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Lupiwighteone (Synonyms: 黄羽扇豆魏特酮; 8-prenylgenistein) 纯度: 98.58%
Lupiwighteone 是一种广泛存在于野生植物中的异黄酮，具有抗氧化、抗菌和抗癌作用。Lupiwighteone 通过抑制 PI3K/Akt/mTOR 通路，诱导人乳腺癌细胞 caspase 依赖性和非依赖性凋亡 (apoptosis)。
Lupiwighteone Chemical Structure
CAS No. : 104691-86-3
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| 生物活性 |
Lupiwighteone is an isoflavone present widely in wild-growing plants, with antioxidant, antimicrobial and anticancer effects. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway[1][2]. |
IC50 & Target |
apoptosis[2] |
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| 体外研究 (In Vitro) |
Lupiwighteone (2-100 μM; 72 hours) shows cytotoxicity towards various cell lines, especially on DU-145 cells and SGC-7901 cells with IC50s of 23.7 μM and 21 μM, respectively[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[2]
Cell Cycle Analysis[2]
Apoptosis Analysis[2]
Western Blot Analysis[2]
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| 分子量 |
338.35 |
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| Formula |
C20H18O5 |
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| CAS 号 |
104691-86-3 |
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| 中文名称 |
黄羽扇豆魏特酮 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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| 参考文献 |
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