Ac-dA Phosphoramidite

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Ac-dA Phosphoramidite 

Ac-dA Phosphoramidite 是一种亚磷酰胺单体,可用于寡核苷酸的制备。

Ac-dA Phosphoramidite

Ac-dA Phosphoramidite Chemical Structure

CAS No. : 1027734-01-5

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生物活性

Ac-dA Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides.

分子量

795.86

Formula

C42H50N7O7P

CAS 号

1027734-01-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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UU-T02

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

UU-T02 

UU-T02 是一种新型强效的 β-Catenin/T-cell factor 蛋白互作的选择性小分子抑制剂 (β-catenin/Tcf PPI)Ki 为 1.36 μM。UU-T02 抑制典型 Wnt 信号的传导和结直肠癌细胞的生长。

UU-T02

UU-T02 Chemical Structure

CAS No. : 1500080-17-0

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生物活性

UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells[2].

IC50 & Target

Ki: 1.36 μM (β-catenin/Tcf PPI)[1].
IC50: 6.3 μM (β-catenin/Tcf4), 680 μM (β-catenin/E-cadherin) , 210 μM (β-catenin/APC-R3)[2].

体外研究
(In Vitro)

UU-T02 displays Ki values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively[2].
UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC50 of 6.3, 680, 210 μM,respectively[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

665.09

Formula

C33H33ClN4O9

CAS 号

1500080-17-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS Chem Biol. 2014;9(1):193-201.

    [2]. Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58(11):4678-4692.

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7-TFA-ap-7-Deaza-dA

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

7-TFA-ap-7-Deaza-dA 

7-TFA-ap-7-Deaza-dA 是一种修饰的核苷酸,可用于脱氧核糖核酸/核糖核酸的合成。

7-TFA-ap-7-Deaza-dA

7-TFA-ap-7-Deaza-dA Chemical Structure

CAS No. : 178420-75-2

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生物活性

7-TFA-ap-7-Deaza-dA is a modified nucleoside. 7-TFA-ap-7-Deaza-dA can be used in the synthesis of deoxyribonucleic acid or nucleic acid.

分子量

399.32

Formula

C16H16F3N5O4

CAS 号

178420-75-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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Girinimbine(Synonyms: Girinimbin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Girinimbine (Synonyms: Girinimbin)

Girinimbine (Girinimbin) 是一种咔唑类生物碱,具有多种生物学作用。Girinimbine 可诱导细胞凋亡 (apoptosis),具有抗锥虫、抗血小板活性、抗菌活性、抗炎、抗氧化和抗肿瘤活性。

Girinimbine(Synonyms: Girinimbin)

Girinimbine Chemical Structure

CAS No. : 23095-44-5

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Girinimbine 相关产品

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生物活性

Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3].

体外研究
(In Vitro)

Girinimbine (1-400 µM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC50 values of 61 µM, 56 µM, and 40 µM respectively. Girinimbine (10-100 µM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells[1].
Girinimbine (56 µM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells[1]. HepG2 cells[1].
Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest[1].
Girinimbine shows a potent antitrypanosomal activitywith an IC50 value of 10.16 µg/mL[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM, 200 µM
Incubation Time: 24 h, 48 h and 72 h
Result: Inhibited the proliferation of HepG2 cells in vitro in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 56 µM
Incubation Time: 24 h, 48 h
Result: Showed typical morphological features of apoptosis.

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 56 µM
Incubation Time: 12 h, 24 h, 48 h
Result: Induced G0/G1-phase arrest in HepG2 cells.

体内研究
(In Vivo)

Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid[2].
In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (25-35 g) treated with carrageenan[2]
Dosage: 10 mg/kg, 30 mg/kg, and 100 mg/kg
Administration: Orally gavage; once
Result: Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.

分子量

263.33

Formula

C18H17NO

CAS 号

23095-44-5

中文名称

吉九里香碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Suvitha Syam, et al. The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest. Molecules. 2011 Aug 23;16(8):7155-70.

    [2]. Venoos Iman, et al. Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. Drug Des Devel Ther. 2016 Dec 28;11:103-121.

    [3]. H O Dyary, et al. Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb. Trop Biomed. 2019 Mar 1;36(1):94-102.

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Deoxythymidine-5′-triphosphate(Synonyms: dTTP)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Deoxythymidine-5′-triphosphate (Synonyms: dTTP)

Deoxythymidine-5′-triphosphate (dTTP),一种三磷酸核苷,可用于 DNA 的合成。

Deoxythymidine-5

Deoxythymidine-5′-triphosphate Chemical Structure

CAS No. : 365-08-2

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Deoxythymidine-5′-triphosphate 的其他形式现货产品:

Deoxythymidine-5′-triphosphate trisodium

生物活性

Deoxythymidine-5′-triphosphate (dTTP) is one of the four nucleoside triphosphates. Deoxythymidine-5′-triphosphate (dTTP) is used in the synthesis of DNA[1].

IC50 & Target

Human Endogenous Metabolite

 

Clinical Trial

分子量

482.17

Formula

C10H17N2O14P3

CAS 号

365-08-2

中文名称

脱氧胸苷三磷酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tattersall MH, et al. Deoxyribonucleoside triphosphates in human cells: changes in disease and following exposure to drugs. Eur J Clin Invest. 1975;5(2):191-202.

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IBU-DC Phosphoramidite

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

IBU-DC Phosphoramidite 

IBU-DC Phosphoramidite 可用于合成寡核苷酸的合成。

IBU-DC Phosphoramidite

IBU-DC Phosphoramidite Chemical Structure

CAS No. : 110522-84-4

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生物活性

IBU-DC Phosphoramidite is used for synthesis of oligonucleotides[1].

分子量

799.89

Formula

C43H54N5O8P

CAS 号

110522-84-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chi Fu, et al. Identification and quantification of protecting groups remaining in commercial oligonucleotide products using monoclonal antibodies. Anal Biochem. 2002 Jul 1;306(1):135-43.

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5′-O-DMT-N4-Bz-2′-F-dC

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

5′-O-DMT-N4-Bz-2′-F-dC  纯度: 99.85%

5′-O-DMT-N4-Bz-2′-F-Dc 是一种具有保护和修饰作用的核苷。

5

5′-O-DMT-N4-Bz-2′-F-dC Chemical Structure

CAS No. : 146954-77-0

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥550 In-stock
100 mg ¥500 In-stock
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5′-O-DMT-N4-Bz-2′-F-dC 相关产品

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  • Nucleotide Compound Library
  • Anti-Lung Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Anti-Cancer Metabolism Compound Library

生物活性

5′-O-DMT-N4-Bz-2′-F-dC is a nucleoside with protective and modification effects.

分子量

651.68

Formula

C37H34FN3O7

CAS 号

146954-77-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (153.45 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5345 mL 7.6725 mL 15.3450 mL
5 mM 0.3069 mL 1.5345 mL 3.0690 mL
10 mM 0.1534 mL 0.7672 mL 1.5345 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (3.84 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (3.84 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.84 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.84 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

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Phoyunnanin E

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Phoyunnanin E 

Phoyunnanin E,分离自铁皮石斛,具有抗迁移活性。Phoyunnanin E可用于癌症研究。

Phoyunnanin E

Phoyunnanin E Chemical Structure

CAS No. : 886747-60-0

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生物活性

Phoyunnanin E, isolated from Dendrobium venustum, possesses anti-migration activity. Phoyunnanin E can be used for the research of cancer[1].

体外研究
(In Vitro)

Phoyunnanin E (0~10 μM; 48 hours; H460 cells) decreases cell migration through integrin downregulation[1].
Phoyunnanin E (0~100 μM; 24 and 48 hours; H460 cells) shows that the proliferation rate of treated cells have significantly decreased in a dose-dependent manner at the concentration of 10 μM at 48 hours[1].
Phoyunnanin E (0~100 μM; 24 hours; H460 cells) induces cytotoxic effects at the concentrations from 50 to 100 μM and induces a significant increase in apoptotic and necrotic cells at 20~100 μM[1].
Phoyunnanin E (0~10 μM; 48 hours; H460, H292 and A549 cells) significantly decreases the number of cells invading across the matrix and transwell filter within 24 hours in a dose-dependent manner[1].
Phoyunnanin E attenuates anchorage-independent growth and migration of lung cancer H460 cells. Phoyunnanin E significantly inhibits cell migration across the wound space at the concentrations of 5 and 10 μM, at 24 h and 48 h, compared to the non-treated control. Phoyunnanin E (0~10 μM; 48 hours) exhibits a significant decrease in filopodia numbers at the protrusion edges of the cells in a dose-dependent manner. Phoyunnanin E decreases cancer cell migration in other human lung cancer cells. Phoyunnanin E decreases cancer cell invasion. Phoyunnanin E suppresses epithelial-mesenchymal transition (EMT). Phoyunnanin E down-regulates integrins αv and β3 and the regulatory proteins in cell migration[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: H460 cells
Concentration: 1~10 μM
Incubation Time: 48 hours
Result: Decreased cell migration through integrin downregulation.

Cell Proliferation Assay[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 and 48 hours
Result: The proliferation rate of treated cells had significantly decreased in a dose-dependent manner at the concentration of 10 μM at 48 h.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 hours
Result: Induced a significant increase in apoptotic and necrotic cells at 20~100 μM.

Cell Cytotoxicity Assay[1]

Cell Line: H460 cells
Concentration: 0~100 μM
Incubation Time: 24 hours
Result: Induced cytotoxic effects at the concentrations from 50 to 100 μM.

Immunofluorescence[1]

Cell Line: H460, H292 and A549 cells
Concentration: 0~10 μM
Incubation Time: 48 hours
Result: Significantly decreased the number of cells invading across the matrix and transwell filter within 24 hours in a dose-dependent manner.

分子量

482.52

Formula

C30H26O6

CAS 号

886747-60-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Petpiroon N, et al. Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin αv and integrin β3. BMC Complement Altern Med. 2017;17(1):553. Published 2017 Dec 29.

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EZH2-IN-4

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

EZH2-IN-4 

EZH2-IN-4 是一种口服有效的 EZH2 抑制剂,对野生型和突变型 5-mer EZH2 的 IC50 分别为 0.923 nM 和 2.65 nM。EZH2-IN-4 具有抗癌活性。

EZH2-IN-4

EZH2-IN-4 Chemical Structure

CAS No. : 2088132-99-2

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生物活性

EZH2-IN-4 is an orally active, potent EZH2 inhibitor with IC50s of 0.923 nM and 2.65 nM against wild type (WT) 5-membered (5-mer) EZH2 and mutant 5-mer EZH2, respectively. EZH2-IN-4 has anti-cancer activity[1].

IC50 & Target[1]

WT 5-mer EZH2

0.923 nM (IC50)

mut 5-mer EZH2

2.65 nM (IC50)

体外研究
(In Vitro)

EZH2-IN-4 (example 38) shows a cell H3K27me3 IC50 of 0.00973 nM in Karpas-422 (EZH2 Y641N) cells[1].
EZH2-IN-4 shows an IC50 of 10.1 nM in Plate Kj«pas-422 cells[1].
EZH2-IN-4 inhibits the proliferation of ovarian cancer cell lines (COV-434, TOV-21G, TOV-112D, A2780, Caov-3, OVCAR3; IC50s=0.02-8.6 μM) and has no effect on SKOV3, HeyA8, HEC59 cell (IC50>20 μM)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

EZH2-IN-4 (example 38; oral gavage; 15 mpk; BID) results in 73% inhibition of tumor methylation in the Karpas-422 xenograft model[1].
EZH2-IN-4 (po; 50 mpk; twice a day; pretreatment for 5 days; followed by co-administration with gemcitabine plus cisplatin for at least 23 additional days) significant inhibits A2780 tumor growth in A2780 xenograft model[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

511.72

Formula

C29H41N3O3S

CAS 号

2088132-99-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Esteban DOMINGUEZ, et al. Inhibitors of ezh2. WO2017035060A1.

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Picrasidine Q

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Picrasidine Q 

Picrasidine Q 是从当归植物中提取的生物碱成分,具有抗细胞转化和抗癌作用。Picrasidine Q 诱导人食管癌细胞凋亡和G1 期阻滞,并直接抑制 FGFR2 激酶活性。

Picrasidine Q

Picrasidine Q Chemical Structure

CAS No. : 101219-61-8

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生物活性

Picrasidine Q, an alkaloid component extracted from Angelica keiskei species, has the capacity of anti-cell transformation and anti-cancer. Picrasidine Q induces cell apoptosis and G1 phase arrest in human esophageal cancer cell lines, and directly inhibits FGFR2 kinase activity[1].

IC50 & Target[1]

FGFR2

 

体外研究
(In Vitro)

Picrasidine Q (0~60 μM; 3 hours; ESCC cells) suppresses downstream signaling of FGFR2 in ESCC cells[1].
Picrasidine Q (0~60 μM; 48 and 72 hours; ESCC cells) induces cell cycle arrest and apoptosis[1].
Picrasidine Q (0~60 μM; 24~72 hours; ESCC cells) suppresses the growth of ESCC cells[1].
Picrasidine Q (0~60 μM; 30 minutes; JB6Cl41 cells) inhibits proliferation by inhibition of G1/S cell cycle transition[1].
Picrasidine Q (12.5, 25 or 50 μM) can inhibit the FGFR2 kinase activity in a dose-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 3 hours
Result: Suppressed downstream signaling of FGFR2 in ESCC cells.

Apoptosis Analysis[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 48 and 72 hours
Result: Induced cell cycle arrest and apoptosis.

Cell Cytotoxicity Assay[1]

Cell Line: ESCC cells
Concentration: 0~60 μM
Incubation Time: 24~72 hours
Result: Suppressed the growth of ESCC cells.

Cell Cycle Analysis[1]

Cell Line: JB6Cl41 cells
Concentration: 0~60 μM
Incubation Time: 30 minutes
Result: Inhibited proliferation by inhibition of G1/S cell cycle transition.

分子量

266.25

Formula

C15H10N2O3

CAS 号

101219-61-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Shi Y, et al. FGFR2 regulation by picrasidine Q inhibits the cell growth and induces apoptosis in esophageal squamous cell carcinoma. J Cell Biochem. 2018;119(2):2231-2239.

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dGTP(Synonyms: 2′-Deoxyguanosine-5′-triphosphate)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

dGTP (Synonyms: 2′-Deoxyguanosine-5′-triphosphate)

dGTP (2′-Deoxyguanosine-5′-triphosphate) 是一种鸟苷核苷酸,可用于脱氧核糖核酸的合成。鸟苷核苷酸 (GDP, GTP, dGDP, dGTP) 对 8-O-GDP (8-O-GDP)、8-O-dGTP、8-O-GTP 和 8-O-dGTP 的氧化损伤高度敏感。

dGTP(Synonyms: 2

dGTP Chemical Structure

CAS No. : 2564-35-4

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dGTP 的其他形式现货产品:

Deoxyguanosine triphosphate trisodium salt

生物活性

dGTP (2′-Deoxyguanosine-5′-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP[1].

分子量

507.18

Formula

C10H16N5O13P3

CAS 号

2564-35-4

中文名称

2′-脱氧鸟苷-5′-三磷酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6.

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7-TFA-ap-7-Deaza-dG

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

7-TFA-ap-7-Deaza-dG 

5′-O-TBDMS-dG 是一种修饰的核苷酸,可用于脱氧核糖核酸或者核糖核酸的合成。

7-TFA-ap-7-Deaza-dG

7-TFA-ap-7-Deaza-dG Chemical Structure

CAS No. : 666847-77-4

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生物活性

5′-O-TBDMS-dG is a modified nucleoside. 5′-O-DMT-2′-O-TBDMS-rI can be used in the synthesis of deoxyribonucleic acid or nucleic acid.

分子量

415.32

Formula

C16H16F3N5O5

CAS 号

666847-77-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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Ro-0335

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ro-0335  纯度: 99.79%

RO-0335 是一种新型高效的二苯醚非核苷逆转录酶抑制剂 (NNTRI)。RO-0335 (IC50= 1.1 nM) 可以抑制 Wt HIV-1 病毒,并且对 92% 的 NNRTI 耐药临床分离株具有保留活性 (IC50<100 nM)。

Ro-0335

Ro-0335 Chemical Structure

CAS No. : 867365-76-2

规格 价格 是否有货 数量
5 mg ¥1500 In-stock
10 mg ¥2500 In-stock
25 mg ¥5500 In-stock
50 mg ¥9500 In-stock
100 mg ¥15500 In-stock
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Ro-0335 相关产品

相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Anti-Cancer Compound Library
  • Antiviral Compound Library

生物活性

RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor(NNRTI). RO-0335 inhibits Wt HIV-1 with an IC50 of 1.1 nM and retained activity (IC50< 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates[1].

分子量

573.22

Formula

C21H13BrCl2FN3O4S

CAS 号

867365-76-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 250 mg/mL (436.13 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7445 mL 8.7227 mL 17.4453 mL
5 mM 0.3489 mL 1.7445 mL 3.4891 mL
10 mM 0.1745 mL 0.8723 mL 1.7445 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (3.63 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (3.63 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献
  • [1]. Javanbakht H, et al. In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitor. Antiviral Res. 2010;86(2):212-219.

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UU-T02

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

UU-T02 

UU-T02 是一种新型强效的 β-Catenin/T-cell factor 蛋白互作的选择性小分子抑制剂 (β-catenin/Tcf PPI)Ki 为 1.36 μM。UU-T02 抑制典型 Wnt 信号的传导和结直肠癌细胞的生长。

UU-T02

UU-T02 Chemical Structure

CAS No. : 1500080-17-0

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生物活性

UU-T02 is a novel potent, selective small-molecule inhibitor of β-Catenin/T-cell factor protein-protein interaction (β-catenin/Tcf PPI) with a Ki of 1.36 μM[1]. UU-T02 inhibits canonical Wnt signaling and the growth of colorectal cancer cells[2].

IC50 & Target

Ki: 1.36 μM (β-catenin/Tcf PPI)[1].
IC50: 6.3 μM (β-catenin/Tcf4), 680 μM (β-catenin/E-cadherin) , 210 μM (β-catenin/APC-R3)[2].

体外研究
(In Vitro)

UU-T02 displays Ki values of 1.4 μM and 1.3 μM for β-catenin/Tcf PPI in FP assay and in AlphaScreen assay, respectively[2].
UU-T02 inhibits β-catenin/Tcf4, β-catenin/E-cadherin, β-catenin/APC-R3, with the IC50 of 6.3, 680, 210 μM,respectively[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

665.09

Formula

C33H33ClN4O9

CAS 号

1500080-17-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Huang Z, et al. Targeting the Tcf4 G13ANDE17 binding site to selectively disrupt β-catenin/T-cell factor protein-protein interactions. ACS Chem Biol. 2014;9(1):193-201.

    [2]. Catrow JL, et al. Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein-Protein Interaction through the Optimization of the Acyl Hydrazone Moiety. J Med Chem. 2015;58(11):4678-4692.

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7-TFA-ap-7-Deaza-dA

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

7-TFA-ap-7-Deaza-dA 

7-TFA-ap-7-Deaza-dA 是一种修饰的核苷酸,可用于脱氧核糖核酸/核糖核酸的合成。

7-TFA-ap-7-Deaza-dA

7-TFA-ap-7-Deaza-dA Chemical Structure

CAS No. : 178420-75-2

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生物活性

7-TFA-ap-7-Deaza-dA is a modified nucleoside. 7-TFA-ap-7-Deaza-dA can be used in the synthesis of deoxyribonucleic acid or nucleic acid.

分子量

399.32

Formula

C16H16F3N5O4

CAS 号

178420-75-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

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CDK12-IN-4

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CDK12-IN-4 

CDK12-IN-4 是一种吡唑并三嗪,是有效的 CDK12 抑制剂,在高 ATP (2 mM) 下的 IC50 为 0.641 μM。CDK12-IN-4 在高 ATP (2 mM) 下对 CDK2/Cyclin E (IC50>20 μM) 和 CDK9/Cyclin T1 (IC50>20 μM) 没有影响(WO2021116178A1)。

CDK12-IN-4

CDK12-IN-4 Chemical Structure

CAS No. : 2651196-69-7

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生物活性

CDK12-IN-4, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 0.641 μM at high ATP (2 mM). CDK12-IN-4 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1].

IC50 & Target[1]

CDK12

0.641 μM (IC50)

CDK2/cyclinE

>20 μM (IC50)

CDK9/cyclinT1

>20 μM (IC50)

体外研究
(In Vitro)

CDK12-IN-4 (Example 172) inhibits BRCA1 MRNA expression in MDA-MB-231 cells (IC50=0.626 nM) and has no effect on CAL-120 cells[1].
CDK12-IN-4 has antproliferative activity in MDA-MB-231 cells (IC50=0.535 nM) and CAL-120 cells (IC50=2.43 nM)[1].
CDK12-IN-4 has a inhibition IC50 CDK12 high ATP to Degradation DC50 CDK12 ratio of 581[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

426.42

Formula

C20H20F2N8O

CAS 号

2651196-69-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

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Girinimbine(Synonyms: Girinimbin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Girinimbine (Synonyms: Girinimbin)

Girinimbine (Girinimbin) 是一种咔唑类生物碱,具有多种生物学作用。Girinimbine 可诱导细胞凋亡 (apoptosis),具有抗锥虫、抗血小板活性、抗菌活性、抗炎、抗氧化和抗肿瘤活性。

Girinimbine(Synonyms: Girinimbin)

Girinimbine Chemical Structure

CAS No. : 23095-44-5

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Girinimbine 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

生物活性

Girinimbine (Girinimbin) is a carbazole alkaloid with a variety of biological effects. Girinimbine can induce apoptosis, and has antitrypanosomal, antiplatelet activity, antibacterial activity, anti-inflammatory, antioxidant and antitumor activities[1][2][3].

体外研究
(In Vitro)

Girinimbine (1-400 µM; 24-72 h) decreases the viability of HepG2 cells in 24, 48 and 72 h with IC50 values of 61 µM, 56 µM, and 40 µM respectively. Girinimbine (10-100 µM; 24-48 h) increase of LDH leakage in both concentration- and time-dependent manner in HepG2 cells[1].
Girinimbine (56 µM; 24-48 h) treatment results in DNA fragmentation and elevates levels of caspase-3 in HepG2 cells[1]. HepG2 cells[1].
Girinimbine (56 µM; 12-48 h) treatment also displays a time-dependent accumulation of the Sub-G0/G1 peak (hypodiploid) and caused G0/G1-phase arrest[1].
Girinimbine shows a potent antitrypanosomal activitywith an IC50 value of 10.16 µg/mL[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 1 µM, 10 µM, 50 µM, 100 µM, 200 µM
Incubation Time: 24 h, 48 h and 72 h
Result: Inhibited the proliferation of HepG2 cells in vitro in a dose- and time-dependent manner.

Apoptosis Analysis[1]

Cell Line: HepG2 cells
Concentration: 56 µM
Incubation Time: 24 h, 48 h
Result: Showed typical morphological features of apoptosis.

Cell Cycle Analysis[1]

Cell Line: HepG2 cells
Concentration: 56 µM
Incubation Time: 12 h, 24 h, 48 h
Result: Induced G0/G1-phase arrest in HepG2 cells.

体内研究
(In Vivo)

Girinimbine (10-100 mg/kg; orally gavage; once) pretreatment helps limit total leukocyte migration, and reduced pro-inflammatory cytokine (IL-1β, TNF-α) levels in the peritoneal fluid[2].
In vivo in zebrafish embryos, Girinimbine (20 μg/mL; 24 hours) shows significant distribution of apoptotic cells in embryos[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (25-35 g) treated with carrageenan[2]
Dosage: 10 mg/kg, 30 mg/kg, and 100 mg/kg
Administration: Orally gavage; once
Result: Helped limit total leukocyte migration, and reduced pro-inflammatory cytokine levels in the peritoneal fluid.

分子量

263.33

Formula

C18H17NO

CAS 号

23095-44-5

中文名称

吉九里香碱

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献
  • [1]. Suvitha Syam, et al. The growth suppressing effects of girinimbine on HepG2 involve induction of apoptosis and cell cycle arrest. Molecules. 2011 Aug 23;16(8):7155-70.

    [2]. Venoos Iman, et al. Anticancer and anti-inflammatory activities of girinimbine isolated from Murraya koenigii. Drug Des Devel Ther. 2016 Dec 28;11:103-121.

    [3]. H O Dyary, et al. Antitrypanosomal and cytotoxic activities of botanical extracts from Murraya koenigii (L.) and Alpinia mutica Roxb. Trop Biomed. 2019 Mar 1;36(1):94-102.

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CDK12-IN-6

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CDK12-IN-6 

CDK12-IN-6 是一种吡唑并三嗪,是有效的 CDK12 抑制剂,在高 ATP (2 mM) 下的 IC50 为 1.19 μM。CDK12-IN-6 在高 ATP (2 mM) 下对 CDK2/Cyclin E (IC50>20 μM) 和 CDK9/Cyclin T1 (IC50>20 μM) 没有影响(WO2021116178A1)。

CDK12-IN-6

CDK12-IN-6 Chemical Structure

CAS No. : 2651196-71-1

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生物活性

CDK12-IN-6, a pyrazolotriazine, is a potent CDK12 inhibitor with an IC50 of 1.19 μM at high ATP (2 mM). CDK12-IN-6 has no effect on CDK2/Cyclin E (IC50>20 μM) and CDK9/Cyclin T1 (IC50>20 μM) at high ATP (2 mM) (WO2021116178A1)[1].

IC50 & Target[1]

CDK12

1.19 μM (IC50)

CDK2/cyclinE

>20 μM (IC50)

CDK9/cyclinT1

>20 μM (IC50)

体外研究
(In Vitro)

CDK12-IN-6 (Example 174) inhibits BRCA1 MRNA expression in MDA-MB-231 cells (IC50=0.872 nM) and has no effect on CAL-120 cells[1].
CDK12-IN-6 has antproliferative activity in MDA-MB-231 cells (IC50=2.19 nM) and CAL-120 cells (IC50=1 nM)[1].
CDK12-IN-6 has a inhibition IC50 CDK12 high ATP to Degradation DC50 CDK12 ratio of 1851[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

425.44

Formula

C20H21F2N9

CAS 号

2651196-71-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Kai Thede, et al. Pyrazolotriazines. WO2021116178A1.

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IBU-DC Phosphoramidite

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

IBU-DC Phosphoramidite 

IBU-DC Phosphoramidite 可用于合成寡核苷酸的合成。

IBU-DC Phosphoramidite

IBU-DC Phosphoramidite Chemical Structure

CAS No. : 110522-84-4

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

IBU-DC Phosphoramidite is used for synthesis of oligonucleotides[1].

分子量

799.89

Formula

C43H54N5O8P

CAS 号

110522-84-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Chi Fu, et al. Identification and quantification of protecting groups remaining in commercial oligonucleotide products using monoclonal antibodies. Anal Biochem. 2002 Jul 1;306(1):135-43.

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5′-O-DMT-N4-Bz-2′-F-dC

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

5′-O-DMT-N4-Bz-2′-F-dC  纯度: 99.85%

5′-O-DMT-N4-Bz-2′-F-Dc 是一种具有保护和修饰作用的核苷。

5

5′-O-DMT-N4-Bz-2′-F-dC Chemical Structure

CAS No. : 146954-77-0

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥550 In-stock
100 mg ¥500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

5′-O-DMT-N4-Bz-2′-F-dC 相关产品

相关化合物库:

  • Covalent Screening Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Cell Cycle/DNA Damage Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Covalent Screening Library
  • Reprogramming Compound Library
  • Nucleotide Compound Library
  • Anti-Lung Cancer Compound Library
  • Anti-Blood Cancer Compound Library
  • Anti-Cancer Metabolism Compound Library

生物活性

5′-O-DMT-N4-Bz-2′-F-dC is a nucleoside with protective and modification effects.

分子量

651.68

Formula

C37H34FN3O7

CAS 号

146954-77-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL (153.45 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5345 mL 7.6725 mL 15.3450 mL
5 mM 0.3069 mL 1.5345 mL 3.0690 mL
10 mM 0.1534 mL 0.7672 mL 1.5345 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (3.84 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (3.84 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.84 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.84 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务