FTO-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

FTO-IN-1 

FTO-IN-1 是一种脂肪和肥胖相关酶 (FTO) 抑制剂,IC50 值 <1 μM。FTO-IN-1 可用于癌症的研究。详细信息请参考专利文献 WO2018157843A1 中的化合物 32。

FTO-IN-1

FTO-IN-1 Chemical Structure

CAS No. : 2243944-92-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

FTO-IN-1 的其他形式现货产品:

FTO-IN-1 TFA

生物活性

FTO-IN-1 is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC50 of <1 μm. fto-in-1 can be used for the research of cancer[1].

IC50 & Target

IC50: <1 μm (fto)[1]

体外研究
(In Vitro)

FTO-IN-1 (50 μM) inhibits FTO enzyme activity by 62% in vitro[1].
FTO-IN-1 (50 μM) inhibits the viability of SCLC-21H, RH30 and KP3 cells, with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

391.25

Formula

C18H16Cl2N4O2

CAS 号

2243944-92-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yang C, et, al. 2-(substituted benzene matrix) aromatic formate fto inhibitor, preparation method therefor, and applications thereof. WO2018157843A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

FTO-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

FTO-IN-1 

FTO-IN-1 是一种脂肪和肥胖相关酶 (FTO) 抑制剂,IC50 值 <1 μM。FTO-IN-1 可用于癌症的研究。详细信息请参考专利文献 WO2018157843A1 中的化合物 32。

FTO-IN-1

FTO-IN-1 Chemical Structure

CAS No. : 2243944-92-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

FTO-IN-1 的其他形式现货产品:

FTO-IN-1 TFA

生物活性

FTO-IN-1 is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC50 of <1 μm. fto-in-1 can be used for the research of cancer[1].

IC50 & Target

IC50: <1 μm (fto)[1]

体外研究
(In Vitro)

FTO-IN-1 (50 μM) inhibits FTO enzyme activity by 62% in vitro[1].
FTO-IN-1 (50 μM) inhibits the viability of SCLC-21H, RH30 and KP3 cells, with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

391.25

Formula

C18H16Cl2N4O2

CAS 号

2243944-92-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yang C, et, al. 2-(substituted benzene matrix) aromatic formate fto inhibitor, preparation method therefor, and applications thereof. WO2018157843A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

FTO-IN-1

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

FTO-IN-1 

FTO-IN-1 是一种脂肪和肥胖相关酶 (FTO) 抑制剂,IC50 值 <1 μM。FTO-IN-1 可用于癌症的研究。详细信息请参考专利文献 WO2018157843A1 中的化合物 32。

FTO-IN-1

FTO-IN-1 Chemical Structure

CAS No. : 2243944-92-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

FTO-IN-1 的其他形式现货产品:

FTO-IN-1 TFA

生物活性

FTO-IN-1 is a fat mass and obesity-associated enzyme (FTO) inhibitor extracted from patent WO2018157843A1, compound 32, with an IC50 of <1 μm. fto-in-1 can be used for the research of cancer[1].

IC50 & Target

IC50: <1 μm (fto)[1]

体外研究
(In Vitro)

FTO-IN-1 (50 μM) inhibits FTO enzyme activity by 62% in vitro[1].
FTO-IN-1 (50 μM) inhibits the viability of SCLC-21H, RH30 and KP3 cells, with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

391.25

Formula

C18H16Cl2N4O2

CAS 号

2243944-92-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Yang C, et, al. 2-(substituted benzene matrix) aromatic formate fto inhibitor, preparation method therefor, and applications thereof. WO2018157843A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

A68930

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

A68930 

A68930 作为 dopamine D1 receptor 激动剂,可用于支气管扩张的研究。

A68930

A68930 Chemical Structure

CAS No. : 130465-45-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1].

IC50 & Target

D1 Receptor

 

体外研究
(In Vitro)

A68930 (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein[1].
A68930 (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression[1].
A68930 (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: 16HBE14o- or NCI-H292 cells
Concentration: 1 μM
Incubation Time: 5~60 minutes
Result: Significantly increased phosphorylation of CREB.

RT-PCR[1]

Cell Line: NCI-H292 cells
Concentration: 1 μM
Incubation Time: 48 hours
Result: Induced MUC5AC mRNA expression.

Immunofluorescence[1]

Cell Line: NCI-H292 cells
Concentration: 1 μM
Incubation Time: 48 hours
Result: The mRNA data of MUC5AC, MUC5AC protein expression were increased.

分子量

271.31

Formula

C16H17NO3

CAS 号

130465-45-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Matsuyama N, et al. The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 2018;19(1):53. Published 2018 Apr 2.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

A68930

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

A68930 

A68930 作为 dopamine D1 receptor 激动剂,可用于支气管扩张的研究。

A68930

A68930 Chemical Structure

CAS No. : 130465-45-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1].

IC50 & Target

D1 Receptor

 

体外研究
(In Vitro)

A68930 (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein[1].
A68930 (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression[1].
A68930 (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: 16HBE14o- or NCI-H292 cells
Concentration: 1 μM
Incubation Time: 5~60 minutes
Result: Significantly increased phosphorylation of CREB.

RT-PCR[1]

Cell Line: NCI-H292 cells
Concentration: 1 μM
Incubation Time: 48 hours
Result: Induced MUC5AC mRNA expression.

Immunofluorescence[1]

Cell Line: NCI-H292 cells
Concentration: 1 μM
Incubation Time: 48 hours
Result: The mRNA data of MUC5AC, MUC5AC protein expression were increased.

分子量

271.31

Formula

C16H17NO3

CAS 号

130465-45-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Matsuyama N, et al. The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 2018;19(1):53. Published 2018 Apr 2.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

A68930

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

A68930 

A68930 作为 dopamine D1 receptor 激动剂,可用于支气管扩张的研究。

A68930

A68930 Chemical Structure

CAS No. : 130465-45-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1].

IC50 & Target

D1 Receptor

 

体外研究
(In Vitro)

A68930 (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein[1].
A68930 (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression[1].
A68930 (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: 16HBE14o- or NCI-H292 cells
Concentration: 1 μM
Incubation Time: 5~60 minutes
Result: Significantly increased phosphorylation of CREB.

RT-PCR[1]

Cell Line: NCI-H292 cells
Concentration: 1 μM
Incubation Time: 48 hours
Result: Induced MUC5AC mRNA expression.

Immunofluorescence[1]

Cell Line: NCI-H292 cells
Concentration: 1 μM
Incubation Time: 48 hours
Result: The mRNA data of MUC5AC, MUC5AC protein expression were increased.

分子量

271.31

Formula

C16H17NO3

CAS 号

130465-45-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Matsuyama N, et al. The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 2018;19(1):53. Published 2018 Apr 2.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Camphor-d6(Synonyms: (±)-Camphor-d6)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Camphor-d6 (Synonyms: (±)-Camphor-d6)

Camphor-d6 ((±)-Camphor-d6) 是 Camphor 的氘代物。Camphor ((±)-Camphor) 是一种外用抗感染和抗瘙痒剂,口服有驱风作用。然而,Camphor 摄入时有毒。Camphor 具有抗病毒,镇咳和抗癌活性。Camphor 是一种 TRPV3 激动剂。

Camphor-d6(Synonyms: (±)-Camphor-d6)

Camphor-d6 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Camphor-d6 ((±)-Camphor-d6) is the deuterium labeled Camphor. Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

158.27

Formula

C10H10D6O

中文名称

樟脑 d6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Chen W, et al. Camphor–a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon–a review. Molecules. 2013 May 10;18(5):5434-54.

    [3]. Billen B, et al. Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealedby intrinsic tryptophan fluorescence quenching. J Biol Chem. 2015 May 15;290(20):12964-74.

    [4]. Tran TA, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015 Dec;29(12):1917-25.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Camphor-d6(Synonyms: (±)-Camphor-d6)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Camphor-d6 (Synonyms: (±)-Camphor-d6)

Camphor-d6 ((±)-Camphor-d6) 是 Camphor 的氘代物。Camphor ((±)-Camphor) 是一种外用抗感染和抗瘙痒剂,口服有驱风作用。然而,Camphor 摄入时有毒。Camphor 具有抗病毒,镇咳和抗癌活性。Camphor 是一种 TRPV3 激动剂。

Camphor-d6(Synonyms: (±)-Camphor-d6)

Camphor-d6 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Camphor-d6 ((±)-Camphor-d6) is the deuterium labeled Camphor. Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

158.27

Formula

C10H10D6O

中文名称

樟脑 d6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Chen W, et al. Camphor–a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon–a review. Molecules. 2013 May 10;18(5):5434-54.

    [3]. Billen B, et al. Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealedby intrinsic tryptophan fluorescence quenching. J Biol Chem. 2015 May 15;290(20):12964-74.

    [4]. Tran TA, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015 Dec;29(12):1917-25.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Camphor-d6(Synonyms: (±)-Camphor-d6)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Camphor-d6 (Synonyms: (±)-Camphor-d6)

Camphor-d6 ((±)-Camphor-d6) 是 Camphor 的氘代物。Camphor ((±)-Camphor) 是一种外用抗感染和抗瘙痒剂,口服有驱风作用。然而,Camphor 摄入时有毒。Camphor 具有抗病毒,镇咳和抗癌活性。Camphor 是一种 TRPV3 激动剂。

Camphor-d6(Synonyms: (±)-Camphor-d6)

Camphor-d6 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Camphor-d6 ((±)-Camphor-d6) is the deuterium labeled Camphor. Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

158.27

Formula

C10H10D6O

中文名称

樟脑 d6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Chen W, et al. Camphor–a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon–a review. Molecules. 2013 May 10;18(5):5434-54.

    [3]. Billen B, et al. Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealedby intrinsic tryptophan fluorescence quenching. J Biol Chem. 2015 May 15;290(20):12964-74.

    [4]. Tran TA, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015 Dec;29(12):1917-25.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

CDK7-IN-5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CDK7-IN-5 

CDK7-IN-5 是一种 CDK7 抑制剂,IC50 值 <100 nM。CDK7-IN-5 具有抗癌作用。(WO2015154022A1 (Compound 104))。

CDK7-IN-5

CDK7-IN-5 Chemical Structure

CAS No. : 1817006-50-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-5 is a CDK7 inhibitor with an IC50 value <100 nm. cdk7-in-5 has anticancer effects. (wo2015154022a1 (compound 104))[1].

IC50 & Target[1]

CDK7

<100 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-5 (Comp 104; 72 hours) inhibits the proliferation of A673 cells with an IC50 <500 nm[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

611.78

Formula

C34H45N9O2

CAS 号

1817006-50-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jason J. MARINEAU, et al. Inhibitors of cyclin-dependent kinase 7 (cdk7). WO2015154022A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

CDK7-IN-5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CDK7-IN-5 

CDK7-IN-5 是一种 CDK7 抑制剂,IC50 值 <100 nM。CDK7-IN-5 具有抗癌作用。(WO2015154022A1 (Compound 104))。

CDK7-IN-5

CDK7-IN-5 Chemical Structure

CAS No. : 1817006-50-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-5 is a CDK7 inhibitor with an IC50 value <100 nm. cdk7-in-5 has anticancer effects. (wo2015154022a1 (compound 104))[1].

IC50 & Target[1]

CDK7

<100 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-5 (Comp 104; 72 hours) inhibits the proliferation of A673 cells with an IC50 <500 nm[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

611.78

Formula

C34H45N9O2

CAS 号

1817006-50-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jason J. MARINEAU, et al. Inhibitors of cyclin-dependent kinase 7 (cdk7). WO2015154022A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

CDK7-IN-5

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CDK7-IN-5 

CDK7-IN-5 是一种 CDK7 抑制剂,IC50 值 <100 nM。CDK7-IN-5 具有抗癌作用。(WO2015154022A1 (Compound 104))。

CDK7-IN-5

CDK7-IN-5 Chemical Structure

CAS No. : 1817006-50-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-5 is a CDK7 inhibitor with an IC50 value <100 nm. cdk7-in-5 has anticancer effects. (wo2015154022a1 (compound 104))[1].

IC50 & Target[1]

CDK7

<100 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-5 (Comp 104; 72 hours) inhibits the proliferation of A673 cells with an IC50 <500 nm[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

611.78

Formula

C34H45N9O2

CAS 号

1817006-50-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Jason J. MARINEAU, et al. Inhibitors of cyclin-dependent kinase 7 (cdk7). WO2015154022A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

CDK7-IN-7

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CDK7-IN-7 

CDK7-IN-7 是一种有效的 CDK7 抑制剂,IC50 为 <50 nM. 详细信息可参考专利 CN112661745A, compound T-01。

CDK7-IN-7

CDK7-IN-7 Chemical Structure

CAS No. : 2640208-01-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-7 is a potent and selective CDK7 kinase inhibitor with an IC50 of <50 nm (patent cn112661745a, compound t-01)[1].

IC50 & Target[1]

CDK7

<50 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-7 shows inhibitory against MDA‑MB 231, MDA-MB453, OVCAR3, A2780, HCT-116, WiDr and Calu-6 cells (IC50 ranging from 12.21 to 144.9 nM)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

513.31

Formula

C20H20BrF3N6O2

CAS 号

2640208-01-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Compounds useful as CDK7 kinase inhibitors and uses thereof. CN112661745A.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

CDK7-IN-7

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CDK7-IN-7 

CDK7-IN-7 是一种有效的 CDK7 抑制剂,IC50 为 <50 nM. 详细信息可参考专利 CN112661745A, compound T-01。

CDK7-IN-7

CDK7-IN-7 Chemical Structure

CAS No. : 2640208-01-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-7 is a potent and selective CDK7 kinase inhibitor with an IC50 of <50 nm (patent cn112661745a, compound t-01)[1].

IC50 & Target[1]

CDK7

<50 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-7 shows inhibitory against MDA‑MB 231, MDA-MB453, OVCAR3, A2780, HCT-116, WiDr and Calu-6 cells (IC50 ranging from 12.21 to 144.9 nM)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

513.31

Formula

C20H20BrF3N6O2

CAS 号

2640208-01-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Compounds useful as CDK7 kinase inhibitors and uses thereof. CN112661745A.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

CDK7-IN-7

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

CDK7-IN-7 

CDK7-IN-7 是一种有效的 CDK7 抑制剂,IC50 为 <50 nM. 详细信息可参考专利 CN112661745A, compound T-01。

CDK7-IN-7

CDK7-IN-7 Chemical Structure

CAS No. : 2640208-01-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CDK7-IN-7 is a potent and selective CDK7 kinase inhibitor with an IC50 of <50 nm (patent cn112661745a, compound t-01)[1].

IC50 & Target[1]

CDK7

<50 nM (IC50)

体外研究
(In Vitro)

CDK7-IN-7 shows inhibitory against MDA‑MB 231, MDA-MB453, OVCAR3, A2780, HCT-116, WiDr and Calu-6 cells (IC50 ranging from 12.21 to 144.9 nM)[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

513.31

Formula

C20H20BrF3N6O2

CAS 号

2640208-01-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Compounds useful as CDK7 kinase inhibitors and uses thereof. CN112661745A.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

GSA-10

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

GSA-10 

GSA-10 是一种有效的平滑 (Smo) 受体激动剂,其 EC50 值为 1.2 μM。GSA-10 是一种新型喹啉甲酰胺衍生物。GSA-10 作用于 Smo,促进多能间充质干细胞分化为成骨细胞。GSA-10 介导 Hedgehog (Hh) 信号传导,这可能对癌症疾病的再生医学具有研究意义。

GSA-10

GSA-10 Chemical Structure

CAS No. : 300833-95-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].

IC50 & Target

Smoothened receptor[1]

分子量

450.53

Formula

C26H30N2O5

CAS 号

300833-95-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016;121:747-757.

    [2]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened [published correction appears in Mol Pharmacol. 2013 Aug;84(2):303]. Mol Pharmacol. 2013;83(5):1020-1029.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

GSA-10

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

GSA-10 

GSA-10 是一种有效的平滑 (Smo) 受体激动剂,其 EC50 值为 1.2 μM。GSA-10 是一种新型喹啉甲酰胺衍生物。GSA-10 作用于 Smo,促进多能间充质干细胞分化为成骨细胞。GSA-10 介导 Hedgehog (Hh) 信号传导,这可能对癌症疾病的再生医学具有研究意义。

GSA-10

GSA-10 Chemical Structure

CAS No. : 300833-95-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].

IC50 & Target

Smoothened receptor[1]

分子量

450.53

Formula

C26H30N2O5

CAS 号

300833-95-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016;121:747-757.

    [2]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened [published correction appears in Mol Pharmacol. 2013 Aug;84(2):303]. Mol Pharmacol. 2013;83(5):1020-1029.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

GSA-10

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

GSA-10 

GSA-10 是一种有效的平滑 (Smo) 受体激动剂,其 EC50 值为 1.2 μM。GSA-10 是一种新型喹啉甲酰胺衍生物。GSA-10 作用于 Smo,促进多能间充质干细胞分化为成骨细胞。GSA-10 介导 Hedgehog (Hh) 信号传导,这可能对癌症疾病的再生医学具有研究意义。

GSA-10

GSA-10 Chemical Structure

CAS No. : 300833-95-8

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

GSA-10 is a potent agonist of Smoothened (Smo) receptor with an EC50 of 1.2 μM. GSA-10 is a novel quinolinecarboxamide derivative. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 mediates Hedgehog (Hh) signaling which may have researching interests in regenerative medicine for cancer disease[1][2].

IC50 & Target

Smoothened receptor[1]

分子量

450.53

Formula

C26H30N2O5

CAS 号

300833-95-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Manetti F, et al. Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives. Eur J Med Chem. 2016;121:747-757.

    [2]. Gorojankina T, et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened [published correction appears in Mol Pharmacol. 2013 Aug;84(2):303]. Mol Pharmacol. 2013;83(5):1020-1029.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

4-Methylhistamine dihydrochloride

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

4-Methylhistamine dihydrochloride 

4-Methylhistamine (dihydrochloride) 是组胺 4 受体 (H4R) 的有效激动剂。4-Methylhistamine (dihydrochloride) 具有研究癌症和自身免疫性疾病等免疫相关疾病的潜力。

4-Methylhistamine dihydrochloride

4-Methylhistamine dihydrochloride Chemical Structure

CAS No. : 36376-47-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders[1].

IC50 & Target

histamine 4 receptor[1]

分子量

198.09

Formula

C6H13Cl2N3

CAS 号

36376-47-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

4-Methylhistamine dihydrochloride

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

4-Methylhistamine dihydrochloride 

4-Methylhistamine (dihydrochloride) 是组胺 4 受体 (H4R) 的有效激动剂。4-Methylhistamine (dihydrochloride) 具有研究癌症和自身免疫性疾病等免疫相关疾病的潜力。

4-Methylhistamine dihydrochloride

4-Methylhistamine dihydrochloride Chemical Structure

CAS No. : 36376-47-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

4-Methylhistamine (dihydrochloride) is the potent agonist of histamine 4 receptor (H4R). 4-Methylhistamine (dihydrochloride) has the potential for the research of immune-related diseases such as cancer and autoimmune disorders[1].

IC50 & Target

histamine 4 receptor[1]

分子量

198.09

Formula

C6H13Cl2N3

CAS 号

36376-47-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Ahmad SF, et al. Stimulation of the histamine 4 receptor with 4-methylhistamine modulates the effects of chronic stress on the Th1/Th2 cytokine balance. Immunobiology. 2015;220(3):341-349.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务