上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
NTA PEG Cholesterol
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- SDS
- DataSheet
NTA PEG Cholesterol Cat. No. PG2-CSNT-3k 3400 Da 25 mg修饰性聚乙二醇
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标签归档：cholesterol
Cholesterol PEG aldehyde, CLS-PEG-CHO Cat. No. PG2-ALCS-5k 5000 Da 50 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG aldehyde, CLS-PEG-CHO
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Description:
Nanocs Cholesterol PEG aldehyde is a lipid PEG derivative with amine reactive aldehyde group. Aldeyde PEG is a common N-terminal amine group pegylation reagent. The reaction between aldehyde group with the α-amine at the N-terminus produces an intermediate Schiff base. Further reduction with hydride will form a stable C-N bond. PEG aldehydes react with n-terminus amine groups at a pH of from 5.0 to 9.5. Higher pH will result in multiple Pegylation with both terminal and lysine groups.
Physical Properties:
- Off-white/white solid;
- Soluble in warm water, DMSO, DMF;
Storage Conditions:
- Store at -20 0C
Reaction Procedures:
Generally, a 5- to 10-fold molar excess of PEG aldehyde over the amount of amine-containing material results in sufficient conjugation.
Materials Required:
- Pegylation buffer: Amine-free aqueous buffer, pH 5.0~6.5.
- PEG aldehyde stock solution: 50 mg in 1 mL conjugation buffer.
- Washing solution: Distilled water or any aqueous buffer.
Reaction Steps:
Dissolve targeted materials in pegylation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add PEG aldehyde stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. Allow mixture agitates at room temperature for 2~4 hrs at room temperature or overnight 4 0C. After reaction, C=N bond can be reduced by sodium borohydride. Conjugate can be purified either by size exclusion chromatography or dialysis.
- SDS
- DataSheet
Cholesterol PEG aldehyde, CLS-PEG-CHO Cat. No. PG2-ALCS-3k 3400 Da 50 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG aldehyde, CLS-PEG-CHO
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Description:
Nanocs Cholesterol PEG aldehyde is a lipid PEG derivative with amine reactive aldehyde group. Aldeyde PEG is a common N-terminal amine group pegylation reagent. The reaction between aldehyde group with the α-amine at the N-terminus produces an intermediate Schiff base. Further reduction with hydride will form a stable C-N bond. PEG aldehydes react with n-terminus amine groups at a pH of from 5.0 to 9.5. Higher pH will result in multiple Pegylation with both terminal and lysine groups.
Physical Properties:
- Off-white/white solid;
- Soluble in warm water, DMSO, DMF;
Storage Conditions:
- Store at -20 0C
Reaction Procedures:
Generally, a 5- to 10-fold molar excess of PEG aldehyde over the amount of amine-containing material results in sufficient conjugation.
Materials Required:
- Pegylation buffer: Amine-free aqueous buffer, pH 5.0~6.5.
- PEG aldehyde stock solution: 50 mg in 1 mL conjugation buffer.
- Washing solution: Distilled water or any aqueous buffer.
Reaction Steps:
Dissolve targeted materials in pegylation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add PEG aldehyde stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. Allow mixture agitates at room temperature for 2~4 hrs at room temperature or overnight 4 0C. After reaction, C=N bond can be reduced by sodium borohydride. Conjugate can be purified either by size exclusion chromatography or dialysis.
- SDS
- DataSheet
Cholesterol PEG aldehyde, CLS-PEG-CHO Cat. No. PG2-ALCS-2k 2000 Da 50 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG aldehyde, CLS-PEG-CHO
|
Description:
Nanocs Cholesterol PEG aldehyde is a lipid PEG derivative with amine reactive aldehyde group. Aldeyde PEG is a common N-terminal amine group pegylation reagent. The reaction between aldehyde group with the α-amine at the N-terminus produces an intermediate Schiff base. Further reduction with hydride will form a stable C-N bond. PEG aldehydes react with n-terminus amine groups at a pH of from 5.0 to 9.5. Higher pH will result in multiple Pegylation with both terminal and lysine groups.
Physical Properties:
- Off-white/white solid;
- Soluble in warm water, DMSO, DMF;
Storage Conditions:
- Store at -20 0C
Reaction Procedures:
Generally, a 5- to 10-fold molar excess of PEG aldehyde over the amount of amine-containing material results in sufficient conjugation.
Materials Required:
- Pegylation buffer: Amine-free aqueous buffer, pH 5.0~6.5.
- PEG aldehyde stock solution: 50 mg in 1 mL conjugation buffer.
- Washing solution: Distilled water or any aqueous buffer.
Reaction Steps:
Dissolve targeted materials in pegylation buffer. Estimate the concentration of primary amine groups on the targeted materials. Add PEG aldehyde stock solution to the targeted conjugation materials with the final concentration keep at least 10 mg/mL. Allow mixture agitates at room temperature for 2~4 hrs at room temperature or overnight 4 0C. After reaction, C=N bond can be reduced by sodium borohydride. Conjugate can be purified either by size exclusion chromatography or dialysis.
- SDS
- DataSheet
Cholesterol PEG Thiol, CLS-PEG-SH Cat. No. PG2-CSTH-3k 3400 Da 100 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG Thiol, CLS-PEG-SH
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Description:
Cholesterol functionalized polyethylene glycol, PEG CLS is a lipophilic lipid PEG conjugate with good water solubility. PEG cholesterol derivatives can be used to make liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents.
Physical Properties:
- Oragne/yellow solid or viscous liquid depends on molecule weight;
- Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
- Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
- SDS
- DataSheet
Cholesterol PEG Azide, CLS-PEG-N3 Cat. No. PG2-AZCS-3k 3400 Da 100 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG Azide, CLS-PEG-N3
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Description:
Cholesterol functionalized polyethylene glycol, PEG CLS is a lipophilic lipid PEG conjugate with good water solubility. PEG cholesterol derivatives can be used to make liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents.
Physical Properties:
- Off-white/white solid or viscous liquid depends on molecule weight;
- Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
- Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
- SDS
- DataSheet
Cholesterol PEG DBCO, CLS-PEG-DBCO Cat. No. PG2-CSDB-5k 5000 Da 50 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG DBCO, CLS-PEG-DBCO
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Cholesterol PEG DBCO Description:
Cholesterol and DBCO functionalized polyethylene glycol, DBCO PEG Cholesterol is a reactive, lipophilic cholesterol PEG that can be used to react with azide groups in aqueous solution through so called copper free Click chemistry. Cholesterol DBCO PEG conjugate have good water solubility and excellent reactivity. PEG cholesterol derivatives can be used to make liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents.
Physical Properties:
- Off-white/white solid or viscous liquid depends on molecule weight;
- Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
- Store at -20 0C, desiccate. Protect from light. Avoid frequent thaw and freeze.
- SDS
- DataSheet
Cholesterol PEG DBCO, CLS-PEG-DBCO Cat. No. PG2-CSDB-3k 3400 Da 50 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG DBCO, CLS-PEG-DBCO
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Cholesterol PEG DBCO Description:
Cholesterol and DBCO functionalized polyethylene glycol, DBCO PEG Cholesterol is a reactive, lipophilic cholesterol PEG that can be used to react with azide groups in aqueous solution through so called copper free Click chemistry. Cholesterol DBCO PEG conjugate have good water solubility and excellent reactivity. PEG cholesterol derivatives can be used to make liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents.
Physical Properties:
- Off-white/white solid or viscous liquid depends on molecule weight;
- Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
- Store at -20 0C, desiccate. Protect from light. Avoid frequent thaw and freeze.
- SDS
- DataSheet
Cholesterol PEG Folic acid Cat. No. PG2-CSFA-2k 2000 Da 25 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG Folic acid
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Synonym: Cholesterol PEG2000 Folic acid, Cholesteryl PEG2000 Folate, Folic acid PEG2000 Cholesterol, Folate PEG2000 Cholesterol, Cholesteryl PEG Folic acid
Cholesterol PEG Folic acid, also called cholesterol PEG folate, is one of Nanocs cholesterol lipid PEG derivatives that can be used for folate receptor targeting. Folic acid is also known as vitamin M, vitamin B9 or pteroyl-L-glutamic acid. Folic acid is an essential bioactive molecule for numerous biological functions. It participates in the synthesis, repairing and methylation of DNA as well as to act as a cofactor in many biological reactions. Cholesterol is an essential lipid component that forms cell membrane. Folic acid functionalized PEG cholesterol is lipophilic and it can dissolved both in organic solvents and aqueous solution. Cholesterol PEG Folate has high affinity towards folate receptor. This material has been used for targeted liposome drug delivery.
Product specifications:
- Appearance (color): Yellow/orange;
- Appearance (form): Solid;
- PEG chain length: PEG2000, 45 PEG units;
- Solubility: Soluble in warm water; DMSO; DMF.
- Purity: >95%
Storage Conditions:
- Store at -20 0C. Desiccate. Protect from light.
References:
- Click here to see hundreds publications using Nanocs PEGs
| PG2-DSFA-2k , Folic acid PEG DSPE, DSPE-PEG-Folate |
Cholesterol PEG Maleimide, CLS-PEG-Mal Cat. No. PG2-CSML-5k 5000 Da 25 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG Maleimide, CLS-PEG-Mal
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Description:
Cholesterol functionalized polyethylene glycol, PEG CLS is a lipophilic lipid PEG conjugate with good water solubility. PEG cholesterol derivatives can be used to make liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents.
Physical Properties:
- Off-white/white solid or viscous liquid depends on molecule weight;
- Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
- Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
- SDS
- DataSheet
Cholesterol PEG Maleimide, CLS-PEG-Mal Cat. No. PG2-CSML-3k 3400 Da 25 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG Maleimide, CLS-PEG-Mal
|
Description:
Cholesterol functionalized polyethylene glycol, PEG CLS is a lipophilic lipid PEG conjugate with good water solubility. PEG cholesterol derivatives can be used to make liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents.
Physical Properties:
- Off-white/white solid or viscous liquid depends on molecule weight;
- Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
- Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
- SDS
- DataSheet
Cholesterol PEG Maleimide, CLS-PEG-Mal Cat. No. PG2-CSML-2k 2000 Da 25 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG Maleimide, CLS-PEG-Mal
|
Description:
Cholesterol functionalized polyethylene glycol, PEG CLS is a lipophilic lipid PEG conjugate with good water solubility. PEG cholesterol derivatives can be used to make liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents.
Physical Properties:
- Off-white/white solid or viscous liquid depends on molecule weight;
- Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
- Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
- SDS
- DataSheet
Cholesterol PEG Maleimide, CLS-PEG-Mal Cat. No. PG2-CSML-10k 10000 Da 25 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG Maleimide, CLS-PEG-Mal
|
Description:
Cholesterol functionalized polyethylene glycol, PEG CLS is a lipophilic lipid PEG conjugate with good water solubility. PEG cholesterol derivatives can be used to make liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents.
Physical Properties:
- Off-white/white solid or viscous liquid depends on molecule weight;
- Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
- Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
- SDS
- DataSheet
Cholesterol PEG PDP, PDP-PEG-Cholesterol Cat. No. PG2-CSPD-3k 3400 Da 25 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG PDP, PDP-PEG-Cholesterol
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Cholesterol myristate(Synonyms: 胆固醇肉豆蔻酸; Cholesteryl myristate; Cholesteryl tetradecanoate)
上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
Cholesterol myristate (Synonyms: 胆固醇肉豆蔻酸; Cholesteryl myristate; Cholesteryl tetradecanoate) 纯度: ≥98.0%
Cholesterol myristate 是中药中天然类固醇。Cholesterol myristate 与多种离子通道结合，例如 nAChR，GABAA receptor 和内向整流钾离子通道 (potassium ion channel)。
Cholesterol myristate Chemical Structure
CAS No. : 1989-52-2
| 规格 | 价格 | 是否有货 | 数量 |
|---|---|---|---|
| Free Sample (0.1-0.5 mg) | Apply now | ||
| 250 mg | ￥600 | In-stock | |
| 500 mg | 询价 | ||
| 1 g | 询价 |
* Please select Quantity before adding items.
Cholesterol myristate 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
| 生物活性 |
Cholesterol myristate is a natural steroid present in traditional Chinese medicine. Cholesterol myristate binds to several ion channels such as the nicotinic acetylcholine receptor, GABAA receptor, and the inward-rectifier potassium ion channel. |
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| IC50 & Target |
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| 体外研究 (In Vitro) |
Mesenchymal stem cells (MSCs) transfected by the Id1 promoter reporter construct, cholesterol myristate increases the activity of Id1 promoter. Cholesterol myristate inhibits the apoptosis of MSCs induced by serum-free. Cholesterol myristate increases the expression of Id1 and its target gene bcl-x/l in MSCs treated with serum-free. Moreover, noggin, a BMP antagonist, reduces the anti-apoptotic effects of cholesterol myristate[1]. Cholesterol myristate inhibits the apoptosis of PC12 cells induced in serum-free condition. Cholesterol myristate significantly increases the expression of BMP4, BMPRIA, p-Smad1/5/8, Id1 and its antiapoptotic target gene Bcl-xL in PC12 cells treated in serum-free condition[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
597.01 |
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| Formula |
C41H72O2 |
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| CAS 号 |
1989-52-2 |
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| 中文名称 |
胆固醇肉豆蔻酸 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
Ethanol : 3.33 mg/mL (5.58 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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| 参考文献 |
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| Cell Assay [1] |
MSCs are cultured with or without serum in 96-well plates and treated with cholesterol myristate in various concentrations (0, 30 and 300 μg/mL) for 3 days. Each sample is repeated in five independent wells and is incubated for 72 h. After incubation, 20 μL MTT (5 mg/mL) is added and the culture is incubated for a further 4 h. The culture medium is discarded and replaced with 150 μL DMSO. The absorbance at 490nm is measured[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 参考文献 |
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Cholesterol succinate Cat. No. CSL01 100 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol succinate
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Cholesterol NHS Cat. No. CSL02 25 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol NHS
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Cholesterol PEG acid, CLS-PEG-COOH Cat. No. PG2-CACS-5k 5000 Da 100 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG acid, CLS-PEG-COOH
|
Description:
Cholesterol functionalized polyethylene glycol, PEG CLS is a lipophilic lipid PEG conjugate with good water solubility. PEG cholesterol derivatives can be used to make liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents.
Physical Properties:
- Off-white/white solid or viscous liquid depends on molecule weight;
- Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
- Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
- SDS
- DataSheet
Cholesterol PEG acid, CLS-PEG-COOH Cat. No. PG2-CACS-3k 3400 Da 100 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG acid, CLS-PEG-COOH
|
Description:
Cholesterol functionalized polyethylene glycol, PEG CLS is a lipophilic lipid PEG conjugate with good water solubility. PEG cholesterol derivatives can be used to make liposome to improve circulation time for encapsulated drugs. They may also be used for non-viral transfection reagents.
Physical Properties:
- Off-white/white solid or viscous liquid depends on molecule weight;
- Soluble in regular aqeous solution as well as most organic solvents;
Storage Conditions:
- Store at -20 0C, dessiccated Protect from light. Avoid frequent thaw and freeze.
- SDS
- DataSheet
Cholesterol PEG hydrazide Cat. No. PG2-CSHZ-3k 3400 Da 25 mg修饰性聚乙二醇
上海金畔生物科技有限公司提供各种分子量和基团修饰性聚乙二醇定制服务。
Cholesterol PEG hydrazide
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- SDS
- DataSheet