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Enterolactone-d6

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Enterolactone-d6 

Enterolactone-d6 是 Enterolactone 的氘代物。Enterolactone 是一种生物活性酚类代谢物，被称为哺乳动物木酚素，来源于膳食木酚素。Enterolactone 具有雌激素特性和抗乳腺癌活性。Enterolactone 是人乳腺癌细胞系的放射增敏剂，通过受损的 DNA修复和增加的细胞凋亡 (apoptosis)。

Enterolactone-d6

Enterolactone-d6 Chemical Structure

CAS No. : 104411-11-2

规格 是否有货
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生物活性

Enterolactone-d6 is the deuterium labeled Enterolactone. Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

304.37

Formula

C18H12D6O4
CAS 号

104411-11-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Bigdeli B, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicol Appl Pharmacol. 2016;313:180-194.

    [3]. Mali AV, et al. Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial-mesenchymal transition. Cancer Biol Med. 2018;15(2):137-156.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Enterolactone

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Enterolactone 

Enterolactone 是一种生物活性酚类代谢物，被称为哺乳动物木酚素，来源于膳食木酚素。Enterolactone 具有雌激素特性和抗乳腺癌活性。Enterolactone 是人乳腺癌细胞系的放射增敏剂，通过受损的 DNA修复和增加的细胞凋亡 (apoptosis)。

Enterolactone

Enterolactone Chemical Structure

CAS No. : 78473-71-9

规格 价格 是否有货
500 μg ￥3500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

体外研究
(In Vitro)

Enterolactone (25-75 μM; 48 hours) arrests the growth of MDA-MB-231 breast cancer cells in the ‘S’ phase[1]
Enterolactone (25-75 μM; 15 hours) triggers apoptosis in MDA-MB-231 breast cancer cells via caspase-3 activation[1].
Enterolactone inhibits TGF-β-induced migration of MDA-MB-231 breast cancer cells. Enterolactone inhibits TGF-β-induced invasion of MDA-MB-231 breast cancer cells through ECM. Enterolactone inhibits the TGF-β-induced EMT program in MDA-MB-231 breast cancer cells. Enterolactone reduces the formation of actin stress fibers by inhibiting the expression of CD44 and MAPK-p38. Enterolactone inhibits the ERK/NF-κB/Snail signaling pathway to revert TGF-β-induced EMT in MDA-MB-231 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 25, 50, 75 μM
Incubation Time: 48 hours
Result: There was a non-significant increase (~24%) in the S phase population following treatment with 25 μM EL, whereas there were significant increases (~34% and ~39%) following treatment with 50 and 75 μM EL, respectively.

分子量

298.33

Formula

C18H18O4
CAS 号

78473-71-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Bigdeli B, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicol Appl Pharmacol. 2016;313:180-194.

    [2]. Mali AV, et al. Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial-mesenchymal transition. Cancer Biol Med. 2018;15(2):137-156.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Enterolactone

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Enterolactone 

Enterolactone 是一种生物活性酚类代谢物，被称为哺乳动物木酚素，来源于膳食木酚素。Enterolactone 具有雌激素特性和抗乳腺癌活性。Enterolactone 是人乳腺癌细胞系的放射增敏剂，通过受损的 DNA修复和增加的细胞凋亡 (apoptosis)。

Enterolactone

Enterolactone Chemical Structure

CAS No. : 78473-71-9

规格 价格 是否有货
500 μg ￥3500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

体外研究
(In Vitro)

Enterolactone (25-75 μM; 48 hours) arrests the growth of MDA-MB-231 breast cancer cells in the ‘S’ phase[1]
Enterolactone (25-75 μM; 15 hours) triggers apoptosis in MDA-MB-231 breast cancer cells via caspase-3 activation[1].
Enterolactone inhibits TGF-β-induced migration of MDA-MB-231 breast cancer cells. Enterolactone inhibits TGF-β-induced invasion of MDA-MB-231 breast cancer cells through ECM. Enterolactone inhibits the TGF-β-induced EMT program in MDA-MB-231 breast cancer cells. Enterolactone reduces the formation of actin stress fibers by inhibiting the expression of CD44 and MAPK-p38. Enterolactone inhibits the ERK/NF-κB/Snail signaling pathway to revert TGF-β-induced EMT in MDA-MB-231 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 25, 50, 75 μM
Incubation Time: 48 hours
Result: There was a non-significant increase (~24%) in the S phase population following treatment with 25 μM EL, whereas there were significant increases (~34% and ~39%) following treatment with 50 and 75 μM EL, respectively.

分子量

298.33

Formula

C18H18O4
CAS 号

78473-71-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Bigdeli B, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicol Appl Pharmacol. 2016;313:180-194.

    [2]. Mali AV, et al. Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial-mesenchymal transition. Cancer Biol Med. 2018;15(2):137-156.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Enterolactone

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Enterolactone 

Enterolactone 是一种生物活性酚类代谢物，被称为哺乳动物木酚素，来源于膳食木酚素。Enterolactone 具有雌激素特性和抗乳腺癌活性。Enterolactone 是人乳腺癌细胞系的放射增敏剂，通过受损的 DNA修复和增加的细胞凋亡 (apoptosis)。

Enterolactone

Enterolactone Chemical Structure

CAS No. : 78473-71-9

规格 价格 是否有货
500 μg ￥3500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Enterolactone is a bioactive phenolic metabolite known as a mammalian lignan derived from dietary lignans. Enterolactone has estrogenic properties and anti-breast cancer activity[1]. Enterolactone is a radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis[2].

体外研究
(In Vitro)

Enterolactone (25-75 μM; 48 hours) arrests the growth of MDA-MB-231 breast cancer cells in the ‘S’ phase[1]
Enterolactone (25-75 μM; 15 hours) triggers apoptosis in MDA-MB-231 breast cancer cells via caspase-3 activation[1].
Enterolactone inhibits TGF-β-induced migration of MDA-MB-231 breast cancer cells. Enterolactone inhibits TGF-β-induced invasion of MDA-MB-231 breast cancer cells through ECM. Enterolactone inhibits the TGF-β-induced EMT program in MDA-MB-231 breast cancer cells. Enterolactone reduces the formation of actin stress fibers by inhibiting the expression of CD44 and MAPK-p38. Enterolactone inhibits the ERK/NF-κB/Snail signaling pathway to revert TGF-β-induced EMT in MDA-MB-231 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MDA-MB-231 cells
Concentration: 25, 50, 75 μM
Incubation Time: 48 hours
Result: There was a non-significant increase (~24%) in the S phase population following treatment with 25 μM EL, whereas there were significant increases (~34% and ~39%) following treatment with 50 and 75 μM EL, respectively.

分子量

298.33

Formula

C18H18O4
CAS 号

78473-71-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Bigdeli B, et al. Enterolactone: A novel radiosensitizer for human breast cancer cell lines through impaired DNA repair and increased apoptosis. Toxicol Appl Pharmacol. 2016;313:180-194.

    [2]. Mali AV, et al. Enterolactone modulates the ERK/NF-κB/Snail signaling pathway in triple-negative breast cancer cell line MDA-MB-231 to revert the TGF-β-induced epithelial-mesenchymal transition. Cancer Biol Med. 2018;15(2):137-156.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

仙茅木酚素对照品

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仙茅木酚素对照品

  【编号】：SPR02811

  【产品名称】：仙茅木酚素对照品

  【规格】：10mg

  【用途】：

　　仙茅木酚素对照品

　　编号：SPR02811
　　英文名称：Curlignan
　　CAS No.：220736-54-9
　　分 子 式：C19H20O7
　　分 子 量：360.362
　　类别：上海金畔生物科技有限公司，天然提取物
　　作为标准品，对照品或者供研究用，不能直接用于人体。

对乙烯基愈疮木酚对照品_7786-61-0

发表于由
对乙烯基愈疮木酚对照品

  【编号】：VIP(DS)1845

  【产品名称】：对乙烯基愈疮木酚对照品

  【规格】：20mg；HPLC≥96%

  【用途】：

　　对乙烯基愈疮木酚对照品

　　编号：VIP(DS)1845
　　别名：2-甲氧基-4-乙烯基苯酚
　　英文名: 2-Methoxy-4-vinylphenol
　　CAS号:7786-61-0
　　分子式:CH3OC6H3(CH=CH2)OH
　　分子量:  150.17
　　规格：20mg/支
　　纯度：HPLC≥98%
　　鉴别方法： NMR，MS
　　贮存条件： 2-8℃冷藏、密封、避光
　　规格：可定做：10mg；25mg；50mg；100mg
　　声明：此对照品、标准品由上海金畔生物科技有限公司提供查询购买服务
　　注：点击cas，或者搜索：名称、编号、cas均可查询产品信息