Rapanone(Synonyms: 拉帕酮)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Rapanone (Synonyms: 拉帕酮) 纯度: 99.20%

Rapanone 是一种天然苯醌。Rapanone 具有广泛的生物作用,包括抗肿瘤、抗氧化、抗炎、抗菌和抗寄生虫。Rapanone 还是一种有效和选择性的人滑膜 PLA2 抑制剂,IC50 值为 2.6 μM。

Rapanone(Synonyms: 拉帕酮)

Rapanone Chemical Structure

CAS No. : 573-40-0

规格 价格 是否有货 数量
5 mg ¥1200 In-stock
10 mg ¥1700 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Rapanone 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Antibacterial Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Antiparasitic Compound library
  • Lipid Metabolism Compound Library

生物活性

Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM[1][2][3][4].

IC50 & Target[4]

PLA2

2.6 μM (IC50)

体外研究
(In Vitro)

Rapanone (10-40 μM; 24 h) inhibits the cell viability, with IC50s of 35.58 μM and 27.89 μM for primary rats hepatocytes and HepG2 cells, respectively[1].
Rapanone (10-40 μM; 24 h) induces a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization in HepG2 cells[1].
Rapanone inhibits electron transport at Complex III and promotes mitochondrial dysfunction[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

322.44

Formula

C19H30O4

CAS 号

573-40-0

中文名称

拉帕酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Andreu GLP, et, al. Rapanone, a naturally occurring benzoquinone, inhibits mitochondrial respiration and induces HepG2 cell death. Toxicol In Vitro. 2020 Mar;63:104737.

    [2]. Morais LS, et, al. Antileishmanial compounds from Connarus suberosus: Metabolomics, isolation and mechanism of action. PLoS One. 2020 Nov 6;15(11):e0241855.

    [3]. Vega-Hernández K, et, al. Discerning the antioxidant mechanism of rapanone: A naturally occurring benzoquinone with iron complexing and radical scavenging activities. J Inorg Biochem. 2017 May;170:134-147.

    [4]. Ospina LF, et, al. Inhibition of acute and chronic inflammatory responses by the hydroxybenzoquinonic derivative rapanone. Planta Med. 2001 Dec;67(9):791-5.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Retrorsine N-oxide

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Retrorsine N-oxide 

Retrorsine N-oxide 是吡咯联啶生物碱的一种 N-氧化物,是一种致癌物。Retrorsine N-oxide 衍生的 DNA 加合物是吡咯里西啶生物碱 N-氧化物的常见毒理学生物标记物。

Retrorsine N-oxide

Retrorsine N-oxide Chemical Structure

CAS No. : 15503-86-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides[1][2].

体内研究
(In Vivo)

Retrorsine N-oxide produces DNA adducts, the common biological biomarker of PA-induced liver tumor formation[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

367.39

Formula

C18H25NO7

CAS 号

15503-86-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. He X, et, al. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides. J Food Drug Anal. 2017 Oct;25(4):984-991.

    [2]. Valese AC, et, al. Quantification of pyrrolizidine alkaloids in Senecio brasiliensis, beehive pollen, and honey by LC-MS/MS. J Environ Sci Health B. 2021;56(7):685-694.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Retrorsine N-oxide

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Retrorsine N-oxide 

Retrorsine N-oxide 是吡咯联啶生物碱的一种 N-氧化物,是一种致癌物。Retrorsine N-oxide 衍生的 DNA 加合物是吡咯里西啶生物碱 N-氧化物的常见毒理学生物标记物。

Retrorsine N-oxide

Retrorsine N-oxide Chemical Structure

CAS No. : 15503-86-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides[1][2].

体内研究
(In Vivo)

Retrorsine N-oxide produces DNA adducts, the common biological biomarker of PA-induced liver tumor formation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

367.39

Formula

C18H25NO7

CAS 号

15503-86-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. He X, et, al. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides. J Food Drug Anal. 2017 Oct;25(4):984-991.

    [2]. Valese AC, et, al. Quantification of pyrrolizidine alkaloids in Senecio brasiliensis, beehive pollen, and honey by LC-MS/MS. J Environ Sci Health B. 2021;56(7):685-694.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Tarasaponin IV

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Tarasaponin IV 

Tarasaponin IV 是一种齐墩烷型三萜皂苷,从楤木树皮中分离得到。Tarasaponin IV 可用于癌症研究。

Tarasaponin IV

Tarasaponin IV Chemical Structure

CAS No. : 156980-31-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Tarasaponin IV, as an oleanane-type triterpene saponin, is isolated from the bark of Aralia elata. Tarasaponin IV can be used for the research of cancer[1].

体外研究
(In Vitro)

Tarasaponin IV (0.1~10 μM; 1 hour; HepG2 cells) shows that the inhibitory effects on NF-κB transcriptional activation in HepG2 cells stimulated with TNFα[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1089.22

Formula

C53H84O23

CAS 号

156980-31-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Nhiem NX, et al. Oleanane-type triterpene saponins from the bark of Aralia elata and their NF-κB inhibition and PPAR activation signal pathway. Bioorg Med Chem Lett. 2011;21(20):6143-6147.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Malvidin chloride(Synonyms: Syringidin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Malvidin chloride (Synonyms: Syringidin)

Malvidin (chloride) 是一种从 Oryza sativacv. Heugjinjubyeo 中分离出来的生物活性化合物。 Malvidin 通过阻止细胞周期的 G2/M 期和诱导细胞凋亡显示出细胞毒性。Malvidin可用于癌症研究。

Malvidin chloride(Synonyms: Syringidin)

Malvidin chloride Chemical Structure

CAS No. : 643-84-5

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Malvidin (chloride) is a bioactive compound isolated from Oryza sativacv. Heugjinjubyeo. Malvidin shows cytotoxicity through the arrest of the G2/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer[1].

体外研究
(In Vitro)

Malvidin (0~80 μg/mL; 96 hours; U937 cells) shows cytotoxic activity in a dose-dependent pattern[1].
The IC50 value of Malvidin for U937 cells is 40 μg/mL. Malvidin (U937 cells) shows arrest at the G2/M phase of the cell cycle and increases sub G1 hypo-diploid population[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U937 cells
Concentration: 0~80 μg/mL
Incubation Time: 96 hours
Result: Showed cytotoxic activity in a dose-dependent pattern.

分子量

366.75

Formula

C17H15ClO7

CAS 号

643-84-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jin W H, et al. Cyanidin and Malvidin fromOryza sativacv. HeugjinjubyeoMediate Cytotoxicity against Human Monocytic Leukemia Cellsby Arrest of G2/M Phase and Induction of Apoptosis. J. Agric. Food Chem. 2004, 52, 8, 2213–2217

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Malvidin chloride(Synonyms: Syringidin)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Malvidin chloride (Synonyms: Syringidin)

Malvidin (chloride) 是一种从 Oryza sativacv. Heugjinjubyeo 中分离出来的生物活性化合物。 Malvidin 通过阻止细胞周期的 G2/M 期和诱导细胞凋亡显示出细胞毒性。Malvidin可用于癌症研究。

Malvidin chloride(Synonyms: Syringidin)

Malvidin chloride Chemical Structure

CAS No. : 643-84-5

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Malvidin (chloride) is a bioactive compound isolated from Oryza sativacv. Heugjinjubyeo. Malvidin shows cytotoxicity through the arrest of the G2/M phase of cell cycle and induction of apoptosis. Malvidin can be used for the research of cancer[1].

体外研究
(In Vitro)

Malvidin (0~80 μg/mL; 96 hours; U937 cells) shows cytotoxic activity in a dose-dependent pattern[1].
The IC50 value of Malvidin for U937 cells is 40 μg/mL. Malvidin (U937 cells) shows arrest at the G2/M phase of the cell cycle and increases sub G1 hypo-diploid population[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U937 cells
Concentration: 0~80 μg/mL
Incubation Time: 96 hours
Result: Showed cytotoxic activity in a dose-dependent pattern.

分子量

366.75

Formula

C17H15ClO7

CAS 号

643-84-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jin W H, et al. Cyanidin and Malvidin fromOryza sativacv. HeugjinjubyeoMediate Cytotoxicity against Human Monocytic Leukemia Cellsby Arrest of G2/M Phase and Induction of Apoptosis. J. Agric. Food Chem. 2004, 52, 8, 2213–2217

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Pasakbumin D(Synonyms: 13β,21-Dihydroxyeurycomanone)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Pasakbumin D (Synonyms: 13β,21-Dihydroxyeurycomanone)

Pasakbumin D 是一种 quassinoid,可用于癌症研究。

Pasakbumin D(Synonyms: 13β,21-Dihydroxyeurycomanone)

Pasakbumin D Chemical Structure

CAS No. : 138874-44-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Pasakbumin D is a quassinoid and can be used for the research of cancer[1].

分子量

442.41

Formula

C20H26O11

CAS 号

138874-44-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Tada, H., et al. New antiulcer quassinoids from Eurycoma longifolia. European Journal of Medicinal Chemistry, 26(3), 345–349.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Valeriandoid F

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Valeriandoid F 

Valeriandoid F 是一种环烯醚萜,可有效抑制 NO 的产生,IC50 值为 0.88 μM。Valeriandoid F 具有抗炎和抗增殖活性。

Valeriandoid F

Valeriandoid F Chemical Structure

CAS No. : 1427162-60-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Valeriandoid F is an iridoid, which potently inhibits NO production with an IC50 value of 0.88 μM. Valeriandoid F has anti-inflammatory and antiproliferative activities[1].

体外研究
(In Vitro)

Valeriandoid F selectively inhibits the proliferation of human glioma stem cell lines, GSC-3 and GSC-18, with IC50 values of 7.16 μM and 5.75 μM, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

454.51

Formula

C23H34O9

CAS 号

1427162-60-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Huan Liu, et al. Iridoids from Valeriana jatamansi with anti-inflammatory and antiproliferative properties. Phytochemistry. 2021 Apr;184:112681.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Valeriandoid F

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Valeriandoid F 

Valeriandoid F 是一种环烯醚萜,可有效抑制 NO 的产生,IC50 值为 0.88 μM。Valeriandoid F 具有抗炎和抗增殖活性。

Valeriandoid F

Valeriandoid F Chemical Structure

CAS No. : 1427162-60-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Valeriandoid F is an iridoid, which potently inhibits NO production with an IC50 value of 0.88 μM. Valeriandoid F has anti-inflammatory and antiproliferative activities[1].

体外研究
(In Vitro)

Valeriandoid F selectively inhibits the proliferation of human glioma stem cell lines, GSC-3 and GSC-18, with IC50 values of 7.16 μM and 5.75 μM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

454.51

Formula

C23H34O9

CAS 号

1427162-60-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Huan Liu, et al. Iridoids from Valeriana jatamansi with anti-inflammatory and antiproliferative properties. Phytochemistry. 2021 Apr;184:112681.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Loureiriol

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Loureiriol 

Loureiriol 是一种同型异黄酮类化合物,具有较弱的抗癌作用。

Loureiriol

Loureiriol Chemical Structure

CAS No. : 479195-44-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Loureiriol is a homoisoflavonoid with weak anticancer effects[1].

体外研究
(In Vitro)

Loureiriol has weak cytotoxicity, with cell inhibition of 15.27% and 25.09% against drug sensitive CCRF-CEM and drug resistant CEM/ADR5000 leukemia cells, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

302.28

Formula

C16H14O6

CAS 号

479195-44-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Vaderament-A.Nchiozem-Ngnitedem, et al. Two new flavonoids from Dracaena usambarensis Engl. Phytochemistry Letters (2020), 36, 80-85.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Poricoic acid AM

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Poricoic acid AM 

Poricic acid AM 是一种具有抗肿瘤活性的三萜类化合物。

Poricoic acid AM

Poricoic acid AM Chemical Structure

CAS No. : 151200-92-9

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Poricoic acid AM is a triterpenoid with ant-tumor activities[1].

分子量

512.72

Formula

C32H48O5

CAS 号

151200-92-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Shuang-Shuang Tian, et al. Quality evaluation of Poria based on specific chromatogram and quantitative analysis of multicomponents. Zhongguo Zhong Yao Za Zhi. 2019 Apr;44(7):1371-1380.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Loureiriol

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Loureiriol 

Loureiriol 是一种同型异黄酮类化合物,具有较弱的抗癌作用。

Loureiriol

Loureiriol Chemical Structure

CAS No. : 479195-44-3

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Loureiriol is a homoisoflavonoid with weak anticancer effects[1].

体外研究
(In Vitro)

Loureiriol has weak cytotoxicity, with cell inhibition of 15.27% and 25.09% against drug sensitive CCRF-CEM and drug resistant CEM/ADR5000 leukemia cells, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

302.28

Formula

C16H14O6

CAS 号

479195-44-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Vaderament-A.Nchiozem-Ngnitedem, et al. Two new flavonoids from Dracaena usambarensis Engl. Phytochemistry Letters (2020), 36, 80-85.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Eupalinolide O(Synonyms: 野马追内酯O)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Eupalinolide O (Synonyms: 野马追内酯O)

Eupalinolide O 是一种具有抗癌活性的倍半萜内酯。Eupalinolide O 在人 MDA-MB-468 乳腺癌细胞中诱导细胞凋亡 (apoptosis)。

Eupalinolide O(Synonyms: 野马追内酯O)

Eupalinolide O Chemical Structure

CAS No. : 2170228-67-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Eupalinolide O is a sesquiterpene lactone with anticancer activities. Eupalinolide O induces cell apoptosis in human MDA-MB-468 breast cancer cells[1].

体外研究
(In Vitro)

Eupalinolide O could induce cell cycle arrest and apoptosis in human MDA-MB-468 breast cancer cells. Eupalinolide O also shows anti-TNBC (triple-negative breast cancer) activity against human MDA-MB-468 breast cancer cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

418.44

Formula

C22H26O8

CAS 号

2170228-67-6

中文名称

野马追内酯O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bo Yang, et al. Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer. Nat Prod Res. 2019 Feb;33(4):477-485.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Eupalinolide O(Synonyms: 野马追内酯O)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Eupalinolide O (Synonyms: 野马追内酯O)

Eupalinolide O 是一种具有抗癌活性的倍半萜内酯。Eupalinolide O 在人 MDA-MB-468 乳腺癌细胞中诱导细胞凋亡 (apoptosis)。

Eupalinolide O(Synonyms: 野马追内酯O)

Eupalinolide O Chemical Structure

CAS No. : 2170228-67-6

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Eupalinolide O is a sesquiterpene lactone with anticancer activities. Eupalinolide O induces cell apoptosis in human MDA-MB-468 breast cancer cells[1].

体外研究
(In Vitro)

Eupalinolide O could induce cell cycle arrest and apoptosis in human MDA-MB-468 breast cancer cells. Eupalinolide O also shows anti-TNBC (triple-negative breast cancer) activity against human MDA-MB-468 breast cancer cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

418.44

Formula

C22H26O8

CAS 号

2170228-67-6

中文名称

野马追内酯O

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Bo Yang, et al. Precise discovery of a STAT3 inhibitor from Eupatorium lindleyanum and evaluation of its activity of anti-triple-negative breast cancer. Nat Prod Res. 2019 Feb;33(4):477-485.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Spiraeoside(Synonyms: Quercetin 4′-O-glucoside)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Spiraeoside (Synonyms: Quercetin 4′-O-glucoside)

Spiraeoside 是具有口服活性的天然产物,具有抗氧化活性,抑制活性氧和丙二醛的生成。Spiraeoside 具有抗过敏、抗炎、抗肿瘤活性。

Spiraeoside(Synonyms: Quercetin 4′-O-glucoside)

Spiraeoside Chemical Structure

CAS No. : 20229-56-5

规格 价格 是否有货
5 mg ¥5700 询问价格 & 货期
10 mg ¥9500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Spiraeoside, an orally active natural compound, exerts antioxidant activity, inhibits reactive oxygen species (ROS) and malondialdehyde production. Spiraeoside possesses antiallergic, anti-inflammatory and antitumor activities[1].

体外研究
(In Vitro)

Spiraeoside elevates HG stimulation-caused the decrease in the expression levels of p-Akt, nuclear Nrf2, and HO-1 in AC16 cells (the effects of Spiraeoside are reversed by LY294002)[1].
Spiraeoside protects AC16 cells against HG-induced oxidative stress, cell injury, and apoptosis[1].
Spiraeoside activates the PI3K/Akt/Nrf2 pathway in AC16 cells on exposure to HG[1].
Spiraeoside protects AC16 cells against HG-induced apoptosis through the PI3K/Akt/Nrf2 pathway[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: AC16 cells.
Concentration: 1, 5, 10, or 20 μM.
Incubation Time: 0, 24, or 48 hours.
Result: Inhibited AC16 cells viability (20 μM).

体内研究
(In Vivo)

Spiraeoside (50 mg/kg, p.o.) shows ulcer preventive ability[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (6-8 weeks old)[2].
Dosage: 50 mg/kg.
Administration: Oral gavage an hour before inducing the lesions.
Result: Decreased severity of the formed lesions.

分子量

464.38

Formula

C21H20O12

CAS 号

20229-56-5

中文名称

螺旋藻苷

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Hongyang Liu, et al. Spiraeoside protects human cardiomyocytes against high glucose-induced injury, oxidative stress, and apoptosis by activation of PI3K/Akt/Nrf2 pathway. J Biochem Mol Toxicol. 2020 Oct;34(10):e22548.

    [2]. Stevan Samardžić, et al. Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. and Filipendula vulgaris Moench. J Ethnopharmacol. 2018 Mar 1;213:132-137.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Epigambogic acid

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Epigambogic acid 

Epigambogic acid 是天然的、具有抗肿瘤、止咳、祛痰和抗炎活性的化合物。

Epigambogic acid

Epigambogic acid Chemical Structure

CAS No. : 887606-04-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Epigambogic acid is a natural anti-tumor, antitussive, expectorant and anti-inflammatory compound[1][2].

分子量

628.75

Formula

C38H44O8

CAS 号

887606-04-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Quanbin Han, et al. Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi. Planta Med. 2006 Feb;72(3):281-4.

    [2]. BAO Shu-yun, et al. Antitussive, Expectorant and Anti-inflammatory Effects of Ethanol Extract and Water Extract from Cotton Root. Natural Product Research & Development . Aug2011, Vol. 23 Issue 4, p730-733. 4p.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Epigambogic acid

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Epigambogic acid 

Epigambogic acid 是天然的、具有抗肿瘤、止咳、祛痰和抗炎活性的化合物。

Epigambogic acid

Epigambogic acid Chemical Structure

CAS No. : 887606-04-4

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Epigambogic acid is a natural anti-tumor, antitussive, expectorant and anti-inflammatory compound[1][2].

分子量

628.75

Formula

C38H44O8

CAS 号

887606-04-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Quanbin Han, et al. Gambogic acid and epigambogic acid, C-2 epimers with novel anticancer effects from Garcinia hanburyi. Planta Med. 2006 Feb;72(3):281-4.

    [2]. BAO Shu-yun, et al. Antitussive, Expectorant and Anti-inflammatory Effects of Ethanol Extract and Water Extract from Cotton Root. Natural Product Research & Development . Aug2011, Vol. 23 Issue 4, p730-733. 4p.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

23-epi-26-Deoxyactein(Synonyms: 27-Deoxyactein)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

23-epi-26-Deoxyactein (Synonyms: 27-Deoxyactein)

23-epi-26-Deoxyactein 是天然的、具有口服活性的抗肥胖和抗肿瘤作用的化合物。

23-epi-26-Deoxyactein(Synonyms: 27-Deoxyactein)

23-epi-26-Deoxyactein Chemical Structure

CAS No. : 501938-01-8

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

23-epi-26-Deoxyactein is a natural and orally active anti-obesity and anti-cancer compound[1][2][3].

体外研究
(In Vitro)

23-epi-26-Deoxyactein (DA :10 μM and 20 μM) inhibits 3T3-L1 adipogenesis through down-regulating the expression of C/ebpα, C/ebpβ, and Pparγ, which are the critical adipogenic transcription factors[1].
23-epi-26-Deoxyactein (DA) promotes mitochondrial biogenesis in pancreatic β-cells preventing methylglyoxal-induced oxidative cell damage and protects osteoblasts against Antimycin A-induced cell damage[2].
23-epi-26-Deoxyactein (DA) inhibits growth of the MCF7 human breast cancer cells and induces cell cycle arrest at G1 (IC50 of 21μM)[3].
23-epi-26-Deoxyactein (0.1-1 μM) protects osteoblasts against Antimycin A-induced cell damage[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Differentiation Assay[1]

Cell Line: 3T3-L1 preadipocytes.
Concentration: 0-50 μM.
Incubation Time: 8 days.
Result: 10 μM DA inhibited the adipogenesis of 3T3-L1 preadipocytes mainly at the early stage of differentiation.

体内研究
(In Vivo)

23-epi-26-Deoxyactein (DA: 5 and 10 mg/kg/d) significantly lowers body weight gain, fat mass, and liver weight in HFD-fed mice. 23-epi-26-Deoxyactein (DA) also reduces insulin resistance and serum lipoprotein levels in HFD-fed mice[1].
23-epi-26-Deoxyactein (DA) promotes adipocyte lipolysis in mice through activating the AMPK signaling and SIRT1-FOXO1 pathway[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Diet induced obesity in C57BL/6 mice[1].
Dosage: 1-10 mg/kg.
Administration: Orally, daily for 12 weeks.
Result: Lowered body weight gain, fat mass, and liver weight.
5 mg/kg/d DA significantly improved HFD-induced glucose intolerance.

分子量

660.83

Formula

C37H56O10

CAS 号

501938-01-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jingjing Yuan, et al. Effects of 23-epi-26-deoxyactein on adipogenesis in 3T3-L1 preadipocytes and diet-induced obesity in C57BL/6 mice. Phytomedicine. 2020 Jun 5;76:153264.

    [2]. Kwang Sik Suh, et al. Deoxyactein protects pancreatic β-cells against methylglyoxal-induced oxidative cell damage by the upregulation of mitochondrial biogenesis. Int J Mol Med. 2017 Aug;40(2):539-548.

    [3]. Einbond, L.S., et al. Growth inhibitory activity of extracts and purified components of black cohosh on human breast cancer cells. Breast Cancer Res. Treat. 83, 221–231. Breast Cancer Res Treat. 2004 Feb;83(3):221-31.

    [4]. Eun Mi Choi, et al. Deoxyactein Isolated from Cimicifuga racemosa protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity. J Appl Toxicol. 2013 Jun;33(6):488-94.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Rapanone(Synonyms: 拉帕酮)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Rapanone (Synonyms: 拉帕酮) 纯度: 99.20%

Rapanone 是一种天然苯醌。Rapanone 具有广泛的生物作用,包括抗肿瘤、抗氧化、抗炎、抗菌和抗寄生虫。Rapanone 还是一种有效和选择性的人滑膜 PLA2 抑制剂,IC50 值为 2.6 μM。

Rapanone(Synonyms: 拉帕酮)

Rapanone Chemical Structure

CAS No. : 573-40-0

规格 价格 是否有货 数量
5 mg ¥1200 In-stock
10 mg ¥1700 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Rapanone 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Antibacterial Compound Library
  • Traditional Chinese Medicine Monomer Library
  • Antiparasitic Compound library
  • Lipid Metabolism Compound Library

生物活性

Rapanone is a natural benzoquinone. Rapanone exhibits a broad spectrum of biological actions, including anti-tumor, antioxidant, anti-inflammatory, antibacterial and antiparasitic. Rapanone also is a potent and selective human synovial PLA2 inhibitor, with an IC50 of 2.6 μM[1][2][3][4].

IC50 & Target[4]

PLA2

2.6 μM (IC50)

体外研究
(In Vitro)

Rapanone (10-40 μM; 24 h) inhibits the cell viability, with IC50s of 35.58 μM and 27.89 μM for primary rats hepatocytes and HepG2 cells, respectively[1].
Rapanone (10-40 μM; 24 h) induces a concentration-dependent mitochondrial membrane potential dissipation, ATP depletion, hydrogen peroxide generation and, phosphatidyl serine externalization in HepG2 cells[1].
Rapanone inhibits electron transport at Complex III and promotes mitochondrial dysfunction[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Rapanone (2.5-10 mg/kg; i.p.) exhibits anti-inflammatory effects in the carrageenan paw oedema model in mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

322.44

Formula

C19H30O4

CAS 号

573-40-0

中文名称

拉帕酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Andreu GLP, et, al. Rapanone, a naturally occurring benzoquinone, inhibits mitochondrial respiration and induces HepG2 cell death. Toxicol In Vitro. 2020 Mar;63:104737.

    [2]. Morais LS, et, al. Antileishmanial compounds from Connarus suberosus: Metabolomics, isolation and mechanism of action. PLoS One. 2020 Nov 6;15(11):e0241855.

    [3]. Vega-Hernández K, et, al. Discerning the antioxidant mechanism of rapanone: A naturally occurring benzoquinone with iron complexing and radical scavenging activities. J Inorg Biochem. 2017 May;170:134-147.

    [4]. Ospina LF, et, al. Inhibition of acute and chronic inflammatory responses by the hydroxybenzoquinonic derivative rapanone. Planta Med. 2001 Dec;67(9):791-5.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Neolancerin

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Neolancerin 

Neolancerin 是一种天然产物,对 HL-60 细胞具有弱细胞毒活性。

Neolancerin

Neolancerin Chemical Structure

CAS No. : 117221-65-5

规格 是否有货
5 mg 询价
10 mg 询价
25 mg 询价

* Please select Quantity before adding items.

生物活性

Neolancerin is a natural product with weak cytotoxic activity against HL-60 cells[1].

体外研究
(In Vitro)

Neolancerin reduces the viability of HL-60 human promyelocytic leukemia cells significantly, with an IC50 values of 86.63 μM[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

406.34

Formula

C19H18O10

CAS 号

117221-65-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Wei Li, et al. of xanthones from adventitious roots of St. John’s Wort (Hypericum perforatum L.) and their antioxidant and cytotoxic activities. Food Science and Biotechnology (2013), 22(4), 945-949.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务