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绿脓菌素测定用培养基（PDP）

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绿脓菌素测定用培养基（PDP）

：
英文名称： Pseudomonas Agar P
产品货号： JP5187
产品规格： 250g
105元
保质期： 三年
产品用途： 用于绿脓杆菌的绿脓菌素测定试验
备  注：

产品介绍:

用途:用于绿脓杆菌的绿脓菌素测定试验。

成分(g/L)：

蛋白胨 20.0
氯化镁 1.4
硫酸钾 10.0
琼脂 18.0
pH值7.4 ± 0.1 25℃

检验原理
蛋白胨和甘油提供碳氮源；氯化镁和硫酸钾促进绿脓色素和荧光素的产生；琼脂是培养基的凝固剂。  

用法

称取本品 49.4g,另称取 10g甘油,溶解于1000ml蒸馏水中,分装,121℃高压灭菌 15 分钟,备用。

绿脓菌素测定用培养基（PDP）中细菌的生长情况：


绿脓菌素生成试验方法及原理：

方法：挑取可疑菌落接种在在绿脓菌素测定用培养基（PDP）斜面上，培养24小时，观察斜面有无色素。如有色素，在试管内加氯仿3.0～5.0mL，充分震摇，使培养物中的绿脓菌素提取在氯仿中，待氯仿提取液呈现绿色时，加1mol/L盐酸约1mL，震摇后静置片刻，上层盐酸溶液中呈现粉红至红色实验结果为阳性，否则为阴性。

原理：铜绿假单胞菌能产生的绿脓菌素能被氯仿提取，且在水中溶解度比氯仿大，并且会发生可逆的氧化还原反应，氧化时碱性呈蓝色，酸性呈红色。所以加入盐酸溶液并震摇后，绿脓菌素会由氯仿转移至盐酸溶液中，并在酸性环境中呈红色。

绿脓菌素测定（PDP）试验流程及现象：.aspasphtml/refere9491.htm

绿脓菌素测定（PDP）试验操作视频：.aspasphtml/video17.htm

绿脓菌素测定培养基(PDP）微生物灵敏度试验:

按标签用法制备培养基，接种以下质控菌株，放置36±1℃需氧培养24±2小时。

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Enniatin B(Synonyms: 恩镰孢菌素 B)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Enniatin B (Synonyms: 恩镰孢菌素 B)

Enniatin B 是一种镰刀菌毒素。在大鼠肝微粒体酶实验中，Enniatin B 抑制酰基辅酶 A：胆固醇酰基转移酶 (ACAT) 活性，IC50 为 113 μM。Enniatins B 可降低 ERK (p44/p42) 活化。

Enniatin B(Synonyms: 恩镰孢菌素 B)

Enniatin B Chemical Structure

CAS No. : 917-13-5

规格 价格 是否有货 数量
5 mg ￥15000 In-stock
10 mg   询价  
50 mg   询价  

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生物活性

Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes[1]. Enniatins B decreases the activation of ERK (p44/p42)[2].

IC50 & Target[1][2]

ACAT

 

ERK

 

分子量

639.82

Formula

C33H57N3O9
CAS 号

917-13-5
中文名称

镰孢菌素 B；恩镰孢菌素 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32.

    [2]. Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40.

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Enniatin B1(Synonyms: 恩镰孢菌素 B1)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Enniatin B1 (Synonyms: 恩镰孢菌素 B1)

Enniatin B1 是一种镰刀菌毒素。在大鼠肝微粒体酶实验中，Enniatin B1 抑制酰基辅酶 A：胆固醇酰基转移酶 (ACAT) 活性，IC50 为 73 μM。Enniatin B1 能透过血脑屏障。Enniatin B1 降低 ERK (p44/p42) 活化。Enniatin B1 抑制 TNF-α 诱导的 NF-κB激活。

Enniatin B1(Synonyms: 恩镰孢菌素 B1)

Enniatin B1 Chemical Structure

CAS No. : 19914-20-6

规格 价格 是否有货 数量
5 mg ￥15000 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

生物活性

Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes[1]. Enniatin B1 crosss the blood-brain barrier[2]. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation[3].

IC50 & Target[1][2]

ACAT

 

ERK

 

NF-κB

 

体外研究
(In Vitro)

CCF-STTG1 cells are sensitive to Enniatin B1 (IC50=4.4 μM)[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

653.85

Formula

C34H59N3O9
CAS 号

19914-20-6
中文名称

镰孢菌素 B1；恩镰孢菌素 B1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
参考文献

  • [1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32.

    [2]. Krug I, et al. Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells. PLoS One. 2018 May 16;13(5):e0197406.

    [3]. Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40.

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Enniatin A1(Synonyms: 恩镰孢菌素 A1)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Enniatin A1 (Synonyms: 恩镰孢菌素 A1)

Enniatin A1 是从镰刀菌霉菌毒素 (Fusarium) 中分离出来的，由交替的 D-α-羟基异戊酸和 N-甲基-L-氨基酸组成的环状十六肽。 Enniatin A1 通过诱导细胞凋亡和破坏 ERK 信号通路而具有抗癌特性。Enniatin A1 在大鼠肝微粒体中抑制 ACAT 的 IC50 为 49 μM。

Enniatin A1(Synonyms: 恩镰孢菌素 A1)

Enniatin A1 Chemical Structure

CAS No. : 4530-21-6

规格 价格 是否有货
5 mg ￥15000 询问价格 & 货期

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生物活性

Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes[1].

IC50 & Target[1]

ERK

 

分子量

667.87

Formula

C35H61N3O9
CAS 号

4530-21-6
中文名称

恩镰孢菌素 A1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40.

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Chaetoglobosin A(Synonyms: 球毛壳菌素 A)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Chaetoglobosin A (Synonyms: 球毛壳菌素 A)

Chaetoglobosin A 是青霉 (Penicillium aquamarinium) 提取物中的活性成分，是细胞松弛素家族 (cytochalasan family) 的成员。 Chaetoglobosin A 优先诱导细胞凋亡 (apoptosis)。Chaetoglobosin A 靶向 CLL 细胞中的丝状肌动蛋白 (filamentous actin)，从而诱导细胞周期停滞并抑制膜皱褶和细胞迁移。

Chaetoglobosin A(Synonyms: 球毛壳菌素 A)

Chaetoglobosin A Chemical Structure

CAS No. : 50335-03-0

规格 价格 是否有货 数量
1 mg ￥2980 In-stock
5 mg ￥9000 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

生物活性

Chaetoglobosin A, the active principle within the extract of Penicillium aquamarinium, is a member of the cytochalasan family. Chaetoglobosin A preferentially induces apoptosis. Chaetoglobosin A targets filamentous actin in CLL cells and thereby induces cell-cycle arrest and inhibits membrane ruffling and cell migration[1].

IC50 & Target

Filamentous actin[1]
Clinical Trial

分子量

528.64

Formula

C32H36N2O5
CAS 号

50335-03-0
中文名称

球毛壳菌素 A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Knudsen PB, et al. Chaetoglobosin A preferentially induces apoptosis in chronic lymphocytic leukemia cells by targeting the cytoskeleton. Leukemia. 2014 Jun;28(6):1289-98.

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Enniatin complex(Synonyms: 恩镰孢菌素复合物)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Enniatin complex (Synonyms: 恩镰孢菌素复合物)

Enniatin complex 是一种主要从 Fusarium 真菌中分离出的环己蛋白酶肽混合物，具有离子载体、抗生素和体外降血脂特性。Enniatin complex 抑制酰基辅酶 A 如胆固醇酰基转移酶并诱导一些癌细胞凋亡。

Enniatin complex(Synonyms: 恩镰孢菌素复合物)

Enniatin complex Chemical Structure

CAS No. : 11113-62-5

规格 价格 是否有货
5 mg ￥5000 询问价格 & 货期
10 mg ￥8100 询问价格 & 货期

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生物活性

Enniatin complex is a mixture of cyclohexadepsipeptides isolated largely from Fusarium species of fungi, and has ionophoric, antibiotic, and in vitro hypolipidaemic properties. Enniatin complex inhibits enzymes like acyl-CoA: cholesterol acyl transferase and induces apoptosis in several cancer lines [1][2].

CAS 号

11113-62-5
中文名称

恩镰孢菌素复合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kamyar M, et al. Investigation of the electrophysiological properties of enniatins. Arch Biochem Biophys. 2004 Sep 15;429(2):215-23.

    [2]. Dornetshuber R, et al. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against humancancer cells. Chem Res Toxicol. 2007 Mar;20(3):465-73.

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Cercosporin(Synonyms: 尾孢菌素)

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Cercosporin (Synonyms: 尾孢菌素)

Cercosporin 由植物病原体 Cercosporakikuchii 和 elsinochromes，elsinoe 家族真菌的色素产生。Cercosporin 是一种有效的光敏剂，具有短的活化波长，主要适用于表面 PDT 光动力研究 (尤其适用于避免穿孔的研究)。Cercosporin 是 PKC 的抑制剂，含有 PKC 活性所必需的醌结构特征, 其 IC50=0.6-1.3 μM。

Cercosporin(Synonyms: 尾孢菌素)

Cercosporin Chemical Structure

CAS No. : 35082-49-6

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生物活性

Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes, pigments of the elsinoe family of fungi. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations[1]. Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM[2].

IC50 & Target

IC50: 0.6-1.3 μM (PKC)[2]
体外研究
(In Vitro)

Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD50 value for the T98G cells (0.14 J cm2) is much less than the LD50 value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm2, respectively)[1].
Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) ≪ S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human GBM cell lines, T98G and U87; Breast carcinoma cell line, MCF-7
Concentration: 0 μM, 1 μM, 2 μM, 3 μM
Incubation Time: 24 hours
Result: Exhibited a synergistic cytotoxicity with copper only in the most respiratory cell lines (MCF-7 and T98G).

分子量

534.51

Formula

C29H26O10
CAS 号

35082-49-6
中文名称

尾孢菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mastrangelopoulou M, et al. Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines. Photochem Photobiol. 2019 Jan;95(1):387-396.

    [2]. Morgan BJ, et al. Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. J Am Chem Soc. 2009 Jul 8;131(26):9413-25.

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Nonactin(Synonyms: 无活菌素; Ammonium ionophore I)

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Nonactin (Synonyms: 无活菌素; Ammonium ionophore I) 纯度: ≥95.0%

Nonactin 来源于 Streptomyces griseus， 是一种抗生素，作为 K+ 和 NH4+ 载体。Nonactin 是一种氧化磷酸化 (OXPHOS) 解偶联剂。Nonactin 选择性诱导含突变 β-catenin 的细胞凋亡。Nonactin 抑制内源性 HSP60 表面表达。

Nonactin(Synonyms: 无活菌素; Ammonium ionophore I)

Nonactin Chemical Structure

CAS No. : 6833-84-7

规格 价格 是否有货 数量
1 mg ￥1650 In-stock
5 mg ￥4500 In-stock
10 mg   询价  
50 mg   询价  

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Nonactin 相关产品

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生物活性

Nonactin is a naturally occurring macrotetrolide antibiotic from Streptomyces griseus. Nonactin acts as an ionophore for monovalent cations, including K+, and NH4+[1]. Nonactin is able to uncouple the oxidative phosphorylation (OXPHOS) of mitochondria. Nonactin selectively induces apoptosis in cell lines harboring active mutant β-catenin[2]. Nonactin inhibits the surface expression of endogenous HSP60[3].

分子量

736.93

Formula

C40H64O12
CAS 号

6833-84-7
中文名称

无活菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Martínez-Haya B, et al. On the ionophoric selectivity of nonactin and related macrotetrolide derivatives. Phys Chem Chem Phys. 2017 Jan 4;19(2):1288-1297.

    [2]. Shikata Y, et al. Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells. Cancer Sci. 2017 Apr;108(4):772-784.

    [3]. Barazi HO, et al. Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res. 2002 Mar 1;62(5):1541-8.

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Illudin S(Synonyms: 隐陡头菌素S)

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Illudin S (Synonyms: 隐陡头菌素S) 纯度: 98.62%

Illudin S 是一种细胞毒性隐陡头菌素，是天然的倍半萜烯，具有高效的抗肿瘤和抗病毒活性。Illudin S 具有遗传毒性。Illudin S 在人类白血病细胞中阻断细胞循环的 G1/S 时相。

Illudin S(Synonyms: 隐陡头菌素S)

Illudin S Chemical Structure

CAS No. : 1149-99-1

规格 价格 是否有货 数量
1 mg ￥9200 In-stock
5 mg   询价  
10 mg   询价  

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Illudin S 相关产品

•相关化合物库:

  • Natural Product Library Plus
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生物活性

Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells[1][2][3][4].

体外研究
(In Vitro)

Illudin S (0-0.26 nM; 24-72 hours) shows cytotoxicity in human fibroblasts[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Human fibroblasts
Concentration: 0-0.26 nM
Incubation Time: 24 hours, 72 hours
Result: Decreased cell survival.

分子量

264.32

Formula

C15H20O4
CAS 号

1149-99-1
中文名称

隐陡头菌素S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (189.16 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.7833 mL 18.9165 mL 37.8329 mL
5 mM 0.7567 mL 3.7833 mL 7.5666 mL
10 mM 0.3783 mL 1.8916 mL 3.7833 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (9.46 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.46 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (9.46 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Hansruedi Glatt, et al. Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells. Arch Toxicol . 2014 Jan;88(1):161-9.

    [2]. Nicolaas G J Jaspers, et al. Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathways. DNA Repair (Amst). 2002 Dec 5;1(12):1027-38.

    [3]. Illudin S, the sole antiviral compound in mature fruiting bodies of Omphalotus illudens

    [4]. M J Kelner, et al. Preclinical evaluation of illudins as anticancer agents. Cancer Res. 1987 Jun 15;47(12):3186-9.

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Destruxin B(Synonyms: 黑僵菌素 B)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Destruxin B (Synonyms: 黑僵菌素 B) 纯度: 99.35%

Destruxin B 是从昆虫病原真菌中分离的绿僵菌 (Metarhizium anisopliae)，是一种具有杀虫和抗癌活性的环肽。 Destruxin B 通过 Bcl-2 家族依赖的线粒体途径在人类非小细胞肺癌细胞中诱导细胞凋亡。Destruxin B 显著激活 caspase-3，并在体外和体内通过 caspase 介导的细胞凋亡减少肿瘤细胞增殖。

Destruxin B(Synonyms: 黑僵菌素 B)

Destruxin B Chemical Structure

CAS No. : 2503-26-6

规格 价格 是否有货 数量
1 mg ￥10500 In-stock
5 mg ￥27500 询价
10 mg   询价  
50 mg   询价  

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生物活性

Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells[1]. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo[2].

IC50 & Target

Bcl-2

 

Caspase-3

 

体外研究
(In Vitro)

Destruxin B (1-30 μM; 48 hours) inhibits cell proliferation of H1299 cells and A549 cells, with IC50s of 4.1 μM and 4.9 μM, respectively[1].
Activation of mitochondria-dependent caspase cascade plays an important role in Destruxin B (1-30 μM; 48 hours) induced apoptotic cell death in A549 cells[1].
Destruxin B (1.25-20.00 μM; 72 hours) treatment significantly inhibits HT-29 human colorectal cancer cells viability in time- and dose-dependent manners[2].
Destruxin B (10 or 20 μM; 12 and 24 hours) treatment markedly increases levels of the proapoptotic protein PUMA and reduces levels of antiapoptotic proteins Mcl-1 of A549 cells in a concentration- and time-dependent manner [1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: H1299 cells
Concentration: 1, 5, 10, 20, 30 μM
Incubation Time: 48  hours
Result: Inhibited H1299 cells proliferation of H1299 cells with an IC50 of 4.1 μM.

Apoptosis Analysis[1]

Cell Line: Lung adenocarcinoma A549 cells
Concentration: 1, 5, 10, 20, 30 μM
Incubation Time: 48  hours
Result: Induces caspase-dependent Lung adenocarcinoma A549 cells death.

Cell Viability Assay[2]

Cell Line: HT-29 human colorectal cancer cells
Concentration: 1.25, 2.50, 5.00, 10.00 and 20.00 μM
Incubation Time: 72 hours
Result: The IC50s at 24 h, 48 h and 72h were determined as 14.97, 2.00 and 0.67 μM, respectively.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 10 or 20 μM
Incubation Time: 12 and 24  hours
Result: Regulates Mcl-1 and PUMA.

体内研究
(In Vivo)

Destruxin B (DB) ( injection; 0.6-15 mg/kg/day for 6 weeks) attenuates the tumor growth in time- and dose-dependent manners[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic female nude mice (BALB/cAnN.Cg-Foxn1nu/CrlNarl), approximately 4-5 weeks old on arrival[2]
Dosage: Low dose (0.6 mg/kg), medium dose (3 mg/kg), high dose (15 mg/kg)
Administration: Injection; daily; for 6 weeks
Result: Low dose, medium dose and high dose indicated a reduction of 23.9%, 33.4% and 55.8% in mean tumor size, respectively.

分子量

621.81

Formula

C32H55N5O7
CAS 号

2503-26-6
中文名称

黑僵菌素 B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Wu CC, et al. Destruxin B Isolated from Entomopathogenic Fungus Metarhizium anisopliae Induces Apoptosis via a Bcl-2 Family-Dependent Mitochondrial Pathway in Human NonsmallCell Lung Cancer Cells. Evid Based Complement Alternat Med. 2013;2013:548929.

    [2]. Lee YP, et al. In vitro and in vivo anticancer effects of destruxin B on human colorectal cancer. Anticancer Res. 2012 Jul;32(7):2735-45.

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Lavendustin B(Synonyms: 薰草菌素B)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Lavendustin B (Synonyms: 薰草菌素B) 纯度: 98.04%

Lavendustin B 是 HIV-1 整合酶与 LEDGF/p75 相互作用的抑制剂，IC50 为 94.07 μM。Lavendustin B 是一种具有 ATP 竞争性的 GLUT1 抑制剂，Ki 为 15 µM。Lavendustin B 也是酪氨酸激酶 (tyrosine kinases) 的弱抑制剂。

Lavendustin B(Synonyms: 薰草菌素B)

Lavendustin B Chemical Structure

CAS No. : 125697-91-8

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1650 In-stock
5 mg ￥1500 In-stock
10 mg ￥2500 In-stock
25 mg ￥5500 In-stock
50 mg ￥9500 In-stock
100 mg ￥15500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

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  • Glutamine Metabolism Compound Library
  • Anti-Cancer Metabolism Compound Library
  • Glucose Metabolism Compound Library
  • Targeted Diversity Library

生物活性

Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 µM. Lavendustin B is also a weak inhibitor of tyrosine kinases[1][2].

IC50 & Target[1][2]

GLUT1

15 μM (Ki)

HIV-1 integrase interaction with LEDGF/p75

94.07 μM (IC50)

体外研究
(In Vitro)

In HL-60 cells, Lavendustin B (0-1000 µM) inhibits the uptake of methylglucose, deoxyglucose, and dehydroascorbic acid in human erythrocytes in a dose-dependent manner, with 50% inhibition observed at approximately 10-30 µM. Moreover, increasing concentrations of Lavendustin B inhibited, in a dose-dependent manner, the binding of cytochalasin B to human erythrocyte membranes[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

365.38

Formula

C21H19NO5
CAS 号

125697-91-8
中文名称

薰草菌素B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (136.84 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7369 mL 13.6844 mL 27.3688 mL
5 mM 0.5474 mL 2.7369 mL 5.4738 mL
10 mM 0.2737 mL 1.3684 mL 2.7369 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.84 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.84 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.84 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.84 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. J C Vera, et al. Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. Biochemistry. 2001 Jan 23;40(3):777-90.

    [2]. Fatima E Agharbaoui, et al. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10;123:673-683.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lavendustin B(Synonyms: 薰草菌素B)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Lavendustin B (Synonyms: 薰草菌素B) 纯度: 98.04%

Lavendustin B 是 HIV-1 整合酶与 LEDGF/p75 相互作用的抑制剂，IC50 为 94.07 μM。Lavendustin B 是一种具有 ATP 竞争性的 GLUT1 抑制剂，Ki 为 15 µM。Lavendustin B 也是酪氨酸激酶 (tyrosine kinases) 的弱抑制剂。

Lavendustin B(Synonyms: 薰草菌素B)

Lavendustin B Chemical Structure

CAS No. : 125697-91-8

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1650 In-stock
5 mg ￥1500 In-stock
10 mg ￥2500 In-stock
25 mg ￥5500 In-stock
50 mg ￥9500 In-stock
100 mg ￥15500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Lavendustin B 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Kinase Inhibitor Library
  • Membrane Transporter/Ion Channel Compound Library
  • Metabolism/Protease Compound Library
  • Anti-Cancer Compound Library
  • Glycolysis Compound Library
  • Glutamine Metabolism Compound Library
  • Anti-Cancer Metabolism Compound Library
  • Glucose Metabolism Compound Library
  • Targeted Diversity Library

生物活性

Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 µM. Lavendustin B is also a weak inhibitor of tyrosine kinases[1][2].

IC50 & Target[1][2]

GLUT1

15 μM (Ki)

HIV-1 integrase interaction with LEDGF/p75

94.07 μM (IC50)

体外研究
(In Vitro)

In HL-60 cells, Lavendustin B (0-1000 µM) inhibits the uptake of methylglucose, deoxyglucose, and dehydroascorbic acid in human erythrocytes in a dose-dependent manner, with 50% inhibition observed at approximately 10-30 µM. Moreover, increasing concentrations of Lavendustin B inhibited, in a dose-dependent manner, the binding of cytochalasin B to human erythrocyte membranes[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

365.38

Formula

C21H19NO5
CAS 号

125697-91-8
中文名称

薰草菌素B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (136.84 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7369 mL 13.6844 mL 27.3688 mL
5 mM 0.5474 mL 2.7369 mL 5.4738 mL
10 mM 0.2737 mL 1.3684 mL 2.7369 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.84 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.84 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.84 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.84 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 Shanghai Jinpan Biotech Co Ltd 网站选购。
参考文献

  • [1]. J C Vera, et al. Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. Biochemistry. 2001 Jan 23;40(3):777-90.

    [2]. Fatima E Agharbaoui, et al. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10;123:673-683.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Lavendustin B(Synonyms: 薰草菌素B)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Lavendustin B (Synonyms: 薰草菌素B) 纯度: 98.04%

Lavendustin B 是 HIV-1 整合酶与 LEDGF/p75 相互作用的抑制剂，IC50 为 94.07 μM。Lavendustin B 是一种具有 ATP 竞争性的 GLUT1 抑制剂，Ki 为 15 µM。Lavendustin B 也是酪氨酸激酶 (tyrosine kinases) 的弱抑制剂。

Lavendustin B(Synonyms: 薰草菌素B)

Lavendustin B Chemical Structure

CAS No. : 125697-91-8

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1650 In-stock
5 mg ￥1500 In-stock
10 mg ￥2500 In-stock
25 mg ￥5500 In-stock
50 mg ￥9500 In-stock
100 mg ￥15500 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Lavendustin B 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Kinase Inhibitor Library
  • Membrane Transporter/Ion Channel Compound Library
  • Metabolism/Protease Compound Library
  • Anti-Cancer Compound Library
  • Glycolysis Compound Library
  • Glutamine Metabolism Compound Library
  • Anti-Cancer Metabolism Compound Library
  • Glucose Metabolism Compound Library
  • Targeted Diversity Library

生物活性

Lavendustin B is an inhibitor of HIV-1 integrase interaction with LEDGF/p75 with an IC50 of 94.07 μM. Lavendustin B is an ATP-competitive GLUT1 inhibitor with a Ki of 15 µM. Lavendustin B is also a weak inhibitor of tyrosine kinases[1][2].

IC50 & Target[1][2]

GLUT1

15 μM (Ki)

HIV-1 integrase interaction with LEDGF/p75

94.07 μM (IC50)

体外研究
(In Vitro)

In HL-60 cells, Lavendustin B (0-1000 µM) inhibits the uptake of methylglucose, deoxyglucose, and dehydroascorbic acid in human erythrocytes in a dose-dependent manner, with 50% inhibition observed at approximately 10-30 µM. Moreover, increasing concentrations of Lavendustin B inhibited, in a dose-dependent manner, the binding of cytochalasin B to human erythrocyte membranes[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

365.38

Formula

C21H19NO5
CAS 号

125697-91-8
中文名称

薰草菌素B
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (136.84 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7369 mL 13.6844 mL 27.3688 mL
5 mM 0.5474 mL 2.7369 mL 5.4738 mL
10 mM 0.2737 mL 1.3684 mL 2.7369 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.84 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.84 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.84 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (6.84 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. J C Vera, et al. Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors. Biochemistry. 2001 Jan 23;40(3):777-90.

    [2]. Fatima E Agharbaoui, et al. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. Eur J Med Chem. 2016 Nov 10;123:673-683.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pyoluteorin (Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin 是一种抗生素 (antibiotic)，可抑制 Oomycete fungi，包括植物病原体 Oomycete fungi，并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin Chemical Structure

CAS No. : 25683-07-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus[1]. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer[2].

体外研究
(In Vitro)

Pyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1].
Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50s of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2].
Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade[2].
Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human triple-negative breast cancer cell MDA-MB-231
Concentration: 0, 0.032, 0.16, 0.8, 4, 20, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited cells proliferation in a dose- and time-dependent manner.

Western Blot Analysis[2]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 0.3, 1, 3, 10 μM
Incubation Time: 24 hours
Result: The levels of the anti-apoptotic proteins Bcl-2, Bcl-XL and PARP were obviously decreased while the pro-apoptotic proteins BAX and caspase 3 were increased in a dose-dependent manner.

分子量

272.08

Formula

C11H7Cl2NO3
CAS 号

25683-07-2
中文名称

藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. B Nowak-Thompson, et al. Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol. 1999 Apr;181(7):2166-74.

    [2]. Ting Ding, et al. Pyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231. J Pharm Pharmacol. 2020 Jul;72(7):969-978.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pyoluteorin (Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin 是一种抗生素 (antibiotic)，可抑制 Oomycete fungi，包括植物病原体 Oomycete fungi，并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin Chemical Structure

CAS No. : 25683-07-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus[1]. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer[2].

体外研究
(In Vitro)

Pyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1].
Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50s of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2].
Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade[2].
Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human triple-negative breast cancer cell MDA-MB-231
Concentration: 0, 0.032, 0.16, 0.8, 4, 20, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited cells proliferation in a dose- and time-dependent manner.

Western Blot Analysis[2]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 0.3, 1, 3, 10 μM
Incubation Time: 24 hours
Result: The levels of the anti-apoptotic proteins Bcl-2, Bcl-XL and PARP were obviously decreased while the pro-apoptotic proteins BAX and caspase 3 were increased in a dose-dependent manner.

分子量

272.08

Formula

C11H7Cl2NO3
CAS 号

25683-07-2
中文名称

藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. B Nowak-Thompson, et al. Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol. 1999 Apr;181(7):2166-74.

    [2]. Ting Ding, et al. Pyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231. J Pharm Pharmacol. 2020 Jul;72(7):969-978.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Pyoluteorin (Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin 是一种抗生素 (antibiotic)，可抑制 Oomycete fungi，包括植物病原体 Oomycete fungi，并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。

Pyoluteorin(Synonyms: 藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素)

Pyoluteorin Chemical Structure

CAS No. : 25683-07-2

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses plant diseases caused by this fungus[1]. Pyoluteorin induces human triple-negative breast cancer MDA-MB-231 cells apoptosis in vitro. Pyoluteorin can be used for the research of human triple-negative breast cancer[2].

体外研究
(In Vitro)

Pyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1].
Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50s of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2].
Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade[2].
Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: Human triple-negative breast cancer cell MDA-MB-231
Concentration: 0, 0.032, 0.16, 0.8, 4, 20, 100 μM
Incubation Time: 24, 48, 72 hours
Result: Inhibited cells proliferation in a dose- and time-dependent manner.

Western Blot Analysis[2]

Cell Line: MDA-MB-231 cells
Concentration: 0.1, 0.3, 1, 3, 10 μM
Incubation Time: 24 hours
Result: The levels of the anti-apoptotic proteins Bcl-2, Bcl-XL and PARP were obviously decreased while the pro-apoptotic proteins BAX and caspase 3 were increased in a dose-dependent manner.

分子量

272.08

Formula

C11H7Cl2NO3
CAS 号

25683-07-2
中文名称

藤黄绿菌素；藤黄绿脓菌素；黄绿脓菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. B Nowak-Thompson, et al. Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5. J Bacteriol. 1999 Apr;181(7):2166-74.

    [2]. Ting Ding, et al. Pyoluteorin induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231. J Pharm Pharmacol. 2020 Jul;72(7):969-978.

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多拉菌素合成

发表于由

多拉菌素合成

有货

多拉菌素合成

CAS编号 117704-25-3 | 品牌：Jinpan
Doramectin synthetic

MSDS

质检证书(CoA)

相似产品

  • 分子式 C50H74O14
  • 分子量899.11
  • MDL号 MFCD00894747
  • PubChem编号 9832750

货号 (SKU) 包装规格 是否现货 价格 数量
D488258-100mg 100mg 期货 多拉菌素合成  

基本信息

产品名称 多拉菌素合成
英文名称 Doramectin synthetic
英文别名 Doramectin, 25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin
运输条件 超低温冰袋运输

一般描述

Description

Doramectin is commonly used in veterinary medicine for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites. It is effective againstHaemonchus spp.,Ostertagia spp.,Trichostrongylus spp.,Cooperia spp.,Oesophagostomum spp.,Dyctiocaulus viviparus,Dermatobia hominis,Boophilus microplus,Psoroptes bovis, as well as other internal and external parasites.

Description

Doramectin is commonly used in veterinary medicine for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites. It is effective againstHaemonchus spp.,Ostertagia spp.,Trichostrongylus spp.,Cooperia spp.,Oesophagostomum spp.,Dyctiocaulus viviparus,Dermatobia hominis,Boophilus microplus,Psoroptes bovis, as well as other internal and external parasites.

相关属性

CAS编号 117704-25-3
溶解性  甲醇：可溶
储存温度 -20°C储存
MDL号 MFCD00894747
分子量 899.11
分子式 C50H74O14
品牌 Jinpan
PubChem CID 9832750

匹马菌素制剂

发表于由

匹马菌素制剂

约2.5%（γ辐照海松霉素）,水悬浮液

有货

匹马菌素制剂

CAS编号 7681-93-8 | 品牌：Jinpan
Pimaricin preparation

MSDS

质检证书(CoA)

相似产品

  • 分子式 C33H47NO13
  • 分子量665.73
  • Beilstein号 1614878
  • EC号 231-683-5
  • MDL号 MFCD00135085
  • PubChem编号 5284447

货号 (SKU) 包装规格 是否现货 价格 数量
P485908-20ml 20ml 期货 匹马菌素制剂  

基本信息

产品名称 匹马菌素制剂
英文名称 Pimaricin preparation
英文别名 Natamycin preparation
规格或纯度 约2.5%（γ辐照海松霉素）,水悬浮液
运输条件 冰袋运输
稳定性与储存 The product is not degraded by a single freeze-thaw cycle. The diluted product should be aliquoted and stored frozen.

一般描述

Description

This product is a saline suspension with approximately 2.5% pimaricin γ-irradiated.Pimaricin is a polyene antifungal antibiotic produced byStreptomyces natalensisfrom soil near Pietermaritzburg, South Africa.1Pimaricin has antimicrobial activity similar to that of nystatin. In addition, it is active againstTrichomonas vaginalis. Pimaricin is used in the treatment of candidiasis, trichomoniasis, fungal keratitis and aspergillosis. It has also been used as a food additive in some countries. In some studies, it has been shown to decrease the amount of mold upon which theDermatophagoides pteronyssinus(house-dust mite) is dependent.2Pimaricin is an amphoteric antibiotic fromStreptomyces natalensisorS. chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. It is used to study pimaricin biosynthesis and as a fungicide in agar media.

Preparation instructions

The product can be further diluted with 0.5 M sodium chloride giving a suspension as well. The product can also be further diluted into an organic solvent such as dimethylformamide (may also be soluble in DMSO).The product and any aqueous dilutions will be suspensions and should not be sterile filtered.

Description

This product is a saline suspension with approximately 2.5% pimaricin γ-irradiated.Pimaricin is a polyene antifungal antibiotic produced byStreptomyces natalensisfrom soil near Pietermaritzburg, South Africa.1Pimaricin has antimicrobial activity similar to that of nystatin. In addition, it is active againstTrichomonas vaginalis. Pimaricin is used in the treatment of candidiasis, trichomoniasis, fungal keratitis and aspergillosis. It has also been used as a food additive in some countries. In some studies, it has been shown to decrease the amount of mold upon which theDermatophagoides pteronyssinus(house-dust mite) is dependent.2Pimaricin is an amphoteric antibiotic fromStreptomyces natalensisorS. chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. It is used to study pimaricin biosynthesis and as a fungicide in agar media.

Preparation instructions

The product can be further diluted with 0.5 M sodium chloride giving a suspension as well. The product can also be further diluted into an organic solvent such as dimethylformamide (may also be soluble in DMSO).The product and any aqueous dilutions will be suspensions and should not be sterile filtered.

相关属性

CAS编号 7681-93-8
熔点 280°C（分解）
沸点 952°C
溶解性  DMSO：可溶
储存温度 2-8°C储存
RTECS TK3325000
MDL号 MFCD00135085
密度 1.0g/mL at 20°C (lit.)
分子量 665.73
分子式 C33H47NO13
EC号 231-683-5
品牌 Jinpan
PubChem CID 5284447

尼日利亚菌素钠盐现成溶液

发表于由

尼日利亚菌素钠盐现成溶液

5mg/mL (DMSO:ethanol 1:1)

有货

尼日利亚菌素钠盐现成溶液

CAS编号 28643-80-3 | 品牌：Jinpan
Nigericin sodium salt Ready Made Solution

MSDS

质检证书(CoA)

相似产品

  • 分子式 C40H67NaO11
  • 分子量746.94
  • Beilstein号 3892398
  • PubChem编号 16760591

货号 (SKU) 包装规格 是否现货 价格 数量
N466621-1ml 1ml 期货 尼日利亚菌素钠盐现成溶液  

基本信息

产品名称 尼日利亚菌素钠盐现成溶液
英文名称 Nigericin sodium salt Ready Made Solution
英文别名 Antibiotic X464, Azalomycin M, Polyetherin A, 3B2-6379, HE331800, sodium;2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,1
规格或纯度 5mg/mL (DMSO:ethanol 1:1)
运输条件 冰袋运输
生化机理 尼日利亚菌素是一种聚醚离子载体，可催化碱金属（K+）与 H+（反位）的电子中性交换。 尼日利亚菌素跨膜转运单价阳离子具有以下特异性：K+>Rb+>Cs+>>Na+，从而破坏膜电位并刺激线粒体中的 ATPase 活性。尼日利亚菌素通过促进离子跨膜扩散来杀死细菌。低浓度（0.5 μM）的尼日利亚菌素会迅速降低 pHi，导致在大脑微血管内皮细胞中刺激 PG 产生 1.5 到 2 倍，并阻止 Erlich 腹水癌细胞中 DNA 的合成。 在脊髓灰质炎病毒进入 Hela 细胞后，用尼日利亚菌素处理可防止脊髓灰质炎病毒对宿主蛋白合成的抑制。尼日利亚菌素还广泛用于研究可变系统中膜电位变化的后果。

一般描述

应用

适用性

原理


制备说明

以 6.7 mM 的浓度提供尼日利亚菌素钠盐制备的溶液。 可用所需溶剂将该溶液进一步稀释至工作浓度（0.5-10 μM）。


外形

相关属性

CAS编号 28643-80-3
储存温度 2-8°C储存
RTECS QT6840000
分子量 746.94
分子式 C40H67NaO11
品牌 Jinpan
Smiles [Na+].CO[C@@H]1C[C@H](C[C@@H]2CC[C@H](C)[C@H](O2)[C@@H](C)C(=O)[O-])O[C@@]2(O[C@](C)(C[C@H]2C)[C@@H]2CC[C@@](C)(O2)[C@H]2O[C@@H](C[C@@H]2C)[C@@H]2O[C@@](O)(CO)[C@H](C)C[C@@H]2C)[C@@H]1C
PubChem CID 16760591

酒石酸泰乐菌素

发表于由

酒石酸泰乐菌素

粉末,生物制剂,适用于细胞培养

有货

酒石酸泰乐菌素

品牌：Jinpan
Tylosin tartrate

MSDS

质检证书(CoA)

相似产品

  • MDL号 MFCD07783824

货号 (SKU) 包装规格 是否现货 价格 数量
T476638-5g 5g 期货 酒石酸泰乐菌素  
T476638-10g 10g 期货 酒石酸泰乐菌素  
T476638-1g 1g 期货 酒石酸泰乐菌素  

基本信息

产品名称 酒石酸泰乐菌素
英文名称 Tylosin tartrate
规格或纯度 粉末,生物制剂,适用于细胞培养

一般描述

外形


重悬


组分

泰乐菌素 A、B、C 和 D 酒石酸盐的混合物。

Description

Chemical structure: macrolideTylosin is a mcrolide antibiotic commonly used in veterinary medicine. It has been used to study protein synthesis at the 50S ribosome, implant site abscess prevention in cattle, disposition kinetics andMycoplasma gallisepticumandMycoplasma meleagridisinfections. It is recommended for use in cell culture applications at 8 mg/L.

相关属性

溶解性  H2O：≤50mg/mL
储存温度 干燥
MDL号 MFCD07783824
品牌 Jinpan