobular injury caused by CCl4 injection, perhaps through suppression of CYP2E1 expression[4].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

354.40

Formula

C21H22O5

CAS 号

199331-35-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hyo Jung Kim, et al. Dehydroglyasperin C, a component of liquorice, attenuates proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells. Br J Nutr. 2013 Aug 28;110(3):391-400.

    [2]. Ji Hoon Lee, et al. Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K. Mol Carcinog. 2016 May;55(5):552-62.

    [3]. Ji Yeon Seo, et al. Dehydroglyasperin C isolated from licorice caused Nrf2-mediated induction of detoxifying enzymes. J Agric Food Chem. 2010 Feb 10;58(3):1603-8.

    [4]. Seo, J.Y, et al. Protective effects of dehydroglyasperin c against carbon tetrachloride-induced liver damage in mice. Food Sci Biotechnol 23, 547–553 (2014).

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TAS-117

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

TAS-117 

TAS-117 是一种有效、选择性、具有口服活性的别构 Akt 抑制剂 (对 Akt1、2 和 3 的 IC50 分别为 4.8、1.6 和 44 nM)。TAS-117 激发抗骨髓瘤活性并增强蛋白酶体抑制诱导的致命内质网应激。TAS-117 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。

TAS-117

TAS-117 Chemical Structure

CAS No. : 1402602-94-1

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5 mg ¥5000 询问价格 & 货期
10 mg ¥8800 询问价格 & 货期
25 mg ¥18500 询问价格 & 货期
50 mg ¥31500 询问价格 & 货期

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TAS-117 的其他形式现货产品:

TAS-117 hydrochloride

生物活性

TAS-117 is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). TAS-117 triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. TAS-117 induces apoptosis and autophagy[1].

IC50 & Target[1]

Akt1

4.8 nM (IC50)

Akt2

1.6 nM (IC50)

Akt3

44 nM (IC50)

体外研究
(In Vitro)

TAS-117 (1 μM; 6 hours) blocks basal phosphorylation of Akt and downstream p-FKHR/FKHRL1 in MM cells with high baseline p-Akt[1].
TAS-117 (0-10 μM; 72 hours) selectively inhibits Akt and induces cytotoxicity in MM cells with high baseline phosphorylation of Akt[1].
TAS-117 abrogates the cytoprotective effect of the bone marrow microenvironment associated with Akt inhibition in both MM cells and BMSCs. TAS-117 enhances Carfilzomib-induced cytotoxicity and fatal ER stress in MM cells. TAS-117 (0.5, 1 μM) triggers G0/G1 arrest followed by apoptosis, associated with induction of autophagy and endoplasmic reticulum stress response[1].
TAS-117 enhances bortezomib-induced cytotoxicity, associated with increased CHOP (a fatal ER-stress marker) and PARP cleavage and blockade of bortezomib-induced p-Akt, suggesting that TAS-117 augments Bortezomib-induced ER stress and apoptotic signaling[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MM cell lines
Concentration: 0-10 μM
Incubation Time: 72 hours
Result: Induced significant growth inhibition in MM cell lines with high baseline p-Akt, but not in cell lines with low baseline p-Akt.

Western Blot Analysis[1]

Cell Line: MM cell lines
Concentration: 0-10 μM
Incubation Time: 72 hours
Result: Blocked basal phosphorylation of Akt and downstream p-FKHR/FKHRL1 in MM cells with high baseline p-Akt, but did not inhibit autophosphorylation of PDK1 which phosphorylates Akt at Thr308.

体内研究
(In Vivo)

TAS-117 (12-16 mg/kg; p.o.; daily for 5 days a week, 21 days) inhibits tumor growth in murine xenograft models of human MM[1].
TAS-117 enhances bortezomib-induced MM cytotoxicity in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice (xenograft models bearing MM.1S cells)[1]
Dosage: 12, 16 mg/kg
Administration: P.o.; daily for 5 days a week, 21 days
Result: Significantly reduced MM.1S tumor growth versus vehicle control.

分子量

424.49

Formula

C26H24N4O2

CAS 号

1402602-94-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Mimura N, et al. Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition. Cancer Res. 2014;74(16):4458-4469.

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hCAIX-IN-5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

hCAIX-IN-5 

hCAIX-IN-5 (compound 6b) 是一种有效的选择性 hCAIX 抑制剂,对 hCAI, hCAII,hCAIV,hCAIX 的 KIs 分别为 >10000, >10000, 130.7, 829.1 nM。

hCAIX-IN-5

hCAIX-IN-5 Chemical Structure

CAS No. : 2451479-57-3

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生物活性

hCAIX-IN-5 (compound 6b) is a potent and selective hCAIX inhibitor with KIs of >10000, >10000, 130.7, 829.1 nM for hCAI, hCAII, hCAIV, hCAIX, respectively[1].

IC50 & Target

KI: >10000 nM (hCAI); >10000 nM (hCAII); 130.7 nM (hCAIV); 829.1 nM (hCAIX)[1]

分子量

309.29

Formula

C18H12FNO3

CAS 号

2451479-57-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Swain B, et al. New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation. Bioorg Med Chem. 2020 Aug 1;28(15):115586.

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Norathyriol(Synonyms: Mangiferitin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Norathyriol (Synonyms: Mangiferitin)

Norathyriol (Mangiferitin) 是芒果苷的天然代谢物。 Norathyriol 以非竞争性方式抑制 α-葡萄糖苷酶 (α-glucosidase ),IC50 为 3.12 μM。Norathyriol 还抑制 PPARαPPARβPPARγIC50 分别为 92.8 µM、102.4 µM 和 153.5 µM。具有抗氧化、抗癌、抗菌、抗炎、抗菌活性。

Norathyriol(Synonyms: Mangiferitin)

Norathyriol Chemical Structure

CAS No. : 3542-72-1

规格 是否有货
5 mg 询价
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25 mg 询价

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生物活性

Norathyriol (Mangiferitin) is a natural metabolite of Mangifera. Norathyriol inhibits α-glucosidase in a noncompetitive manner with an IC50 of 3.12 μM[1]. Norathyriol inhibits PPARα, PPARβ, and PPARγ with IC50s of 92.8 µM, 102.4 µM, and 153.5 µM, respectively[2]. Antioxidant, anticancer, antimicrobial, anti-inflammatory, anti-bacterial activities.

IC50 & Target[2]

PPARα

92.8 μM (IC50)

PPARβ

102.4 μM (IC50)

PPARγ

153.5 μM (IC50)

体外研究
(In Vitro)

Norathyriol (1-25 µM) inhibits growth by inducing cell cycle arrest in JB6 P+ cells. Norathyriol inhibits JB6 cell growth by inducing G2-M arrest[3].
Norathyriol suppresses UVB-induced phosphorylation of ERKs, AP-1 and NF-κB activation in JB6 P+ cells[3] Cell Growth Assay WB

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: Mouse skin epidermal JB6 P+ cells
Concentration: 0, 1, 10, or 25 µM
Incubation Time: 24 or 72 hours
Result: Inhibited cell growth in a dose- as well as time-dependent manner but does not cause cell death.

Western Blot Analysis[3]

Cell Line: JB6 P+ cells
Concentration: 0, 1, 10, or 25 µM
Incubation Time: 2 hours
Result: Inhibited UVB-induced phosphorylation of ERKs and p90RSK.

体内研究
(In Vivo)

Norathyriol is a natural metabolite of Mangifera in the human intestine with the oral availability and safety[1].
Norathyriol (0.92, 1.85 and 3.7 mg/kg) dose dependently decreased the serum urate levels by 27.0, 33.6 and 37.4%, respectively[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Kunming mice weighing 18-22 g[4]
Dosage: 0.92, 1.85 and 3.7 mg/kg
Administration: Administered intragastrically; twice daily for five times
Result: The serum uric acid levels were decreased by 27.0%, 33.6% and 37.4%.

分子量

260.20

Formula

C13H8O6

CAS 号

3542-72-1

中文名称

芒果苷元

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhi-Long Shi, et al. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase. Biochem Res Int. 2017;2017:1206015.

    [2]. Ashley S Wilkinson,et al. Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 2008 May 14;56(9):3037-42.

    [3]. Jixia Li, et al. Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. Cancer Res. 2012 Jan 1;72(1):260-70.

    [4]. Yanfen Niu, et al. Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. Pharm Biol. 2016 Sep;54(9):1680-6.

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8-Aminoadenosine(Synonyms: 8-氨基腺苷; 8-NH2-Ado)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

8-Aminoadenosine (Synonyms: 8-氨基腺苷; 8-NH2-Ado)

8-Aminoadenosine (8-NH2-Ado) 是一种 RNA 导向的核苷类似物,可降低细胞 ATP 水平并抑制 mRNA 合成。8-Aminoadenosine 阻断 Akt/mTOR 信号,并诱导 p53 非依赖性的自噬和细胞凋亡。8-Aminoadenosine 具有抗肿瘤活性。

8-Aminoadenosine(Synonyms: 8-氨基腺苷; 8-NH2-Ado)

8-Aminoadenosine Chemical Structure

CAS No. : 3868-33-5

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生物活性

8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity[1][2][3].

IC50 & Target[1][2]

Akt

 

mTOR

 

体外研究
(In Vitro)

8-Aminoadenosine (8-NH2-Ado; 0.1-10 μM; for 48 h) has IC50s of 1.5 μM and 8.88 μM in MM.1S and U266 cells, respectively[1].
8-Aminoadenosine (10 μM; for 24 h) induces significant apoptotic death of MCF-7 cells in p53-independent pathway. 8-Aminoadenosine causes PARP cleavage in MCF-7 cells[2].
8-Aminoadenosine (3 μM; 0.5-4 h) induces autophagy in the MM.1S cell line[1].
8-Aminoadenosine (3 μM; 2-16 h) causes a greater drop in ATP levels in the MM.1S cells[1].
8-Aminoadenosine (3 μM; 5 h) causes a 50% reduction in glucose consumption in MM.1S cells[1].
8-Aminoadenosine (3 μM; 5 h) indicates a time-dependent decrease in GLUT1 expression at 5 h, whereas at 24 h there was a down-regulation of both transporters (GLUT1 and GLUT4) in MM.1S cells[1].
8-Aminoadenosine inhibits cell proliferation, activated cell death, and does not activate transcription of the p53 target gene p21 or increase protein levels of either p53 or p21[1].
The toxic effects of 8-Aminoadenosine require adenosine kinase activity to convert 8-Aminoadenosine to 8-NH2-ATP in adenosine kinase-deficient cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MM.1S and U266 cells
Concentration: 0.1, 0.3, 1, 3, 10 μM
Incubation Time: For 48 hours
Result: Had IC50s of 1.5 μM and 8.88 μM in MM.1S and U266 cells, respectively.

Apoptosis Analysis[2]

Cell Line: MCF-7 cells
Concentration: 10 μM
Incubation Time: For 24 hours
Result: Induced significant apoptotic death.
Apoptosis was not inhibited by knockdown of functional p53.

Apoptosis Analysis[1]

Cell Line: MM.1S cell line
Concentration: 3 μM
Incubation Time: 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 hours
Result: Induced the formation of LC3-II protein.
Caused the appearance of a population with a high AVO content with 1 μM for 24 hours.

分子量

282.26

Formula

C10H14N6O4

CAS 号

3868-33-5

中文名称

8-氨基腺苷;8-氨基腺苷酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据
In Vitro: 

DMSO : 83.33 mg/mL (295.22 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5428 mL 17.7142 mL 35.4283 mL
5 mM 0.7086 mL 3.5428 mL 7.0857 mL
10 mM 0.3543 mL 1.7714 mL 3.5428 mL

参考文献
  • [1]. Mala Shanmugam, et al. Targeting glucose consumption and autophagy in myeloma with the novel nucleoside analogue 8-aminoadenosine. J Biol Chem. 2009 Sep 25;284(39):26816-30.

    [2]. Alla Polotskaia, et al. 8-Amino-adenosine activates p53-independent cell death of metastatic breast cancers. Mol Cancer Ther. 2012 Nov;11(11):2495-504.

    [3]. Jennifer Ann Frey, et al. 8-Amino-adenosine inhibits multiple mechanisms of transcription. Mol Cancer Ther. 2010 Jan;9(1):236-45.

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Pom-8PEG

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Pom-8PEG 

Pom-8PEG,一种 E3 连接酶配体-linker 偶联物,包含一个用于 E3 泛素连接酶的 cereblon (CRBN) 配体和一个 8 单元 PEG 连接子。Pom-8PEG 可用于合成 PROTAC,如 IDO1 PROTAC 降解剂。

Pom-8PEG

Pom-8PEG Chemical Structure

CAS No. : 2488761-03-9

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50 mg ¥10500 In-stock
100 mg ¥17000 In-stock
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500 mg   询价  

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生物活性

Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader[1].

IC50 & Target[1]

Cereblon

 

分子量

625.66

Formula

C29H43N3O12

CAS 号

2488761-03-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献
  • [1]. Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10(10):1943-1953.

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PROTAC PTK6 ligand-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC PTK6 ligand-1 

PROTAC PTK6 ligand-1 是 BTK 激酶抑制剂合成的中间体。PROTAC PTK6 ligand-1 可用于 ARD-61 (HY-139659) 的合成。

PROTAC PTK6 ligand-1

PROTAC PTK6 ligand-1 Chemical Structure

CAS No. : 2408341-98-8

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生物活性

PROTAC PTK6 ligand-1 is an intermediate for BTK kinase inhibitor preparation[1]. PROTAC PTK6 ligand-1 can be used in the synthesis of ARD-61 (HY-139659)[2].

分子量

540.63

Formula

C27H32N4O6S

CAS 号

2408341-98-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pyrrolo-aromatic heterocyclic compound, preparation method therefor, and medical use thereof. Patent WO2020010204.

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DOTA Zoledronate

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

DOTA Zoledronate 

DOTA Zoledronate是骨靶向放射性核素、用于诊断骨转移的试剂。

DOTA Zoledronate

DOTA Zoledronate Chemical Structure

CAS No. : 1908409-18-6

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生物活性

DOTA Zoledronate is a next-generation agent for bone targeted radionuclide therapy for diagnosing bone metastases[1].

体外研究
(In Vitro)

DOTA-Zoledronate is a promising agent for the development of other future-oriented radionuclide therapy concepts for personalized nuclear oncology[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

701.56

Formula

C23H41N7O14P2

CAS 号

1908409-18-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. The ITM Group Announces In-Licensing of DOTA-Zoledronate Theranostic Agent.

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TAS-117

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

TAS-117 

TAS-117 是一种有效、选择性、具有口服活性的别构 Akt 抑制剂 (对 Akt1、2 和 3 的 IC50 分别为 4.8、1.6 和 44 nM)。TAS-117 激发抗骨髓瘤活性并增强蛋白酶体抑制诱导的致命内质网应激。TAS-117 诱导细胞凋亡 (apoptosis) 和自噬 (autophagy)。

TAS-117

TAS-117 Chemical Structure

CAS No. : 1402602-94-1

规格 价格 是否有货
5 mg ¥5000 询问价格 & 货期
10 mg ¥8800 询问价格 & 货期
25 mg ¥18500 询问价格 & 货期
50 mg ¥31500 询问价格 & 货期

* Please select Quantity before adding items.

TAS-117 的其他形式现货产品:

TAS-117 hydrochloride

生物活性

TAS-117 is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively). TAS-117 triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. TAS-117 induces apoptosis and autophagy[1].

IC50 & Target[1]

Akt1

4.8 nM (IC50)

Akt2

1.6 nM (IC50)

Akt3

44 nM (IC50)

体外研究
(In Vitro)

TAS-117 (1 μM; 6 hours) blocks basal phosphorylation of Akt and downstream p-FKHR/FKHRL1 in MM cells with high baseline p-Akt[1].
TAS-117 (0-10 μM; 72 hours) selectively inhibits Akt and induces cytotoxicity in MM cells with high baseline phosphorylation of Akt[1].
TAS-117 abrogates the cytoprotective effect of the bone marrow microenvironment associated with Akt inhibition in both MM cells and BMSCs. TAS-117 enhances Carfilzomib-induced cytotoxicity and fatal ER stress in MM cells. TAS-117 (0.5, 1 μM) triggers G0/G1 arrest followed by apoptosis, associated with induction of autophagy and endoplasmic reticulum stress response[1].
TAS-117 enhances bortezomib-induced cytotoxicity, associated with increased CHOP (a fatal ER-stress marker) and PARP cleavage and blockade of bortezomib-induced p-Akt, suggesting that TAS-117 augments Bortezomib-induced ER stress and apoptotic signaling[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MM cell lines
Concentration: 0-10 μM
Incubation Time: 72 hours
Result: Induced significant growth inhibition in MM cell lines with high baseline p-Akt, but not in cell lines with low baseline p-Akt.

Western Blot Analysis[1]

Cell Line: MM cell lines
Concentration: 0-10 μM
Incubation Time: 72 hours
Result: Blocked basal phosphorylation of Akt and downstream p-FKHR/FKHRL1 in MM cells with high baseline p-Akt, but did not inhibit autophosphorylation of PDK1 which phosphorylates Akt at Thr308.

体内研究
(In Vivo)

TAS-117 (12-16 mg/kg; p.o.; daily for 5 days a week, 21 days) inhibits tumor growth in murine xenograft models of human MM[1].
TAS-117 enhances bortezomib-induced MM cytotoxicity in vivo[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice (xenograft models bearing MM.1S cells)[1]
Dosage: 12, 16 mg/kg
Administration: P.o.; daily for 5 days a week, 21 days
Result: Significantly reduced MM.1S tumor growth versus vehicle control.

分子量

424.49

Formula

C26H24N4O2

CAS 号

1402602-94-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Mimura N, et al. Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition. Cancer Res. 2014;74(16):4458-4469.

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CDC25B-IN-2

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CDC25B-IN-2 

CDC25B-IN-2 是一种有效的 cdc25B 抑制剂。

CDC25B-IN-2

CDC25B-IN-2 Chemical Structure

CAS No. : 134271-74-2

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5 mg ¥800 In-stock
10 mg ¥1300 In-stock
25 mg ¥2500 In-stock
50 mg ¥4000 In-stock
100 mg ¥6500 In-stock
200 mg   询价  
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CDC25B-IN-2 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Anti-Cancer Compound Library
  • Phosphatase Inhibitor Library

生物活性

CDC25B-IN-2 is a potent cdc25B inhibitor[1].

体外研究
(In Vitro)

CDC25B-IN-2 (compound 27; 20 μg/mL) has cdc25B enzyme inhibitory activities 16.11% in vitro[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

268.27

Formula

C15H12N2O3

CAS 号

134271-74-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (931.90 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7276 mL 18.6379 mL 37.2759 mL
5 mM 0.7455 mL 3.7276 mL 7.4552 mL
10 mM 0.3728 mL 1.8638 mL 3.7276 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.75 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (7.75 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (7.75 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.08 mg/mL (7.75 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Zhao, F., et al. Synthesis and cdc25B inhibitory activity evaluation of chalcones. Chemistry of Natural Compounds, 2013,49(2), 206-214.

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Astragenol

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Astragenol  纯度: ≥98.0%

Astragenol 是一种用于合成黄芪醇衍生物的中间体。Astragenol 衍生物具有抗炎活性,可用于前列腺癌。

Astragenol

Astragenol Chemical Structure

CAS No. : 86541-79-9

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10 mg ¥800 In-stock
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50 mg   询价  
100 mg   询价  

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Astragenol 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Medicine Food Homology Compound Library

生物活性

Astragenol is an intermediate used for Astragenol derivative synthesis. Astragenol derivatives are promising anti-inflammatory agents for prostate cancer research[1].

分子量

490.72

Formula

C30H50O5

CAS 号

86541-79-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

Ethanol : 50 mg/mL (101.89 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0378 mL 10.1891 mL 20.3782 mL
5 mM 0.4076 mL 2.0378 mL 4.0756 mL
10 mM 0.2038 mL 1.0189 mL 2.0378 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (4.08 mM); Clear solution

    此方案可获得 ≥ 2 mg/mL (4.08 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.0 mg/mL 的澄清 EtOH 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: 2 mg/mL (4.08 mM); Suspended solution; Need ultrasonic

    此方案可获得 2 mg/mL (4.08 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 20.0 mg/mL 的澄清 EtOH 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% EtOH    90% corn oil

    Solubility: ≥ 2 mg/mL (4.08 mM); Clear solution

    此方案可获得 ≥ 2 mg/mL (4.08 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.0 mg/mL 的澄清 EtOH 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Bilge Debeleç-Bütüner, et al. Cycloartane-type sapogenol derivatives inhibit NF-κB activation as chemopreventive strategy for inflammation-induced prostate carcinogenesis. Steroids. 2018 Jul;135:9-20.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

PROTAC PTK6 ligand-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

PROTAC PTK6 ligand-1 

PROTAC PTK6 ligand-1 是 BTK 激酶抑制剂合成的中间体。PROTAC PTK6 ligand-1 可用于 ARD-61 (HY-139659) 的合成。

PROTAC PTK6 ligand-1

PROTAC PTK6 ligand-1 Chemical Structure

CAS No. : 2408341-98-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

PROTAC PTK6 ligand-1 is an intermediate for BTK kinase inhibitor preparation[1]. PROTAC PTK6 ligand-1 can be used in the synthesis of ARD-61 (HY-139659)[2].

分子量

540.63

Formula

C27H32N4O6S

CAS 号

2408341-98-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Pyrrolo-aromatic heterocyclic compound, preparation method therefor, and medical use thereof. Patent WO2020010204.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Cdc7-IN-8

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Cdc7-IN-8 

Cdc7-IN-8 是 Cdc7 的有效抑制剂。Cdc7 是一种丝氨酸/苏氨酸激酶,它通过磷酸化微染色体维持蛋白 (MCM 蛋白) 来激活 MCM 促进作用,该蛋白是 DNA 复制引发剂的重要元素。Cdc7-IN-8 具有研究癌症疾病的潜力 (摘自专利 WO2021032170A1,化合物 1-1/1-2)。

Cdc7-IN-8

Cdc7-IN-8 Chemical Structure

CAS No. : 2606780-38-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Cdc7-IN-8 is a potent inhibitor of Cdc7. Cdc7 is a serine/threonine kinase which activates MCM promotion by phosphorylating the microchromosome maintenance protein (MCM protein), an important element of the DNA replication initiator. Cdc7-IN-8 has the potential for the research of cancer diseases (extracted from patent WO2021032170A1, compound 1-1/1-2)[1].

分子量

351.40

Formula

C19H21N5O2

CAS 号

2606780-38-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Lun Lu, et al. Tetracyclic compound used as cdc7 inhibitor. Patent WO2021032170A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Corixetan

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Corixetan 

Corixetan 是一种高效钍螯合剂,能有效地配合 Th-227,在体内具有足够的稳定性。

Corixetan

Corixetan Chemical Structure

CAS No. : 1952359-26-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Corixetan is a highly efficient thorium chelator. Corixetan can efficiently complex Th-227 with sufficient in vivo stability[1].

IC50 & Target[1]

Traditional Cytotoxic Agents

 

分子量

1056.08

Formula

C50H61N11O15

CAS 号

1952359-26-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ramdahl T, et al. An efficient chelator for complexation of thorium-227. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4318-21.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务