Chemical structure: macrolideUsed to study bacterial protein synthesis.Clindamycin is used to study bacterial infections, such as group B streptococcal disease, bacterial resistance and plasma protein binding.
Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases)in vivo. Doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease acne, rosacea, and rickettsial infections and prophylaxis of anthrax (caused byBacillus anthracis). It is also effective againstYersinia pestis. Treatment with doxycycline inhibits collagen synthesis.Doxycycline hydrochloride has been used for the induction of shRNA expression and induction of expression vectors.
Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases)in vivo. Doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease acne, rosacea, and rickettsial infections and prophylaxis of anthrax (caused byBacillus anthracis). It is also effective againstYersinia pestis. Treatment with doxycycline inhibits collagen synthesis.
Cefepime is a semi-synthetic fourth-generation cephalosporin. It is resistant to hydrolysis by common plasmid and/or chromosomally-mediated β-lactamases.Cefepime was used in antimicrobial susceptibility testing forAcinetobacter baumanniiand extended-spectrum-β-lactamase-producingEscherichia coliisolated from various samples.
Allylamine derivative.Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.
Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.
Halofuginone Hydrochloride is the hydrochloride salt preparation of Halofuginone, a halogenated analog of the antimalarial alkaloid febrifugine. The bromide and chloride substitutions of Halofuginone Hydrochloride replace the metabolically vulnerable aromatic protons of febrifugine. Halofuginone Hydrochloride is described to produce antiprotozoal, antiangiogenic, and antiproliferative effects. Halofuginone Hydrochloride is also reported to inhibit the biosynthesis of type 1 collagen. Halofuginone Hydrochloride blocks fibrosis and tumor progression in a variety of different models.
相关属性
CAS编号
1217623-74-9
折光率
n20D1.71 (Predicted)
熔点
237-242° C (dec.)
pKa值
pKa: 8.73
溶解性
Soluble in DMSO, and methanol.
储存温度
-20°C储存
RTECS
VA2397066
分子量
451.14
分子式
C16H18BrCl2N3O3
品牌
Jinpan
备注
Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month. Packaged under inert gas, protect from light.
Desipramine hydrochloride is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively.
IC50 & Target
Ki: 4 nM (NET), 61 nM (SERT), 78720 nM (DAT)[1]
体内研究 (In Vivo)
Treatment of rats with Desipramine hydrochloride for 14 days reduces norepinephrine transporter (NET) expression in a dose-dependent manner, as indicated by a reduction of the specific binding of 3H-nisoxetine to the NET in preparations of cerebral cortex (F(3,16)=4.33, p<0.05) and hippocampus (F(3,16)=4.34, p<0.05). This NET down regulation is observed 2 days after discontinuation of chronic Desipramine hydrochloride treatment, a time when plasma and brain concentrations of Desipramine hydrochloride and desmethyldesipramine are undetectable (ie below the 25 ng detection limit of the assay)[2].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量
302.84
Formula
C18H23ClN2
CAS 号
58-28-6
中文名称
盐酸去甲咪嗪；盐酸地昔帕明
运输条件
Room temperature in continental US; may vary elsewhere.
[1]. Torres GE, et al. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003 Jan;4(1):13-25.
[2]. Zhao Z, et al. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology. 2008 Dec;33(13):3190-200.
Animal Administration [2]
Rats are anesthetized with ketamine (100 mg/kg) and xylazine (10 mg/kg) and implanted subcutaneously with osmotic minipumps preloaded with either vehicle (50% saline, 40% DMSO, and 10% ethanol) or Desipramine hydrochloride at a concentration that delivered 5, 10, or 15 mg/kg per day of the free base. Minipumps are removed, under anesthesia, 14 days later. Rats are tested for antidepressant-like behavior in the forced-swim test 2 to 8 days after pump removal and discontinuation of Desipramine hydrochloride treatment. Following the completion of the behavioral tests, rats are killed by decapitation, their brains are removed, and cerebral cortex and hippocampus are dissected for neurochemical analyses[2].
上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献
[1]. Torres GE, et al. Plasma membrane monoamine transporters: structure, regulation and function. Nat Rev Neurosci. 2003 Jan;4(1):13-25.
[2]. Zhao Z, et al. Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. Neuropsychopharmacology. 2008 Dec;33(13):3190-200.
Cefotiam Dihydrochloride is a cephalosporin antibiotic that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
Cefotiam Dihydrochloride is a cephalosporin antibiotic that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms.
