标签归档：印楝素

Azadirachtin B(Synonyms: 印楝素 B)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Azadirachtin B (Synonyms: 印楝素 B)

Azadirachtin B 是从 Azadirachta indica 种子仁中分离的柠檬苦素。Azadirachtin B 增加碱性磷酸酶 (ALP) 活性并刺激成骨细胞分化。Azadirachtin B 对爱泼斯坦-巴尔病毒早期抗原 (EBV-EA) 具有活性。Azadirachtin B 具有杀虫，杀线虫，抗癌，抗炎，抗病毒和成骨特性。

Azadirachtin B(Synonyms: 印楝素 B)

Azadirachtin B Chemical Structure

CAS No. : 106500-25-8

规格 价格 是否有货
1 mg ￥1500 询问价格 & 货期
5 mg ￥6600 询问价格 & 货期
10 mg ￥11000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties[1][2][3].

IC50 & Target

Plutella xylostella[1]
Alkaline phosphatase (ALP)[2]
Epstein-Barr virus early antigen (EBV-EA)[3]
体外研究
(In Vitro)

Azadirachtin B (1 pM-100 µM; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells[1].
Azadirachtin B increases expression of RunX-2 ∼2.5 fold at 10 nM concentration, ALP expression ∼2.8 fold at 10 nM and 100 pM concentration and OCN expression ∼2.5 folds at 10 nM as compared with control[1].
Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 4.85-1.06 µg/g body weight, in 92 h[2].
Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA)[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Osteoblast cells
Concentration: 1 pM, 100 pM, 10 nM, 1 µM, 100 µM
Incubation Time: 48 hours
Result: Showed highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells.

体内研究
(In Vivo)

On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

662.68

Formula

C33H42O14
CAS 号

106500-25-8
中文名称

印楝素 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kushwaha P, et al. Azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3719-24.

    [2]. Kanokmedhakul S, et al. Azadirachtin derivatives from seed kernels of Azadirachta excelsa. J Nat Prod. 2005 Jul;68(7):1047-50.

    [3]. Akihisa T, et al. Melanogenesis inhibitory, anti-inflammatory, and chemopreventive effects of limonoids from the seeds of Azadirachta indicia A. Juss. (neem). J Oleo Sci. 2009;58(11):581-94.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Azadirachtin B(Synonyms: 印楝素 B)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Azadirachtin B (Synonyms: 印楝素 B)

Azadirachtin B 是从 Azadirachta indica 种子仁中分离的柠檬苦素。Azadirachtin B 增加碱性磷酸酶 (ALP) 活性并刺激成骨细胞分化。Azadirachtin B 对爱泼斯坦-巴尔病毒早期抗原 (EBV-EA) 具有活性。Azadirachtin B 具有杀虫，杀线虫，抗癌，抗炎，抗病毒和成骨特性。

Azadirachtin B(Synonyms: 印楝素 B)

Azadirachtin B Chemical Structure

CAS No. : 106500-25-8

规格 价格 是否有货
1 mg ￥1500 询问价格 & 货期
5 mg ￥6600 询问价格 & 货期
10 mg ￥11000 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Azadirachtin B is an limonoid isolated from seed kernels of Azadirachta indica. Azadirachtin B increases alkaline phosphatase (ALP) activity and stimulates osteoblast differentiation. Azadirachtin B is active against the Epstein-Barr virus early antigen (EBV-EA). Azadirachtin B has insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral and osteogenic properties[1][2][3].

IC50 & Target

Plutella xylostella[1]
Alkaline phosphatase (ALP)[2]
Epstein-Barr virus early antigen (EBV-EA)[3]
体外研究
(In Vitro)

Azadirachtin B (1 pM-100 µM; 48 hours; Osteoblast cells) treatment shows highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells[1].
Azadirachtin B increases expression of RunX-2 ∼2.5 fold at 10 nM concentration, ALP expression ∼2.8 fold at 10 nM and 100 pM concentration and OCN expression ∼2.5 folds at 10 nM as compared with control[1].
Azadirachtin B (Compound 4) exhibits toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 4.85-1.06 µg/g body weight, in 92 h[2].
Azadirachtin B (compound 21) exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA)[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: Osteoblast cells
Concentration: 1 pM, 100 pM, 10 nM, 1 µM, 100 µM
Incubation Time: 48 hours
Result: Showed highest proliferation at 10 nM and 100 pM concentrations in osteoblast cells.

体内研究
(In Vivo)

On evaluation of Azadirachtin B (compound 21; oral administration) for its anti-tumor-initiating activity on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) as an initiator and TPA as a promoter, this exhibited marked inhibitory activity[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

662.68

Formula

C33H42O14
CAS 号

106500-25-8
中文名称

印楝素 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kushwaha P, et al. Azadirachta indica triterpenoids promote osteoblast differentiation and mineralization in vitro and in vivo. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3719-24.

    [2]. Kanokmedhakul S, et al. Azadirachtin derivatives from seed kernels of Azadirachta excelsa. J Nat Prod. 2005 Jul;68(7):1047-50.

    [3]. Akihisa T, et al. Melanogenesis inhibitory, anti-inflammatory, and chemopreventive effects of limonoids from the seeds of Azadirachta indicia A. Juss. (neem). J Oleo Sci. 2009;58(11):581-94.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

印楝素对照品

发表于由
印楝素对照品

  【编号】：SPR02317

  【产品名称】：印楝素对照品

  【规格】：10mg

  【用途】：

　　印楝素对照品

　　编号：SPR02317
　　英文名称：Nimbin
　　CAS No.：5945-86-8
　　分 子 式：C30H36O9
　　分 子 量：540.609
　　类别：上海金畔生物科技有限公司，天然提取物
　　作为标准品，对照品或者供研究用，不能直接用于人体。

脱乙酰基印楝素对照品

发表于由
脱乙酰基印楝素对照品

  【编号】：SPR02362

  【产品名称】：脱乙酰基印楝素对照品

  【规格】：10mg

  【用途】：

　　脱乙酰基印楝素对照品

　　编号：SPR02362
　　英文名称：Deacetylnimbin
　　CAS No.：18609-16-0
　　分 子 式：C28H34O8
　　分 子 量：498.572
　　类别：上海金畔生物科技有限公司，天然提取物
　　作为标准品，对照品或者供研究用，不能直接用于人体。