RP-3500(Synonyms: ATR inhibitor 4)

发表于2024年2月27日由上海金畔生物科技有限公司

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

RP-3500 (Synonyms: ATR inhibitor 4)

RP-3500 (ATR inhibitor 4) 是一种口服有效的，选择性 ATR 激酶抑制剂 (ATRi)，在生化试验中的 IC₅₀ 为 1.00 nM。RP-3500 对 ATR 的选择性是 mTOR 的 30 倍 (IC₅₀=120 nM)，是 ATM、DNA-PK 和 PI3Kα 激酶的 > 2,000 倍。RP-3500 具有有效的抗肿瘤活性。

RP-3500 Chemical Structure

CAS No. : 2417489-10-0

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生物活性

RP-3500 (ATR inhibitor 4) is an orally active, selective ATR kinase inhibitor (ATRi) with an IC₅₀ of 1.00 nM in biochemical assays. RP-3500 shows 30-fold selectivity for ATR over mTOR (IC₅₀=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. RP-3500 has potent antitumor activity^[1].

IC₅₀ & Target^[1]

ATR

ATM

>30 μM (IC₅₀)

mTOR

120 nM (IC₅₀)

体外研究
(In Vitro)

RP-3500 (ATR inhibitor 4; 1 μM; 1-24 hours) inhibits CHK1(Ser345) phosphorylation from 1 to 3 hours^[1].
RP-3500 inhibits Gemcitabine stimulated ATR phosphorylation of its substrate pCHK1(Ser345) with an IC₅₀ of 0.33 nM in a LoVo cell-based assay^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	LoVo and CW-2 human colon cancer cell lines
Concentration:	1 μM
Incubation Time:	1, 2, 4, 6, 8, 16, 24 hours
Result:	Inhibited CHK1(Ser345) phosphorylation from 1 to 3 hours. Starting at 4 hours, CHK1(Ser345) became re-phosphorylated as DNA-PKcs became activated in treated cells, along with its substrates KAP1 and H2AX.

体内研究
(In Vivo)

RP-3500 (ATR inhibitor 4; 3, 7, 15 mg/kg; Orally; once daily for 18 days) produces dose-dependent tumor growth inhibition with a minimum effective dose (MED) of 7 mg/kg in LoVo xenografts^[1].
RP-3500 (5, 10 mg/kg; Orally; once daily) produces statistically significant tumor growth inhibition in the CW-2 colon xenograft model^[1].
RP-3500 (7 mg/kg; for 7 days) results in 8.1- and 2.7-fold inductions of KAP1 and DNA-PKcs phosphorylation in mice bearing LoVo tumors^[1].
RP-3500 has a more profound anti-tumor effect occurred at higher doses on the 3 days on/4 days off (30 mg/kg) and 5 days on/2 days off (25 mg/kg) schedules compared with consecutive daily administrations (10 mg/kg) at a lower dose for 14 days^[1].
RP-3500 (15mg/kg) combined PARPi Olaparib (80mg/kg; both agents days 1-3 on/4 days off) or sequential (PARPi for 3 days followed by RP-3500 for 3 days then 1 day off) schedules produces greater antiTumor effects compared with sequential administration without affecting tolerability^[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female mice (6-8 weeks old) bearing LoVo xenografts^[1]
Dosage:	3, 7, 15 mg/kg (0.5% methylcellulose/0.02% SDS vehicle)
Administration:	Orally; once daily for 18 days
Result:	Produced dose-dependent tumor growth inhibition with a minimum effective dose (MED) of 7 mg/kg. The maximum tolerated dose (MTD) was 10 mg/kg once daily on a continuous dosing schedule.

分子量

410.47

Formula

C₂₁H₂₆N₆O₃

CAS 号

2417489-10-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Anne Roulston, et al. RP-3500: A Novel, Potent and Selective ATR Inhibitor that is Effective in Preclinical Models as a Monotherapy and in Combination with PARP Inhibitors. Mol Cancer Ther

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NU6027

发表于2024年2月23日由上海金畔生物科技有限公司

NU6027 纯度: 99.35%

NU6027 是一种有效且的、ATP竞争性的 CDK1 和 CDK2 的抑制剂，K_i 值分别为 2.5 µM 和 1.3 µM。NU6027 也是 ATR 的有效抑制剂，以 ATR 依赖性方式增强羟基脲和顺铂的细胞毒性。

NU6027 Chemical Structure

CAS No. : 220036-08-8

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25 mg	￥2500	In-stock
50 mg	￥4000	In-stock
100 mg	￥6000	In-stock
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NU6027 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Cell Cycle/DNA Damage Compound Library
Kinase Inhibitor Library
PI3K/Akt/mTOR Compound Library
Anti-Cancer Compound Library
Anti-Aging Compound Library
Oxygen Sensing Compound Library
Glycolysis Compound Library
Cytoskeleton Compound Library
Anti-Breast Cancer Compound Library
Anti-Pancreatic Cancer Compound Library
Anti-Blood Cancer Compound Library
Anti-Cancer Metabolism Compound Library
Glucose Metabolism Compound Library

生物活性

NU6027 is a potent and ATP-competitive inhibitor of both CDK1 and CDK2, with K_is of 2.5 µM and 1.3 µM, respectively. NU6027 is also a potent inhibitor of ATR and enhances hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner^[1]^[2].

IC₅₀ & Target^[1]^[2]

CDK1

2.5 μM (Ki)

CDK2

1.3 μM (Ki)

ATR

体外研究
(In Vitro)

NU6027 (1 nM-100 µM; 48 h) inhibits the growth of human tumor cells with a GI₅₀ of 10±6 µM^[1].
NU6027 (0.1-25 µM; 24 h) inhibits ATR activity with an IC₅₀ of 2.8 µM in GM847KD cells. NU6027 (1-10 µM; 24 h) inhibits ATR activity with an IC₅₀ of 6.7±2.3 µM in MCF7 cells^[2].
NU6027 (4 or 10 µM; 24 h) attenuates G2/M arrest following DNA damage in MCF7 cells^[2].
NU6027 (10 µM; 24 h) significantly reduces RAD51 foci in both control and PF-01367338-treated V-C8 B2 cells^[2].
NU6027 (4 µM; 24 h) causes 82% suppression of the increase in RAD51 foci-positive cells treated by PF-01367338^[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:	MCF7 cells
Concentration:	0, 1, 5, 10 μM
Incubation Time:	24 h
Result:	Inhibited CDK2-mediated pRb^T821 by 42±27% compared with 70±12% inhibition of pCHK1^S345 with the concentration of 10 µM.

分子量

251.28

Formula

C₁₁H₁₇N₅O₂

CAS 号

220036-08-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 12.5 mg/mL (49.75 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.9796 mL	19.8981 mL	39.7962 mL
5 mM	0.7959 mL	3.9796 mL	7.9592 mL
10 mM	0.3980 mL	1.9898 mL	3.9796 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 1.25 mg/mL (4.97 mM); Clear solution

此方案可获得 ≥ 1.25 mg/mL (4.97 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.25 mg/mL (4.97 mM); Clear solution

此方案可获得 ≥ 1.25 mg/mL (4.97 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Arris CE, et, al. Identification of novel purine and pyrimidine cyclin-dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles. J Med Chem. 2000 Jul 27; 43(15): 2797-804.

[2]. Peasland A, et, al. Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines. Br J Cancer. 2011 Jul 26;105(3):372-81.

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ATR inhibitor 1

发表于2024年1月14日由上海金畔生物科技有限公司

ATR inhibitor 1

ATR inhibitor 1 是一种 ATR 抑制剂，K_i 值低于 1 µΜ，详细信息请参考专利 WO2015187451A1，化合物 I-l。

ATR inhibitor 1 Chemical Structure

CAS No. : 1613200-51-3

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生物活性	ATR inhibitor 1 is a ATR inhibitor extracted from patent WO2015187451A1, compound I-l, has a K_i value below 1 µΜ^[1].
IC₅₀ & Target	Ki: ﹤1 uM^[1]
分子量	370.32
Formula	C₁₆H₁₂F₂N₈O
CAS 号	1613200-51-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Nadia AHMAD, et al. Radiolabelled derivatives of a 2-amino-6-fluoro-n-[5-fluoro-pyridin-3-yl]- pyrazolo[1,5-a]pyrimidin-3-carboxamide compound useful as atr kinase inhibitor, the preparation of said compound and different solid forms thereof. WO2015187451A1

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ATR-IN-13

发表于2023年12月21日由上海金畔生物科技有限公司

ATR-IN-13

ATR-IN-13 (化合物 A9) 是一种有效的 ATR 激酶抑制剂，其 IC₅₀ 值为 2 nM。ATR-IN-13 可用于 ATR 激酶介导的疾病研究，如增生性疾病和癌症。

ATR-IN-13 Chemical Structure

CAS No. : 2758113-84-5

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生物活性

ATR-IN-13 (compound A9) is a potent ATR kinase inhibitor, with an IC₅₀ of 2 nM. ATR-IN-13 can be used for ATR kinase mediated diseases research, such as proliferative diseases and cancer^[1].

IC₅₀ & Target

ATR

2 nM (IC₅₀)

分子量

473.51

Formula

C₂₄H₂₄FN₉O

CAS 号

2758113-84-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Xiangling Zheng, et al. Pyrazolopyrimidine compounds as ATR kinase inhibitors. CN113929688A.

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ATR-IN-15

发表于2023年12月21日由上海金畔生物科技有限公司

ATR-IN-15

ATR-IN-15 (化合物 1) 是一种口服有效的 ATR 激酶抑制剂，其 IC₅₀ 值为 8 nM。ATR-IN-15 还抑制人结肠癌肿瘤细胞 LoVo、DNA-PK 和 PI3K，IC₅₀ 值分别为 47、663 和 5131 nM。

ATR-IN-15 Chemical Structure

CAS No. : 2756665-52-6

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生物活性

ATR-IN-15 (compound 1) is an orally active and potent ATR kinase inhibitor, with an IC₅₀ of 8 nM. ATR-IN-15 also inhibits human colon tumor cells LoVo, DNA-PK and PI3K, with IC₅₀ values of 47, 663 and 5131 nM, respectively^[1].

IC₅₀ & Target

ATR

8 nM (IC₅₀)

PI3K

5131 nM (IC₅₀)

ATM

> 10000 nM (IC₅₀)

分子量

378.43

Formula

C₁₉H₂₂N₈O

CAS 号

2756665-52-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Xin Li, et al. Imidazopyrimidine derivative, preparation method therefor and medical use thereof. WO2022002243A1.

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ATR-IN-16

发表于2023年12月20日由上海金畔生物科技有限公司

ATR-IN-16

ATR-IN-16 (化合物 46) 是一种有效的 ATR 激酶抑制剂。ATR-IN-16 在 LoVo 细胞中表现出良好的抗癌活性，IC₅₀ 为 410 nM。

ATR-IN-16 Chemical Structure

CAS No. : 2756589-62-3

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生物活性

ATR-IN-16 (compound 46) is a potent ATR kinase inhibitor. ATR-IN-16 shows good anticancer activity in LoVo cells, with an IC₅₀ of 410 nM^[1].

IC₅₀ & Target

ATR

分子量

367.45

Formula

C₁₉H₂₅N₇O

CAS 号

2756589-62-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Bo Shan, et al. Atr inhibitors and uses thereof. WO2022002245A1.

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ATR-IN-10

发表于2023年12月7日由上海金畔生物科技有限公司

ATR-IN-10

ATR-IN-10 是一种有效且高选择性 ATR 激酶的抑制剂，其IC₅₀值为 2.978 μM。

ATR-IN-10 Chemical Structure

CAS No. : 2713577-93-4

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生物活性

ATR-IN-10 is a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase with an IC₅₀ value of 2.978 μM.

IC₅₀ & Target

ATR

2.978 μM (IC₅₀)

分子量

420.51

Formula

C₂₇H₂₄N₄O

CAS 号

2713577-93-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Bin H, et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187.

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ATR-IN-10

发表于2023年12月7日由上海金畔生物科技有限公司

ATR-IN-10

ATR-IN-10 是一种有效且高选择性 ATR 激酶的抑制剂，其IC₅₀值为 2.978 μM。

ATR-IN-10 Chemical Structure

CAS No. : 2713577-93-4

规格		是否有货
100 mg		询价
250 mg		询价
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生物活性

ATR-IN-10 is a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase with an IC₅₀ value of 2.978 μM.

IC₅₀ & Target

ATR

2.978 μM (IC₅₀)

分子量

420.51

Formula

C₂₇H₂₄N₄O

CAS 号

2713577-93-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Bin H, et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187.

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ATR-IN-10

发表于2023年12月7日由上海金畔生物科技有限公司

ATR-IN-10

ATR-IN-10 是一种有效且高选择性 ATR 激酶的抑制剂，其IC₅₀值为 2.978 μM。

ATR-IN-10 Chemical Structure

CAS No. : 2713577-93-4

规格		是否有货
100 mg		询价
250 mg		询价
500 mg		询价

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生物活性

ATR-IN-10 is a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase with an IC₅₀ value of 2.978 μM.

IC₅₀ & Target

ATR

2.978 μM (IC₅₀)

分子量

420.51

Formula

C₂₇H₂₄N₄O

CAS 号

2713577-93-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献

[1]. Bin H, et al. Discovery of a potent and highly selective inhibitor of ataxia telangiectasia mutated and Rad3-Related (ATR) kinase: Structural activity relationship and antitumor activity both in vitro and in vivo. Eur J Med Chem. 2022 Feb 12;232:114187.

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ATR-IN-5

发表于2023年12月3日由上海金畔生物科技有限公司

ATR-IN-5

ATR-IN-5 是一种有效的 ATR 抑制剂。ATR 是一类参与基因组稳定性和 DNA 损伤修复的蛋白激酶，是 PIKK 家族的成员。ATR-IN-5具有研究ATR激酶介导的疾病如增殖性疾病和癌症的潜力 (信息摘自专利CN112047938A，化合物D24)。

ATR-IN-5 Chemical Structure

CAS No. : 2601571-19-9

规格		是否有货
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生物活性	ATR-IN-5 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-5 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent CN112047938A, compound D24)^[1].
分子量	555.60
Formula	C₂₇H₃₂F₃N₉O
CAS 号	2601571-19-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zhao, Yanping, et al. 2,4,6-Trisubstituted pyrimidine compounds as atr kinase inhibitors. Patent CN112047938A.

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ATR-IN-6

发表于2023年12月3日由上海金畔生物科技有限公司

ATR-IN-6

ATR-IN-6 是一种有效的 ATR 抑制剂。ATR 是一类参与基因组稳定性和 DNA 损伤修复的蛋白激酶，是 PIKK 家族的成员。ATR-IN-6 具有研究ATR激酶介导的疾病如增殖性疾病和癌症的潜力 (信息摘自专利 WO2021233376A1，化合物 A22)。

ATR-IN-6 Chemical Structure

CAS No. : 2746446-99-9

规格		是否有货
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生物活性	ATR-IN-6 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-6 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent WO2021233376A1, compound A22)^[1].
分子量	513.57
Formula	C₂₈H₂₈FN₇O₂
CAS 号	2746446-99-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zhao, Yanping, et al. 2,4,6-Trisubstituted pyrimidine compounds as atr kinase inhibitors. Patent WO2021233376A1.

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ATR-IN-5

发表于2023年12月3日由上海金畔生物科技有限公司

ATR-IN-5

ATR-IN-5 Chemical Structure

CAS No. : 2601571-19-9

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生物活性	ATR-IN-5 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-5 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent CN112047938A, compound D24)^[1].
分子量	555.60
Formula	C₂₇H₃₂F₃N₉O
CAS 号	2601571-19-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zhao, Yanping, et al. 2,4,6-Trisubstituted pyrimidine compounds as atr kinase inhibitors. Patent CN112047938A.

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ATR-IN-5

发表于2023年12月3日由上海金畔生物科技有限公司

ATR-IN-5

ATR-IN-5 Chemical Structure

CAS No. : 2601571-19-9

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100 mg		询价
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生物活性	ATR-IN-5 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-5 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent CN112047938A, compound D24)^[1].
分子量	555.60
Formula	C₂₇H₃₂F₃N₉O
CAS 号	2601571-19-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zhao, Yanping, et al. 2,4,6-Trisubstituted pyrimidine compounds as atr kinase inhibitors. Patent CN112047938A.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

ATR-IN-6

发表于2023年12月3日由上海金畔生物科技有限公司

ATR-IN-6

ATR-IN-6 Chemical Structure

CAS No. : 2746446-99-9

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生物活性	ATR-IN-6 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-6 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent WO2021233376A1, compound A22)^[1].
分子量	513.57
Formula	C₂₈H₂₈FN₇O₂
CAS 号	2746446-99-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zhao, Yanping, et al. 2,4,6-Trisubstituted pyrimidine compounds as atr kinase inhibitors. Patent WO2021233376A1.

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ATR-IN-7

发表于2023年12月3日由上海金畔生物科技有限公司

ATR-IN-7

ATR-IN-7 是一种有效的 ATR 抑制剂。ATR 是一类参与基因组稳定性和 DNA 损伤修复的蛋白激酶，是 PIKK 家族的成员。ATR-IN-7 具有研究ATR激酶介导的疾病如增殖性疾病和癌症的潜力 (信息摘自专利 WO2021238999A1，化合物 1)。

ATR-IN-7 Chemical Structure

CAS No. : 2741917-74-6

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生物活性	ATR-IN-7 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-7 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent WO2021238999A1, compound 1)^[1].
分子量	407.44
Formula	C₂₁H₂₂FN₇O
CAS 号	2741917-74-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Kun Fang, et al. Fluorinated pyrrolopyridines and their applications. Patent WO2021238999A1.

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ATR-IN-6

发表于2023年12月3日由上海金畔生物科技有限公司

ATR-IN-6

ATR-IN-6 Chemical Structure

CAS No. : 2746446-99-9

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生物活性	ATR-IN-6 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-6 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent WO2021233376A1, compound A22)^[1].
分子量	513.57
Formula	C₂₈H₂₈FN₇O₂
CAS 号	2746446-99-9
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Zhao, Yanping, et al. 2,4,6-Trisubstituted pyrimidine compounds as atr kinase inhibitors. Patent WO2021233376A1.

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ATR-IN-7

发表于2023年12月3日由上海金畔生物科技有限公司

ATR-IN-7

ATR-IN-7 Chemical Structure

CAS No. : 2741917-74-6

规格		是否有货
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生物活性	ATR-IN-7 is a potent inhibitor of ATR. ATR is a class of protein kinases involved in genome stability and DNA damage repair, and is a member of the PIKK family. ATR-IN-7 has the potential for the research of ATR kinase-mediated diseases such as proliferative diseases and cancer (extracted from patent WO2021238999A1, compound 1)^[1].
分子量	407.44
Formula	C₂₁H₂₂FN₇O
CAS 号	2741917-74-6
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Kun Fang, et al. Fluorinated pyrrolopyridines and their applications. Patent WO2021238999A1.

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ATR-IN-12

发表于2023年11月26日由上海金畔生物科技有限公司

ATR-IN-12

ATR-IN-12 (Compound 5g) 是一种有效的共济失调毛细血管扩张和 Rad3 相关 (ATR) 激酶抑制剂，IC₅₀ 值 0.007 μM。ATR-IN-12 显示出良好的抗肿瘤活性并显着降低 ATR 及其下游信号蛋白的磷酸化水平。ATR-IN-12 是一种很有前途的先导化合物，可用于后续针对 ATR 激酶的药物发现。

ATR-IN-12 Chemical Structure

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生物活性	ATR-IN-12 (Compound 5g) is a potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase with an IC₅₀ value of 0.007 μM. ATR-IN-12 displays good anti-tumor activity and significantly reduces the phosphorylation level of ATR and its downstream signaling protein. ATR-IN-12 is a promising lead compound for subsequent drug discovery targeting ATR kinase^[1].
分子量	441.55
Formula	C₂₂H₂₇N₅O₃S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Chen P, et al. Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors. Bioorg Med Chem Lett. 2022;63:128651.

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ATR-IN-12

发表于2023年11月26日由上海金畔生物科技有限公司

ATR-IN-12

ATR-IN-12 Chemical Structure

规格		是否有货
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生物活性	ATR-IN-12 (Compound 5g) is a potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase with an IC₅₀ value of 0.007 μM. ATR-IN-12 displays good anti-tumor activity and significantly reduces the phosphorylation level of ATR and its downstream signaling protein. ATR-IN-12 is a promising lead compound for subsequent drug discovery targeting ATR kinase^[1].
分子量	441.55
Formula	C₂₂H₂₇N₅O₃S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Chen P, et al. Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors. Bioorg Med Chem Lett. 2022;63:128651.

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ATR-IN-12

发表于2023年11月26日由上海金畔生物科技有限公司

ATR-IN-12

ATR-IN-12 Chemical Structure

规格		是否有货
100 mg		询价
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生物活性	ATR-IN-12 (Compound 5g) is a potent inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase with an IC₅₀ value of 0.007 μM. ATR-IN-12 displays good anti-tumor activity and significantly reduces the phosphorylation level of ATR and its downstream signaling protein. ATR-IN-12 is a promising lead compound for subsequent drug discovery targeting ATR kinase^[1].
分子量	441.55
Formula	C₂₂H₂₇N₅O₃S
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Chen P, et al. Discovery of 6,7-dihydro-5H-pyrrolo[3,4-d] pyrimidine derivatives as a new class of ATR inhibitors. Bioorg Med Chem Lett. 2022;63:128651.

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赛默飞Acros试剂中国官网 Alfa aesar阿法埃莎中国代理商

标签归档：atr

RP-3500(Synonyms: ATR inhibitor 4)

NU6027

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