标签归档：cgp

CGP52411(Synonyms: DAPH)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CGP52411 (Synonyms: DAPH)

CGP52411 (DAPH) 是一种高选择性，有效，口服活性和 ATP 竞争性的 EGFR 抑制剂，IC50 为 0.3 μM。CGP52411 阻止有毒的 Ca2+ 离子流入神经元细胞，并显着抑制和逆转与阿尔茨海默症相关的 β-amyloid (Aβ42) 原纤维聚集物的形成。

CGP52411(Synonyms: DAPH)

CGP52411 Chemical Structure

CAS No. : 145915-58-8

规格 价格 是否有货
5 mg ￥6600 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

CGP52411 (DAPH) is a high selective, potent, orally active and ATP-competitive EGFR inhibitor with an IC50 of 0.3 μM. CGP52411 blocks the toxic influx of Ca2+ ions into neuronal cells, and dramatic inhibits and reverses the formation of β-amyloid (Aβ42) fibril aggregates associated with Alzheimer’s disease[1][2].

IC50 & Target[1][2]

EGFR

0.3 μM (IC50)

Amyloid-β

 

体外研究
(In Vitro)

CGP52411 (DAPH; 0-100 μM; 90 minutes; A431 cells) treatment inhibits autophosphorylation and c-src autophosphorylation in vitro in a dose-dependent manner with IC50s of 1 μM and 16 μM, respectively. CGP52411 treatment also shows a concentration-dependent reduction in tyrosine phosphorylation of p185c-erbB2 with an IC50 value of 10 μM[1].
CGP52411 (DAPH) inhibits c-src kinase with an IC50 value of 16 μM. CGP52411 inhibits PKC isozymes isolated from porcine brain with an IC50 of 80 μM. CGP52411 inhibits conventional PKC isozymes (cPKCs α, β-1, β-2, and γ) but not nonconventional PKC isozymes (nPKCs δ, ε, and ζ) or atypical PKC isozymes (aPKC η)[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: A431 cells
Concentration: 0 μM, 0.1 μM, 1 μM, 10 μM, 50 μM, 100 μM
Incubation Time: 90 minutes
Result: Inhibited autophosphorylation in vitro in a dose-dependent manner with an IC50 of 1 μM. c-src autophosphorylation was inhibited with an IC50 of 16 μM. And also resulted in a concentration-dependent reduction in tyrosine phosphorylation of p185c-erbB2, with an estimated IC50 value of 10 μM.

体内研究
(In Vivo)

CGP52411 (3.2 mg/kg, 6.3 mg/kg, 12.5 mg/kg, 25 mg/kg, and 50 mg/kg; oral administration; daily; for 15 days; female BALB/c nude mice) treatment in vivo against xenografts of the A431 and SK-OV-3 tumors, and has antitumor activity[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nude mice injected with A431cells[1]
Dosage: 3.2 mg/kg, 6.3 mg/kg, 12.5 mg/kg, 25 mg/kg, and 50 mg/kg
Administration: Oral administration; daily; for 15 days
Result: Antitumor efficacy was obtained at doses between 50 mg/kg and 6.3 mg/kg.

分子量

329.35

Formula

C20H15N3O2
CAS 号

145915-58-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Buchdunger E, et al. 4,5-Dianilinophthalimide: a protein-tyrosine kinase inhibitor with selectivity for the epidermal growth factor receptor signal transduction pathway and potent in vivo antitumor activity. Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2334-8.

    [2]. Blanchard BJ, et al. Efficient reversal of Alzheimer’s disease fibril formation and elimination of neurotoxicity by a small molecule. Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14326-32.

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适用于96孔PCR板,白色,无菌CGP-9-W-

发表于由

适用于96孔PCR板,白色,无菌

  • 产品型号：CGP-9-W-
  • 简要描述：适用于96孔PCR板,白色,无菌上海金畔生物科技有限公司供应：光度计，检测仪，免疫仪，全系荧光定量PCR耗材，移液器，钻石吸嘴，离心管，冻存管，培养皿，培养板，培养瓶，吸头，仪器及手套，色谱耗材，针头过滤器。
产品咨询在线客服
  • 产品简介

适用于96孔PCR板,白色,无菌上海金畔生物科技有限公司供应：光度计，检测仪，移液器，钻石吸嘴，离心管，冻存管，培养皿，全系荧光定量PCR耗材。

PCR 板      

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CGP-9-IMP-W- PCR板硅胶片，适用于96孔PCR板，“-”开口，白色，化学耐受型

CGP-9-IMP-WS- PCR板硅胶片，适用于96孔PCR板，“-”开口，白色，灭菌，化学耐受型

包装规格  ： 10片/袋，5袋/箱(50片/箱）

适用于96孔PCR板,白色,无菌CGP-9-W-

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温馨提示：不可用于临床治疗。

CGP77675

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CGP77675  纯度: 98.85%

CGP77675 是一种口服有效的 Src 家族激酶抑制剂。CGP77675 抑制肽底物的磷酸化和纯化 Src 的自磷酸化 (IC50 分别为 5-20 和 40 nM)，并且还抑制 Src，EGFR，KDR，v-Abl 和 Lck，IC50 分别为 20、150、1000、310 和 290 nM。具有抗肿瘤活性。

CGP77675

CGP77675 Chemical Structure

CAS No. : 234772-64-6

规格 价格 是否有货 数量
5 mg ￥5500 In-stock
10 mg ￥8250 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

CGP77675 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus

生物活性

CGP77675 is an orally active and potent inhibitor of Src family kinases. CGP77675 inhibits phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50s of 5-20 and 40 nM, respectively), and also inhibits Src, EGFR, KDR, v-Abl, and Lck with IC50s of 5-20, 40, 20, 150, 1000, 310, and 290 nM, respectively. Anticancer activity[1].

IC50 & Target

IC50: 0.02 μM (Src), 0.15 μM (EGFR), 1.0 μM (KDR), 0.31 μM (v-Abl), 0.29 μM (Lck)[1]
体外研究
(In Vitro)

CGP77675 dose dependently inhibits phosphorylation of poly-Glu-Tyr with an IC50 value of 5.5 nM, and of the optimal Src substrate (OSS) peptide with an IC50 value of 16.7 nM. These IC50 values are similar to the value obtained with chicken Src (20 nM)[1].
CGP77675 inhibits the parathyroid hormone-induced bone resorption in rat fetal long bone cultures with an IC50 of 0.8 μM[1].
CGP77675 (0.04-10 μM; 2 hours) potently inhibits tyrosine phosphorylation of the Src substrates Fak and paxillin, but has much less effect on Src (IC50 values 0.2, 0.5, and 5.7μM) in IC8.1 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MC3T3-E1 cells
Concentration: 0.2, 1, and 5 μM
Incubation Time: 3 days
Result: Did not influence cell viability for up to 3 days of treatment.

Western Blot Analysis[1]

Cell Line: Src-overexpressing IC8.1 cells
Concentration: 0.04, 0.2, 1, 5, and 10 μM
Incubation Time: 2 hours
Result: Dose dependently inhibited phosphorylation of Fak and paxillin, but not of Src.

体内研究
(In Vivo)

CGP77675 (1, 5, and 25 mg/kg; injected s.c.; twice a day) inhibits IL-1β-induced hypercalcemia in Mice[1].
CGP77675 (10 and 50 mg/kg; administered orally; twice a day for 6 weeks) partially prevents bone loss and rescues bone microarchitectural features in young ovx rats[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice (Tif:MAGf; Novartis Animal Farm) of 25-30 g body[1]
Dosage: 1, 5, and 25 mg/kg
Administration: Injected s.c.; twice a day
Result: Prevented IL-1β-induced hypercalcemia in mice without affecting serum amyloid protein levels.
Animal Model: Eight-week-old (175-209 g) female rats of the Sprague-Dawley-derived strain Tif:RAlf[1]
Dosage: 10 and 50 mg/kg
Administration: Administered orally; twice a day for 6 weeks
Result: Partly prevented bone loss.

分子量

443.54

Formula

C26H29N5O2
CAS 号

234772-64-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献

  • [1]. Missbach M, et al. A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellularsubstrates and reduces bone resorption in vitro and in rodent models in vivo. Bone. 1999 May;24(5):437-49.

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(S)-3-Hydroxy Midostaurin(Synonyms: (S)-CGP52421)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(S)-3-Hydroxy Midostaurin (Synonyms: (S)-CGP52421)

(S)-3-Hydroxy Midostaurin ((S)-CGP52421) 是一种有效的激酶抑制剂，对 VEGFR-2，TRK-A，FLT3 等 13 种激酶的 IC50 值为 <400 nM。(S)-3-Hydroxy Midostaurin 是 Midostaurin (PKC412; HY-10230) 通过肝 CYP3A4 酶代谢的次要代谢产物。(S)-3-Hydroxy Midostaurin 具有潜在的用于急性髓细胞性白血病 (AML) 的潜力。

(S)-3-Hydroxy Midostaurin(Synonyms: (S)-CGP52421)

(S)-3-Hydroxy Midostaurin Chemical Structure

CAS No. : 945260-14-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nm for 13 kinases (vegfr-2, trk-a, flt3, et). (s)-3-hydroxy midostaurin is a minor metabolite of (pkc412; hy-10230) undergoing by the hepatic cyp3a4 enzyme. has potential acute myeloid leukemia (aml)[1].

体外研究
(In Vitro)

(S)-3-Hydroxy Midostaurin ((S)-CGP52421; compound 4) has IC50 values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme[1].
The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI50=63 nM), KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

586.64

Formula

C35H30N4O5
CAS 号

945260-14-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590.

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(R)-3-Hydroxy Midostaurin(Synonyms: (R)-CGP52421)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(R)-3-Hydroxy Midostaurin (Synonyms: (R)-CGP52421)

(R)-3-Hydroxy Midostaurin ((R)-CGP52421) 是有效的激酶抑制剂。(R)-3-Hydroxy Midostaurin 是 Midostaurin (PKC412; HY-10230) 通过肝 CYP3A4 酶代谢的主要代谢产物。(R)-3-Hydroxy Midostaurin 具有潜在的用于急性髓细胞性白血病 (AML) 的潜力。

(R)-3-Hydroxy Midostaurin(Synonyms: (R)-CGP52421)

(R)-3-Hydroxy Midostaurin Chemical Structure

CAS No. : 155848-20-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].

体外研究
(In Vitro)

(R)-3-Hydroxy Midostaurin ((R)-CGP52421; compound 5) has IC50 values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme[1].
The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI50=63 nM), KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

586.64

Formula

C35H30N4O5
CAS 号

155848-20-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

(S)-3-Hydroxy Midostaurin(Synonyms: (S)-CGP52421)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(S)-3-Hydroxy Midostaurin (Synonyms: (S)-CGP52421)

(S)-3-Hydroxy Midostaurin ((S)-CGP52421) 是一种有效的激酶抑制剂，对 VEGFR-2，TRK-A，FLT3 等 13 种激酶的 IC50 值为 <400 nM。(S)-3-Hydroxy Midostaurin 是 Midostaurin (PKC412; HY-10230) 通过肝 CYP3A4 酶代谢的次要代谢产物。(S)-3-Hydroxy Midostaurin 具有潜在的用于急性髓细胞性白血病 (AML) 的潜力。

(S)-3-Hydroxy Midostaurin(Synonyms: (S)-CGP52421)

(S)-3-Hydroxy Midostaurin Chemical Structure

CAS No. : 945260-14-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nm for 13 kinases (vegfr-2, trk-a, flt3, et). (s)-3-hydroxy midostaurin is a minor metabolite of (pkc412; hy-10230) undergoing by the hepatic cyp3a4 enzyme. has potential acute myeloid leukemia (aml)[1].

体外研究
(In Vitro)

(S)-3-Hydroxy Midostaurin ((S)-CGP52421; compound 4) has IC50 values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme[1].
The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI50=63 nM), KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

586.64

Formula

C35H30N4O5
CAS 号

945260-14-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

(R)-3-Hydroxy Midostaurin(Synonyms: (R)-CGP52421)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

(R)-3-Hydroxy Midostaurin (Synonyms: (R)-CGP52421)

(R)-3-Hydroxy Midostaurin ((R)-CGP52421) 是有效的激酶抑制剂。(R)-3-Hydroxy Midostaurin 是 Midostaurin (PKC412; HY-10230) 通过肝 CYP3A4 酶代谢的主要代谢产物。(R)-3-Hydroxy Midostaurin 具有潜在的用于急性髓细胞性白血病 (AML) 的潜力。

(R)-3-Hydroxy Midostaurin(Synonyms: (R)-CGP52421)

(R)-3-Hydroxy Midostaurin Chemical Structure

CAS No. : 155848-20-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].

体外研究
(In Vitro)

(R)-3-Hydroxy Midostaurin ((R)-CGP52421; compound 5) has IC50 values in the range of 200-400 nM against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme[1].
The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ (GI50=63 nM), KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

586.64

Formula

C35H30N4O5
CAS 号

155848-20-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

PCR板硅胶片,于96孔PCR板,“-”开口,白色CGP-9-W-

发表于由

PCR板硅胶片,于96孔PCR板,“-”开口,白色

  • 产品型号：CGP-9-W-
  • 简要描述：PCR板硅胶片,于96孔PCR板,“-“开口,白色上海金畔生物科技有限公司供应：光度计，检测仪，免疫仪，全系荧光定量PCR耗材，移液器，钻石吸嘴，离心管，冻存管，培养皿，培养板，培养瓶，吸头，仪器及手套，色谱耗材，针头过滤器。
产品咨询在线客服
  • 产品简介

PCR板硅胶片,于96孔PCR板,“-”开口,白色上海金畔生物科技有限公司供应：光度计，检测仪，移液器，钻石吸嘴，离心管，冻存管，培养皿，全系荧光定量PCR耗材。

PCR 板      

CG编号   ：CGP-9-W-

产品描述  ：PCR板硅胶片，适用于96孔PCR板，“-”开口，白色

包装规格  ： 10片/袋，5袋/箱(50片/箱）

PCR板硅胶片,于96孔PCR板,“-”开口,白色相关产品推荐：

SR6190    PCR板封膜超薄透明    100张/盒    
SR6590    进口PCR板封膜超薄透明，可用于荧光定量qPCR    100张/盒    
CGP-9-W-    PCR板硅胶片，适用于96孔PCR板，“-”开口，白色    10片/袋，5袋/箱(50片/箱）    
CGP-9-WS-    PCR板硅胶片，适用于96孔PCR板，“-”开口，白色，灭菌    10片/袋，5袋/箱(50片/箱）    

细胞（组织）培养瓶，大强度贴壁 Cell Plus            
191-003108    T-25，50ml细胞培养瓶，斜口，密封盖，螺口，灭菌    10个/组，200个/箱    
191-203018    T-25，50ml细胞培养瓶，透气滤膜盖，斜口，螺口，灭菌    10个/组，200个/箱    
191-003118    T-75, 250ml细胞培养瓶，斜口，密封盖，螺口，灭菌    5个/组，100个/箱    
191-2003118    T-75, 250ml细胞培养瓶，透气滤膜盖，斜口，螺口，灭菌    5个/组，100个/箱    
191-003218    T-175, 650ml细胞培养瓶，斜口，密封盖，螺口，灭菌    5个/组，40个/箱    
191-203218    T-175, 650ml细胞培养瓶，透气滤膜盖，斜口，螺口，灭菌    5个/组，40个/箱    

23-2084-1    0.2ml 12联排PCR管+盖，凸盖，透明， 超薄壁, 非灭菌    200套/盒，10盒/箱    
23-2086    0.2mlPCR单管，薄壁，透明，平盖，非灭菌    1000支/包，10包/箱（10000支/箱）    
23-2085    0.5mlPCR单管，薄壁，透明，平盖，非灭菌    1000支/包，10包/箱（10000支/箱）    
进口PCR            
L-2081    0.2ml 8联排超薄清晰PCR管, 无DNA酶无RNA酶无热源, 无色.       125 条/包, 10包/箱    
L-2082    0.2ml 8联排管盖, 拱顶盖(凸盖), 无DNA酶无RNA酶无热源, 无色.      125 条/包 10盒/箱 (包装在L-2081 箱内)    
L-2087    0.2ml 8联排实时荧光定量PCR管,  超薄壁 无DNA酶无RNA酶无热源, 无色.     125 条/盒, 10盒/箱     
L-2088    0.2ml 8联排实时荧光定量PCR管盖, 平盖, 无DNA酶无RNA酶无热源, 无色.     125条/包，10包/箱 (包装在L-2087 箱内)    
PCR板            
23-2197N    200μl 96孔无裙边 PCR 板，透明，非灭菌    10块/袋，5袋/箱(50块/箱）    
23-35601    200μl 96孔半裙边 PCR 板，透明，非灭菌    10块/袋，5袋/箱(50块/箱）    
23-35601B    200μl 96孔半裙边 PCR 板，黑色，非灭菌    10块/袋，5袋/箱(50块/箱）    适应客户：医院检验科PCR实验室，中心实验室，肝病中心；第三方检测机构，科研院所，大专院校，制药厂，试剂生产厂家，疾控中心，检验检疫。 

 

注：主要经营地点—江浙沪！！产品其他相关详情请电询！

“-”开口硅胶片白色灭菌适用于96孔PCR板CGP-9-IMP-WS-

发表于由

“-”开口硅胶片白色灭菌适用于96孔PCR板

  • 产品型号：CGP-9-IMP-WS-
  • 简要描述：“-“开口硅胶片白色灭菌适用于96孔PCR板上海金畔生物科技有限公司供应：光度计，检测仪，免疫仪，全系荧光定量PCR耗材，移液器，钻石吸嘴，离心管，冻存管，培养皿，培养板，培养瓶，吸头，仪器及手套，色谱耗材，针头过滤器。
产品咨询在线客服
  • 产品简介

“-”开口硅胶片白色灭菌适用于96孔PCR板上海金畔生物科技有限公司供应：光度计，检测仪，移液器，钻石吸嘴，离心管，冻存管，培养皿，全系荧光定量PCR耗材。

PCR 板      

CG编号   ：CGP-9-IMP-WS-

产品描述  ：PCR板硅胶片，适用于96孔PCR板，“-”开口，白色，灭菌，化学耐受型

包装规格  ： 10片/袋，5袋/箱(50片/箱）

“-”开口硅胶片白色灭菌适用于96孔PCR板相关产品推荐：

SR6190    PCR板封膜超薄透明    100张/盒    
SR6590    进口PCR板封膜超薄透明，可用于荧光定量qPCR    100张/盒    
CGP-9-W-    PCR板硅胶片，适用于96孔PCR板，“-”开口，白色    10片/袋，5袋/箱(50片/箱）    
CGP-9-WS-    PCR板硅胶片，适用于96孔PCR板，“-”开口，白色，灭菌    10片/袋，5袋/箱(50片/箱）    

23-P002-T    0.2ML 8联排实时荧光定量PCR管+盖，平盖 无DNA/RNA酶 无热源 白色    125 条/盒, 10盒/箱     
23-2083    0.2ml 8联排PCR管+盖，凸盖，透明， 超薄壁, 非灭菌    125 套/盒, 10盒/箱 （1250套/箱）    
23-2084    0.2ml 12联排实时荧光定量PCR管+盖，透明，超薄壁, 平盖,非灭菌    200套/盒，10盒/箱    
23-2084-1    0.2ml 12联排PCR管+盖，凸盖，透明， 超薄壁, 非灭菌    200套/盒，10盒/箱    
23-2086    0.2mlPCR单管，薄壁，透明，平盖，非灭菌    1000支/包，10包/箱（10000支/箱）    
23-2085    0.5mlPCR单管，薄壁，透明，平盖，非灭菌    1000支/包，10包/箱（10000支/箱）    
进口PCR            
L-2081    0.2ml 8联排超薄清晰PCR管, 无DNA酶无RNA酶无热源, 无色.       125 条/包, 10包/箱    
L-2082    0.2ml 8联排管盖, 拱顶盖(凸盖), 无DNA酶无RNA酶无热源, 无色.      125 条/包 10盒/箱 (包装在L-2081 箱内)    
L-2087    0.2ml 8联排实时荧光定量PCR管,  超薄壁 无DNA酶无RNA酶无热源, 无色.     125 条/盒, 10盒/箱     
L-2088    0.2ml 8联排实时荧光定量PCR管盖, 平盖, 无DNA酶无RNA酶无热源, 无色.     125条/包，10包/箱 (包装在L-2087 箱内)    
PCR板            
23-2197N    200μl 96孔无裙边 PCR 板，透明，非灭菌    10块/袋，5袋/箱(50块/箱）    
23-35601    200μl 96孔半裙边 PCR 板，透明，非灭菌    10块/袋，5袋/箱(50块/箱）    
23-35601B    200μl 96孔半裙边 PCR 板，黑色，非灭菌    10块/袋，5袋/箱(50块/箱）    适应客户：医院检验科PCR实验室，中心实验室，肝病中心；第三方检测机构，科研院所，大专院校，制药厂，试剂生产厂家，疾控中心，检验检疫。 

 

注：主要经营地点—江浙沪！！产品其他相关详情请电询！

“-”开口PCR板白色硅胶片,适用于96孔PCR板CGP-9-IMP-W-

发表于由

“-”开口PCR板白色硅胶片,适用于96孔PCR板

  • 产品型号：CGP-9-IMP-W-
  • 简要描述：“-“开口PCR板白色硅胶片,适用于96孔PCR板上海金畔生物科技有限公司供应：光度计，检测仪，免疫仪，全系荧光定量PCR耗材，移液器，钻石吸嘴，离心管，冻存管，培养皿，培养板，培养瓶，吸头，仪器及手套，色谱耗材，针头过滤器。
产品咨询在线客服
  • 产品简介

“-”开口PCR板白色硅胶片,适用于96孔PCR板上海金畔生物科技有限公司供应：光度计，检测仪，移液器，钻石吸嘴，离心管，冻存管，培养皿，全系荧光定量PCR耗材。

PCR 板      

CG编号   ：CGP-9-IMP-W-

产品描述  ：PCR板硅胶片，适用于96孔PCR板，“-”开口，白色，化学耐受型

包装规格  ： 10片/袋，5袋/箱(50片/箱）

“-”开口PCR板白色硅胶片,适用于96孔PCR板相关产品推荐：

SR6190    PCR板封膜超薄透明    100张/盒    
SR6590    进口PCR板封膜超薄透明，可用于荧光定量qPCR    100张/盒    
CGP-9-W-    PCR板硅胶片，适用于96孔PCR板，“-”开口，白色    10片/袋，5袋/箱(50片/箱）    
CGP-9-WS-    PCR板硅胶片，适用于96孔PCR板，“-”开口，白色，灭菌    10片/袋，5袋/箱(50片/箱）    

货号    产品名称    颜色    包装规格    单位    
单管                    
V101-C    0.1ml PCR平盖单管    透明    1000个/盒，10盒/箱    盒    
VB201-C    0.2ml PCR平盖带托架单管    透明    1000个/盒，10盒/箱    盒    
V201-C    0.2ml PCR平盖单管    透明    1000个/盒，10盒/箱    盒    
V221-C    0.2ml PCR凸盖单管    透明    1000个/盒，10盒/箱    盒    
V-UCS    荧光定量PCR光学封板膜    高透明    10张/包    包    
辅助器                    
V-96AD    Roche 480辅助器    棕色    1块/包    块    96孔板                    

VP1011-C    0.1ml 无裙边96孔PCR板    透明    10块/盒，20盒/箱    盒    
VP1011-M    0.1ml 无裙边96孔PCR板    乳白色    10块/盒，20盒/箱    盒    
VP1021-C    0.1ml半裙边96孔PCR板    透明    10块/盒，20盒/箱    盒    
VP1031-C    0.1ml全裙边96孔PCR板    透明    10块/盒，20盒/箱    盒    
VP2001-C    0.2ml 无裙边96孔PCR板    透明    10块/盒，20盒/箱    盒    
VP2011-C    0.2ml 半裙边96孔PCR板    透明    10块/盒，20盒/箱    盒    
VP2021-C    0.2ml 半裙边96孔PCR板    透明    10块/盒，20盒/箱    盒    
VP2031-C    0.2ml 无裙边96孔上凸PCR板    透明    10块/盒，20盒/箱    盒    
V4801-M    Roche48096孔PCR板    乳白色    10块/盒，20盒/箱    盒    
V4802-M    Roche9696孔PCR板    乳白色    10块/盒，20盒/箱    盒    
V3841-M    40ul全裙边384孔PCR板    透明加白色    10块/盒，20盒/箱    盒    

适应客户：医院检验科PCR实验室，中心实验室，肝病中心；第三方检测机构，科研院所，大专院校，制药厂，试剂生产厂家，疾控中心，检验检疫。 

 

注：主要经营地点—江浙沪！！产品其他相关详情请电询！

CGP78850

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CGP78850 

CGP78850 是 Grb2 SH2-phosphopeptide 相互作用的有力和选择性竞争者。CGP78850可用于癌症研究。

CGP78850

CGP78850 Chemical Structure

CAS No. : 258326-83-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer[1].

IC50 & Target

Grb2 SH2-phosphopeptide[1]
体外研究
(In Vitro)

CGP78850 (0~100 μM; 90 minutes; MDA-MB-468 cells) reduces the amount of associated Grb2 protein in a dose-dependent manner[1].
CGP78850 blocks epidermal growth factor receptor (EGFR)-Grb2 and Shc-Grb2 interaction in living cells. CGP78850 inhibits MDA-MB-468 cells to form colonies in soft agar in a dose-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0~100 μM
Incubation Time: 90 minutes
Result: Reduced the amount of associated Grb2 protein in a dose-dependent manner.

分子量

723.75

Formula

C36H46N5O9P
CAS 号

258326-83-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gay B, et al. Selective GRB2 SH2 inhibitors as anti-Ras therapy. Int J Cancer. 1999;83(2):235-241.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CGP78850

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CGP78850 

CGP78850 是 Grb2 SH2-phosphopeptide 相互作用的有力和选择性竞争者。CGP78850可用于癌症研究。

CGP78850

CGP78850 Chemical Structure

CAS No. : 258326-83-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer[1].

IC50 & Target

Grb2 SH2-phosphopeptide[1]
体外研究
(In Vitro)

CGP78850 (0~100 μM; 90 minutes; MDA-MB-468 cells) reduces the amount of associated Grb2 protein in a dose-dependent manner[1].
CGP78850 blocks epidermal growth factor receptor (EGFR)-Grb2 and Shc-Grb2 interaction in living cells. CGP78850 inhibits MDA-MB-468 cells to form colonies in soft agar in a dose-dependent manner[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0~100 μM
Incubation Time: 90 minutes
Result: Reduced the amount of associated Grb2 protein in a dose-dependent manner.

分子量

723.75

Formula

C36H46N5O9P
CAS 号

258326-83-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gay B, et al. Selective GRB2 SH2 inhibitors as anti-Ras therapy. Int J Cancer. 1999;83(2):235-241.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CGP78850

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CGP78850 

CGP78850 是 Grb2 SH2-phosphopeptide 相互作用的有力和选择性竞争者。CGP78850可用于癌症研究。

CGP78850

CGP78850 Chemical Structure

CAS No. : 258326-83-9

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

CGP78850 is a potent and selective competitor of Grb2 SH2-phosphopeptide interactions. CGP78850 can be used for the research of cancer[1].

IC50 & Target

Grb2 SH2-phosphopeptide[1]
体外研究
(In Vitro)

CGP78850 (0~100 μM; 90 minutes; MDA-MB-468 cells) reduces the amount of associated Grb2 protein in a dose-dependent manner[1].
CGP78850 blocks epidermal growth factor receptor (EGFR)-Grb2 and Shc-Grb2 interaction in living cells. CGP78850 inhibits MDA-MB-468 cells to form colonies in soft agar in a dose-dependent manner[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0~100 μM
Incubation Time: 90 minutes
Result: Reduced the amount of associated Grb2 protein in a dose-dependent manner.

分子量

723.75

Formula

C36H46N5O9P
CAS 号

258326-83-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gay B, et al. Selective GRB2 SH2 inhibitors as anti-Ras therapy. Int J Cancer. 1999;83(2):235-241.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CGP77675 hydrate

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CGP77675 hydrate 

CGP77675 hydrate 是一种口服有效的 Src 家族激酶抑制剂。CGP77675 hydrate 抑制肽底物的磷酸化和纯化 Src 的自磷酸化 (IC50 分别为 5-20 和 40 nM)，并且还抑制 Src，EGFR，KDR，v-Abl 和 Lck，IC50 分别为 0.02、0.15、1.0、0.31 和 0.29 μM。具有抗肿瘤活性。

CGP77675 hydrate

CGP77675 hydrate Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

CGP77675 hydrate 的其他形式现货产品:

CGP77675

生物活性

CGP77675 hydrate is an orally active and potent inhibitor of Src family kinases. CGP77675 hydrate inhibits phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50s of 5-20 and 40 nM, respectively),and also inhibits Src, EGFR, KDR, v-Abl, and Lck with IC50s of 0.02, 0.15, 1.0, 0.31, and 0.29 μM, respectively. Anticancer activity[1].

IC50 & Target

IC50: 0.02 μM (Src), 0.15 μM (EGFR), 1.0 μM (KDR), 0.31 μM (v-Abl), 0.29 μM (Lck)[1]
体外研究
(In Vitro)

CGP77675 hydrate dose dependently inhibits phosphorylation of poly-Glu-Tyr with an IC50 value of 5.5 nM, and of the optimal Src substrate (OSS) peptide with an IC50 value of 16.7 nM. These IC50 values are similar to the value obtained with chicken Src (20 nM)[1].
CGP77675 hydrate inhibits the parathyroid hormone-induced bone resorption in rat fetal long bone cultures with an IC50 of 0.8 μM[1].
CGP77675 hydrate (0.04-10 μM; 2 hours) potently inhibits tyrosine phosphorylation of the Src substrates Fak and paxillin, but has much less effect on Src (IC50 values 0.2, 0.5, and 5.7μM) in IC8.1 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MC3T3-E1 cells
Concentration: 0.2, 1, and 5 μM
Incubation Time: 3 days
Result: Did not influence cell viability for up to 3 days of treatment.

Western Blot Analysis[1]

Cell Line: Src-overexpressing IC8.1 cells
Concentration: 0.04, 0.2, 1, 5, and 10 μM
Incubation Time: 2 hours
Result: Dose dependently inhibited phosphorylation of Fak and paxillin, but not of Src.

体内研究
(In Vivo)

CGP77675 hydrate (1, 5, and 25 mg/kg; injected s.c.; twice a day) inhibits IL-1β-induced hypercalcemia in Mice[1].
CGP77675 hydrate (10 and 50 mg/kg; administered orally; twice a day for 6 weeks) partially prevents bone loss and rescues bone microarchitectural features in young ovx rats[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice (Tif:MAGf; Novartis Animal Farm) of 25-30 g body[1]
Dosage: 1, 5, and 25 mg/kg
Administration: Injected s.c.; twice a day
Result: Prevented IL-1β-induced hypercalcemia in mice without affecting serum amyloid protein levels.
Animal Model: Eight-week-old (175-209 g) female rats of the Sprague-Dawley-derived strain Tif:RAlf[1]
Dosage: 10 and 50 mg/kg
Administration: Administered orally; twice a day for 6 weeks
Result: Partly prevented bone loss.

Formula

C26H29N5O2.xH2O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Missbach M, et al. A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellularsubstrates and reduces bone resorption in vitro and in rodent models in vivo. Bone. 1999 May;24(5):437-49.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CGP77675 hydrate

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CGP77675 hydrate 

CGP77675 hydrate 是一种口服有效的 Src 家族激酶抑制剂。CGP77675 hydrate 抑制肽底物的磷酸化和纯化 Src 的自磷酸化 (IC50 分别为 5-20 和 40 nM)，并且还抑制 Src，EGFR，KDR，v-Abl 和 Lck，IC50 分别为 0.02、0.15、1.0、0.31 和 0.29 μM。具有抗肿瘤活性。

CGP77675 hydrate

CGP77675 hydrate Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

CGP77675 hydrate 的其他形式现货产品:

CGP77675

生物活性

CGP77675 hydrate is an orally active and potent inhibitor of Src family kinases. CGP77675 hydrate inhibits phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50s of 5-20 and 40 nM, respectively),and also inhibits Src, EGFR, KDR, v-Abl, and Lck with IC50s of 0.02, 0.15, 1.0, 0.31, and 0.29 μM, respectively. Anticancer activity[1].

IC50 & Target

IC50: 0.02 μM (Src), 0.15 μM (EGFR), 1.0 μM (KDR), 0.31 μM (v-Abl), 0.29 μM (Lck)[1]
体外研究
(In Vitro)

CGP77675 hydrate dose dependently inhibits phosphorylation of poly-Glu-Tyr with an IC50 value of 5.5 nM, and of the optimal Src substrate (OSS) peptide with an IC50 value of 16.7 nM. These IC50 values are similar to the value obtained with chicken Src (20 nM)[1].
CGP77675 hydrate inhibits the parathyroid hormone-induced bone resorption in rat fetal long bone cultures with an IC50 of 0.8 μM[1].
CGP77675 hydrate (0.04-10 μM; 2 hours) potently inhibits tyrosine phosphorylation of the Src substrates Fak and paxillin, but has much less effect on Src (IC50 values 0.2, 0.5, and 5.7μM) in IC8.1 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MC3T3-E1 cells
Concentration: 0.2, 1, and 5 μM
Incubation Time: 3 days
Result: Did not influence cell viability for up to 3 days of treatment.

Western Blot Analysis[1]

Cell Line: Src-overexpressing IC8.1 cells
Concentration: 0.04, 0.2, 1, 5, and 10 μM
Incubation Time: 2 hours
Result: Dose dependently inhibited phosphorylation of Fak and paxillin, but not of Src.

体内研究
(In Vivo)

CGP77675 hydrate (1, 5, and 25 mg/kg; injected s.c.; twice a day) inhibits IL-1β-induced hypercalcemia in Mice[1].
CGP77675 hydrate (10 and 50 mg/kg; administered orally; twice a day for 6 weeks) partially prevents bone loss and rescues bone microarchitectural features in young ovx rats[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice (Tif:MAGf; Novartis Animal Farm) of 25-30 g body[1]
Dosage: 1, 5, and 25 mg/kg
Administration: Injected s.c.; twice a day
Result: Prevented IL-1β-induced hypercalcemia in mice without affecting serum amyloid protein levels.
Animal Model: Eight-week-old (175-209 g) female rats of the Sprague-Dawley-derived strain Tif:RAlf[1]
Dosage: 10 and 50 mg/kg
Administration: Administered orally; twice a day for 6 weeks
Result: Partly prevented bone loss.

Formula

C26H29N5O2.xH2O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Missbach M, et al. A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellularsubstrates and reduces bone resorption in vitro and in rodent models in vivo. Bone. 1999 May;24(5):437-49.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CGP77675 hydrate

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CGP77675 hydrate 

CGP77675 hydrate 是一种口服有效的 Src 家族激酶抑制剂。CGP77675 hydrate 抑制肽底物的磷酸化和纯化 Src 的自磷酸化 (IC50 分别为 5-20 和 40 nM)，并且还抑制 Src，EGFR，KDR，v-Abl 和 Lck，IC50 分别为 0.02、0.15、1.0、0.31 和 0.29 μM。具有抗肿瘤活性。

CGP77675 hydrate

CGP77675 hydrate Chemical Structure

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

CGP77675 hydrate 的其他形式现货产品:

CGP77675

生物活性

CGP77675 hydrate is an orally active and potent inhibitor of Src family kinases. CGP77675 hydrate inhibits phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50s of 5-20 and 40 nM, respectively),and also inhibits Src, EGFR, KDR, v-Abl, and Lck with IC50s of 0.02, 0.15, 1.0, 0.31, and 0.29 μM, respectively. Anticancer activity[1].

IC50 & Target

IC50: 0.02 μM (Src), 0.15 μM (EGFR), 1.0 μM (KDR), 0.31 μM (v-Abl), 0.29 μM (Lck)[1]
体外研究
(In Vitro)

CGP77675 hydrate dose dependently inhibits phosphorylation of poly-Glu-Tyr with an IC50 value of 5.5 nM, and of the optimal Src substrate (OSS) peptide with an IC50 value of 16.7 nM. These IC50 values are similar to the value obtained with chicken Src (20 nM)[1].
CGP77675 hydrate inhibits the parathyroid hormone-induced bone resorption in rat fetal long bone cultures with an IC50 of 0.8 μM[1].
CGP77675 hydrate (0.04-10 μM; 2 hours) potently inhibits tyrosine phosphorylation of the Src substrates Fak and paxillin, but has much less effect on Src (IC50 values 0.2, 0.5, and 5.7μM) in IC8.1 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MC3T3-E1 cells
Concentration: 0.2, 1, and 5 μM
Incubation Time: 3 days
Result: Did not influence cell viability for up to 3 days of treatment.

Western Blot Analysis[1]

Cell Line: Src-overexpressing IC8.1 cells
Concentration: 0.04, 0.2, 1, 5, and 10 μM
Incubation Time: 2 hours
Result: Dose dependently inhibited phosphorylation of Fak and paxillin, but not of Src.

体内研究
(In Vivo)

CGP77675 hydrate (1, 5, and 25 mg/kg; injected s.c.; twice a day) inhibits IL-1β-induced hypercalcemia in Mice[1].
CGP77675 hydrate (10 and 50 mg/kg; administered orally; twice a day for 6 weeks) partially prevents bone loss and rescues bone microarchitectural features in young ovx rats[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice (Tif:MAGf; Novartis Animal Farm) of 25-30 g body[1]
Dosage: 1, 5, and 25 mg/kg
Administration: Injected s.c.; twice a day
Result: Prevented IL-1β-induced hypercalcemia in mice without affecting serum amyloid protein levels.
Animal Model: Eight-week-old (175-209 g) female rats of the Sprague-Dawley-derived strain Tif:RAlf[1]
Dosage: 10 and 50 mg/kg
Administration: Administered orally; twice a day for 6 weeks
Result: Partly prevented bone loss.

Formula

C26H29N5O2.xH2O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Missbach M, et al. A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellularsubstrates and reduces bone resorption in vitro and in rodent models in vivo. Bone. 1999 May;24(5):437-49.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CGP-82996(Synonyms: CINK4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CGP-82996 (Synonyms: CINK4)

GP-82996 (CINK4) 是 CDK4/6 的药理学抑制剂。GP-82996 对 CDK4/cyclin D1、CDK6/cyclin D1 和 Cdk5/p35 的 IC50s 分别为 1.5、5.6 和 25 μM。GP-82996 诱导肿瘤细胞 U2OS 的凋亡 (apoptosis)。GP-82996可用于癌症研究。

CGP-82996(Synonyms: CINK4)

CGP-82996 Chemical Structure

CAS No. : 359886-84-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer[1][2].

IC50 & Target[1]

Cdk4/cyclin D1

1.5 μM (IC50)

CDK6/cyclinD1

5.6 μM (IC50)

CDK5/p35

25 μM (IC50)

CDK2/cyclinA

>50 μM (IC50)

CDK1/cyclinB

>100 μM (IC50)

CDK2/cyclin E

>50 μM (IC50)

CDK4/cyclin D2

>50 μM (IC50)

Cdk6/cyclin D2

>50 μM (IC50)

V-abl

>10 μM (IC50)

c-met

>10 μM (IC50)

IGF-1R

>10 μM (IC50)

Insulin-R

>10 μM (IC50)

体外研究
(In Vitro)

GP-82996 (5, 10 μM; 24 hours) induces G1 arrest and G0-G1/S ratio increase in U2OS (p16 negative) and MRC-5 (p16 positive) cells[1].
GP-82996 (5, 10 μM; 24 hours) reduces hyperphosphorylation of pRb, but has no changes in the levels of CDK4 in U2OS, MRC-5 cells[1].
GP-82996 (5, 10 μM; 48 hours) induces aooptosis in 83% of U2OS cells in concentration of 10μM[1].
GP-82996 (0.1-40 μM; 24,48, 72 hours) inhibits the cell proliferation of A549, H358, SKLU-1, H23, PC14 cells with IC50 values of 72 h are 4-7 μM[2].
GP-82996 (3, 5, 10 μM; 48 hours) induces G1 arrest in A549 and H23 cells[2].
GP-82996 ((1, 3, 5, 10 μM; 72 hours) enhances Paclitaxel sensitivity in KRAS mutation-bearing lung cancer cells (A549, SKLU-1, H23 cells) [2].
GP-82996 (10 μM; 72 hours) combined with Paclitaxel (3 nM; 72 hours) increases the apoptosis of A549 and H23 cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

GP-82996 (30 mg/kg, i.p. for 29 days) shows smaller final tumor volume compared with vehicle control in mouse xenograft models[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 19-21 g female BALB/c nu/nu mice xenograft model (HCT116 tumors volume=100 mm3)[1]
Dosage: 30 mg/kg
Administration: i.p. every 12 hours for 29 days
Result: Showed smaller final tumor volume compared with vehicle control in mouse xenograft models.

分子量

456.58

Formula

C27H32N6O
CAS 号

359886-84-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vivo:
  • 1.

    5% DMSO, 0.05% Tween 80, and 95% physiologic saline
参考文献

  • [1]. Soni R, et al. Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. J Natl Cancer Inst. 2001 Mar 21;93(6):436-46.

    [2]. Zhang XH, et al. A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS. Cancer Biol Ther. 2013;14(7):597-605.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CGP-82996(Synonyms: CINK4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CGP-82996 (Synonyms: CINK4)

GP-82996 (CINK4) 是 CDK4/6 的药理学抑制剂。GP-82996 对 CDK4/cyclin D1、CDK6/cyclin D1 和 Cdk5/p35 的 IC50s 分别为 1.5、5.6 和 25 μM。GP-82996 诱导肿瘤细胞 U2OS 的凋亡 (apoptosis)。GP-82996可用于癌症研究。

CGP-82996(Synonyms: CINK4)

CGP-82996 Chemical Structure

CAS No. : 359886-84-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer[1][2].

IC50 & Target[1]

Cdk4/cyclin D1

1.5 μM (IC50)

CDK6/cyclinD1

5.6 μM (IC50)

CDK5/p35

25 μM (IC50)

CDK2/cyclinA

>50 μM (IC50)

CDK1/cyclinB

>100 μM (IC50)

CDK2/cyclin E

>50 μM (IC50)

CDK4/cyclin D2

>50 μM (IC50)

Cdk6/cyclin D2

>50 μM (IC50)

V-abl

>10 μM (IC50)

c-met

>10 μM (IC50)

IGF-1R

>10 μM (IC50)

Insulin-R

>10 μM (IC50)

体外研究
(In Vitro)

GP-82996 (5, 10 μM; 24 hours) induces G1 arrest and G0-G1/S ratio increase in U2OS (p16 negative) and MRC-5 (p16 positive) cells[1].
GP-82996 (5, 10 μM; 24 hours) reduces hyperphosphorylation of pRb, but has no changes in the levels of CDK4 in U2OS, MRC-5 cells[1].
GP-82996 (5, 10 μM; 48 hours) induces aooptosis in 83% of U2OS cells in concentration of 10μM[1].
GP-82996 (0.1-40 μM; 24,48, 72 hours) inhibits the cell proliferation of A549, H358, SKLU-1, H23, PC14 cells with IC50 values of 72 h are 4-7 μM[2].
GP-82996 (3, 5, 10 μM; 48 hours) induces G1 arrest in A549 and H23 cells[2].
GP-82996 ((1, 3, 5, 10 μM; 72 hours) enhances Paclitaxel sensitivity in KRAS mutation-bearing lung cancer cells (A549, SKLU-1, H23 cells) [2].
GP-82996 (10 μM; 72 hours) combined with Paclitaxel (3 nM; 72 hours) increases the apoptosis of A549 and H23 cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

GP-82996 (30 mg/kg, i.p. for 29 days) shows smaller final tumor volume compared with vehicle control in mouse xenograft models[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 19-21 g female BALB/c nu/nu mice xenograft model (HCT116 tumors volume=100 mm3)[1]
Dosage: 30 mg/kg
Administration: i.p. every 12 hours for 29 days
Result: Showed smaller final tumor volume compared with vehicle control in mouse xenograft models.

分子量

456.58

Formula

C27H32N6O
CAS 号

359886-84-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vivo:
  • 1.

    5% DMSO, 0.05% Tween 80, and 95% physiologic saline
参考文献

  • [1]. Soni R, et al. Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. J Natl Cancer Inst. 2001 Mar 21;93(6):436-46.

    [2]. Zhang XH, et al. A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS. Cancer Biol Ther. 2013;14(7):597-605.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

CGP-82996(Synonyms: CINK4)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

CGP-82996 (Synonyms: CINK4)

GP-82996 (CINK4) 是 CDK4/6 的药理学抑制剂。GP-82996 对 CDK4/cyclin D1、CDK6/cyclin D1 和 Cdk5/p35 的 IC50s 分别为 1.5、5.6 和 25 μM。GP-82996 诱导肿瘤细胞 U2OS 的凋亡 (apoptosis)。GP-82996可用于癌症研究。

CGP-82996(Synonyms: CINK4)

CGP-82996 Chemical Structure

CAS No. : 359886-84-3

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

GP-82996 (CINK4) is a pharmacological inhibitor of CDK4/6. GP-82996 has IC50s of 1.5, 5.6 and 25 μM for CDK4/cyclin D1, CDK6/cyclin D1 and Cdk5/p35, respectively. GP-82996 induces the apoptosis of cancer cells U2OS. GP-82996 can be used in the research of cancer[1][2].

IC50 & Target[1]

Cdk4/cyclin D1

1.5 μM (IC50)

CDK6/cyclinD1

5.6 μM (IC50)

CDK5/p35

25 μM (IC50)

CDK2/cyclinA

>50 μM (IC50)

CDK1/cyclinB

>100 μM (IC50)

CDK2/cyclin E

>50 μM (IC50)

CDK4/cyclin D2

>50 μM (IC50)

Cdk6/cyclin D2

>50 μM (IC50)

V-abl

>10 μM (IC50)

c-met

>10 μM (IC50)

IGF-1R

>10 μM (IC50)

Insulin-R

>10 μM (IC50)

体外研究
(In Vitro)

GP-82996 (5, 10 μM; 24 hours) induces G1 arrest and G0-G1/S ratio increase in U2OS (p16 negative) and MRC-5 (p16 positive) cells[1].
GP-82996 (5, 10 μM; 24 hours) reduces hyperphosphorylation of pRb, but has no changes in the levels of CDK4 in U2OS, MRC-5 cells[1].
GP-82996 (5, 10 μM; 48 hours) induces aooptosis in 83% of U2OS cells in concentration of 10μM[1].
GP-82996 (0.1-40 μM; 24,48, 72 hours) inhibits the cell proliferation of A549, H358, SKLU-1, H23, PC14 cells with IC50 values of 72 h are 4-7 μM[2].
GP-82996 (3, 5, 10 μM; 48 hours) induces G1 arrest in A549 and H23 cells[2].
GP-82996 ((1, 3, 5, 10 μM; 72 hours) enhances Paclitaxel sensitivity in KRAS mutation-bearing lung cancer cells (A549, SKLU-1, H23 cells) [2].
GP-82996 (10 μM; 72 hours) combined with Paclitaxel (3 nM; 72 hours) increases the apoptosis of A549 and H23 cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

GP-82996 (30 mg/kg, i.p. for 29 days) shows smaller final tumor volume compared with vehicle control in mouse xenograft models[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 19-21 g female BALB/c nu/nu mice xenograft model (HCT116 tumors volume=100 mm3)[1]
Dosage: 30 mg/kg
Administration: i.p. every 12 hours for 29 days
Result: Showed smaller final tumor volume compared with vehicle control in mouse xenograft models.

分子量

456.58

Formula

C27H32N6O
CAS 号

359886-84-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
In Vivo:
  • 1.

    5% DMSO, 0.05% Tween 80, and 95% physiologic saline
参考文献

  • [1]. Soni R, et al. Selective in vivo and in vitro effects of a small molecule inhibitor of cyclin-dependent kinase 4. J Natl Cancer Inst. 2001 Mar 21;93(6):436-46.

    [2]. Zhang XH, et al. A CDK4/6 inhibitor enhances cytotoxicity of paclitaxel in lung adenocarcinoma cells harboring mutant KRAS as well as wild-type KRAS. Cancer Biol Ther. 2013;14(7):597-605.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Imatinib carbaldehyde(Synonyms: CGP-57148B carbaldehyde; STI571 carbaldehyde; PROTAC ABL binding moiety 1)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Imatinib carbaldehyde (Synonyms: CGP-57148B carbaldehyde; STI571 carbaldehyde; PROTAC ABL binding moiety 1)

Imatinib carbaldehyde (CGP-57148B carbaldehyde) 是一种基于 Imatinib (ABL抑制剂) 的 moiety，可通过 linker 与 IAP 配体结合从而形成 SNIPER 分子。

Imatinib carbaldehyde(Synonyms: CGP-57148B carbaldehyde; STI571 carbaldehyde; PROTAC ABL binding moiety 1)

Imatinib carbaldehyde Chemical Structure

CAS No. : 1436868-85-7

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生物活性

Imatinib carbaldehyde (CGP-57148B carbaldehyde), the Imatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER[1].

分子量

507.59

Formula

C29H29N7O2
CAS 号

1436868-85-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务