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8-Aminoadenosine (Synonyms: 8-氨基腺苷; 8-NH2-Ado)
8-Aminoadenosine (8-NH2-Ado) 是一种 RNA 导向的核苷类似物,可降低细胞 ATP 水平并抑制 mRNA 合成。8-Aminoadenosine 阻断 Akt/mTOR 信号,并诱导 p53 非依赖性的自噬和细胞凋亡。8-Aminoadenosine 具有抗肿瘤活性。
8-Aminoadenosine Chemical Structure
CAS No. : 3868-33-5
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生物活性 |
8-Aminoadenosine (8-NH2-Ado), a RNA-directed nucleoside analogue, reduces cellular ATP levels and inhibits mRNA synthesis. 8-Aminoadenosine blocks Akt/mTOR signaling and induces autophagy and apoptosis in a p53-independent manner. 8-Aminoadenosine has antitumor activity[1][2][3]. |
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IC50 & Target[1][2] |
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体外研究 (In Vitro) |
8-Aminoadenosine (8-NH2-Ado; 0.1-10 μM; for 48 h) has IC50s of 1.5 μM and 8.88 μM in MM.1S and U266 cells, respectively[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability Assay[1]
Apoptosis Analysis[2]
Apoptosis Analysis[1]
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分子量 |
282.26 |
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Formula |
C10H14N6O4 |
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CAS 号 |
3868-33-5 |
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中文名称 |
8-氨基腺苷;8-氨基腺苷酸 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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溶解性数据 |
In Vitro:
DMSO : 83.33 mg/mL (295.22 mM; Need ultrasonic) 配制储备液
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参考文献 |
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