标签归档：erythro

D-erythro-Sphingosine-d7(Synonyms: Erythrosphingosine-d7; erythro-C18-Sphingosine-d7; trans-4-Sphingenine-d7)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

D-erythro-Sphingosine-d7 (Synonyms: Erythrosphingosine-d7; erythro-C18-Sphingosine-d7; trans-4-Sphingenine-d7)

D-erythro-Sphingosine-d7 (Erythrosphingosine-d7) 是 D-erythro-Sphingosine 的氘代物。D-erythro-Sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶活化剂，EC50 为 8 μM。D-erythro-Sphingosine 抑制蛋白激酶 C (PKC)。D-erythro-Sphingosine (Erythrosphi

D-erythro-Sphingosine-d7(Synonyms: Erythrosphingosine-d7; erythro-C18-Sphingosine-d7; trans-4-Sphingenine-d7)

D-erythro-Sphingosine-d7 Chemical Structure

CAS No. : 1246304-34-6

规格 是否有货
500 μg 询价

* Please select Quantity before adding items.

生物活性

D-erythro-Sphingosine-d7 (Erythrosphingosine-d7) is the deuterium labeled D-erythro-Sphingosine. D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

306.54

Formula

C18H30D7NO2
CAS 号

1246304-34-6
中文名称

D-赤式鞘氨醇 d7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Pushkareva MYu, et al. Regulation of sphingosine-activated protein kinases: selectivity of activation by sphingoid basesand inhibition by non-esterified fatty acids. Biochem J. 1993 Sep 15;294 ( Pt 3):699-703.

    [3]. Khan WA, et al. Protein kinase C and platelet inhibition by D-erythro-Sphingosine: comparison with N,N-dimethylsphingosine and commercial preparation. Biochem Biophys Res Commun. 1990 Oct 30;172(2):683-91.

    [4]. Pham VT, et al. A concise synthesis of a promising protein kinase C inhibitor: D-erythro-Sphingosine. Arch Pharm Res. 2007 Jan;30(1):22-7.

    [5]. Cheng P, et al. Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS. J Neurol Sci. 2015 Dec 15;359(1-2):48-56.

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D-Erythro-dihydrosphingosine

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

D-Erythro-dihydrosphingosine 

D-Erythro-dihydrosphingosin 直接抑制细胞溶质中的磷脂酶 A2α (cPLA2α) 活性。

D-Erythro-dihydrosphingosine

D-Erythro-dihydrosphingosine Chemical Structure

CAS No. : 764-22-7

规格 价格 是否有货
5 mg ￥1400 询问价格 & 货期
10 mg ￥2400 询问价格 & 货期
25 mg ￥4600 询问价格 & 货期
50 mg ￥7700 询问价格 & 货期

* Please select Quantity before adding items.

D-Erythro-dihydrosphingosine 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Human Endogenous Metabolite Compound Library
  • Lipid Compound Library
  • Lipid Metabolism Compound Library
  • Food-Sourced Compound Library

生物活性

D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

D-Erythro-dihydrosphingosine (D-erythro-DHS) significantly inhibits mastoparan-, but not Na3VO4-, stimulated arachidonic acid release in PC12 cells. D-Erythro-dihydrosphingosine at 100 AM slightly inhibits [3H]Arachidonic acid release, and 5 μM Ionomycin alone stimulates the release significantly. In the presence of 5 μM Ionomycin, 100 μM C2-ceramide stimulates the release, but D-Erythro-dihydrosphingosine (100 μM) inhibits the release. D-Erythro-dihydrosphingosine inhibits arachidonic acid release in cells and/or cPLA2α activity[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

301.51

Formula

C18H39NO2
CAS 号

764-22-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

DMSO : 10 mg/mL (33.17 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3166 mL 16.5832 mL 33.1664 mL
5 mM 0.6633 mL 3.3166 mL 6.6333 mL
10 mM 0.3317 mL 1.6583 mL 3.3166 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1 mg/mL (3.32 mM); Clear solution

    此方案可获得 ≥ 1 mg/mL (3.32 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (3.32 mM); Clear solution

    此方案可获得 ≥ 1 mg/mL (3.32 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (3.32 mM); Clear solution

    此方案可获得 ≥ 1 mg/mL (3.32 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 上海金畔生物科技有限公司 网站选购。
参考文献

  • [1]. Nakamura H, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

D-erythro-MAPP(Synonyms: D-e-MAPP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

D-erythro-MAPP (Synonyms: D-e-MAPP)

D-erythro-MAPP (D-e-MAPP) 是神经酰胺酶的抑制剂，其在体外的 IC50 值为 1-5 μM。

D-erythro-MAPP(Synonyms: D-e-MAPP)

D-erythro-MAPP Chemical Structure

CAS No. : 143492-38-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro[1].

体外研究
(In Vitro)

D-erythro-MAPP (D-e-MAPP) reduces the viability of MCF-7 cells in a dose-dependent manner with IC50 value of 4.4 μM, and 15.6 μM, respectively[1].
D-erythro-MAPP (D-e-MAPP) induces G0/G1 arrest in cell cycle progression resulting in growth suppression[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human breast cancer MCF-7 cells.
Concentration: 24 h.
Incubation Time: 3.13-100 μM.
Result: Inhibited cell viability.

分子量

361.56

Formula

C23H39NO2
CAS 号

143492-38-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hüseyin İzgördü, et al. Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor. Cytotechnology. 2020 Dec;72(6):907-919.

    [2]. A Bielawska, et al. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem. 1996 May 24;271(21):12646-54.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

D-erythro-MAPP(Synonyms: D-e-MAPP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

D-erythro-MAPP (Synonyms: D-e-MAPP)

D-erythro-MAPP (D-e-MAPP) 是神经酰胺酶的抑制剂，其在体外的 IC50 值为 1-5 μM。

D-erythro-MAPP(Synonyms: D-e-MAPP)

D-erythro-MAPP Chemical Structure

CAS No. : 143492-38-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro[1].

体外研究
(In Vitro)

D-erythro-MAPP (D-e-MAPP) reduces the viability of MCF-7 cells in a dose-dependent manner with IC50 value of 4.4 μM, and 15.6 μM, respectively[1].
D-erythro-MAPP (D-e-MAPP) induces G0/G1 arrest in cell cycle progression resulting in growth suppression[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human breast cancer MCF-7 cells.
Concentration: 24 h.
Incubation Time: 3.13-100 μM.
Result: Inhibited cell viability.

分子量

361.56

Formula

C23H39NO2
CAS 号

143492-38-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hüseyin İzgördü, et al. Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor. Cytotechnology. 2020 Dec;72(6):907-919.

    [2]. A Bielawska, et al. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem. 1996 May 24;271(21):12646-54.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

D-erythro-MAPP(Synonyms: D-e-MAPP)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

D-erythro-MAPP (Synonyms: D-e-MAPP)

D-erythro-MAPP (D-e-MAPP) 是神经酰胺酶的抑制剂，其在体外的 IC50 值为 1-5 μM。

D-erythro-MAPP(Synonyms: D-e-MAPP)

D-erythro-MAPP Chemical Structure

CAS No. : 143492-38-0

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

D-erythro-MAPP (D-e-MAPP) is a ceramidase inhibitor, with an IC50 of 1-5 μM in vitro[1].

体外研究
(In Vitro)

D-erythro-MAPP (D-e-MAPP) reduces the viability of MCF-7 cells in a dose-dependent manner with IC50 value of 4.4 μM, and 15.6 μM, respectively[1].
D-erythro-MAPP (D-e-MAPP) induces G0/G1 arrest in cell cycle progression resulting in growth suppression[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Human breast cancer MCF-7 cells.
Concentration: 24 h.
Incubation Time: 3.13-100 μM.
Result: Inhibited cell viability.

分子量

361.56

Formula

C23H39NO2
CAS 号

143492-38-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hüseyin İzgördü, et al. Characteristics of apoptosis induction in human breast cancer cells treated with a ceramidase inhibitor. Cytotechnology. 2020 Dec;72(6):907-919.

    [2]. A Bielawska, et al. (1S,2R)-D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase. J Biol Chem. 1996 May 24;271(21):12646-54.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

D-Erythro-dihydrosphingosine-d7

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

D-Erythro-dihydrosphingosine-d7 

D-Erythro-dihydrosphingosine-d7 是 D-Erythro-dihydrosphingosine 的氘代物。D-Erythro-dihydrosphingosin 直接抑制细胞溶质中的磷脂酶 A2α (cPLA2α) 活性。

D-Erythro-dihydrosphingosine-d7

D-Erythro-dihydrosphingosine-d7 Chemical Structure

CAS No. : 1246304-35-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

D-Erythro-dihydrosphingosine-d7 is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

308.55

Formula

C18H32D7NO2
CAS 号

1246304-35-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Nakamura H, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

D-Erythro-dihydrosphingosine-d7

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

D-Erythro-dihydrosphingosine-d7 

D-Erythro-dihydrosphingosine-d7 是 D-Erythro-dihydrosphingosine 的氘代物。D-Erythro-dihydrosphingosin 直接抑制细胞溶质中的磷脂酶 A2α (cPLA2α) 活性。

D-Erythro-dihydrosphingosine-d7

D-Erythro-dihydrosphingosine-d7 Chemical Structure

CAS No. : 1246304-35-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

D-Erythro-dihydrosphingosine-d7 is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

308.55

Formula

C18H32D7NO2
CAS 号

1246304-35-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Nakamura H, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

D-Erythro-dihydrosphingosine-d7

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

D-Erythro-dihydrosphingosine-d7 

D-Erythro-dihydrosphingosine-d7 是 D-Erythro-dihydrosphingosine 的氘代物。D-Erythro-dihydrosphingosin 直接抑制细胞溶质中的磷脂酶 A2α (cPLA2α) 活性。

D-Erythro-dihydrosphingosine-d7

D-Erythro-dihydrosphingosine-d7 Chemical Structure

CAS No. : 1246304-35-7

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

生物活性

D-Erythro-dihydrosphingosine-d7 is the deuterium labeled D-Erythro-dihydrosphingosine. D-Erythro-dihydrosphingosin directly inhibits cytosolic phospholipase A2α (cPLA2α) activity.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

308.55

Formula

C18H32D7NO2
CAS 号

1246304-35-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Nakamura H, et al. Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine. Eur J Pharmacol. 2004 Jan 19;484(1):9-17.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sphinganine 1-phosphate(Synonyms: D-erythro-Dihydrosphingosine 1-phosphate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sphinganine 1-phosphate (Synonyms: D-erythro-Dihydrosphingosine 1-phosphate)

Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) 是一种极性鞘脂代谢物，可调节细胞迁移、细胞分化等众多生理过程。

Sphinganine 1-phosphate(Synonyms: D-erythro-Dihydrosphingosine 1-phosphate)

Sphinganine 1-phosphate Chemical Structure

CAS No. : 19794-97-9

规格 价格 是否有货
1 mg ￥3500 询问价格 & 货期
5 mg ￥10800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes[1].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Sphinganine 1-phosphate (S1P) is a potent signaling molecule involved in cell stress responses, cancer, angiogenesis and lymphocyte trafficking. Sphinganine 1-phosphate functions primarily by activating a subgroup of the endothelial differentiation gene (EDG) family of G-protein coupled cell surface receptors. Sphinganine 1-phosphate has opposite effects in the regulation of cell metabolism. Sphinganine 1-phosphate regulates skeletal muscle differentiation and regeneration[1].
Sphinganine 1-phosphate (S1P) is involved in cancer. Sphinganine 1-phosphate regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival[1].
Sphinganine-1-Phosphate (1 μM) phosphorylates ERK MAPK, Akt, and HSP27 and induces HSP27 in human renal endothelial cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Human renal endothelial cells or human kidney proximal tubule (HK-2) cells
Concentration: 1 μM
Incubation Time: 2 or 4 hours
Result: Induced HSP27 mRNA in cultured human renal endothelial cells.
Phosphorylated ERK MAPK and AKT in human renal endothelial cells in a time-dependent manner.
Phosphorylated and induced HSP27.

体内研究
(In Vivo)

Sphinganine 1-phosphate can enhance wound healing in diabetic mice[1]. Sphinganine 1-phosphate provides renal and hepatic protection after liver ischemia and reperfusion (IR) injury in mice through selective activation of S1P1 receptors and pertussis toxin-sensitive G-proteins with subsequent activation of ERK and Akt. Sphinganine 1-phosphate (administered 0.1 mg/kg i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion) protects against hepatic and renal injury after liver IR[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (20-25 g)[2]
Dosage: 0.1 mg/kg
Administration: Administered i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion
Result: The plasma level of alanine aminotransferase (ALT) and Creatinine (Cr) was 80±6 U/L and 0.46±0.05 mg/dL, respectively.
The increases in ALT (7474±557 U/L) and Cr (0.55±0.05 mg/dL) were significantly suppressed at 24 h after reperfusion in mice treated with 0.1 mg/kg i.v. before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion.

分子量

381.49

Formula

C18H40NO5P
CAS 号

19794-97-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Montserrat Serra, et al. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzyme Regul. 2010;50(1):349-62.

    [2]. Sang Won Park, et al. Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. Lab Invest. 2010 Aug;90(8):1209-24.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sphinganine 1-phosphate(Synonyms: D-erythro-Dihydrosphingosine 1-phosphate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sphinganine 1-phosphate (Synonyms: D-erythro-Dihydrosphingosine 1-phosphate)

Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) 是一种极性鞘脂代谢物，可调节细胞迁移、细胞分化等众多生理过程。

Sphinganine 1-phosphate(Synonyms: D-erythro-Dihydrosphingosine 1-phosphate)

Sphinganine 1-phosphate Chemical Structure

CAS No. : 19794-97-9

规格 价格 是否有货
1 mg ￥3500 询问价格 & 货期
5 mg ￥10800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes[1].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Sphinganine 1-phosphate (S1P) is a potent signaling molecule involved in cell stress responses, cancer, angiogenesis and lymphocyte trafficking. Sphinganine 1-phosphate functions primarily by activating a subgroup of the endothelial differentiation gene (EDG) family of G-protein coupled cell surface receptors. Sphinganine 1-phosphate has opposite effects in the regulation of cell metabolism. Sphinganine 1-phosphate regulates skeletal muscle differentiation and regeneration[1].
Sphinganine 1-phosphate (S1P) is involved in cancer. Sphinganine 1-phosphate regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival[1].
Sphinganine-1-Phosphate (1 μM) phosphorylates ERK MAPK, Akt, and HSP27 and induces HSP27 in human renal endothelial cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Human renal endothelial cells or human kidney proximal tubule (HK-2) cells
Concentration: 1 μM
Incubation Time: 2 or 4 hours
Result: Induced HSP27 mRNA in cultured human renal endothelial cells.
Phosphorylated ERK MAPK and AKT in human renal endothelial cells in a time-dependent manner.
Phosphorylated and induced HSP27.

体内研究
(In Vivo)

Sphinganine 1-phosphate can enhance wound healing in diabetic mice[1]. Sphinganine 1-phosphate provides renal and hepatic protection after liver ischemia and reperfusion (IR) injury in mice through selective activation of S1P1 receptors and pertussis toxin-sensitive G-proteins with subsequent activation of ERK and Akt. Sphinganine 1-phosphate (administered 0.1 mg/kg i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion) protects against hepatic and renal injury after liver IR[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (20-25 g)[2]
Dosage: 0.1 mg/kg
Administration: Administered i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion
Result: The plasma level of alanine aminotransferase (ALT) and Creatinine (Cr) was 80±6 U/L and 0.46±0.05 mg/dL, respectively.
The increases in ALT (7474±557 U/L) and Cr (0.55±0.05 mg/dL) were significantly suppressed at 24 h after reperfusion in mice treated with 0.1 mg/kg i.v. before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion.

分子量

381.49

Formula

C18H40NO5P
CAS 号

19794-97-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Montserrat Serra, et al. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzyme Regul. 2010;50(1):349-62.

    [2]. Sang Won Park, et al. Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. Lab Invest. 2010 Aug;90(8):1209-24.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Sphinganine 1-phosphate(Synonyms: D-erythro-Dihydrosphingosine 1-phosphate)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Sphinganine 1-phosphate (Synonyms: D-erythro-Dihydrosphingosine 1-phosphate)

Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) 是一种极性鞘脂代谢物，可调节细胞迁移、细胞分化等众多生理过程。

Sphinganine 1-phosphate(Synonyms: D-erythro-Dihydrosphingosine 1-phosphate)

Sphinganine 1-phosphate Chemical Structure

CAS No. : 19794-97-9

规格 价格 是否有货
1 mg ￥3500 询问价格 & 货期
5 mg ￥10800 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes[1].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Sphinganine 1-phosphate (S1P) is a potent signaling molecule involved in cell stress responses, cancer, angiogenesis and lymphocyte trafficking. Sphinganine 1-phosphate functions primarily by activating a subgroup of the endothelial differentiation gene (EDG) family of G-protein coupled cell surface receptors. Sphinganine 1-phosphate has opposite effects in the regulation of cell metabolism. Sphinganine 1-phosphate regulates skeletal muscle differentiation and regeneration[1].
Sphinganine 1-phosphate (S1P) is involved in cancer. Sphinganine 1-phosphate regulates processes such as inflammation, which can drive tumorigenesis; neovascularization, which provides cancer cells with nutrients and oxygen; and cell growth and survival[1].
Sphinganine-1-Phosphate (1 μM) phosphorylates ERK MAPK, Akt, and HSP27 and induces HSP27 in human renal endothelial cells[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Human renal endothelial cells or human kidney proximal tubule (HK-2) cells
Concentration: 1 μM
Incubation Time: 2 or 4 hours
Result: Induced HSP27 mRNA in cultured human renal endothelial cells.
Phosphorylated ERK MAPK and AKT in human renal endothelial cells in a time-dependent manner.
Phosphorylated and induced HSP27.

体内研究
(In Vivo)

Sphinganine 1-phosphate can enhance wound healing in diabetic mice[1]. Sphinganine 1-phosphate provides renal and hepatic protection after liver ischemia and reperfusion (IR) injury in mice through selective activation of S1P1 receptors and pertussis toxin-sensitive G-proteins with subsequent activation of ERK and Akt. Sphinganine 1-phosphate (administered 0.1 mg/kg i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion) protects against hepatic and renal injury after liver IR[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (20-25 g)[2]
Dosage: 0.1 mg/kg
Administration: Administered i.v. immediately before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion
Result: The plasma level of alanine aminotransferase (ALT) and Creatinine (Cr) was 80±6 U/L and 0.46±0.05 mg/dL, respectively.
The increases in ALT (7474±557 U/L) and Cr (0.55±0.05 mg/dL) were significantly suppressed at 24 h after reperfusion in mice treated with 0.1 mg/kg i.v. before reperfusion and 0.2 mg/kg s.c. 2 h after reperfusion.

分子量

381.49

Formula

C18H40NO5P
CAS 号

19794-97-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Montserrat Serra, et al. Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. Adv Enzyme Regul. 2010;50(1):349-62.

    [2]. Sang Won Park, et al. Sphinganine-1-phosphate protects kidney and liver after hepatic ischemia and reperfusion in mice through S1P1 receptor activation. Lab Invest. 2010 Aug;90(8):1209-24.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

erythro-Guaiacylglycerol β-coniferyl ether

发表于由
erythro-Guaiacylglycerol β-coniferyl ether

  【编号】：SPR00915

  【产品名称】：erythro-Guaiacylglycerol β-coniferyl ether

  【规格】：10mg

  【用途】：

　　erythro-Guaiacylglycerol β-coniferyl ether对照品

　　编号：SPR00915
　　英文名称：erythro-Guaiacylglycerol β-coniferyl ether
　　CAS No.：890317-92-7
　　分 子 式：C20H24O7
　　分 子 量：376.405
　　类别：上海金畔生物科技有限公司，天然提取物
　　作为标准品，对照品或者供研究用，不能直接用于人体。

erythro-Guaiacylglycerol-β-O-4′-dehydrodisinapyl ether

发表于由
erythro-Guaiacylglycerol-β-O-4′-dehydrodisinapyl ether

  【编号】：SPR03750

  【产品名称】：erythro-Guaiacylglycerol-β-O-4′-dehydrodisinapyl ether

  【规格】：10mg

  【用途】：

　　erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether对照品

　　编号：SPR03750
　　英文名称：erythro-Guaiacylglycerol-β-O-4'-dehydrodisinapyl ether
　　CAS No.：613684-55-2
　　分 子 式：C31H36O11
　　分 子 量：584.618
　　类别：上海金畔生物科技有限公司，天然提取物
　　作为标准品，对照品或者供研究用，不能直接用于人体。

erythro-Guaiacylglycerol β-sinapyl ether

发表于由
erythro-Guaiacylglycerol β-sinapyl ether

  【编号】：SPR03227

  【产品名称】：erythro-Guaiacylglycerol β-sinapyl ether

  【规格】：10mg

  【用途】：

　　erythro-Guaiacylglycerol β-sinapyl ether对照品

　　编号：SPR03227
　　英文名称：erythro-Guaiacylglycerol β-sinapyl ether
　　CAS No.：877875-96-2
　　分 子 式：C21H26O8
　　分 子 量：406.431
　　类别：上海金畔生物科技有限公司，天然提取物
　　作为标准品，对照品或者供研究用，不能直接用于人体。

erythro-1-Phenylpropane-1,2-diol

发表于由
erythro-1-Phenylpropane-1,2-diol

  【编号】：SPR03215

  【产品名称】：erythro-1-Phenylpropane-1,2-diol

  【规格】：10mg

  【用途】：

　　erythro-1-Phenylpropane-1,2-diol对照品

　　编号：SPR03215
　　英文名称：erythro-1-Phenylpropane-1,2-diol
　　CAS No.：40421-52-1
　　分 子 式：C9H12O2
　　分 子 量：152.193
　　类别：上海金畔生物科技有限公司，天然提取物
　　作为标准品，对照品或者供研究用，不能直接用于人体。

erythro-Guaiacylglycerol对照品

发表于由
erythro-Guaiacylglycerol对照品

  【编号】：SPR01670

  【产品名称】：erythro-Guaiacylglycerol对照品

  【规格】：10mg

  【用途】：

　　erythro-Guaiacylglycerol对照品

　　编号：SPR01670
　　英文名称：erythro-Guaiacylglycerol
　　CAS No.：38916-91-5
　　分 子 式：C10H14O5
　　分 子 量：214.217
　　类别：上海金畔生物科技有限公司，天然提取物
　　作为标准品，对照品或者供研究用，不能直接用于人体。

erythro-1-(4-Hydroxyphenyl)propane-1,2,3-triol_25743-67-3

发表于由
erythro-1-(4-Hydroxyphenyl)propane-1,2,3-triol

  【编号】：VIP(XL)05784

  【产品名称】：erythro-1-(4-Hydroxyphenyl)propane-1,2,3-triol

  【规格】：5mg

  【用途】：

　　erythro-1-(4-Hydroxyphenyl)propane-1,2,3-triol对照品

　　编号：VIP(XL)05784
　　英文：erythro-1-(4-Hydroxyphenyl)propane-1,2,3-triol
　　CAS号：25743-67-3
　　分子式：C9H12O4
erythro-1-(4-Hydroxyphenyl)propane-1,2,3-triol_25743-67-3
　　规格：可定做：10mg；25mg；50mg；100mg
　　声明：此对照品、标准品由上海金畔生物科技有限公司提供网站查询购买服务
　　注：点击cas，或者搜索：名称、编号、cas均可查询产品信息

D-erythro-Sphingosine(Synonyms: 鞘氨醇; Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

D-erythro-Sphingosine (Synonyms: 鞘氨醇; Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine) 纯度: ≥98.0%

D-erythro-Sphingosine (Erythrosphingosine) 是一种非常有效的 p32 激酶活化剂，EC50 为 8 μM。D-erythro-Sphingosine 抑制蛋白激酶 C (PKC)。D-erythro-Sphingosine (Erythrosphingosine) 也是一种 PP2A 激活剂。

D-erythro-Sphingosine(Synonyms: 鞘氨醇; Erythrosphingosine; erythro-C18-Sphingosine; trans-4-Sphingenine)

D-erythro-Sphingosine Chemical Structure

CAS No. : 123-78-4

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥715 In-stock
10 mg ￥650 In-stock
25 mg ￥1100 In-stock
50 mg ￥1800 In-stock
100 mg ￥2600 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

D-erythro-Sphingosine 相关产品

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生物活性

D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator[1][2][3][4].

IC50 & Target

PKC

 

Human Endogenous Metabolite

 

p32

8 μM (EC50)

PP2A

 

体外研究
(In Vitro)

A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines[1]. D-erythro-Sphingosine inhibits protein kinase C in vitro[2]. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

299.49

Formula

C18H37NO2
CAS 号

123-78-4
中文名称

D-赤式鞘氨醇；D-赤型神经胺；D-鞘氨醇；鞘氨醇；D-神经鞘氨醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 50 mg/mL (166.95 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.3390 mL 16.6950 mL 33.3901 mL
5 mM 0.6678 mL 3.3390 mL 6.6780 mL
10 mM 0.3339 mL 1.6695 mL 3.3390 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.35 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.35 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂： 10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.35 mM); Clear solution

    此方案可获得 ≥ 2.5 mg/mL (8.35 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

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参考文献

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