Ceramide C6-d7

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Ceramide C6-d7 

Ceramide C6-d7 是 Ceramide C6 的氘代物。Ceramide C6, a Ceramide pathway activator, is an exogenous short-chain ceramide which can induce apoptosis of multiple cancer cells.

Ceramide C6-d7

Ceramide C6-d7 Chemical Structure

CAS No. : 2692624-22-7

规格 是否有货
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生物活性

Ceramide C6-d7 is the deuterium labeled Ceramide C6. Ceramide C6 是神经酰胺途径激活剂,是一种外源性短链神经酰胺,可诱导多种癌细胞凋亡。

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

404.68

Formula

C24H40D7NO3

CAS 号

2692624-22-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Qiu L, et al. C6-ceramide induces salivary adenoid cystic carcinoma cell apoptosis via IP3R-activated UPR and UPR-independent pathways. Biochem Biophys Res Commun. 2020;525(4):997-1003.

    [3]. Liu L, et al. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020;18(1):298. Published 2020 Aug 3.

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C8 Dihydroceramide

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

C8 Dihydroceramide 

C8 Dihydroceramide 是C8 Ceramide 的阴性对照。C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) 是一种细胞渗透性的内源性神经酰胺类似物。C8-Ceramide 具有具有抗增殖特性,能作为化疗试剂。C8-Ceramide 能刺激树突状细胞促进 T 细胞对病毒感染的反应。C8-Ceramide 在体外能轻微地诱导 PKC 活化。

C8 Dihydroceramide

C8 Dihydroceramide Chemical Structure

CAS No. : 145774-33-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

C8 Dihydroceramide is a negative control of C8 Ceramide. C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro[1][2][3][4].

体外研究
(In Vitro)

C8-dihydro-ceramide had no effect on cell viability in any of the cell lines tested[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

427.70

Formula

C26H53NO3

CAS 号

145774-33-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Rebeca López-Marure , et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293(3):1028-36.

    [2]. Yuli C. Chang, et al. Exogenous C8-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018 Oct; 19(10): 3010.

    [3]. H W Huang, et al. Ceramides modulate protein kinase C activity and perturb the structure of Phosphatidylcholine/Phosphatidylserine bilayers. Biophys J. 1999 Sep; 77(3): 1489-1497.

    [4]. Lan Weiss, et al. Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy. Hum Mol Genet. 2021 Jan 7;ddaa248.

    [5]. Rebeca López-Marure, et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293(3):1028-36.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

C8 Dihydroceramide

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

C8 Dihydroceramide 

C8 Dihydroceramide 是C8 Ceramide 的阴性对照。C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) 是一种细胞渗透性的内源性神经酰胺类似物。C8-Ceramide 具有具有抗增殖特性,能作为化疗试剂。C8-Ceramide 能刺激树突状细胞促进 T 细胞对病毒感染的反应。C8-Ceramide 在体外能轻微地诱导 PKC 活化。

C8 Dihydroceramide

C8 Dihydroceramide Chemical Structure

CAS No. : 145774-33-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

C8 Dihydroceramide is a negative control of C8 Ceramide. C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro[1][2][3][4].

体外研究
(In Vitro)

C8-dihydro-ceramide had no effect on cell viability in any of the cell lines tested[5].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

427.70

Formula

C26H53NO3

CAS 号

145774-33-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Rebeca López-Marure , et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293(3):1028-36.

    [2]. Yuli C. Chang, et al. Exogenous C8-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018 Oct; 19(10): 3010.

    [3]. H W Huang, et al. Ceramides modulate protein kinase C activity and perturb the structure of Phosphatidylcholine/Phosphatidylserine bilayers. Biophys J. 1999 Sep; 77(3): 1489-1497.

    [4]. Lan Weiss, et al. Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy. Hum Mol Genet. 2021 Jan 7;ddaa248.

    [5]. Rebeca López-Marure, et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293(3):1028-36.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

C8 Dihydroceramide

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

C8 Dihydroceramide 

C8 Dihydroceramide 是C8 Ceramide 的阴性对照。C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) 是一种细胞渗透性的内源性神经酰胺类似物。C8-Ceramide 具有具有抗增殖特性,能作为化疗试剂。C8-Ceramide 能刺激树突状细胞促进 T 细胞对病毒感染的反应。C8-Ceramide 在体外能轻微地诱导 PKC 活化。

C8 Dihydroceramide

C8 Dihydroceramide Chemical Structure

CAS No. : 145774-33-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

C8 Dihydroceramide is a negative control of C8 Ceramide. C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro[1][2][3][4].

体外研究
(In Vitro)

C8-dihydro-ceramide had no effect on cell viability in any of the cell lines tested[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

427.70

Formula

C26H53NO3

CAS 号

145774-33-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Rebeca López-Marure , et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293(3):1028-36.

    [2]. Yuli C. Chang, et al. Exogenous C8-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018 Oct; 19(10): 3010.

    [3]. H W Huang, et al. Ceramides modulate protein kinase C activity and perturb the structure of Phosphatidylcholine/Phosphatidylserine bilayers. Biophys J. 1999 Sep; 77(3): 1489-1497.

    [4]. Lan Weiss, et al. Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy. Hum Mol Genet. 2021 Jan 7;ddaa248.

    [5]. Rebeca López-Marure, et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293(3):1028-36.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

C6 Ceramide(Synonyms: C6-Cer; N-Hexanoylsphingosine)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

C6 Ceramide (Synonyms: C6-Cer; N-Hexanoylsphingosine)

C6-ceramide是一种神经酰胺途径激活剂,对多种癌细胞系具有活性。C6-ceramide 可用作化疗剂的佐剂,以增强抗肿瘤作用。

C6 Ceramide(Synonyms: C6-Cer;  N-Hexanoylsphingosine)

C6 Ceramide Chemical Structure

CAS No. : 124753-97-5

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

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生物活性

C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects[1][2].

分子量

397.63

Formula

C24H47NO3

CAS 号

124753-97-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Zhu Q, et, al. C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. Cell Death Dis. 2011 Jan 27;2(1):e117.

    [2]. Liu L, et, al. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020 Aug 3;18(1):298.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

C12-Ceramide(Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

C12-Ceramide (Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

C12-Ceramide (N-Lauroyl-D-erythro-sphingosine) 是一种天然存在的神经酰胺,由 C12 鞘磷脂水解形成。C12-Ceramide 可以增强 MDA-MB-231 细胞中 Doxorubicin 的毒性。C12-Ceramide 还可用于诊断 A 型和 B 型尼曼匹克症。

C12-Ceramide(Synonyms: N-Lauroyl-D-erythro-sphingosine;  N-Laurylsphingosine)

C12-Ceramide Chemical Structure

CAS No. : 74713-60-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1].

体外研究
(In Vitro)

C12-Ceramide (1 μM; 24-72 h) enhances the liposomal Doxorubicin toxicity in MDA-MB-231 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

481.79

Formula

C30H59NO3

CAS 号

74713-60-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. He X, et, al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314(1):116-20.

    [2]. Øverbye A, et, al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8(44):76921-76934.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

C12-Ceramide(Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

C12-Ceramide (Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

C12-Ceramide (N-Lauroyl-D-erythro-sphingosine) 是一种天然存在的神经酰胺,由 C12 鞘磷脂水解形成。C12-Ceramide 可以增强 MDA-MB-231 细胞中 Doxorubicin 的毒性。C12-Ceramide 还可用于诊断 A 型和 B 型尼曼匹克症。

C12-Ceramide(Synonyms: N-Lauroyl-D-erythro-sphingosine;  N-Laurylsphingosine)

C12-Ceramide Chemical Structure

CAS No. : 74713-60-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1].

体外研究
(In Vitro)

C12-Ceramide (1 μM; 24-72 h) enhances the liposomal Doxorubicin toxicity in MDA-MB-231 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

481.79

Formula

C30H59NO3

CAS 号

74713-60-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. He X, et, al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314(1):116-20.

    [2]. Øverbye A, et, al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8(44):76921-76934.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

C12-Ceramide(Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

C12-Ceramide (Synonyms: N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine)

C12-Ceramide (N-Lauroyl-D-erythro-sphingosine) 是一种天然存在的神经酰胺,由 C12 鞘磷脂水解形成。C12-Ceramide 可以增强 MDA-MB-231 细胞中 Doxorubicin 的毒性。C12-Ceramide 还可用于诊断 A 型和 B 型尼曼匹克症。

C12-Ceramide(Synonyms: N-Lauroyl-D-erythro-sphingosine;  N-Laurylsphingosine)

C12-Ceramide Chemical Structure

CAS No. : 74713-60-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

C12-Ceramide (N-Lauroyl-D-erythro-sphingosine), a naturally occurring ceramide, is formed by hydrolysis of C12 sphingomyelin. C12-Ceramide can enhance the Doxorubicin toxicity in MDA-MB-231 cells. C12-Ceramide also can be used to diagnose types A and B Niemann-Pick disease[1][1].

体外研究
(In Vitro)

C12-Ceramide (1 μM; 24-72 h) enhances the liposomal Doxorubicin toxicity in MDA-MB-231 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

481.79

Formula

C30H59NO3

CAS 号

74713-60-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. He X, et, al. A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal Biochem. 2003 Mar 1;314(1):116-20.

    [2]. Øverbye A, et, al. Ceramide-containing liposomes with doxorubicin: time and cell-dependent effect of C6 and C12 ceramide. Oncotarget. 2017 Aug 12;8(44):76921-76934.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

C2 Ceramide (d14:1/2:0)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

C2 Ceramide (d14:1/2:0) 

C2 Ceramide (d14:1/2:0) 是一种用于诊断与环氧合酶 2 (COX2) 过度表达相关的疾病的组合物。C2 Ceramide (d14:1/2:0) 对 COX2 蛋白具有很强的结合活性 (信息提取自专利 WO2019235824A1)。

C2 Ceramide (d14:1/2:0)

C2 Ceramide (d14:1/2:0) Chemical Structure

CAS No. : 2097561-20-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

C2 Ceramide (d14:1/2:0) is a composition for diagnosing diseases associated with cyclooxygenase 2 (COX2) overexpression. C2 Ceramide (d14:1/2:0) exhibits a strong binding activity to COX2 protein (extracted from patent WO2019235824A1).

分子量

285.42

Formula

C16H31NO3

CAS 号

2097561-20-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Composition for diagnosing diseases associated with cox2 overexpression and screening method therefor. Patent WO2019235824A1.

所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

C2 Ceramide (d14:1/2:0)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

C2 Ceramide (d14:1/2:0) 

C2 Ceramide (d14:1/2:0) 是一种用于诊断与环氧合酶 2 (COX2) 过度表达相关的疾病的组合物。C2 Ceramide (d14:1/2:0) 对 COX2 蛋白具有很强的结合活性 (信息提取自专利 WO2019235824A1)。

C2 Ceramide (d14:1/2:0)

C2 Ceramide (d14:1/2:0) Chemical Structure

CAS No. : 2097561-20-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

C2 Ceramide (d14:1/2:0) is a composition for diagnosing diseases associated with cyclooxygenase 2 (COX2) overexpression. C2 Ceramide (d14:1/2:0) exhibits a strong binding activity to COX2 protein (extracted from patent WO2019235824A1).

分子量

285.42

Formula

C16H31NO3

CAS 号

2097561-20-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Composition for diagnosing diseases associated with cox2 overexpression and screening method therefor. Patent WO2019235824A1.

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C2 Ceramide (d14:1/2:0)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

C2 Ceramide (d14:1/2:0) 

C2 Ceramide (d14:1/2:0) 是一种用于诊断与环氧合酶 2 (COX2) 过度表达相关的疾病的组合物。C2 Ceramide (d14:1/2:0) 对 COX2 蛋白具有很强的结合活性 (信息提取自专利 WO2019235824A1)。

C2 Ceramide (d14:1/2:0)

C2 Ceramide (d14:1/2:0) Chemical Structure

CAS No. : 2097561-20-9

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生物活性

C2 Ceramide (d14:1/2:0) is a composition for diagnosing diseases associated with cyclooxygenase 2 (COX2) overexpression. C2 Ceramide (d14:1/2:0) exhibits a strong binding activity to COX2 protein (extracted from patent WO2019235824A1).

分子量

285.42

Formula

C16H31NO3

CAS 号

2097561-20-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Composition for diagnosing diseases associated with cox2 overexpression and screening method therefor. Patent WO2019235824A1.

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C8-Ceramide(Synonyms: N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

C8-Ceramide (Synonyms: N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine) 纯度: ≥98.0%

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) 是一种细胞渗透性的内源性神经酰胺类似物。C8-Ceramide 具有具有抗增殖特性,能作为化疗试剂。C8-Ceramide 能刺激树突状细胞促进 T 细胞对病毒感染的反应。C8-Ceramide 在体外能轻微地诱导 PKC 活化。

C8-Ceramide(Synonyms: N-辛酰基-D-神经鞘氨醇; N-Octanoyl-D-erythro-sphingosine)

C8-Ceramide Chemical Structure

CAS No. : 74713-59-0

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C8-Ceramide 相关产品

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生物活性

C8-Ceramide (N-Octanoyl-D-erythro-sphingosine) is a cell-permeable analog of naturally occurring ceramides. C8-Ceramide has anti-proliferation properties and acts as a potent chemotherapeutic agent. C8-Ceramide stimulates dendritic cells to promote T cell responses upon virus infections. C8-Ceramide induces slight activation of protein kinase (PKC) in vitro[1][2][3][4].

IC50 & Target[2][4][5]

PKC

 

apoptosis

 

autophagy

 

体外研究
(In Vitro)

C8-ceramide (3 μM; 48 hours) irreversibly reduces tumor-cell proliferation and induces morphological changes[1].
C8-ceramide can induce necrosis-like cell death, but does not induce caspase-dependent cleavage of PARP (biochemical marker of apoptosis) in human cervical tumor cells[1].
C8-ceramide may increase the endogenous ROS level (10-30 µM; 24 hours) by regulating the switch of SOD1 and SOD2, causing the anti-proliferation (10-50 µM; 24 hours), and consequently triggering the apoptosis (10-50 µM; 48 hours) of NSCLC H1299 cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: CALO cells, INBL cells, HeLa cells
Concentration: 3 μM
Incubation Time: 48 hours
Result: Markedly reduced the tumor cell number.

Cell Proliferation Assay[2]

Cell Line: H1299 cells
Concentration: 10 µM, 20 µM, 30 µM, 40 µM, 50 µM
Incubation Time: 24 hours
Result: Decreased the rate of cellular proliferation in a dose-dependent manner, with an IC50 of 22.9 µM.

Cell Cycle Analysis[2]

Cell Line: H1299 cells
Concentration: 10 µM, 20 µM, 30 µM, 40 µM, 50 µM
Incubation Time: 24 hours
Result: Caused the G1 arrest.

Apoptosis Analysis[2]

Cell Line: H1299 cells
Concentration: 10 µM, 20 µM, 30 µM
Incubation Time: 24 hours, 48 hours
Result: Increased the level of cleaved caspase-3.

体内研究
(In Vivo)

C8-ceramide (0.1 mg/kg; intranasal administration) induces more robust CD8+ and CD4+ T cell responses to viral infections in virus infected mice[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice, with lymphocytic choriomeningitis virus infected[3]
Dosage: 0.1 mg/kg
Administration: Intranasal administration
Result: Increased the CD8+ T cell response to influenza in the lungs.

分子量

425.69

Formula

C26H51NO3

CAS 号

74713-59-0

中文名称

N-辛酰基-D-神经鞘氨醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

参考文献
  • [1]. Rebeca López-Marure , et al. Ceramide promotes the death of human cervical tumor cells in the absence of biochemical and morphological markers of apoptosis. Biochem Biophys Res Commun. 2002 May 10;293(3):1028-36.

    [2]. Yuli C. Chang, et al. Exogenous C8-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018 Oct; 19(10): 3010.

    [3]. Curtis J. Pritzl, et al. A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections. J Immunol. 2015 May 1; 194(9): 4339-4349.

    [4]. H W Huang, et al. Ceramides modulate protein kinase C activity and perturb the structure of Phosphatidylcholine/Phosphatidylserine bilayers. Biophys J. 1999 Sep; 77(3): 1489-1497.

    [5]. Lan Weiss, et al. Ceramide contributes to pathogenesis and may be targeted for therapy in VCP inclusion body myopathy. Hum Mol Genet. 2021 Jan 7;ddaa248.

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