Antiproliferative against-7 (compound 8a) is a potent antitumor agent. Antiproliferative against-7 has antiproliferative activity against cancer cell lines HCT116, MCF-7, H460 and non-tumor aneuploid immortal keratinocyte HaCaT cells with GI₅₀s of 0.5 μM, 2 μM, 0.7 μM and 3.5 μM, respectively^[1].

GI₅₀: 0.5 μM (HCT116), 2 μM (MCF-7), 0.7 μM (H460), 3.5 μM (HaCaT)^[1]

404.83

C₂₁H₁₄ClFN₆

2389016-82-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Meščić Macan A, et al. Synthesis, antiproliferative activity and DNA/RNA-binding properties of mono- and bis-(1,2,3-triazolyl)-appended benzimidazo[1,2-a]quinoline derivatives. Eur J Med Chem. 2020;185:111845.

Antiproliferative against-6 (compound 4o) can significantly and irreversibly inhibit proliferation of gastric cancer cells. Antiproliferative against-6 causes the G2/M phase arrest, and induces ROS accumulation and activation of autophagy. Antiproliferative against-6 can be used for researching anticancer^[1].

ROS, Autophagy^[1]

597.49

C₂₈H₂₁BrN₈OS

2459892-41-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang S, et al. Discovery of new [1,2,4] Triazolo[1,5-a]Pyrimidine derivatives that Kill gastric cancer cells via the mitochondria pathway. Eur J Med Chem. 2020;203:112630.

Antiproliferative against-5 (compound 2y) has excellent anti-proliferative activity against certain cancer cell lines. Antiproliferative against-5 reduces the mitochondrial membrane potential, and increases the apoptosis rate and the level of ROS on EC109. Antiproliferative against-5 inhibits tumour growth in nude mice, with low toxicity^[1].

IC₅₀: 0.13 ± 0.01 μM in EC109, 0.27 ± 0.02 μM in TE-1, 0.20 ± 0.01 μM in MGC-803, 0.35 ± 0.03 μM in MCF-7^[1]

Antiproliferative against-5 has inhibitory activity against cancer cell lines EC109, TE-1, MGC-803 and MCF-7 with IC₅₀s of 0.13 ± 0.01 μM, 0.27 ± 0.02 μM, 0.20 ± 0.01 μM and 0.35 ± 0.03 μM^[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

547.04

C₂₉H₃₅ClO₈

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Huo JF, et al. Synthesis and in vitro and in vivo biological evaluation of novel derivatives of flexicaulin A as antiproliferative agents. Eur J Med Chem. 2020;208:112789.

Antiproliferative against-8 (compound 8f) is a potent anti-proliferative agent. Antiproliferative against-8 has antiproliferative activity against cancer cell lines MCF-7, MDA-MB-231, HCT-116 and FR-2 with IC₅₀s of 3.5 μM, 15.54 μM, 30.43 μM and 34.8 μM, respectively. Antiproliferative against-8 can increase ROS production and induce apoptosis^[1].

IC₅₀: 3.5 μM (MCF-7), 15.54 μM (MDA-MB-231), 30.43 μM (HCT-116), 34.8 μM (FR-2)^[1]

440.58

C₂₈H₃₂N₄O

2497687-47-3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Dheer D,et al.Design, synthesis and comparative analysis of triphenyl-1,2,3-triazoles as anti-proliferative agents. Eur J Med Chem. 2020 Dec 1;207:112813.