Pentachloropseudilin(Synonyms: Antibiotic A 15104 Y; PClP)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Pentachloropseudilin (Synonyms: Antibiotic A 15104 Y; PClP)

Pentachloropseudilin (Antibiotic A 15104 Y; PClP) 是一种可逆的、变构有效的肌球蛋白 (Myo1s) 抑制剂,对 Myo1s 的 IC50 范围为 1 至 5 μM,对于 2 类和 5 类肌球蛋白,IC50 范围 > 90 μM。Pentachloropseudilin 是转化生长因子-β (TGF-β) 刺激的信号传导的有效抑制剂,对 TGF-β 的 IC50 值为 0.1-0.2 μM。

Pentachloropseudilin(Synonyms: Antibiotic A 15104 Y;  PClP)

Pentachloropseudilin Chemical Structure

CAS No. : 69640-38-6

规格 价格 是否有货
5 mg ¥9800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β[1][2].

体外研究
(In Vitro)

Pentachloropseudilin (PClP) inhibits TGF-β-stimulated Smad2/3 phosphorylation and plasminogen activator inhibitor-1 (PAI-1) promoter activation with an IC50 of 0.1 μM in target cells (A549, HepG2, and Mv1Lu cells)[1].
Pentachloropseudilin attenuates TGF-β-stimulated expression of vimentin, N-cadherin, and fibronectin and, thus, blocks TGF-β-induced epithelial to mesenchymal transition (EMT) in these cells. Pentachloropseudilin (0.05 to 1 μΜ; 0-6 hours) pretreatment inhibits TGF-β-mediated (50 or 100 pM) increases in p-Smad2/3 expression to 47% (Mv1Lu) and 79% (A549), respectively[1].
Pentachloropseudilin (0.2 μM) suppresses TGF-β-stimulated cellular responses by attenuating cell-surface expression of the type II TGF-β receptor through accelerating caveolae-mediated internalization followed by primarily lysosome-dependent degradation of the receptor, as demonstrated by sucrose density gradient analysis and immune fluorescence staining[1].
Pentachloropseudilin (200 μM; 24 hours) exhibits and altered cell viability in HUVECs[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

331.41

Formula

C10H4Cl5NO

CAS 号

69640-38-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Chinthalapudi K, et al. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. J Biol Chem. 2011;286(34):29700-29708.

    [2]. Chung CL, et al. Pentachloropseudilin Inhibits Transforming Growth Factor-β (TGF-β) Activity by Accelerating Cell-Surface Type II TGF-β Receptor Turnover in Target Cells. Chembiochem. 2018;19(8):851-864.

    [3]. Cota Teixeira S, et al. Pentachloropseudilin Impairs Angiogenesis by Disrupting the Actin Cytoskeleton, Integrin Trafficking and the Cell Cycle. Chembiochem. 2019;20(18):2390-2401.

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Leucinostatin A(Synonyms: Antibiotic P168)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Leucinostatin A (Synonyms: Antibiotic P168)

Leucinostatin A (Antibiotic P168) 是一种九肽,对白色念珠菌和新型隐球菌具有显着的活性。 Leucinostatin A 是一种疏水性九肽抗生素。Leucinostatin A 通过减少前列腺基质细胞中胰岛素样生长因子-I 的表达来抑制前列腺癌的生长。具有抗原虫活性。

Leucinostatin A(Synonyms: Antibiotic P168)

Leucinostatin A Chemical Structure

CAS No. : 76600-38-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies[1].

分子量

1218.61

Formula

C62H111N11O13

CAS 号

76600-38-9

Sequence Shortening

P-{Nva}-L-{Aib}-LL-{Aib}-{Aib}-{Bal}

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Csermely P, et al. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim Biophys Acta. 1994;1221(2):125-132.

    [2]. Ricci M, et al. Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Int J Pharm. 2004;275(1-2):61-72.

    [3]. Brand M, et al. Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621.

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Leucinostatin A(Synonyms: Antibiotic P168)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Leucinostatin A (Synonyms: Antibiotic P168)

Leucinostatin A (Antibiotic P168) 是一种九肽,对白色念珠菌和新型隐球菌具有显着的活性。 Leucinostatin A 是一种疏水性九肽抗生素。Leucinostatin A 通过减少前列腺基质细胞中胰岛素样生长因子-I 的表达来抑制前列腺癌的生长。具有抗原虫活性。

Leucinostatin A(Synonyms: Antibiotic P168)

Leucinostatin A Chemical Structure

CAS No. : 76600-38-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies[1].

分子量

1218.61

Formula

C62H111N11O13

CAS 号

76600-38-9

Sequence Shortening

P-{Nva}-L-{Aib}-LL-{Aib}-{Aib}-{Bal}

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Csermely P, et al. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim Biophys Acta. 1994;1221(2):125-132.

    [2]. Ricci M, et al. Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Int J Pharm. 2004;275(1-2):61-72.

    [3]. Brand M, et al. Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Leucinostatin A(Synonyms: Antibiotic P168)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Leucinostatin A (Synonyms: Antibiotic P168)

Leucinostatin A (Antibiotic P168) 是一种九肽,对白色念珠菌和新型隐球菌具有显着的活性。 Leucinostatin A 是一种疏水性九肽抗生素。Leucinostatin A 通过减少前列腺基质细胞中胰岛素样生长因子-I 的表达来抑制前列腺癌的生长。具有抗原虫活性。

Leucinostatin A(Synonyms: Antibiotic P168)

Leucinostatin A Chemical Structure

CAS No. : 76600-38-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies[1].

分子量

1218.61

Formula

C62H111N11O13

CAS 号

76600-38-9

Sequence Shortening

P-{Nva}-L-{Aib}-LL-{Aib}-{Aib}-{Bal}

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Csermely P, et al. The nonapeptide leucinostatin A acts as a weak ionophore and as an immunosuppressant on T lymphocytes. Biochim Biophys Acta. 1994;1221(2):125-132.

    [2]. Ricci M, et al. Leucinostatin-A loaded nanospheres: characterization and in vivo toxicity and efficacy evaluation. Int J Pharm. 2004;275(1-2):61-72.

    [3]. Brand M, et al. Antiprotozoal Structure-Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action. Angew Chem Int Ed Engl. 2021;60(28):15613-15621.

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Ansamitocin P-3(Synonyms: Antibiotic C 15003P3; Maytansinol isobutyrate)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ansamitocin P-3 (Synonyms: Antibiotic C 15003P3; Maytansinol isobutyrate) 纯度: ≥98.0%

Ansamitocin P-3 (Antibiotic C 15003P3) 是一种微管 (microtubule)抑制剂。Ansamitocin P-3 是一种大环抗肿瘤抗生素。

Ansamitocin P-3(Synonyms: Antibiotic C 15003P3;  Maytansinol isobutyrate)

Ansamitocin P-3 Chemical Structure

CAS No. : 66584-72-3

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥1817 In-stock
2 mg ¥866 In-stock
5 mg ¥1300 In-stock
10 mg ¥1900 In-stock
50 mg ¥4500 In-stock
100 mg ¥6000 In-stock
200 mg   询价  
500 mg   询价  

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Ansamitocin P-3 相关产品

相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Anti-Infection Compound Library
  • Cell Cycle/DNA Damage Compound Library
  • Natural Product Library
  • Toxins for Antibody-Drug Conjugate Research Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Covalent Screening Library
  • Macrocyclic Compound Library
  • Antibacterial Compound Library
  • Cytoskeleton Compound Library
  • FDA Approved & Pharmacopeial Drug Library
  • Antibiotics Library
  • Anti-Lung Cancer Compound Library
  • Microbial Metabolite Library

生物活性

Ansamitocin P-3 (Antibiotic C 15003P3) is a microtubule inhibitor. Ansamitocin P-3 is a macrocyclic antitumor antibiotic.

IC50 & Target

Maytansinoids

 

体外研究
(In Vitro)

Ansamitocin P-3 (Antibiotic C 15003P3) potently inhibits the proliferation of MCF-7, HeLa, EMT-6/AR1 and MDA-MB-231 cells in culture with a half-maximal inhibitory concentration of 20±3, 50±0.5, 140±17, and 150±1.1 pM, respectively. Further, Ansamitocin P3 is found to bind to purified tubulin in vitro with a dissociation constant (Kd) of 1.3±0.7 µM. The binding of Ansamitocin P3 induces conformational changes in tubulin. Ansamitocin P3 inhibits the proliferation of MCF-7, HeLa, EMT-6/AR1 and MDA-MB-231 cells in culture in a concentration dependent manner. Flow cytometric analysis of PI-stained cells suggests that Ansamitocin P3 inhibits the cell cycle progression of MCF-7 cells in G2/M phase. For example, 26, 50 and 70% of the cells are found to be in G2/M phase in the absence and presence of 50 and 100 pM Ansamitocin P3, respectively[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

635.14

Formula

C32H43ClN2O9

CAS 号

66584-72-3

中文名称

安丝菌素 P-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 100 mg/mL (157.45 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5745 mL 7.8723 mL 15.7446 mL
5 mM 0.3149 mL 1.5745 mL 3.1489 mL
10 mM 0.1574 mL 0.7872 mL 1.5745 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (3.94 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.94 mM,饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中,混合均匀;向上述体系中加入50 μL Tween-80,混合均匀;然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠,完全溶解于 100 mL ddH₂O 中,得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (3.94 mM); Suspended solution; Need ultrasonic

    此方案可获得 2.5 mg/mL (3.94 mM) 的均匀悬浊液,悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中,混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中,再用生理盐水定容至 10 mL,完全溶解,澄清透明
  • 3.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (3.94 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (3.94 mM,饱和度未知) 的澄清溶液,此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例,取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中,混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献
  • [1]. Kiso T, et al. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrob Agents Chemother. 2004 May;48(5):1739-48

    [2]. Venghateri JB, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at thevinblastine site. PLoS One. 2013 Oct 4;8(10):e75182.

Cell Assay
[2]

MCF-7, EMT-6/AR1, HeLa and MDA-MB-231 cells are seeded in 96 well plates. Subsequently, cells are incubated with vehicle (0.1% DMSO) or different concentrations (1-1000 pM) of Ansamitocin P3 for 48 h in MCF-7 cells and 24 h for EMT-6/AR1, HeLa and MDA-MB-231 cells, respectively. The half maximal inhibitory concentration of cell proliferation (IC50) for Ansamitocin P3 is determined by sulforhodamine B assay. Four independent experiments are carried out in MCF-7 cells and three independent sets of experiments are performed in EMT-6/AR1, HeLa and MDA-MB-231 cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • [1]. Kiso T, et al. Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss. Antimicrob Agents Chemother. 2004 May;48(5):1739-48

    [2]. Venghateri JB, et al. Ansamitocin P3 depolymerizes microtubules and induces apoptosis by binding to tubulin at thevinblastine site. PLoS One. 2013 Oct 4;8(10):e75182.

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Antibiotic TS 155-2

Antibiotic TS 155-2

凝血酶刺激引起的钙进入细胞的抑制剂

有货

Antibiotic TS 155-2

CAS编号 303009-07-6 | 品牌:Jinpan
Antibiotic TS 155-2

MSDS

质检证书(CoA)

相似产品

  • 分子式 C₃₉H₆₀O₁₁
  • 分子量704.9

货号 (SKU) 包装规格 是否现货 价格 数量
A329294-1mg 1mg 期货 Antibiotic TS 155-2  

基本信息

产品名称 Antibiotic TS 155-2
英文名称 Antibiotic TS 155-2
运输条件 超低温冰袋运输

一般描述

抗生素TS155-2是与潮霉素相关的大环内酯,但由不同的链霉菌种产生。据报道,抗生素TS155-2是钙通过凝血酶刺激而进入细胞的抑制剂。除了暗示降压,抗血小板,抗缺血和抗炎活性的原始专利外,尚无关于TS155-2的文献研究。

Antibiotic TS155-2 is a macrocyclic lactone related to hygrolidin but produced by a different Streptomyces species. Antibiotic TS155-2 is reported to be an inhibitor of calcium entry into the cell induced by thrombin stimulation. With the exception of the original patent suggesting hypotensive, anti-platelet, anti-ischaemic and anti-inflammatory activity, no literature investigation of TS155-2 is available.

相关属性

CAS编号 303009-07-6
溶解性 Soluble in ethanol, methanol, DMF, DMSO, and water (poor).
储存温度 -20°C储存
分子量 704.9
分子式 C₃₉H₆₀O₁₁
品牌 Jinpan

Concanamycin A(Synonyms: 刀豆素A; Antibiotic X 4357B; Concanamycin; X 4357B)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Concanamycin A (Synonyms: 刀豆素A; Antibiotic X 4357B; Concanamycin; X 4357B) 纯度: 97.84%

Concanamycin A (Antibiotic X 4357B) 是一种大环内酯类抗生素,也是特异的空泡状 H+– ATP 酶 (V-ATPase) 抑制剂。

Concanamycin A(Synonyms: 刀豆素A; Antibiotic X 4357B;  Concanamycin;  X 4357B)

Concanamycin A Chemical Structure

CAS No. : 80890-47-7

规格 价格 是否有货 数量
25 μg ¥2300 In-stock
50 μg ¥3650 In-stock

* Please select Quantity before adding items.

生物活性

Concanamycin A (Antibiotic X 4357B) is a macrolide antibiotic and a specific vacuolar type H+-ATPase (V-ATPase) inhibitor[1].

IC50 & Target

Vacuolar type H+-ATPase[1]

分子量

866.09

Formula

C46H75NO14

CAS 号

80890-47-7

中文名称

刀豆素A

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

Methanol : 10 mg/mL (11.55 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1546 mL 5.7731 mL 11.5461 mL
5 mM 0.2309 mL 1.1546 mL 2.3092 mL
10 mM 0.1155 mL 0.5773 mL 1.1546 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Togashi K, et al. Concanamycin A, a vacuolar type H(+)-ATPase inhibitor, induces cell death in activated CD8(+) CTL. Cytotechnology. 1997 Nov;25(1-3):127-35.

    [2]. Eswarappa SM, et al. Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages. Innate Immun. 2008 Feb;14(1):13-24.

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链脲佐菌素

链脲佐菌素

Antineoplastic and Immunosuppressive Antibiotics
10mM in DMSO

有货

链脲佐菌素

CAS编号 18883-66-4(DMSO) | 品牌:Jinpan
Streptozotocin (STZ)

MSDS

质检证书(CoA)

相似产品

  • 分子式 C8H15N3O7
  • 分子量265.22

货号 (SKU) 包装规格 是否现货 价格 数量
S408311-1ml 1ml 期货 链脲佐菌素  

基本信息

产品名称 链脲佐菌素
英文名称 Streptozotocin (STZ)
英文别名 NSC-85998, Streptozocin, U 9889;1-methyl-1-nitroso-3-((2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-3-yl)urea
规格或纯度 10mM in DMSO
运输条件 超低温冰袋运输
生化机理 Streptozotocin (STZ, NSC-85998, Streptozocin, U 9889) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Solutions are best fresh-prepared.

一般描述

Information

Streptozotocin (STZ, NSC-85998, Streptozocin, U 9889) is a glucosamine-nitrosourea derivative, which is a DNA-methylating , carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis . Solutions are best fresh-pre
In vitro

Streptozotocin directly methylates DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. Free radicals are involved in the production of DNA and chromosome damage by Streptozotocin. Streptozotocin is toxic to pancreatic beta cell. Exposed to 15 mM Streptozotocin for 1 hr followed by a 24 hrs recovery period induces apoptosis in murine pancreatic beta cell line, INS-1. Streptozotocin (30 mM) causes the cells to undergo necrosis (22%) as well as apoptosis (17%).

In vivo

Streptozotocin is often used to induce diabetes mellitus in experimental animals. Streptozotocin is selectively accumulated in pancreatic beta cells via the low-affinity GLUT 2 glucose transporter. Streptozotocin (60 mg/kg) injection for 4 month induces rapid degranulation of beta cells without necrosis, development of cataracts and accumulation of glycogen in the proximal convoluted tubules of the kidney. Streptozotocin (100 mg/kg) produces lesions in the exocrine cells of the pancreas, and persistence of small, possibly secretory, granules in the Golgi zone of beta cells in rats of ‘Streptozotocin diabetes’. Streptozotocin is found to be carcinogenic in rats, mice and hamster. A single administration of Streptozotocin is able to induce tumors in kidney, liver, lung, pancreas, uterine and liver tumors in hamster. Intraperitoneally injected with Streptozotocin (100-150 mg/kg) for normotensive Wistar Kyoto rats (WKY) for 12 months induces carcinogenesis with tumors incidence of 70% in liver, 20% in kidney and 10% in liver and kidney.
Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

相关属性

CAS编号 18883-66-4(DMSO)
储存温度 -80℃储存
分子量 265.22
分子式 C8H15N3O7
品牌 Jinpan
Smiles CN(N=O)C(=O)NC1C(O)OC(CO)C(O)C1O

抗生素培养基5号(USP)(Antibiotic Medium 5)

上海金畔生物科技有限公司可以定制生产国产培养基,可以访问官网了解更多产品信息。
抗生素培养基5号(USP)(Antibiotic Medium 5)

英文名称: Antibiotic Medium 5
产品货号: JP8906
产品规格: 250g
190元
保质期: 三年
产品用途: 用于微生物方法测定抗生素效价
备  注:

产品介绍:

Approximate Formula:

Peptone

6.0 g

Yeast Extract

3.0 g

Beef Extract

1.5 g

Agar

15.0 g

Water

1000 mL

pH after sterilization: 7.9 ± 0.1

Intended use:

Suspend 25.5g/liter, heat  up and  milling  to  dissolve,dispense in  conical  flask,autoclave  at 121 ℃ for   15   min.

抗生素培养基5(USP)微生物灵敏度试验:

按标签用法制备培养基,接种以下质控菌株,放置36±1℃需氧培养18-24小时。
注:回收率计算时,用TSA琼脂做对照培养基。


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抗生素培养基11号(USP)(Antibiotic Medium 11)

上海金畔生物科技有限公司可以定制生产国产培养基,可以访问官网了解更多产品信息。
抗生素培养基11号(USP)(Antibiotic Medium 11)

英文名称: Antibiotic Medium 11
产品货号: JP8907
产品规格: 250g
190元
保质期: 三年
产品用途: 用于微生物方法测定抗生素效价
备  注:

产品介绍:

Approximate Formula:

Peptone

6.0 g

Pancreatic Digest of Casein

4.0 g

Yeast Extract

3.0 g

Beef Extract

1.5 g

Dextrose

1.0 g

Agar

15.0 g

Water

1000 mL

pH after sterilization: 8.3 ± 0.1.

 

Intended use:

Suspend 30.5g/liter, heat  up and  milling  to  dissolve,dispense in  conical  flask,autoclave  at 121 ℃ for   15   min.

抗生素培养基11(USP)微生物灵敏度试验:

按标签用法制备培养基,接种以下质控菌株,放置36±1℃需氧培养18-24小时。
注:回收率计算时,用TSA琼脂做对照培养基。


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Fluid Thioglycollate Medium
250g 用于药品、生物制品无菌检测,检测好氧菌和厌氧菌
JP0124-5 哥伦比亚琼脂(USP)(Columbia agar )
Columbia agar
250g 营养非常丰富,用于各种细菌的基础培养
JP0173-3 亮绿琼脂培养基(USP)(Brilliant Green Agar Medium)
Brilliant Green Agar Medium
250g 用于沙门氏菌(除伤寒沙门氏菌和志贺氏菌外)的分离培养
JP0116-5 紫红胆盐葡萄糖琼脂(USP)(Violet Red Bile Glucose Agar)
Violet Red Bile Glucose Agar
250g 用于肠道菌计数和肠杆菌科鉴别
JP4198-22 RV沙门菌增菌液体培养基(USP)(Rappaport Vassiliadis Salmonella Enrichment Broth)
Rappaport Vassiliadis Salmonella Enrichment Broth
250g 用于沙门氏菌选择性增菌培养
JP8484-3 荧光色素测定用培养基(USP)(Pseudomonas Agar Medium for Detection of Fluorescin )
Pseudomonas Agar Medium for Detection
250g 用于假单胞菌 ,特别是绿脓假单胞菌的分离和增殖培养,主要作荧光素鉴别用
JP5187-2 绿脓菌素测定用培养基(USP)(Pseudomonas Agar Medium for Detection of Pyocyanin)
Pseudomonas Agar Medium for Detection of Pyocyanin
250g 用于绿脓杆菌的绿脓菌素测定试验
JP9601 培养基34(USP)(Medium 34)
Medium 34
250g 用于微生物方法测定抗生素效价
JP9602 培养基35(USP)(Medium 35)
Medium 35
250g 用于微生物方法测定抗生素效价
JP9603 培养基36(USP)(Medium 36)
Medium 36
250g 用于微生物方法测定抗生素效价
JP9604 培养基40(USP)(Medium 40)
Medium 40
250g 用于微生物方法测定抗生素效价
JP9605 培养基41(USP)(Medium 41)
Medium 41
250g 用于微生物方法测定抗生素效价
JPKP8313 麦康凯肉汤(USP)(颗粒)(MacConkey Broth)
MacConkey Broth
250g 用于大肠杆菌、大肠菌群的检测