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Mycestericin C

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Mycestericin C 

Mycestericin C 是从Mycelia sterilia ATCC 20349 的培养液中分离得到的化合物。Mycestericin C 在小鼠同种异体混合淋巴细胞反应中抑制淋巴细胞的增殖。

Mycestericin C

Mycestericin C Chemical Structure

CAS No. : 37817-99-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Mycestericin C is a compound isolated from the culture broth of Mycelia sterilia ATCC 20349. Mycestericin C suppresses the proliferation of lymphocytes in the mouse allogeneic mixed lymphocyte reaction[1].

分子量

403.55

Formula

C21H41NO6
CAS 号

37817-99-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Sasaki S, et al. Fungal metabolites. Part 14. Novel potent immunosuppressants, mycestericins, produced by Mycelia sterilia. J Antibiot (Tokyo). 1994;47(4):420-433.

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GRP78-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

GRP78-IN-1 

GRP78-IN-1 与 GRP78 残基具有多种相互作用，结合能为 -8.07 kcal/mol。GRP78-IN-1 在癌细胞中显示出有效的细胞毒性、抗增殖作用。GRP78-IN-1 在乳腺癌细胞中表现出有前景的凋亡和伤口愈合特性。

GRP78-IN-1

GRP78-IN-1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

GRP78-IN-1 exhibits several interactions with GRP78 residues with binding energy of -8.07 kcal/mol. GRP78-IN-1 shows the potent cytotoxic, anti-proliferative in cancer cells. GRP78-IN-1 exhibits promising apoptosis in breast cancer cells and wound healing properties[1].

IC50 & Target

Grp78

 

体外研究
(In Vitro)

GRP78-IN-1 (compound 3i) (0.01, 0.1, 1, 10, 100 µM; 48 h) shows the most potent cytotoxic effect (IC50s of 2.06, 12.57, 9, 18, 4.9, 2.19, 62.48 µM in MCF-1, PANC-1, HCT-116, PC-3, A549, MDA-MB-231 and FR-2 cells, respectively)[1].
GRP78-IN-1 (1, 2, 4, 6 µM) shows a steady increase in the expression of pro-apoptotic proteins viz. Par-4, apoptotic cascade in BAX and cleaved caspase 9 cells[1].
GRP78-IN-1 (1, 2, 4, 6 µM; 48 h) inhibits the motility of MCF-7 and A549 cells in a dose-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MCF-1, MDA-MB-231, PANC-1, HCT-116, PC-3, A549, FR-2cells
Concentration: 0.01, 0.1, 1, 10, 100 µM
Incubation Time: 48 h
Result: Showed the most promising cytotoxic effect (IC50s is 2.06, 12.57, 9, 18, 4.9, 2.19, 62.48 µM in MCF-1, PANC-1, HCT-116, PC-3, A549, MDA-MB-231 and FR-2 cells, respectively).

Western Blot Analysis[1]

Cell Line: BCL-2, BAX, cleaved caspase 9, MCF-7, A549 cells
Concentration: 1, 2, 4, 6 µM
Incubation Time:
Result: Showed a steady increase in the expression of pro-apoptotic proteins viz. Par-4, apoptotic cascade in BAX and cleaved caspase 9 cells.

分子量

342.40

Formula

C21H23FO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Rasool JU, et al. Palladium catalyzed migratory heck coupling of arteannuin B and boronic acids: An approach towards the synthesis of antiproliferative agents in breast and lung cancer cells. Bioorg Chem. 2022, 122:105694.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

GRP78-IN-1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

GRP78-IN-1 

GRP78-IN-1 与 GRP78 残基具有多种相互作用，结合能为 -8.07 kcal/mol。GRP78-IN-1 在癌细胞中显示出有效的细胞毒性、抗增殖作用。GRP78-IN-1 在乳腺癌细胞中表现出有前景的凋亡和伤口愈合特性。

GRP78-IN-1

GRP78-IN-1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

GRP78-IN-1 exhibits several interactions with GRP78 residues with binding energy of -8.07 kcal/mol. GRP78-IN-1 shows the potent cytotoxic, anti-proliferative in cancer cells. GRP78-IN-1 exhibits promising apoptosis in breast cancer cells and wound healing properties[1].

IC50 & Target

Grp78

 

体外研究
(In Vitro)

GRP78-IN-1 (compound 3i) (0.01, 0.1, 1, 10, 100 µM; 48 h) shows the most potent cytotoxic effect (IC50s of 2.06, 12.57, 9, 18, 4.9, 2.19, 62.48 µM in MCF-1, PANC-1, HCT-116, PC-3, A549, MDA-MB-231 and FR-2 cells, respectively)[1].
GRP78-IN-1 (1, 2, 4, 6 µM) shows a steady increase in the expression of pro-apoptotic proteins viz. Par-4, apoptotic cascade in BAX and cleaved caspase 9 cells[1].
GRP78-IN-1 (1, 2, 4, 6 µM; 48 h) inhibits the motility of MCF-7 and A549 cells in a dose-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MCF-1, MDA-MB-231, PANC-1, HCT-116, PC-3, A549, FR-2cells
Concentration: 0.01, 0.1, 1, 10, 100 µM
Incubation Time: 48 h
Result: Showed the most promising cytotoxic effect (IC50s is 2.06, 12.57, 9, 18, 4.9, 2.19, 62.48 µM in MCF-1, PANC-1, HCT-116, PC-3, A549, MDA-MB-231 and FR-2 cells, respectively).

Western Blot Analysis[1]

Cell Line: BCL-2, BAX, cleaved caspase 9, MCF-7, A549 cells
Concentration: 1, 2, 4, 6 µM
Incubation Time:
Result: Showed a steady increase in the expression of pro-apoptotic proteins viz. Par-4, apoptotic cascade in BAX and cleaved caspase 9 cells.

分子量

342.40

Formula

C21H23FO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Rasool JU, et al. Palladium catalyzed migratory heck coupling of arteannuin B and boronic acids: An approach towards the synthesis of antiproliferative agents in breast and lung cancer cells. Bioorg Chem. 2022, 122:105694.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

GRP78-IN-1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

GRP78-IN-1 

GRP78-IN-1 与 GRP78 残基具有多种相互作用，结合能为 -8.07 kcal/mol。GRP78-IN-1 在癌细胞中显示出有效的细胞毒性、抗增殖作用。GRP78-IN-1 在乳腺癌细胞中表现出有前景的凋亡和伤口愈合特性。

GRP78-IN-1

GRP78-IN-1 Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

GRP78-IN-1 exhibits several interactions with GRP78 residues with binding energy of -8.07 kcal/mol. GRP78-IN-1 shows the potent cytotoxic, anti-proliferative in cancer cells. GRP78-IN-1 exhibits promising apoptosis in breast cancer cells and wound healing properties[1].

IC50 & Target

Grp78

 

体外研究
(In Vitro)

GRP78-IN-1 (compound 3i) (0.01, 0.1, 1, 10, 100 µM; 48 h) shows the most potent cytotoxic effect (IC50s of 2.06, 12.57, 9, 18, 4.9, 2.19, 62.48 µM in MCF-1, PANC-1, HCT-116, PC-3, A549, MDA-MB-231 and FR-2 cells, respectively)[1].
GRP78-IN-1 (1, 2, 4, 6 µM) shows a steady increase in the expression of pro-apoptotic proteins viz. Par-4, apoptotic cascade in BAX and cleaved caspase 9 cells[1].
GRP78-IN-1 (1, 2, 4, 6 µM; 48 h) inhibits the motility of MCF-7 and A549 cells in a dose-dependent manner[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: MCF-1, MDA-MB-231, PANC-1, HCT-116, PC-3, A549, FR-2cells
Concentration: 0.01, 0.1, 1, 10, 100 µM
Incubation Time: 48 h
Result: Showed the most promising cytotoxic effect (IC50s is 2.06, 12.57, 9, 18, 4.9, 2.19, 62.48 µM in MCF-1, PANC-1, HCT-116, PC-3, A549, MDA-MB-231 and FR-2 cells, respectively).

Western Blot Analysis[1]

Cell Line: BCL-2, BAX, cleaved caspase 9, MCF-7, A549 cells
Concentration: 1, 2, 4, 6 µM
Incubation Time:
Result: Showed a steady increase in the expression of pro-apoptotic proteins viz. Par-4, apoptotic cascade in BAX and cleaved caspase 9 cells.

分子量

342.40

Formula

C21H23FO3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Rasool JU, et al. Palladium catalyzed migratory heck coupling of arteannuin B and boronic acids: An approach towards the synthesis of antiproliferative agents in breast and lung cancer cells. Bioorg Chem. 2022, 122:105694.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

YMU1

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

YMU1 

YMU1 是人胸苷酸激酶 (hTMPK) 的选择性抑制剂，其 IC50 为 610 nM。

YMU1

YMU1 Chemical Structure

CAS No. : 902589-96-2

规格 是否有货
5 mg 询价
10 mg 询价
50 mg 询价
100 mg 询价

* Please select Quantity before adding items.

生物活性

YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM[1].

分子量

378.45

Formula

C17H22N4O4S
CAS 号

902589-96-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hu CM, et al. Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair. Cancer Cell. 2012 Jul 10;22(1):36-50.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

YMU1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

YMU1 

YMU1 是人胸苷酸激酶 (hTMPK) 的选择性抑制剂，其 IC50 为 610 nM。

YMU1

YMU1 Chemical Structure

CAS No. : 902589-96-2

规格 是否有货
5 mg 询价
10 mg 询价
50 mg 询价
100 mg 询价

* Please select Quantity before adding items.

生物活性

YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM[1].

分子量

378.45

Formula

C17H22N4O4S
CAS 号

902589-96-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hu CM, et al. Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair. Cancer Cell. 2012 Jul 10;22(1):36-50.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pixinol

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pixinol 

Pixinol 是一种天然糖苷，对人肺癌 GLC4 和腺癌 COLO 320 细胞株具有细胞毒性 (IC50 分别为 71 µM，43 µM)。

Pixinol

Pixinol Chemical Structure

CAS No. : 162062-88-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pixinol, a natural glycoside, shows cytotoxicity against the human lung carcinoma GLC4 and adenocarcinoma COLO 320 cell lines (IC50=71 µM and 43 µM, respectively)[1].

分子量

476.73

Formula

C30H52O4
CAS 号

162062-88-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Atopkina LN, et al. Cytotoxicity of natural ginseng glycosides and semisynthetic analogues. Planta Med. 1999;65(1):30-34.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

YMU1

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

YMU1 

YMU1 是人胸苷酸激酶 (hTMPK) 的选择性抑制剂，其 IC50 为 610 nM。

YMU1

YMU1 Chemical Structure

CAS No. : 902589-96-2

规格 是否有货
5 mg 询价
10 mg 询价
50 mg 询价
100 mg 询价

* Please select Quantity before adding items.

生物活性

YMU1 is a selective inhibitor of human thymidylate kinase (hTMPK) with an IC50 of 610 nM[1].

分子量

378.45

Formula

C17H22N4O4S
CAS 号

902589-96-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hu CM, et al. Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair. Cancer Cell. 2012 Jul 10;22(1):36-50.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Capsanthin

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Capsanthin 

Capsanthin 是在青蒿中发现的一种类胡萝卜素，具有抗氧化、抗肿瘤和抗炎作用。

Capsanthin

Capsanthin Chemical Structure

CAS No. : 465-42-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Capsanthin is a carotenoid that has been found in C. annuum. Capsanthin has antioxidant[1]、antitumor[2] and anti-inflammatory[3] effects.

分子量

584.87

Formula

C40H56O3
CAS 号

465-42-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kim JS, et al. Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communication. Chem Biol Interact. 2016 Jul 25;254:146-55.

    [2]. Narisawa T, et al. Prevention of N-methylnitrosourea-induced colon carcinogenesis in rats by oxygenated carotenoid capsanthin and capsanthin-rich paprika juice. Proc Soc Exp Biol Med. 2000 Jun;224(2):116-22.

    [3]. Horie S, et al. Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response. Lipids. 2010 Aug;45(8):713-21.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pixinol

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pixinol 

Pixinol 是一种天然糖苷，对人肺癌 GLC4 和腺癌 COLO 320 细胞株具有细胞毒性 (IC50 分别为 71 µM，43 µM)。

Pixinol

Pixinol Chemical Structure

CAS No. : 162062-88-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pixinol, a natural glycoside, shows cytotoxicity against the human lung carcinoma GLC4 and adenocarcinoma COLO 320 cell lines (IC50=71 µM and 43 µM, respectively)[1].

分子量

476.73

Formula

C30H52O4
CAS 号

162062-88-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Atopkina LN, et al. Cytotoxicity of natural ginseng glycosides and semisynthetic analogues. Planta Med. 1999;65(1):30-34.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Capsanthin

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Capsanthin 

Capsanthin 是在青蒿中发现的一种类胡萝卜素，具有抗氧化、抗肿瘤和抗炎作用。

Capsanthin

Capsanthin Chemical Structure

CAS No. : 465-42-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Capsanthin is a carotenoid that has been found in C. annuum. Capsanthin has antioxidant[1]、antitumor[2] and anti-inflammatory[3] effects.

分子量

584.87

Formula

C40H56O3
CAS 号

465-42-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kim JS, et al. Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communication. Chem Biol Interact. 2016 Jul 25;254:146-55.

    [2]. Narisawa T, et al. Prevention of N-methylnitrosourea-induced colon carcinogenesis in rats by oxygenated carotenoid capsanthin and capsanthin-rich paprika juice. Proc Soc Exp Biol Med. 2000 Jun;224(2):116-22.

    [3]. Horie S, et al. Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response. Lipids. 2010 Aug;45(8):713-21.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pixinol

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pixinol 

Pixinol 是一种天然糖苷，对人肺癌 GLC4 和腺癌 COLO 320 细胞株具有细胞毒性 (IC50 分别为 71 µM，43 µM)。

Pixinol

Pixinol Chemical Structure

CAS No. : 162062-88-6

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pixinol, a natural glycoside, shows cytotoxicity against the human lung carcinoma GLC4 and adenocarcinoma COLO 320 cell lines (IC50=71 µM and 43 µM, respectively)[1].

分子量

476.73

Formula

C30H52O4
CAS 号

162062-88-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Atopkina LN, et al. Cytotoxicity of natural ginseng glycosides and semisynthetic analogues. Planta Med. 1999;65(1):30-34.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Capsanthin

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Capsanthin 

Capsanthin 是在青蒿中发现的一种类胡萝卜素，具有抗氧化、抗肿瘤和抗炎作用。

Capsanthin

Capsanthin Chemical Structure

CAS No. : 465-42-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Capsanthin is a carotenoid that has been found in C. annuum. Capsanthin has antioxidant[1]、antitumor[2] and anti-inflammatory[3] effects.

分子量

584.87

Formula

C40H56O3
CAS 号

465-42-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kim JS, et al. Red paprika (Capsicum annuum L.) and its main carotenoids, capsanthin and β-carotene, prevent hydrogen peroxide-induced inhibition of gap-junction intercellular communication. Chem Biol Interact. 2016 Jul 25;254:146-55.

    [2]. Narisawa T, et al. Prevention of N-methylnitrosourea-induced colon carcinogenesis in rats by oxygenated carotenoid capsanthin and capsanthin-rich paprika juice. Proc Soc Exp Biol Med. 2000 Jun;224(2):116-22.

    [3]. Horie S, et al. Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response. Lipids. 2010 Aug;45(8):713-21.

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dAURK-4

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

dAURK-4 

dAURK-4 是 Alisertib 的一种衍生物，是一种有效的选择性 AURKA (Aurora A) 降解剂。dAURK-4 具有抗癌作用。

dAURK-4

dAURK-4 Chemical Structure

CAS No. : 2705844-81-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

dAURK-4, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 has anticancer effects[1].

IC50 & Target[1]

Aurora A

 

体外研究
(In Vitro)

dAURK-4 (125-1000 nM; 4-24 hours) shows degradation of AURKA in a dose-depended manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MM.1S cells
Concentration: 125 nM, 250 nM, 500 nM, 1000 nM
Incubation Time: 4 hours or 24 hours
Result: Inhibited the protein level of AURKA (Aurora A).

分子量

1035.47

Formula

C52H52ClFN8O12
CAS 号

2705844-81-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

dAURK-4

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

dAURK-4 

dAURK-4 是 Alisertib 的一种衍生物，是一种有效的选择性 AURKA (Aurora A) 降解剂。dAURK-4 具有抗癌作用。

dAURK-4

dAURK-4 Chemical Structure

CAS No. : 2705844-81-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

dAURK-4, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 has anticancer effects[1].

IC50 & Target[1]

Aurora A

 

体外研究
(In Vitro)

dAURK-4 (125-1000 nM; 4-24 hours) shows degradation of AURKA in a dose-depended manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MM.1S cells
Concentration: 125 nM, 250 nM, 500 nM, 1000 nM
Incubation Time: 4 hours or 24 hours
Result: Inhibited the protein level of AURKA (Aurora A).

分子量

1035.47

Formula

C52H52ClFN8O12
CAS 号

2705844-81-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

dAURK-4

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

dAURK-4 

dAURK-4 是 Alisertib 的一种衍生物，是一种有效的选择性 AURKA (Aurora A) 降解剂。dAURK-4 具有抗癌作用。

dAURK-4

dAURK-4 Chemical Structure

CAS No. : 2705844-81-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

dAURK-4, an Alisertib derivative, is a potent and selective AURKA (Aurora A) degrader. dAURK-4 has anticancer effects[1].

IC50 & Target[1]

Aurora A

 

体外研究
(In Vitro)

dAURK-4 (125-1000 nM; 4-24 hours) shows degradation of AURKA in a dose-depended manner[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MM.1S cells
Concentration: 125 nM, 250 nM, 500 nM, 1000 nM
Incubation Time: 4 hours or 24 hours
Result: Inhibited the protein level of AURKA (Aurora A).

分子量

1035.47

Formula

C52H52ClFN8O12
CAS 号

2705844-81-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

2-NP

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回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-NP 

2-NP 是一种选择性的 STAT1 转录增强剂。2-NP 可以增强 IFN-γ 抑制人乳腺癌和纤维肉瘤细胞增殖的能力。

2-NP

2-NP Chemical Structure

CAS No. : 65182-56-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells[1].

分子量

222.25

Formula

C14H10N2O
CAS 号

65182-56-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lynch RA, et, al. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 1;67(3):1254-61.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

BGTC

发表于由
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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BGTC 

BGTC 是一种非氨基酸阳离子脂质。BGTC 可用于核酸递送。

BGTC

BGTC Chemical Structure

CAS No. : 182056-06-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

BGTC is a non-amino acid cationic lipid. BGTC can be used for delivery of nucleic acids[1].

分子量

642.96

Formula

C36H66N8O2
CAS 号

182056-06-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hajri A, et, al. Combined suicide gene therapy for pancreatic peritoneal carcinomatosis using BGTC liposomes. Cancer Gene Ther. 2004 Jan;11(1):16-27.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

2-NP

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

2-NP 

2-NP 是一种选择性的 STAT1 转录增强剂。2-NP 可以增强 IFN-γ 抑制人乳腺癌和纤维肉瘤细胞增殖的能力。

2-NP

2-NP Chemical Structure

CAS No. : 65182-56-1

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

2-NP is a selective enhancer of STAT1 transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells[1].

分子量

222.25

Formula

C14H10N2O
CAS 号

65182-56-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lynch RA, et, al. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 1;67(3):1254-61.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

BGTC

发表于由
回复

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

BGTC 

BGTC 是一种非氨基酸阳离子脂质。BGTC 可用于核酸递送。

BGTC

BGTC Chemical Structure

CAS No. : 182056-06-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

BGTC is a non-amino acid cationic lipid. BGTC can be used for delivery of nucleic acids[1].

分子量

642.96

Formula

C36H66N8O2
CAS 号

182056-06-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hajri A, et, al. Combined suicide gene therapy for pancreatic peritoneal carcinomatosis using BGTC liposomes. Cancer Gene Ther. 2004 Jan;11(1):16-27.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务