Enalapril(Synonyms: 依那普利; MK-421)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。

Enalapril (Synonyms: 依那普利; MK-421)

Enalapril (MK-421) 是一种血管紧张素转换酶 (ACE) 抑制剂,可用于高血压疾病的研究。

Enalapril(Synonyms: 依那普利; MK-421)

Enalapril Chemical Structure

CAS No. : 75847-73-3

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Enalapril 的其他形式现货产品:

Enalapril maleate

生物活性

Enalapril (MK-421) is an angiotensin-converting enzyme (ACE) inhibitor, can be used for hypertensive diseases research[1][2].

体外研究
(In Vitro)

Enalapril (10-20 μM) has an antiarrhythmic effect in ultrafiltered PV sleeve preparation isolated from canine hearts which can inhibit EAD and DAD-induced activity[1].
Enalapril (50 μM, 24 hours) inhibits the induction of apoptosis by patient serum only when used prior to treatment of HUVEC with Alzheimer’s disease (AD) serum[2].
Pure Enalapril has better thermal stability than pure Enalapril[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: Human umbilical vein ECs (HUVECs)
Concentration: 50 μM
Incubation Time: 24 hours
Result: Inhibited the induction of apoptosis by patient serum.

体内研究
(In Vivo)

Enalapril (intraperitoneal injection, 0.03 mg/kg, once, 1 hour) reduces infarct volume due to middle cerebral artery occlusion and lower or higher doses are ineffective in Male NMRI mice[4].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NMRI mice 20-40 g[4]
Dosage: 0.03 mg/kg
Administration: Intraperitoneal injection; once; 1 hour
Result: Reduced the area of middle cerebral artery infarction in mice at 0.03 mg/kg.

Clinical Trial

分子量

376.45

Formula

C20H28N2O5

CAS 号

75847-73-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Serge Sicouri, et al. Antiarrhythmic effects of losartan and enalapril in canine pulmonary vein sleeve preparations. J Cardiovasc Electrophysiol. 2011 Jun;22(6):698-705.

    [2]. Rokhsareh Meamar, et al. Enalapril protects endothelial cells against induced apoptosis in Alzheimer’s disease. J Res Med Sci. 2013 Mar;18(Suppl 1):S1-5.

    [3]. Talita A Cunha, et al. Effect of stearic acid on enalapril stability and dissolution from multiparticulate solid dosage forms. AAPS PharmSciTech. 2013 Sep;14(3):1150-7.

    [4]. A Ravati, et al. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. Eur J Pharmacol. 1999 May 28;373(1):21-33.

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