β-胡萝卜素对照品

β-胡萝卜素对照品

  【编号】:PR0318

  【产品名称】:β-胡萝卜素对照品

  【规格】:10mg

  【用途】:

  β-胡萝卜素对照品

  编号:PR0318
  英文名称:Beta-Carotene
  英文别名:Betacarotene, Carotaben; Phenoro; Solatene; β,β-Carotene; Provatene
  Cas 号: 7235-40-7
  分 子 式:C40H56
  分 子 量:536.888
  来源: Widespread in plant and animal kingdoms. In plants it is almost always associated with chlorophyll. Occurs in marine organisms, e.g. sponges, esp. of the Poecilosclerida and Axinellida.
  纯度: 95%~99%
  分析方法: HPLC-DAD or/and HPLC-ELSD
  鉴定方法: 质谱(Mass), 核磁(NMR)
  包装: 棕色小玻璃瓶,标准包装10mg,20mg,50mg;可以按客户需求包装。
  类别:上海金畔生物科技有限公司,中药对照品
  作为标准品,对照品或者供研究用,不能直接用于人体。

β-Carotene(Synonyms: β-胡萝卜素; Provitamin A; beta-Carotene)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

β-Carotene (Synonyms: β-胡萝卜素; Provitamin A; beta-Carotene) 纯度: ≥98.0%

β-Carotene (Provitamin A) 属于类胡萝卜素化合物,是天然存在的维生素 A 前体。β-Carotene 是一种 ROS 调节剂,具有抗氧化和抗炎活性。β-Carotene 可作为抗氧化剂或者促氧化剂,取决于它的内在特性以及它所作用的生物环境的氧化还原电位。 β-Carotene 可诱导乳腺癌细胞凋亡 (apoptosis),具有抗癌活性。

β-Carotene(Synonyms: β-胡萝卜素; Provitamin A;  beta-Carotene)

β-Carotene Chemical Structure

CAS No. : 7235-40-7

规格 价格 是否有货 数量
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50 mg ¥500 In-stock
100 mg ¥800 In-stock
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500 mg   询价  

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β-Carotene 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • Bioactive Compound Library Plus

生物活性

β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities[1][2][3][4][5].

IC50 & Target[3]

Human Endogenous Metabolite

 

ROS

 

apoptosis

 

体外研究
(In Vitro)

β-Carotene up-regulates PPAR-γ expression and ROS production in MCF-7 cancer cells[3].
β-Carotene (1-100 μM; 72 hours) remarkably decreases the survival of MCF-7 cells in a dose-dependent manner[3].
β-Carotene (50 μM; 24-72 hours) significantly enhances the expression levels of PPAR-γ mRNA and protein in a time-dependent manner[3].
β-Carotene down-regulates the COX-2 but up-regulates the p21 mRNA level and protein expression in a time dependent manner[3].
β-Carotene significantly increases the percentage of early apoptosis and the effect was partly attenuated by pre-incubation with GW9662 (HY-16578) or GSH (HY-D0187)[3].
β-Carotene induces cytochrome C release[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[5]

Cell Line: MCF-7 cells
Concentration: 1 μM, 10 μM, 20 μM, 50 μM, 100 μM
Incubation Time: 72 hours
Result: Decreased the numbers of viable cells to 70% and 50% at 20 μM and 50 μM, respectively.

RT-PCR[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Up-regulated the PPAR-γ mRNA.

Western Blot Analysis[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Up-regulated PPAR-γ protein expression levels.

Apoptosis Analysis[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 72 hours
Result: Induced MCF-7 cells apoptosis.

Clinical Trial

分子量

536.87

Formula

C40H56

CAS 号

7235-40-7

中文名称

β-胡萝卜素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
In Vitro: 

THF : 20 mg/mL (37.25 mM; Need ultrasonic)

Acetone : 5 mg/mL (9.31 mM; Need ultrasonic)

DMSO : 1 mg/mL (1.86 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8626 mL 9.3132 mL 18.6265 mL
5 mM 0.3725 mL 1.8626 mL 3.7253 mL
10 mM 0.1863 mL 0.9313 mL 1.8626 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Tanumihardjo, S.A., Factors influencing the conversion of carotenoids to retinol: bioavailability to bioconversion to bioefficacy. Int J Vitam Nutr Res, 2002. 72(1): p. 40-5.

    [2]. Leo, M.A., et al. Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity. Am J Clin Nutr, 1999. 69(6): p. 1071-85.

    [3]. Yanhong Cui, et al. beta-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor gamma expression and reactive oxygen species production in MCF-7 cancer cells. Eur J Cancer. 2007 Nov;43(17):2590-601.

    [4]. AKIFUMI KAWATA, et al. Anti-inflammatory Activity of β-Carotene, Lycopene and Tri-n-butylborane, a Scavenger of Reactive Oxygen Species. In Vivo. 2018 Mar-Apr; 32(2): 255-264.

    [5]. Paola Palozza, et al. Prooxidant effects of beta-carotene in cultured cells. Mol Aspects Med. 2003 Dec;24(6):353-62.

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