标签归档：aminohexylgeldanamycin

Aminohexylgeldanamycin(Synonyms: AHGDM)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Aminohexylgeldanamycin (Synonyms: AHGDM)

Aminohexylgeldanamycin (AHGDM)，Geldanamycin 的衍生物，是一种热休克蛋白 90 (HSP90) 抑制剂。Aminohexylgeldanamycin 具有抗血管生成和抗肿瘤活性。

Aminohexylgeldanamycin(Synonyms: AHGDM)

Aminohexylgeldanamycin Chemical Structure

CAS No. : 485395-71-9

规格 价格 是否有货 数量
5 mg ￥3000 In-stock
10 mg ￥4800 In-stock
25 mg ￥9500 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Aminohexylgeldanamycin 相关产品

•相关化合物库:

  • Covalent Screening Library Plus
  • Bioactive Compound Library Plus
  • Cell Cycle/DNA Damage Compound Library
  • Metabolism/Protease Compound Library
  • Anti-Cancer Compound Library
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  • Covalent Screening Library
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  • Cytoskeleton Compound Library

生物活性

Aminohexylgeldanamycin (AHGDM), a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin shows antiangiogenic and antitumor activities[1].

IC50 & Target[1]

HSP90

 

体外研究
(In Vitro)

HPMA copolymer-aminohexylgeldanamycin conjugates target cell surface expressed GRP78 in prostate cancer[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

644.80

Formula

C34H52N4O8
CAS 号

485395-71-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶解性数据
In Vitro: 

DMSO : 110 mg/mL (170.60 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5509 mL 7.7543 mL 15.5087 mL
5 mM 0.3102 mL 1.5509 mL 3.1017 mL
10 mM 0.1551 mL 0.7754 mL 1.5509 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 4.25 mg/mL (6.59 mM); Clear solution

    此方案可获得 ≥ 4.25 mg/mL (6.59 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 42.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4.25 mg/mL (6.59 mM); Clear solution

    此方案可获得 ≥ 4.25 mg/mL (6.59 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 42.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270.

    [2]. Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Aminohexylgeldanamycin hydrochloride(Synonyms: AHGDM hydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Aminohexylgeldanamycin hydrochloride (Synonyms: AHGDM hydrochloride)

Aminohexylgeldanamycin (AHGDM) hydrochloride，Geldanamycin 的衍生物，是一种热休克蛋白 90 (HSP90) 抑制剂。Aminohexylgeldanamycin hydrochloride 具有抗血管生成和抗肿瘤活性。

Aminohexylgeldanamycin hydrochloride(Synonyms: AHGDM hydrochloride)

Aminohexylgeldanamycin hydrochloride Chemical Structure

CAS No. : 1146534-45-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Aminohexylgeldanamycin hydrochloride 的其他形式现货产品:

Aminohexylgeldanamycin

生物活性

Aminohexylgeldanamycin (AHGDM) hydrochloride, a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin hydrochloride shows antiangiogenic and antitumor activities[1].

IC50 & Target[1]

HSP90

 

体外研究
(In Vitro)

HPMA copolymer-aminohexylgeldanamycin conjugates target cell surface expressed GRP78 in prostate cancer[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

681.26

Formula

C34H53ClN4O8
CAS 号

1146534-45-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270.

    [2]. Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Aminohexylgeldanamycin hydrochloride(Synonyms: AHGDM hydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Aminohexylgeldanamycin hydrochloride (Synonyms: AHGDM hydrochloride)

Aminohexylgeldanamycin (AHGDM) hydrochloride，Geldanamycin 的衍生物，是一种热休克蛋白 90 (HSP90) 抑制剂。Aminohexylgeldanamycin hydrochloride 具有抗血管生成和抗肿瘤活性。

Aminohexylgeldanamycin hydrochloride(Synonyms: AHGDM hydrochloride)

Aminohexylgeldanamycin hydrochloride Chemical Structure

CAS No. : 1146534-45-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Aminohexylgeldanamycin hydrochloride 的其他形式现货产品:

Aminohexylgeldanamycin

生物活性

Aminohexylgeldanamycin (AHGDM) hydrochloride, a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin hydrochloride shows antiangiogenic and antitumor activities[1].

IC50 & Target[1]

HSP90

 

体外研究
(In Vitro)

HPMA copolymer-aminohexylgeldanamycin conjugates target cell surface expressed GRP78 in prostate cancer[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

681.26

Formula

C34H53ClN4O8
CAS 号

1146534-45-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270.

    [2]. Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Aminohexylgeldanamycin hydrochloride(Synonyms: AHGDM hydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Aminohexylgeldanamycin hydrochloride (Synonyms: AHGDM hydrochloride)

Aminohexylgeldanamycin (AHGDM) hydrochloride，Geldanamycin 的衍生物，是一种热休克蛋白 90 (HSP90) 抑制剂。Aminohexylgeldanamycin hydrochloride 具有抗血管生成和抗肿瘤活性。

Aminohexylgeldanamycin hydrochloride(Synonyms: AHGDM hydrochloride)

Aminohexylgeldanamycin hydrochloride Chemical Structure

CAS No. : 1146534-45-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Aminohexylgeldanamycin hydrochloride 的其他形式现货产品:

Aminohexylgeldanamycin

生物活性

Aminohexylgeldanamycin (AHGDM) hydrochloride, a Geldanamycin derivative, is a potent HSP90 inhibitor. Aminohexylgeldanamycin hydrochloride shows antiangiogenic and antitumor activities[1].

IC50 & Target[1]

HSP90

 

体外研究
(In Vitro)

HPMA copolymer-aminohexylgeldanamycin conjugates target cell surface expressed GRP78 in prostate cancer[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

681.26

Formula

C34H53ClN4O8
CAS 号

1146534-45-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Greish K, et al. Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy. J Control Release. 2011;151(3):263-270.

    [2]. Larson N, et al. HPMA copolymer-aminohexylgeldanamycin conjugates targeting cell surface expressed GRP78 in prostate cancer. Pharm Res. 2010;27(12):2683-2693.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务